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The Whole-Brain "Global" Signal from Resting State fMRI as a Potential Biomarker of Quantitative State Changes in Glucose Metabolism

Garth J. Thompson, Valentin Riedl, Timo Grimmer, Alexander Drzezga, Peter Herman, Fahmeed Hyder
2016 Brain Connectivity  
The evolution of functional magnetic resonance imaging to resting state (R-fMRI) allows measurement of changes in brain networks attributed to state changes, such as in neuropsychiatric diseases versus  ...  As most previous studies have excluded the spatial means of R-fMRI metrics from their analysis, this work presents the first evidence of a potential R-fMRI biomarker for baseline shifts in quantifiable  ...  The acknowledged funding sources were not involved in the design of this study.  ... 
doi:10.1089/brain.2015.0394 pmid:27029438 pmcid:PMC4976226 fatcat:bhvafp4lonbvhpaxfd6u2tl4nq

Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain

Kristian N. Mortensen, Albert Gjedde, Garth J. Thompson, Peter Herman, Maxime J. Parent, Douglas L. Rothman, Ron Kupers, Maurice Ptito, Johan Stender, Steven Laureys, Valentin Riedl, Michael T. Alkire (+1 others)
2018 Neural Plasticity  
Because the human brain consumes a disproportionate fraction of the resting body's energy, positron emission tomography (PET) measurements of absolute glucose metabolism (CMRglc) can serve as disease biomarkers  ...  Global mean normalization (GMN) of PET data reveals disease-based differences from healthy individuals as fractional changes across regions relative to a global mean.  ...  Conflicts of Interest The authors declare no conflict of interest.  ... 
doi:10.1155/2018/6120925 pmid:30008742 pmcid:PMC6020504 fatcat:d66kymwdb5c5pieiosk7esy5ym

Diet modulates brain network stability, a biomarker for brain aging, in young adults

Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey (+4 others)
2020 Proceedings of the National Academy of Sciences of the United States of America  
We first established network stability as a biomarker for brain aging using two large-scale (n = 292, ages 20 to 85 y; n = 636, ages 18 to 88 y) 3 T functional MRI (fMRI) datasets.  ...  Dietary interventions resulting in ketone utilization increase available energy and thus may show potential in protecting the aging brain.  ...  of neurons, as with other cells in the body and as per brain glucose hypometabolism commonly seen in dementia.  ... 
doi:10.1073/pnas.1913042117 pmid:32127481 pmcid:PMC7084077 fatcat:pc6c4gupurgjzhbcojcwbzsdae

Simultaneous task-based BOLD-fMRI and [18-F] FDG functional PET for measurement of neuronal metabolism in the human visual cortex [article]

Sharna D Jamadar, Phillip G D Ward, Shenpeng Li, Francesco Sforazzini, Jakub Baran, Zhaolin Chen, Gary F Egan
2018 bioRxiv   pre-print
BOLD-fMRI indirectly infers neuronal activity from regional changes in blood oxygenation and is not a quantitative metric of brain function.  ...  However, while the temporal resolution of BOLD-fMRI is in the order of seconds, standard FDG-PET protocols provide a static snapshot of glucose metabolism.  ...  A venous component may indicate global variations in glucose metabolism, identified by fluctuations in the residual FDG draining from the cerebral compartment to the body.  ... 
doi:10.1101/451468 fatcat:tvqo2wqj5balvnzb6k6u7ugf5y

Resting state cerebral blood flow with arterial spin labeling MRI in developing human brains

Feng Liu, Yunsuo Duan, Bradley S. Peterson, Iris Asllani, Fernando Zelaya, David Lythgoe, Alayar Kangarlu
2018 European journal of paediatric neurology  
networks show distinct patterns of metabolic activity during the resting state in the developing brains.  ...  Studying the characteristics of CBF during resting state in developing brain can be a complementary way to understand the functional connectivity of the developing brain.  ...  Consequently, ASL can detect changes in the very low frequency range, which is not achievable with BOLD fMRI. Regional CBF can be used as a reasonable surrogate of metabolism in resting states.  ... 
doi:10.1016/j.ejpn.2018.03.003 pmid:29656926 fatcat:jnrjptnrkrfirezuaom5o3q43m

Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease

Feng Luo, Nathan R. Rustay, Ulrich Ebert, Vincent P. Hradil, Todd B. Cole, Daniel A. Llano, Sarah R. Mudd, Yumin Zhang, Gerard B. Fox, Mark Day
2012 Neurobiology of Aging  
Using a combination of FDG-PET and functional magnetic resonance imaging (fMRI), we examined the Tg2576 mouse for global and regional measures of brain glucose metabolism at 7 and 19 months of age.  ...  For example, early in AD, patients present with decreased glucose metabolism in the entorhinal cortex and several regions of the brain associated with disease pathology and cognitive decline.  ...  accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care.  ... 
doi:10.1016/j.neurobiolaging.2010.08.005 pmid:20961663 fatcat:5yhpi33hrjarnaerysijkiicxi

Combined PET/MRI: Global Warming—Summary Report of the 6th International Workshop on PET/MRI, March 27–29, 2017, Tübingen, Germany

D. L. Bailey, B. J. Pichler, B. Gückel, G. Antoch, H. Barthel, Z. M. Bhujwalla, S. Biskup, S. Biswal, M. Bitzer, R. Boellaard, R. F. Braren, C. Brendle (+24 others)
2017 Molecular Imaging and Biology  
The meeting openly questioned whether PET/MRI should, in all cases, be used as a whole-body imaging modality or whether in many circumstances it would best be employed to give an in-depth study of previously  ...  identified disease in a single organ or region. nature of disease processes, metabolism, evolution of cancer and the monitoring of response to pharmacological interventions and therapies.  ...  In particular, we like to acknowledge the contributions from A. Beer  ... 
doi:10.1007/s11307-017-1123-5 pmid:28971346 pmcid:PMC5775351 fatcat:7anothz3znc4tnace5xawadvju

Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry

Najmeh Khalili-Mahani, Serge A.R.B. Rombouts, Matthias J.P. van Osch, Eugene P. Duff, Felix Carbonell, Lisa D. Nickerson, Lino Becerra, Albert Dahan, Alan C Evans, Jean-Paul Soucy, Richard Wise, Alex P. Zijdenbos (+1 others)
2017 Human Brain Mapping  
in Wiley Online Library (wileyonlinelibrary.com). r Human Brain Mapping 38:2276-2325 (2017) r V C 2017 Wiley Periodicals, Inc. r r Abstract: A decade of research and development in resting-state functional  ...  Overall, RSfMRIderived biomarkers seem to be sensitive to spatiotemporal dynamics of drug interactions with the brain.  ...  Although these global effects may reflect the global state of consciousness and metabolism, the regional network properties do not change in a single direction.  ... 
doi:10.1002/hbm.23516 pmid:28145075 fatcat:o6h7ahdzerbbngzx6vcfsvbn3q

Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales

Hans F Wehrl, Mosaddek Hossain, Konrad Lankes, Chih-Chieh Liu, Ilja Bezrukov, Petros Martirosian, Fritz Schick, Gerald Reischl, Bernd J Pichler
2013 Nature Medicine  
This study was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft PI 771/11, PI 771/51), the Wilhelm SchulerFoundation and the Werner SiemensFoundation.  ...  Finally, we discuss the dependencies between glucose metabolism and neuro vascular parameters in the brain and the potential of PETMRI for depicting a multitude of brain networks.  ...  The fMRI VOIs show highly significant or significant (*P < 0.05) relative changes in CMRGlc in certain cases. (c) Average relative change in glucose metabolism, as assessed by PET.  ... 
doi:10.1038/nm.3290 pmid:23975025 fatcat:cuovjfa5szh3pnp7l2xy2dxray

Brain aerobic glycolysis and motor adaptation learning

Benjamin J. Shannon, Sanjeev Neil Vaishnavi, Andrei G. Vlassenko, Joshua S. Shimony, Jerrel Rutlin, Marcus E. Raichle
2016 Proceedings of the National Academy of Sciences of the United States of America  
Ten percent to 15% of glucose used by the brain is metabolized nonoxidatively despite adequate tissue oxygenation, a process termed aerobic glycolysis (AG).  ...  to activity during the task and altered resting-state, functional connectivity after the task.  ...  This work was supported by US National Institutes of Health Grants NS006833, NS057901, NS048056, and MH077967 and a grant from the James S. McDonnell Foundation.  ... 
doi:10.1073/pnas.1604977113 pmid:27217563 pmcid:PMC4932971 fatcat:5xrqraioqbawdfhaw4arus4hvm

Overview of Functional Magnetic Resonance Imaging

Gary H. Glover
2011 Neurosurgery clinics of North America  
ACKNOWLEDGMENTS The author is indebted to C.E. Chang for suggestions on the manuscript.  ...  [1] [2] [3] These metabolic changes can be consequent to task-induced cognitive state changes or the result of unregulated processes in the resting brain.  ...  Functional magnetic resonance imaging (fMRI) is a class of imaging methods developed to demonstrate regional, time-varying changes in brain metabolism.  ... 
doi:10.1016/j.nec.2010.11.001 pmid:21435566 pmcid:PMC3073717 fatcat:f5hyjhei7nbmlliapwbvvd2l4e

Hybrid PET/MR Imaging and Brain Connectivity

Marco Aiello, Carlo Cavaliere, Marco Salvatore
2016 Frontiers in Neuroscience  
In recent years, brain connectivity is gaining ever-increasing interest from the interdisciplinary research community.  ...  The study of brain connectivity is characterized by a multifaceted approach providing both structural and functional evidence of the relationship between cerebral regions at different scales.  ...  by fMRI, which has better spatial and temporal resolution than PET imaging, and resting-state fMRI, a significant temporal correlation in fMRI signal in subjects who were not cognitively engaged (Biswal  ... 
doi:10.3389/fnins.2016.00064 pmid:26973446 pmcid:PMC4771762 fatcat:4lozyt6omzdeveoygnz3vt55um

Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease

Bradford C. Dickerson, Reisa A. Sperling
2005 Neurotherapeutics  
As this work has matured, it has become clear that neuroimaging measures may serve a variety of potential roles in clinical trials of candidate neurotherapeutic agents for AD, depending in part on the  ...  A number of in vivo neuroimaging techniques, which can reliably and noninvasively assess aspects of neuroanatomy, chemistry, physiology, and pathology, hold promise as biomarkers.  ...  Annual whole brain atrophy rates measured by BBSI are 2-3% in AD patients, whereas they are 0.2-0.5% for normal aging. 37 Rates of whole brain atrophy relate to global decline in cognitive function and  ... 
doi:10.1007/bf03206676 fatcat:vxn4i7zmi5bi3ajc7jypgitoqe

Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease

Bradford C. Dickerson, Reisa A. Sperling
2005 NeuroRx  
As this work has matured, it has become clear that neuroimaging measures may serve a variety of potential roles in clinical trials of candidate neurotherapeutic agents for AD, depending in part on the  ...  A number of in vivo neuroimaging techniques, which can reliably and noninvasively assess aspects of neuroanatomy, chemistry, physiology, and pathology, hold promise as biomarkers.  ...  Annual whole brain atrophy rates measured by BBSI are 2-3% in AD patients, whereas they are 0.2-0.5% for normal aging. 37 Rates of whole brain atrophy relate to global decline in cognitive function and  ... 
doi:10.1602/neurorx.2.2.348 pmid:15897955 pmcid:PMC1064996 fatcat:e6rhpuvtgvf4jmr72dw6txmtym

Network-Based Biomarkers in Alzheimer's Disease: Review and Future Directions

Jaime Gomez-Ramirez, Jinglong Wu
2014 Frontiers in Aging Neuroscience  
In this review, we summarize recent research on the study of AD as a connectivity syndrome.  ...  We introduce a new framework for the quantitative study of biomarkers that can help shorten the transition between academic research and clinical diagnosis in AD.  ...  ACKNOWLEDGMENTS This work has been funded in part with funds from the Erasmus Mundus Building European Asian Mobility Program of the European Commission (EM-BEAM), Grant Number L03100048.  ... 
doi:10.3389/fnagi.2014.00012 pmid:24550828 pmcid:PMC3912507 fatcat:fgjcbbec5rgljdsgtxx3qs7sqy
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