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3D palaeogeographic reconstructions of the Phanerozoic versus sea-level and Sr-ratio variations

Christian Vérard, Cyril Hochard, Peter O. Baumgartner, Gérard M. Stampfli, Min Liu
2015 Journal of Palaeogeography  
Strontium isotope stra‑ Sequence and systems tract models.  ...  The amount of sediment (for wedges and abysses) is 1) The rift trough subsides over a period of 7 Ma, and if modulated according to the  ... 
doi:10.3724/sp.j.1261.2015.00068 fatcat:h546qu62enajjl6hwhvpw7ys5m

Series of modulated structures inSrxCoO2and the modulation rule

L. D. Yao, Y. Q. Guo, J. L. Luo, W. Zhang, F. Y. Li, C. Q. Jin, R. C. Yu
2007 Physical Review B  
The results of EDX analyses confirm the variation of Sr content in corresponding modulated phases.  ...  Besides a well-defined ͱ 3a p ϫ ͱ 3a p modulated structure, a series of long periodic modulated structures ͑n ͱ 3a p ϫ 3a p ͒ was revealed by high-resolution transmission electron microscopy ͑HRTEM͒ in  ...  In view of the feature of the HRTEM image, it is concluded that the modulated structure can be induced by alternate position ordering of Sr cations on the basis of the basic modulated structure.  ... 
doi:10.1103/physrevb.75.174118 fatcat:tasalh4iqvdwzgepgj6pmq64fy

A spatial-temporal gated attention module for molecular property prediction based on molecular geometry

Chunyan Li, Jianmin Wang, Zhangming Niu, Junfeng Yao, Xiangxiang Zeng
2021 Briefings in Bioinformatics  
It is grid-based 3D convolutional neural network with spatial-temporal gated attention module, which can extract the geometric features for molecular prediction tasks in the process of convolution.  ...  The 3D characteristics of molecules largely determine the properties of the drug and the binding characteristics of the target.  ...  Conf licts of Interest The authors have no conf licts of interest to declare. Data Availability The datasets and source code are publicly available at https://github.com/anny0316/Drug3D-Net.  ... 
doi:10.1093/bib/bbab078 pmid:33822856 fatcat:l573lg5ujrcupmux2dtljsemwy

Universal Face Restoration With Memorized Modulation [article]

Jia Li, Huaibo Huang, Xiaofei Jia, Ran He
2021 arXiv   pre-print
noise embeddings are integrated, with the guidance of attentional maps generated from layer normalization, instance normalization, and the original feature map.  ...  We store the spatial feature of the low-resolution image and the corresponding wavelet style code as key and value in the memory unit, respectively.  ...  AdaAO integrates the feature maps from AdaALN and AdaAIN that adaptively fuse the LR feature, wavelet memory and noise prior with corresponding attentional maps in the layer and instance modulation view  ... 
arXiv:2110.01033v1 fatcat:nbj7iccb5rawpoye5yxjycswle

REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function

Lei Yao, Duanyang Xie, Li Geng, Dan Shi, Jian Huang, Yufei Wu, Fei Lv, Dandan Liang, Li Li, Yi Liu, Jun Li, Yi‐Han Chen
2018 Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease  
); however, the modulators of the SR architecture remain unknown.  ...  This study aimed to determine the role of REEPs in SR membrane shaping and thus cardiac function.  ...  sections of heart tissues to produce data sets optimized for final 3D reconstruction of the SR membrane structures.  ... 
doi:10.1161/jaha.117.007205 pmid:29431104 pmcid:PMC5850239 fatcat:jwix6mfvqrdblnw45j7hpgzutu

Modulating Alginate Hydrogels for Improved Biological Performance as Cellular 3D Microenvironments

Mariana Isabel Neves, Lorenzo Moroni, Cristina Carvalho Barrias
2020 Frontiers in Bioengineering and Biotechnology  
These modifications enable the addition of new features for greater versatility and control over alginate-based systems, extending the plethora of applications and procedures where they can be used.  ...  Alginate, a marine-derived polysaccharide obtained from seaweeds, is one of the most widely used polymers in the biomedical field, particularly to build three dimensional (3D) systems for in vitro culture  ...  Gillette et al. (2010) developed a hybrid hydrogel combining alginate and collagen I, where the dynamic switch of alginate gelation was used to modulate the structural features of the microenvironment  ... 
doi:10.3389/fbioe.2020.00665 pmid:32695759 pmcid:PMC7338591 fatcat:bdlar4m7pfhqlacqudlr3qyav4

Pharmacology of Modulators of Alternative Splicing

David O. Bates, Jonathan C. Morris, Sebastian Oltean, Lucy F. Donaldson, Christopher J. Garland
2016 Pharmacological Reviews  
Authorship Contributions Participated in research design: Bates, Morris, Oltean, and Donaldson. Wrote or contributed to the writing of the manuscript: Bates, Morris, Oltean, and Donaldson.  ...  Phosphorylation also has a role in the SR proteins' localization and distribution in the nucleus and in the organization of the speckles, which are subnuclear structures where the SR proteins are concentrated  ...  Background information was gleaned from recent reviews, textbooks, and integrated from the authors' own knowledge of the systems.  ... 
doi:10.1124/pr.115.011239 pmid:28034912 pmcid:PMC5226212 fatcat:vrsxjadrgvcp7bda45xad2mf4a

Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein [article]

Christopher R. Carlson, Jonathan B. Asfaha, Chloe M. Ghent, Conor J. Howard, Nairi Hartooni, David O. Morgan
2020 biorxiv/medrxiv  
We speculate that distinct oligomeric states support the two functions of the N protein: unmodified protein forms a structured oligomer that is suited for nucleocapsid assembly, and phosphorylated protein  ...  Unmodified N protein forms partially ordered gel-like structures that depend on multivalent RNA-protein and protein-protein interactions.  ...  FIGURE 2 Figure 3 . 3 Phosphorylation modulates N protein condensate properties. a, Sequences of the SR regions of SARS-CoV N protein (aa 177-210) and SARS-CoV-2 N protein (aa 176-209).  ... 
doi:10.1101/2020.06.28.176248 pmid:32637943 pmcid:PMC7337373 fatcat:it4z77jeebe3dhci4m6vx3zt4u

Web Audio Modules

Jari Kleimola, Oliver Larkin
2015 Proceedings of the SMC Conferences  
This work also explores how WAMs integrate with existing and emerging APIs such as Web MIDI, WebGL, and Web Components. The remainder of this paper is structured as follows.  ...  to provide cross platform GUI and file system features.  ... 
doi:10.5281/zenodo.851148 fatcat:me6ld54v7vgqjhfd4muz2kj3p4

A micro-optical module for multi-wavelength addressing of trapped ions

Matthew Day, Kaushal Choonee, Zachary Chaboyer, Simon Gross, Michael J Withford, Alastair Sinclair, Graham Marshall
2021 Quantum Science and Technology  
The module is intended for use with an ion microtrap of 3D electrode geometry.  ...  The module occupies ∼ 10^4 times less volume than a conventional bulk-optic equivalent and is suited to different ion species.  ...  This paper presents the design, development and characterization of an efficient micro-optical module, the principle of which is scalable to multiple trapping zones of an ion microtrap array of 3D micro-structured  ... 
doi:10.1088/2058-9565/abdf38 fatcat:7plvyaooe5alva2s5rhoroucj4

3D sub-nanoscale imaging of unit cell doubling due to octahedral tilting and cation modulation in strained perovskite thin films [article]

Magnus Nord, Andrew Ross, Damien McGrouther, Juri Barthel, Magnus Moreau, Ingrid Hallsteinsen, Thomas Tybell, Ian MacLaren
2018 arXiv   pre-print
This results from a combination of La-site modulation along the beam direction, and modulation of oxygen positions resulting from octahedral tilting.  ...  This method is used together with conventional atomic resolution imaging in the plane perpendicular to the beam direction to gain information about the 3D crystal structure in an epitaxial thin film of  ...  This work was funded by the Engineering and Physical Sciences Research Council via the grant "Fast Pixel Detectors: a paradigm shift in STEM imaging" (EP/M009963/1).  ... 
arXiv:1810.07501v2 fatcat:cqtvzw6fcrek5ejfppdav7k57y

Interfacing Sail Modules for Use with "Space Tugs"

Florio Dalla Vedova, Pierre Morin, Thibault Roux, Roberta Brombin, Alberto Piccinini, Nigel Ramsden
2018 Aerospace (Basel)  
.); Abstract: The paper introduces and describes the recent and still ongoing development activities performed in Luxembourg for In-Orbit Attach Mechanisms for (Drag) Sails Modules to be operated from  ...  have been proposed and completed for their 3D (Metal and Plastic) Printing, a new manufacturing technology assessed within this project.  ...  Acknowledgments: The presented project for the pre-development of In-Orbit Attach Mechanisms for (Drag) Sails Modules to be operated from Space Tugs largely benefitted from the grant received by the still  ... 
doi:10.3390/aerospace5020048 fatcat:52l2fsmqdnhvrgz2bdt665hmxi

Structural modulation in potassium birnessite single crystals

Liliia Kulish, Pavan Nukala, Rick Scholtens, Mike Uiterwijk, Ruben Hamming-Green, Graeme Blake
2021 Journal of Materials Chemistry C  
We report on the growth of single-crystal potassium birnessite (K0.31MnO2·0.41H2O) and present both the average and local structural characterization of this frustrated magnetic system.  ...  On the local scale, more complex features of the K-bir layered structure are observed, such as stacking disorder, modulation of the structure and the presence of nanoscopic domains in which there is evidence  ...  Modulation of the layered structure Precession images generated from the raw XRD data show a number of complex features, some of which are depicted in Fig.  ... 
doi:10.1039/d0tc05396a fatcat:w56mgqq5gjecdnz6qo7w4hbdqq

NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo

Young-Dae Kim, Jung-Yoon Lee, Kyu-Man Oh, Masatake Araki, Kimi Araki, Ken-ichi Yamamura, Chang-Duk Jun
2011 Nucleic Acids Research  
Accordingly, using CD44, Tra2b1 and Fas constructs as splicing reporter minigenes, we found that NSrp70 modulated alternative splice site selection in vivo.  ...  We report here the identification and characterization of a novel speckle protein, referred to as NSrp70, based on its subcellular localization and apparent molecular weight.  ...  Morris for the Tra2b1, CD44 and Srp20 minigenes, and the pEGFP-ASF/SF2 plasmid; Dr Michael Sattler for the Fas minigene; and Dr M. Andrea Markus for discussion and suggestions throughout the study.  ... 
doi:10.1093/nar/gkq1267 pmid:21296756 pmcid:PMC3105421 fatcat:z7enb5xlvnh3fid5nvurayuad4

Intensity modulated radiotherapy: advantages, limitations and future development

KY Cheung
2006 Biomedical Imaging and Intervention Journal  
The beams are modulated to the required intensity maps for delivering highly conformal doses of radiation to the treatment targets, while sparing the adjacent normal tissue structures.  ...  Therefore, tight tolerance levels for random and systematic errors, compared with conventional 2D and 3D treatments, must be applied in all treatment and pre-treatment procedures.  ...  ACKNOWLEDGEMENTS The author would like to thank Peter ML Teo, Sherry Ng, Ricky MC Chau, Louis KY Lee and KH Yeung for their help in preparing figures presented in this article.  ... 
doi:10.2349/biij.2.1.e19 pmid:21614217 pmcid:PMC3097603 fatcat:7kfhlaoa5jhqjbbwj47xarkmgq
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