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The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects

Peter Kochunov, Paul M. Thompson, Anderson Winkler, Mary Morrissey, Mao Fu, Thomas R. Coyle, Xiaoming Du, Florian Muellerklein, Anya Savransky, Christopher Gaudiot, Hemalatha Sampath, George Eskandar (+8 others)
2016 NeuroImage  
Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP).  ...  To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations.  ...  Acknowledgments We are grateful of the Amish families who have supported this research. This research was supported by NIH grants U01MH108148, R01EB015611, R01DA027680 and R01MH085646.  ... 
doi:10.1016/j.neuroimage.2015.10.050 pmid:26499807 pmcid:PMC4691385 fatcat:jdf424leijdmpnjfzc5heos46u

Genetics of structural connectivity and information processing in the brain

Sudheer Giddaluru, Thomas Espeseth, Alireza Salami, Lars T. Westlye, Anders Lundquist, Andrea Christoforou, Sven Cichon, Rolf Adolfsson, Vidar M. Steen, Ivar Reinvang, Lars Göran Nilsson, Stéphanie Le Hellard (+1 others)
2016 Brain Structure and Function  
These findings provide novel data on the genetics of WM pathways and processing speed, and highlight a role of ZFPM2 and CSMD1 in information processing in the brain.  ...  Here, we present results from genomewide association studies (GWASs) of whole-brain white matter (WM) fractional anisotropy (FA), an index of microstructural coherence measured using diffusion tensor imaging  ...  RHF (Grant 911554) to SLH, grants from the Bergen Research Foundation and the University of Bergen to SLH, grants from the Dr Einar Martens Fund and the K.G.  ... 
doi:10.1007/s00429-016-1194-0 pmid:26852023 pmcid:PMC5102980 fatcat:w64t5xqedvgkfdu5t5juwr7nvu

ACNP 58th Annual Meeting: Poster Session III

2019 Neuropsychopharmacology  
Pain symptoms were assessed by items from the Symptom Checklist-90-R (SCL-90-R) querying headache, chest pain, muscle soreness, and low back pain over the past 7 days.  ...  The ABC-DS, a novel assessment tool for AD is an effective tool in assessing symptoms and the severity of AD over time.  ...  The Old Order Amish and Mennonite (OOA/M) population is a founder population that is an ideal cohort to explore genetic contribution to disease due to relative genetic uniformity and large, well-documented  ... 
doi:10.1038/s41386-019-0547-9 pmid:31801974 pmcid:PMC6957926 fatcat:dd7d43ysfvc5bbbstfl73szya4

ACNP 57th Annual Meeting: Poster Session III

2018 Neuropsychopharmacology  
There is growing evidence that the biological mechanisms of depression significantly overlap with those observed during the aging process, leading to an acceleration of brain and systemic aging in depressed  ...  SASP biomarkers were derived from proteomic panel measured by multiplex immunoassay, and the SASP index was derived the regression analysis from a previously published study.  ...  Neuroimaging data from 36 patients and 33 healthy participants were preprocessed using the Human Connectome Project preprocessing pipeline and analyzed in grayordinate space.  ... 
doi:10.1038/s41386-018-0268-5 fatcat:wiooxnisvfhovadauljiso4ie4

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
catalyzes proteins from the ECM.  ...  Our prediction model provides insight in the role several risk factors may play in the development of symptoms over time. Abstract not included. M11.  ...  Methods: Our sample included 326 Old Order Amish/Old Order Mennonite individuals (110 participants with psychiatric disorders and 216 controls).  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334