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The clinical relevance of distortion correction in presurgical fMRI at 7 T

Pedro Lima Cardoso, Barbara Dymerska, Beáta Bachratá, Florian Ph.S. Fischmeister, Nina Mahr, Eva Matt, Siegfried Trattnig, Roland Beisteiner, Simon Daniel Robinson
2018 NeuroImage  
Distortion correction is shown to be effective and clinically relevant in presurgical planning at 7 T.  ...  We evaluate the effectiveness of a dynamic distortion correction (DDC) method based on unmodified singleecho EPI in the context of simulated presurgical planning fMRI at 7 T and compare it with static  ...  Christine Marosi for helping with the selection and recruitment of the patients who participated in this study.  ... 
doi:10.1016/j.neuroimage.2016.12.070 pmid:28027961 pmcid:PMC5831987 fatcat:hb4vpmldkzeh3e2zzmvmcjerai

Language Mapping Using T2-Prepared BOLD Functional MRI in the Presence of Large Susceptibility Artifacts—Initial Results in Patients With Brain Tumor and Epilepsy

2017 Tomography  
reactivity (CVR) At present, presurgical functional mapping is the most prevalent clinical application of functional magnetic resonance imaging (fMRI).  ...  of fMRI in several brain regions, many of which are related to language mapping in presurgical planning.  ...  ACKNOWLEDGMENTS The authors thank Mr. Joseph S. Gillen, Mrs.  ... 
doi:10.18383/j.tom.2017.00006 pmid:28804779 pmcid:PMC5552052 fatcat:jhjlui6cdvhp5e5k7fuimfzota

Objective Bayesian fMRI analysis—a pilot study in different clinical environments

Joerg Magerkurth, Laura Mancini, William Penny, Guillaume Flandin, John Ashburner, Caroline Micallef, Enrico De Vita, Pankaj Daga, Mark J. White, Craig Buckley, Adam K. Yamamoto, Sebastien Ourselin (+3 others)
2015 Frontiers in Neuroscience  
As a clinical case study, we tested passive motor task activation in a brain tumor patient at 3T under clinical conditions.  ...  extents of the activations were smaller than at 3T.  ...  This work was funded by a project grant from the Department of Health's NIHR Comprehensive Biomedical Research Centre at UCLH/UCL.  ... 
doi:10.3389/fnins.2015.00168 pmid:26029041 pmcid:PMC4428130 fatcat:7l6ovzeuebgaphtnm6wfptl62u

Clinical fMRI: Evidence for a 7T benefit over 3T

R. Beisteiner, S. Robinson, M. Wurnig, M. Hilbert, K. Merksa, J. Rath, I. Höllinger, N. Klinger, Ch. Marosi, S. Trattnig, A. Geißler
2011 NeuroImage  
Here we performed presurgical localization of the primary motor hand area on 3 T and 7 T Siemens scanners with identical investigational procedures and comparable system specific sequence optimizations  ...  On the other hand, 7 T data suffered from a significant increase of artifacts (ghosting, head motion).  ...  Acknowledgment This study was supported by the Austrian Science Fund (P18057-B13) and the Vienna Spots of Excellence Programme "VIACLIC".  ... 
doi:10.1016/j.neuroimage.2011.05.010 pmid:21620980 pmcid:PMC3134943 fatcat:h2owhu5mefevzalqpxnpyccsfq

Differential functional benefits of ultra highfield MR systems within the language network

A. Geißler, E. Matt, F. Fischmeister, M. Wurnig, B. Dymerska, E. Knosp, M. Feucht, S. Trattnig, E. Auff, W.T. Fitch, S. Robinson, R. Beisteiner
2014 NeuroImage  
were investigated with a standardized overt language fMRI paradigm on both 3 T and 7 T MR scanners.  ...  Here we provide an initial investigation on a prominent and clinically highly-relevant cognitive function: language processing in individual brains. 26 patients evaluated for presurgical language localization  ...  Acknowledgment This study was supported by the Vienna Spots of Excellence Program of the Centre of Innovation and Technology, City of Vienna (ZIT), University grant number FA102A001, a research cluster  ... 
doi:10.1016/j.neuroimage.2014.09.036 pmid:25255049 pmcid:PMC4263528 fatcat:gsextwpm25btzpbqovohthsry4

Applying Independent Component Analysis to Clinical fMRI at 7 T

Simon Daniel Robinson, Veronika Schöpf, Pedro Cardoso, Alexander Geissler, Florian Ph. S. Fischmeister, Moritz Wurnig, Siegfried Trattnig, Roland Beisteiner
2013 Frontiers in Human Neuroscience  
Increased BOLD sensitivity at 7 T offers the possibility to increase the reliability of fMRI, but ultra-high field is also associated with an increase in artifacts related to head motion, Nyquist ghosting  ...  Promising applications of ICA in clinical fMRI include presurgical planning and the study of pathologies affecting subcortical brain areas.  ...  Motion artifacts are the most frequent reason for the failure of presurgical fMRI even at 1.5 T (Krings et al., 2001) .  ... 
doi:10.3389/fnhum.2013.00496 pmid:24032007 pmcid:PMC3759034 fatcat:6vndqvgbhzhmviajg5swkde4fm

Presurgical Localization of the Primary Sensorimotor Cortex in Gliomas

Natalie L. Voets, Puneet Plaha, Oiwi Parker Jones, Pieter Pretorius, Andreas Bartsch
2020 Clinical Neuroradiology  
The use of fMRI in patients with residual or intact presurgical motor function added value to uncertain anatomical localization in just a single peri-Rolandic glioma case.  ...  Task fMRI finger tapping data were acquired in 45 patients. Group differences in fMRI reproducibility, spatial overlap and success frequencies were assessed with t‑tests and χ2-tests.  ...  Difficulties in predicting function from anatomy, coupled with the potential for pathological distortion, motivated motor mapping as the first clinical application of fMRI.  ... 
doi:10.1007/s00062-020-00879-1 pmid:32274518 fatcat:uxga2vmopfdw3czvi5lb45optq

Resting-state Functional Magnetic Resonance Imaging in Presurgical Functional Mapping

Donna Dierker, Jarod L. Roland, Mudassar Kamran, Jerrel Rutlin, Carl D. Hacker, Daniel S. Marcus, Mikhail Milchenko, Michelle M. Miller-Thomas, Tammie L. Benzinger, Abraham Z. Snyder, Eric C. Leuthardt, Joshua S. Shimony
2017 Neuroimaging clinics of North America  
Synopsis The goal of this article is to compare resting state fMRI with task fMRI as a tool for presurgical functional mapping of the sensorimotor (SM) region.  ...  The SM area was anatomically defined using two different software tools. Overlap of anatomical regions of interest with task activation maps and resting state networks was measured in the SM region.  ...  Acknowledgments Acknowledgements and Disclosure of Funding: Leuthardt  ... 
doi:10.1016/j.nic.2017.06.011 pmid:28985933 pmcid:PMC5773116 fatcat:vuemof24frgtvo6k5ixtek3rt4

The Impact of Echo Time Shifts and Temporal Signal Fluctuations on BOLD Sensitivity in Presurgical Planning at 7 T

Barbara Dymerska, Pedro De Lima Cardoso, Beata Bachrata, Florian Fischmeister, Eva Matt, Roland Beisteiner, Siegfried Trattnig, Simon Daniel Robinson
2019 Investigative Radiology  
Local echo time changes are not considered in the most commonly used metric for BOLD sensitivity, temporal signal-to-noise ratio (tSNR), but may be significant, particularly at ultrahigh field close to  ...  Gradients in the static magnetic field caused by tissues with differing magnetic susceptibilities lead to regional variations in the effective echo time, which modifies both image signal and BOLD sensitivity  ...  volunteers and patients with brain tumors at 7 T, with a focus on the proximity of pathologies and postoperative cavities, which are frequently encountered in presurgical mapping.  ... 
doi:10.1097/rli.0000000000000546 pmid:30724813 fatcat:cqlzsacypjhmpj6rqjrm2tqajm

MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery

Elaine Foley, J. Helen Cross, Ngoc J. Thai, A. Richard Walsh, Peter Bill, Paul Furlong, Amanda G. Wood, Antonella Cerquiglini, Stefano Seri
2019 Brain Topography  
Establishing language dominance is an important step in the presurgical evaluation of patients with refractory epilepsy.  ...  Magnetoencephalography (MEG) has the advantage of being insensitive to the distortive effects of anatomical lesions on brain microvasculature and to differences in the metabolism or vascularization of  ...  Lateralization index (LI) was computed based on t-values of the event related power decrease in Brodmann areas (BA) 6, 44, 45 and 22 in the left (t L ) and right hemisphere (t R ).  ... 
doi:10.1007/s10548-019-00703-1 fatcat:lq337mowsrdihmwgzqswjnftiy

Patterns and predictors of language representation and the influence of epilepsy surgery on language reorganization in children and young adults with focal lesional epilepsy

Carmen Barba, Domenico Montanaro, Laura Grisotto, Francesca Frijia, Simona Pellacani, Anna Cavalli, Susanna Rizzi, Matteo Lenge, Gayane Aghakhanyan, Valentina Sibilia, Flavio Giordano, Tiziana Pisano (+7 others)
2020 PLoS ONE  
Twenty out of 29 patients also underwent postoperative language fMRI. We analyzed possible changes of fMRI and DTI LIs and their clinical predictors.  ...  clinical variables would influence the patterns of language representation and the ensuing impact of the latter on cognitive performances.  ...  Tiziana Metitieri for her help in neuropsychological assessment of children included in the study.  ... 
doi:10.1371/journal.pone.0238389 pmid:32898166 fatcat:7kgeiiid3vdw7mb3egeskrkiwq

Key clinical benefits of neuroimaging at 7 T

Siegfried Trattnig, Elisabeth Springer, Wolfgang Bogner, Gilbert Hangel, Bernhard Strasser, Barbara Dymerska, Pedro Lima Cardoso, Simon Daniel Robinson
2018 NeuroImage  
Of specific clinical interest for neuro applications is the cerebral cortex at 7 T, for the detection of changes in cortical structure, like the visualization of cortical microinfarcts and cortical plaques  ...  A B S T R A C T The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7 T, is related to improved clinical results with regard to morphological as well  ...  Acknowledgements This work was supported by the FFG Bridge Early Stage Grant #846505, the Anniversary Fund of the Oesterreichische Nationalbank, project number 15680 and the Austrian Science Fund (FWF)  ... 
doi:10.1016/j.neuroimage.2016.11.031 pmid:27851995 pmcid:PMC5832016 fatcat:snjc6lnyxrgsbkrve3fui7cgzm

A Novel Data-Driven Approach to Preoperative Mapping of Functional Cortex Using Resting-State Functional Magnetic Resonance Imaging

Timothy J. Mitchell, Carl D. Hacker, Jonathan D. Breshears, Nick P. Szrama, Mohit Sharma, David T. Bundy, Mrinal Pahwa, Maurizio Corbetta, Abraham Z. Snyder, Joshua S. Shimony, Eric C. Leuthardt
2013 Neurosurgery  
Of these 7, the motor and language networks were then compared with electrocortical stimulation (ECS) as the gold standard in the epilepsy patients.  ...  RSNs were plotted in the tumor patients to observe RSN distortions in altered anatomy. RESULTS: The algorithm robustly identified all networks in all patients, including those with distorted anatomy.  ...  Results in Tumor Patients The results of the MLP analysis of tumor subjects can be seen in Figures 7 and 8. Figure 7 reveals network distortion in the presence of tumors.  ... 
doi:10.1227/neu.0000000000000141 pmid:24264234 pmcid:PMC3871406 fatcat:ttdpvf32uzclhioa2afz6h6ura

fMRI-Targeted High-Angular Resolution Diffusion MR Tractography to Identify Functional Language Tracts in Healthy Controls and Glioma Patients

Francesco Sanvito, Eduardo Caverzasi, Marco Riva, Kesshi M. Jordan, Valeria Blasi, Paola Scifo, Antonella Iadanza, Sofia Allegra Crespi, Sara Cirillo, Alessandra Casarotti, Antonella Leonetti, Guglielmo Puglisi (+6 others)
2020 Frontiers in Neuroscience  
In healthy controls, normalized MNI atlases of fMRI-T and Anatomical-T were obtained.  ...  MR Tractography enables non-invasive preoperative depiction of language subcortical tracts, which is crucial for the presurgical work-up of brain tumors; however, it cannot evaluate the exact function  ...  ACKNOWLEDGMENTS The authors are grateful to Valentina Pieri and Gian Marco Conte for the useful discussion about the results of this study.  ... 
doi:10.3389/fnins.2020.00225 pmid:32296301 pmcid:PMC7136614 fatcat:npn5n7psjzg6pneomtgpfmb4d4

Functional MRI for presurgical planning: problems, artefacts, and solution strategies

T Krings
2001 Journal of Neurology, Neurosurgery and Psychiatry  
Ojectives-Presurgical mapping of motor function is a widely used clinical application of functional (f) MRI, employing the blood oxygenation level dependent contrast.  ...  Results-Functional MRI identified the motor regions in 85% of all investigated paradigms. In 11% of the investigated patients no information at all on functional localisation was obtained.  ...  At T 0 =2-4 only 7% of the functional runs demonstrated significant MR signal increase; the remaining 23% were equally distributed over T 0 =5-10 (for examples of time courses with abrupt head movement  ... 
doi:10.1136/jnnp.70.6.749 pmid:11385009 pmcid:PMC1737418 fatcat:sd3viah6c5ggjpizg2evge36wa
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