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Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes

Jan Schönberger, Andreas Draguhn, Martin Both
2014 Frontiers in Neural Circuits  
We recorded SPW-R with extracellular electrodes along the different layers of area CA1 in mouse hippocampal slices.  ...  Together, our data illustrate a complementary role of spatially confined excitatory and inhibitory transmission during highly ordered network patterns in the hippocampus.  ...  ACKNOWLEDGMENTS Support was provided by SFB636/B6, the FRONTIER-program of the Initiative for Excellence of Heidelberg University and a grant by the DFG (Mexican-German collaboration, PAK 520).  ... 
doi:10.3389/fncir.2014.00103 pmid:25202239 pmcid:PMC4142707 fatcat:qoau2lm3h5erlppw52rz37pq6u

At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes

Costas Papatheodoropoulos, Evangelos Sotiriou, Dimitrios Kotzadimitriou, Panagiota Drimala
2007 BMC Neuroscience  
The drug disrupted the synchrony of SPWs within the CA1 region at 50 µM (by 19 ± 12%; n = 5, P < 0.05). Similar effects of thiopental were observed at higher concentrations.  ...  In this study we examined and compared the actions of two barbiturates with distinct amnesic actions, the general anesthetic thiopental and the anticonvulsant phenobarbital, on in vitro SPW-R activity.  ...  Acknowledgements This work was supported by the European Social Fund (ESF), Operational Program for Educational and Vocational Training II (EPEAEK II), and particularly the Program PYTHAGORAS II.  ... 
doi:10.1186/1471-2202-8-60 pmid:17672909 pmcid:PMC1950312 fatcat:f2bsw7p2hjdnfczqeqa4dzbila

Fine-grained change impact analysis for component-based product families

Amir Reza Yazdanshenas, Leon Moonen
2012 2012 28th IEEE International Conference on Software Maintenance (ICSM)  
We use static program slicing as the underlying analysis technique, and use model-driven engineering (MDE) techniques to propagate the ripple effects from a source code modification into all members of  ...  In addition, our approach ranks results based on an approximation of the scale of their impact.  ...  Acknowledgments: We thank the safety experts and software engineers from Kongsberg Maritime that participated in our workshop and interviews for their time and feedback.  ... 
doi:10.1109/icsm.2012.6405262 dblp:conf/icsm/YazdanshenasM12 fatcat:3zu4yhuiv5f63lpa77donnlzgu

Hippocampal Network Oscillations in APP/APLP2-Deficient Mice

Xiaomin Zhang, Ulrike Herrmann, Sascha W. Weyer, Martin Both, Ulrike C. Müller, Martin Korte, Andreas Draguhn, Jon T. Brown
2013 PLoS ONE  
Together, our data indicate that APLP2 and the intracellular domain of APP are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning  ...  There is, however, almost no data on the role of APP or APLP at the network level which forms a critical interface between cellular functions and behavior.  ...  Claus Bruehl and Daniel Durstewitz for discussions and excellent support with measurements and data analysis.  ... 
doi:10.1371/journal.pone.0061198 pmid:23585881 pmcid:PMC3621758 fatcat:yznfj5yrp5gbnd6dyivdlwq5da

Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation

Dong V Wang, Hau-Jie Yau, Carl J Broker, Jen-Hui Tsou, Antonello Bonci, Satoshi Ikemoto
2015 Nature Neuroscience  
Our results demonstrate a critical role of the MnR in regulating ripples and memory consolidation.  ...  Moreover, selective disruption of ripple activities after learning trials of a task results in poor performance of the task, an effect likely caused by disrupted Users may view, print, copy, and download  ...  Acknowledgments We thank the NIDA OTTC for producing AAVs, Evan Deneris for providing the ePet-Cre mouse line, Roger Cachope, Joe Cheer, Carlos Mejias-Aponte, Marisela Moralas, Andrew Kesner, Anton Ilango  ... 
doi:10.1038/nn.3998 pmid:25867120 pmcid:PMC4414896 fatcat:lzgibqntl5ckpd6tyfsjufy3am

Cholinergic Plasticity of Oscillating Neuronal Assemblies in Mouse Hippocampal Slices

Maura M. Zylla, Xiaomin Zhang, Susanne Reichinnek, Andreas Draguhn, Martin Both, Gennady Cymbalyuk
2013 PLoS ONE  
These results show that activation of cholinergic receptors induces plasticity at the level of oscillating hippocampal assemblies, in line with the different role of gamma-and SPW-R network activity for  ...  Coherent spatiotemporal network patterns were measured during SPW-R activity in mouse hippocampal slices.  ...  We additionally controlled for direct effects of atropine in a third group of slices (''atropine''; n = 8 slices).  ... 
doi:10.1371/journal.pone.0080718 pmid:24260462 pmcid:PMC3832478 fatcat:j2knnd2luzh47kanp4xogwd36q

Mechanisms of Sharp Wave Initiation and Ripple Generation

D. Schlingloff, S. Kali, T. F. Freund, N. Hajos, A. I. Gulyas
2014 Journal of Neuroscience  
To understand the mechanisms underlying the initiation of irregularly occurring SWRs and the generation of periodic ripples, we selectively manipulated different components of the CA3 network in mouse  ...  hippocampal slices.  ...  Optogenetic silencing of PV؉ inhibitory cells blocks sharp wave-ripples To strengthen our claim for the role of PVϩ cells in SWR generation, we tested the effect of temporarily silencing PVϩ cells by optogenetic  ... 
doi:10.1523/jneurosci.0867-14.2014 pmid:25143618 pmcid:PMC6615505 fatcat:orjrxwhdnngerp6sgai32tsvxe

The hippocampal CA3 region can generate two distinct types of sharp wave-ripple complexes, in vitro

Katharina T. Hofer, Ágnes Kandrács, István Ulbert, Ildikó Pál, Csilla Szabó, László Héja, Lucia Wittner
2014 Hippocampus  
AQ1 ABSTRACT: Hippocampal sharp wave-ripples (SPW-Rs) occur during slow wave sleep and behavioral immobility and are thought to play an important role in memory formation.  ...  We investigated the cellular and network properties of SPW-Rs with simultaneous laminar multielectrode and intracellular recordings in a rat hippocampal slice model, using physiological bathing medium.  ...  Acknowledgments The authors wish to thank Rich ard Csercsa and Andor Magony for the data analysis program SpikeSolution and WaveSolution. Thanks to Dr.  ... 
doi:10.1002/hipo.22361 pmid:25209976 fatcat:vt6uechiyjhvxeyhmmi2uoaqxe

Program Slicing Techniques and its Applications

N Sasirekha, A Edwin Robert, M Hemalatha
2011 International Journal of Software Engineering & Applications  
Understanding the program is related to execution behaviour and relationship of variable involved in the program.  ...  The task of finding all statements in a program that directly or indirectly influence the value for an occurrence of a variable gives the set of statements that can affect the value of a variable at some  ...  INTRODUCTION One of the program analysis techniques is program slicing.  ... 
doi:10.5121/ijsea.2011.2304 fatcat:ui7emhzff5d4nkd2nlbmnndkom

Mechanisms of Fast Ripples in the Hippocampus

V. I. Dzhala
2004 Journal of Neuroscience  
To characterize the mechanisms underlying FR oscillations (200 -600 Hz), we studied activity of single neurons and neuronal networks in rat hippocampal slices in vitro.  ...  Blockade of ionotropic glutamate receptors desynchronized onset of action potential bursts in individual pyramidal cells and abolished fast ripples.  ...  Fast ripple oscillations in the hippocampus. A, Example of population burst in hippocampal slice of P20 rat.  ... 
doi:10.1523/jneurosci.3112-04.2004 pmid:15470156 fatcat:prw4tuzls5g2vkhscl677ppufy

Early appearance and spread of fast ripples in the hippocampus in a model of cortical traumatic brain injury

F. Ortiz, W.P.K. Zapfe, A. Draguhn, R. Gutiérrez
2018 Journal of Neuroscience  
Here we study the propagation of these events between different subregions of the male rat hippocampus in a recently introduced experimental model of FRs in entorhinal cortex-hippocampal slices in vitro  ...  Fast ripples (FRs; activity of >250 Hz) have been considered as a biomarker of epileptic activity in the hippocampus and entorhinal cortex; it is thought that they signal the focus of seizure generation  ...  Recordings were acquired on a PC with the program Brain Wave in 5 min time windows (3Brain) and stored for off-line analysis.  ... 
doi:10.1523/jneurosci.3507-17.2018 pmid:30190413 pmcid:PMC6705981 fatcat:4qaaf7bkyjcsbo3spdmbjyoi4e

Cellular correlate of assembly formation in oscillating hippocampal networks in vitro

F. Bahner, E. K. Weiss, G. Birke, N. Maier, D. Schmitz, U. Rudolph, M. Frotscher, R. D. Traub, M. Both, A. Draguhn
2011 Proceedings of the National Academy of Sciences of the United States of America  
Recordings in vivo (11) and in vitro (12) have provided strong evidence for a major role of inhibitory interneurons in the temporal organization of cortical oscillations.  ...  These spikes had unique properties, because they were generated in the axon without prior depolarization of the soma. GABA A receptors had a dual role in pyramidal cell recruitment.  ...  Quantities Saved by the Simulation Program for Plotting and Analysis.  ... 
doi:10.1073/pnas.1103546108 pmid:21768381 pmcid:PMC3167520 fatcat:5jqgwvxlqfhylk555q4tfgwb4e

Extracellular Calcium Controls the Expression of Two Different Forms of Ripple-Like Hippocampal Oscillations

P. Aivar, M. Valero, E. Bellistri, L. Menendez de la Prida
2014 Journal of Neuroscience  
In the epileptic hippocampus, fast ripples (>200 Hz) reflect population spikes (PSs) from clusters of bursting cells, but HFOs in the ripple and the fast ripple range are vastly intermixed.  ...  Surprisingly, we found that this sole manipulation results in the emergence of two forms of HFOs reminiscent of ripples and fast ripples recorded in vivo from normal and epileptic rats, respectively.  ...  Notes Supplemental material for this article is available at  ... 
doi:10.1523/jneurosci.2826-13.2014 pmid:24553939 pmcid:PMC6608517 fatcat:ltsfr5x35zhp5epz6vssydthre

GABAergic transmission facilitates ictogenesis and synchrony between CA3, hilus, and dentate gyrus in slices from epileptic rats

Boris Gafurov, Suzanne B. Bausch
2013 Journal of Neurophysiology  
In: Random Data: Analysis and Measurement Procedures. New York: Wiley-Interscience, 1971. Borck C, Jefferys JG. Seizure-like events in disinhibited ventral slices of adult rat hippocampus.  ...  Reduced spike-timing reliability correlates with the emergence of fast ripples in the rat epileptic hippocampus. Neuron 55: 930 -941, 2007. Freund TF.  ...  The role of GABA A receptor-mediated transmission in cortico-hippocampal interactions in the epileptic brain is also unresolved.  ... 
doi:10.1152/jn.00679.2012 pmid:23615549 pmcid:PMC3727068 fatcat:imsv4azjzjbvjf3d2xlutzcjje

A taxonomy for software change impact analysis

Steffen Lehnert
2011 Proceedings of the 12th international workshop and the 7th annual ERCIM workshop on Principles on software evolution and software evolution - IWPSE-EVOL '11  
They are further classified according to the criteria of the taxonomy to enable the comparison and evaluation of approaches proposed in literature.  ...  We perform an evaluation of our taxonomy regarding the coverage of its classification criteria in studied literature, which is the second contribution.  ...  The aim of Bilal and Black [42] is to improve the ripple effect algorithm introduced by Yau et al. [41] in 1978, by optimizing the ripple effect metric.  ... 
doi:10.1145/2024445.2024454 dblp:conf/iwpse/Lehnert11 fatcat:s5ucqjzsr5c2pdoi3oeodnocpm
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