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Ethical Considerations in Animal Research: The Principle of 3R�s

Lorenza Díaz, Elena Zambrano-González, María E. Flores, Mariela Contreras, Jose C. Crispín, Gabriela Alemán, César Bravo, Alejandra Armenta-Espinosa, Victor J. Valdés, Armando Tovar, Gerardo Gamba, Jorge Barrios-Payán (+1 others)
2020 Revista de investigación clínica  
In the first part, the significance of experimental research, the main functions of IACUC, and the principle of the three R's (replacement, reduction, and refinement) are addressed.  ...  The main intention of these contributions is to sensitize users of laboratory animals for the proper and rational use of them in experimental research, as well as to disseminate the permitted and unpermitted  ...  Schematic representation of the principle of the three R's: Replacement: in experimental research, look for well-established and emerging methodologies as alternatives for replacement of animals.  ... 
doi:10.24875/ric.20000380 pmid:33090120 fatcat:y3sttbu235ggzmtge2rxzsknie

The role of metadata in reproducible computational research [article]

Jeremy Leipzig, Daniel Nüst, Charles Tapley Hoyt, Stian Soiland-Reyes, Karthik Ram, Jane Greenberg
2021 arXiv   pre-print
Reproducible computational research (RCR) is the keystone of the scientific method for in silico analyses, packaging the transformation of raw data to published results.  ...  In addition to its role in research integrity, RCR has the capacity to significantly accelerate evaluation and reuse.  ...  Acknowledgements Acknowledgements We wish to thank Jian Qin and Farah Zaib Khan for their helpful comments and suggestions.  ... 
arXiv:2006.08589v2 fatcat:txxkodvwezc6bcdngu3by6wnni

Enabling Reproducible Analysis of Complex Workflows on the Edge-to-Cloud Continuum [article]

Daniel Rosendo
2021 arXiv   pre-print
We introduce a rigorous methodology for such a process and validate it through E2Clab.  ...  Preliminary results with real-life use cases show that E2Clab allows one to understand and improve performance, by correlating it to the parameter settings, the resource usage and the specifics of the  ...  PHD OBJECTIVES In order to allow other researchers to leverage the experimental results and advance knowledge in different domains, experimental methodologies need to enable three R's of research quality  ... 
arXiv:2109.01379v1 fatcat:moc5jgjzcjctjis4dbodkhxazm

Fact and fancy in personality research

Donald W. Mackinnon
1953 American Psychologist  
use both for the maximal benefit of per- sonality research.  ...  We proclaim that science is the most democratic of procedures; only Fact AND FANCY IN PERSONALITY RESEARCH 145 that which can be tested and reproduced by all investigators is to be accepted as fact.  ... 
doi:10.1037/h0057411 fatcat:zwb2xicvwfg4xej7i4mjow3cea

Cut to the chase: Revisiting the relevance of software engineering research [article]

Vahid Garousi, Markus Borg, Markku Oivo
2018 arXiv   pre-print
The goal of this paper is to act as another "wake-up call" for the community to reflect and act on the relevance of SE research.  ...  discussed in the community for improving the situation; (3) a summary of the experience of the authors in conducting SE research with varying degrees of relevance; and (4) a review of recent activities  ...  rigor and relevance in information systems research Information systems (IS) [133] Our new three R's: Rigor, relevance, and readability Governance science [134] Rigor and relevance: a PhD student's  ... 
arXiv:1812.01395v2 fatcat:devw2rmdnfchdbhjq2bz6wiglm

Ethical considerations in tissue engineering research: Case studies in translation

Hannah B. Baker, John P. McQuilling, Nancy M.P. King
2016 Methods  
Topics at the bench level include maintaining data integrity, appropriate reporting and dissemination of results, and ensuring that studies are designed to yield results suitable for advancing research  ...  The comparison of these two technologies and  ...  Research for this publication was supported in part by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number T32EB014836.  ... 
doi:10.1016/j.ymeth.2015.08.010 pmid:26282436 pmcid:PMC4869966 fatcat:x5nrzodnjnciplrhb4grxsd6zu

An Equilibrium Model of 'Global Imbalances' Revisited

Finn Marten Körner
2011 Social Science Research Network  
The PhD program Globalization and Employment therefore focuses on the employment effects of structural change and macroeconomic developments and encourages research by granting scholarships.  ...  The dissertation projects address topics such as new technologies, processes of internationalization and system transformation, endogenous finance constraints and various strategies of fiscal and monetary  ...  . ⇒ No ' over-shooting' of the interest rate at impact because the initial appreciation of q R 0 + does not affect post-shock dynamics. • Repeat system for t = 2 → ∞ and calculate all other values for  ... 
doi:10.2139/ssrn.1973110 fatcat:iyiyvlb5g5hojbgpzvdmnovswy

Psycholinguistics: a survey of theory and research problems

John W. Gardner, John B. Carroll, Leonard D. Newmark, Susan M. Ervin, Sol Saporta, Joseph H. Greenberg, Donald E. Walker, James J. Jenkins, Kellogg Wilson, Floyd G. Lounsbury, Charles E. Osgood, Thomas A. Sebeok
1954 Journal of Abnormal & Social Psychology  
At the time of presentation of these research problems for preliminary discussion by the seminar, it became clear that we could not organize this field in terms of the three methodological approaches,  ...  In the main, however, it has proved to be quite durable. The system has been tremendously successful in stimulating research and providing a frame of reference for new material.  ...  A group of people that has an elaborate and complicated kinship and marriage system should have an equally elaborate and complicated system of kinship and marriage terms.  ... 
doi:10.1037/h0063655 fatcat:hf2c57s3ozetxju46nywrwcdzu

How to model the neurocognitive dynamics of decision making: A methodological primer with ACT-R

Cvetomir Dimov, Patrick H. Khader, Julian N. Marewski, Thorsten Pachur
2019 Behavior Research Methods  
This implementation allows us to predict the dynamics of behavior and the temporal and spatial patterns of brain activity.  ...  Higher cognitive functions are the product of a dynamic interplay of perceptual, mnemonic, and other cognitive processes.  ...  In our case, the simulation of the complete decision task, consisting of 132 trials, was repeated 100 times for each participant.  ... 
doi:10.3758/s13428-019-01286-2 pmid:31396864 fatcat:szbgyykgvvfc3lv22jghyg5j7a

A source activation theory of working memory: cross-task prediction of performance in ACT-R

Marsha C. Lovett, Larry Z. Daily, Lynne M. Reder
2000 Cognitive Systems Research  
Over the decades, computational models of human cognition have advanced from programs that produce output similar to that of human problem solvers to systems that mimic both the products and processes  ...  We demonstrate this capability in the context of a model of working memory, where the individual difference parameter for each participant represents working memory capacity.  ...  Note that in each of the above cases from the 1990's, researchers were improving their models in ways suggested (and tested) by the data.  ... 
doi:10.1016/s1389-0417(99)00012-1 fatcat:55lsbt3nwreetcnfg3dlpr2nji

FlyClockbase: Importance of Biological Model Curation for Analyzing Variability in the Circadian Clock of Drosophila melanogaster by Integrating Time Series from 25 Years of Research [article]

Katherine S. Scheuer, Bret Hanlon, Jerdon W. Dresel, Erik D. Nolan, John C. Davis, Laurence Loewe
2017 bioRxiv   pre-print
We aim to simplify the preservation of more raw data and relevant annotations from experiments in order to multiply the long-term value of wet-lab datasets for modelers interested in meta-analyses, parameter  ...  We designed FlyClockbase for integrating such scattered data to enable robust efficient access for biologists and modelers.  ...  We assessed the impact of manually identified rare extreme 5 outliers by excluding them from a copy of the dataset (termed "NoXtremes") for which 6 we repeated all analyses, including R's automated  ... 
doi:10.1101/099192 fatcat:446gqznfofdo3pyuzgvst7bolm

Improved Intensity-Based Label-Free Quantification via Proximity-Based Intensity Normalization (PIN)

Susan K. Van Riper, Ebbing P. de Jong, LeeAnn Higgins, John V. Carlis, Timothy J. Griffin
2014 Journal of Proteome Research  
Unfortunately, HPLC−ESI−MS/MS workflows using these strategies produce results with poor repeatability and reproducibility, primarily due to systematic bias and complex variability.  ...  Our results show the PIN enables the discovery of statistically significant biological variation that otherwise is falsely reported or missed.  ...  We thank the Center for Mass Spectrometry and Proteomics at the University of Minnesota, the Minnesota Supercomputing Institute for instrumental access and infrastructure support. We also thank Dr.  ... 
doi:10.1021/pr400866r pmid:24571364 pmcid:PMC3993879 fatcat:zlxt7krtrffynhzyoptk64seeq

Second annual review of research in science teaching

Kenneth E. Anderson, Herbert A. Smith, Nathan S. Washton, George W. Haupt
1954 Science Education  
is rigorous, genuine, and fundamental in nature.  ...  and _ their personal welfare—topics such as the nature and control of disease, human reproduc- tion, and heredity.  ... 
doi:10.1002/sce.3730380502 fatcat:ci6a5ss3rzbdzovzk5oymkxieq

Development, standardization, and validation of a biofilm efficacy test: The single tube method

Darla M. Goeres, Diane K. Walker, Kelli Buckingham-Meyer, Lindsey Lorenz, Jennifer Summers, Blaine Fritz, Danielle Goveia, Grace Dickerman, Johanna Schultz, Albert E. Parker
2019 Journal of Microbiological Methods  
In support of the reproducibility assessment, a six-laboratory study was performed using three antimicrobials: a sodium hypochlorite, a phenolic and a quaternary/alcohol blend, each tested at low and high  ...  This is because standard methods are demonstrably reproducible when performed in different laboratories by different researchers, responsive to different products, and rugged when small (usually inadvertent  ...  Table 2 provides a quantitative assessment of the repeatability and reproducibility of the LRs for each antimicrobial and efficacy level combination.  ... 
doi:10.1016/j.mimet.2019.105694 pmid:31491442 fatcat:khdb6dgxafeivmaaiujqf6wdjq

Under Construction: Working at the Intersections of Composition Theory, Research, and Practice

Christine Farris, Chris M. Anson
1999 College composition and communication  
English language-Rhetoric-Study and teaching. 2. English language-Rhetoric-Study and teaching-Theory, etc. 3. Report writing-Study and teaching. 4. Report writing-Study and teaching-Theory, etc.  ...  Haswell's research report "Gendership and the Miswriting of Students" (1995) includes student texts as well as photographs of students.  ...  Co-authored research like that of Lisa Ede and Andrea Lunsford's in Singular Texts/Plural Authors (1990) can produce writing voices that are so clearly intertwined that the scholarly traditions of listing  ... 
doi:10.2307/358971 fatcat:zaxqzkckajezhipiwf3kyfpqtm
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