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Optical measurements reveal nature of intercellular coupling across ventricular wall

Steven Poelzing, Bradley J. Roth, David S. Rosenbaum
2005 American Journal of Physiology. Heart and Circulatory Physiology  
Optical measurements reveal nature of intercellular coupling across ventricular wall.  ...  The paraffinized blocks were then sectioned from epicardial to midmyocardial to endocardial layers every 2 mm, allowing for selective quantification of fiber orientation for each layer.  ...  A: summary data for all experiments demonstrate that coupling in the longitudinal direction on the epicardial surface is significantly different from coupling transverse and transmural to epicardial fibers  ... 
doi:10.1152/ajpheart.01245.2004 pmid:15863452 fatcat:m5rwcupi5bbrjn37fl62ouve5a

Electrophysiological Consequences of Cardiac Fibrosis

Sander Verheule, Ulrich Schotten
2021 Cells  
The impact of fibrosis on propagation depends on exactly how the patterns of electrical connections between myocytes are altered.  ...  Finally, we will discuss a histological quantification of fibrosis.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cells10113220 pmid:34831442 pmcid:PMC8625398 fatcat:oy2ybdaborfqjc4lns47qv74xi

Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure

Patrick A. Helm, Hsiang-Jer Tseng, Laurent Younes, Elliot R. McVeigh, Raimond L. Winslow
2005 Magnetic Resonance in Medicine  
The method was applied to the ex vivo reconstruction of the fiber architecture of seven canine hearts.  ...  of the diffusion tensor (DT) defines the sheet normal.  ...  Studies of electrical activation patterns have shown that current propagates most rapidly in the direction of the longitudinal fiber axis, and that spatial change of fiber orientation influences conduction  ... 
doi:10.1002/mrm.20622 pmid:16149057 pmcid:PMC2396270 fatcat:7pzjkaw5y5hyjjasafefdo52um

Surgical Reinforcement Alters Collagen Alignment and Turnover in Healing Myocardial Infarcts

Laura Rose Caggiano, Jia-Jye Lee, Jeffrey W. Holmes
2018 American Journal of Physiology. Heart and Circulatory Physiology  
We found that collagen in healing infarcts aligned parallel to regional strain and perpendicular to the preinfarction muscle and collagen fiber direction, strongly supporting our hypothesis that mechanical  ...  Previous studies have suggested that the composition and global mechanical properties of the scar tissue that forms after a myocardial infarction (MI) are key determinants of long-term survival, and emerging  ...  ACKNOWLEDGMENTS The authors thank the group at the Institute for Sports Medicine Copenhagen for assistance establishing the microdialysis method in our laboratory. GRANTS  ... 
doi:10.1152/ajpheart.00088.2018 pmid:30028201 fatcat:q6vxcsoa2nd6blhuax4mbetygu

Modern Imaging Techniques in Cardiomyopathies

M. Fuad Jan, A. Jamil Tajik
2017 Circulation Research  
The new catchphrase in the evaluation of cardiomyopathies is multimodality imaging, which is purported to be the efficient integration of various methods of cardiovascular imaging to improve the ability  ...  In contemporary cardiology practice, echocardiography and cardiac magnetic resonance imaging are widely used to provide a basic framework in the evaluation and management of cardiomyopathies.  ...  Services for editorial preparation of the article.  ... 
doi:10.1161/circresaha.117.309600 pmid:28912188 fatcat:zrtfpo4bwjbk5kq3qatzwqmnry

Therapeutic Targets in Heart Failure

Erik B. Schelbert, Gregg C. Fonarow, Robert O. Bonow, Javed Butler, Mihai Gheorghiade
2014 Journal of the American College of Cardiology  
These capabilities may provide a mechanistic platform to advance understanding of the role of the ECM, foster the development of novel therapeutics, and target specific disease-modifying pathways intrinsic  ...  Improved left ventricular characterization permits the identification and targeting of the intrinsic fundamental disease-modifying pathways that culminate in HF.  ...  Acknowledgment The authors are grateful for the expertise of Peter Kellman, PhD, from the National Heart, Lung, and Blood Institute, who provided invaluable assistance in creating Figure 3 .  ... 
doi:10.1016/j.jacc.2014.01.068 pmid:24657693 fatcat:f2nwrkrh6vhbfcj3qszfeuejae

Multiphysics Modeling of the Atrial Systole under Standard Ablation Strategies

Julia M. Hörmann, Cristóbal Bertoglio, Andreas Nagler, Martin R. Pfaller, Felix Bourier, Martin Hadamitzky, Isabel Deisenhofer, Wolfgang A. Wall
2017 Cardiovascular Engineering and Technology  
for the choice of the ablation concept in the future.  ...  We found that our computational model is able to detect the differences in the left atrial contractility and ejection fraction for various electrical activation sequences resulting from different ablation  ...  ACKNOWLEDGMENTS The authors would like to thank the Centers for Radiology of Klinikum rechts der Isar and German Heart Center, Munich, for image data used in this work.  ... 
doi:10.1007/s13239-017-0308-z pmid:28512679 fatcat:h3iglnfc2zfxnceg7nrtbstfnu

Uncertainty in cardiac myofiber orientation and stiffnesses dominate the variability of left ventricle deformation response

Rocío Rodríguez‐Cantano, Joakim Sundnes, Marie E. Rognes
2019 International Journal for Numerical Methods in Biomedical Engineering  
In this study, we apply UQ in computational heart mechanics to study uncertainty both in material parameters characterizing global myocardial stiffness and in the local muscle fiber orientation that governs  ...  In addition, in order to study variability in the muscle fiber architecture, we model the uncertainty in orientation of the fiber field as an approximated random field using a truncated Karhunen-Loéve  ...  Modelling uncertainty in the input parameters for the LDRB algorithm examines only one aspect of the influence of randomness in myocardial fiber architecture.  ... 
doi:10.1002/cnm.3178 pmid:30632711 pmcid:PMC6618163 fatcat:2j7b3zkjrrasjpzmgvc63hrqe4

Predicting the cardiac toxicity of drugs using a novel multiscale exposure–response simulator

Francisco Sahli Costabal, Jiang Yao, Ellen Kuhl
2018 Computer Methods in Biomechanics and Biomedical Engineering  
Torsadogenic risk has traditionally been associated with blockage of a specific potassium channel and an increased recovery period in the electrocardiogram.  ...  Here we establish a computational model to explore how drug-induced effects propagate from the single channel, via the single cell, to the whole heart level.  ...  Acknowledgements This research received the Hyperion Innovation Excellence Award and the HPC Wire Editors' Choice Award for Best Use  ... 
doi:10.1080/10255842.2018.1439479 pmid:29493299 fatcat:2lv2rvhemvhsbom45izg3rl2ue

Computational Modeling for Cardiac Resynchronization Therapy

Angela W C Lee, Caroline Mendonca Costa, Marina Strocchi, Christopher A Rinaldi, Steven A Niederer
2018 Journal of Cardiovascular Translational Research  
In the future, once these technical challenges are overcome, biophysically based models of the heart have the potential to become a clinical tool to aid in the diagnosis and treatment of HF.  ...  Cardiac modeling of the electrophysiology, electromechanics, and hemodynamics of the heart has been used to study mechanisms behind HF pathology and CRT response.  ...  [67] investigated the role of myocardial properties in the activation sequence on the LV endocardial surface and the ECG morphology in HF patients.  ... 
doi:10.1007/s12265-017-9779-4 pmid:29327314 pmcid:PMC5908824 fatcat:kaphptosk5d35aglppwv4q6z7u

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias

Edmond M. Cronin, Frank M. Bogun, Philippe Maury, Petr Peichl, Minglong Chen, Narayanan Namboodiri, Luis Aguinaga, Luiz Roberto Leite, Sana M. Al-Khatib, Elad Anter, Antonio Berruezo, David J. Callans (+26 others)
2019 Heart Rhythm  
Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab.  ...  Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them.  ...  Purkinje and myocardial fibers located in the pap- illary muscles (S2.2.4.53).  ... 
doi:10.1016/j.hrthm.2019.03.002 pmid:31085023 pmcid:PMC8453449 fatcat:s4tb4vmbhreebb7trwrfq76zeq

Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity

Dirk L. Brutsaert
2003 Physiological Reviews  
pattern of the peripheral Purkinje fiber network has yet to be established (202, 384) .  ...  Role of epicardial mesothelial cells in the modification of phenotype and function of adult rat ventricular myocytes in primary coculture. Circ Res 71: 40 -50, 1992. 138.  ... 
doi:10.1152/physrev.00017.2002 pmid:12506127 fatcat:lcbvm5gilbdbbbggl4rgjggbku

Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology

Shankarjee Krishnamoorthi, Luigi E. Perotti, Nils P. Borgstrom, Olujimi A. Ajijola, Anna Frid, Aditya V. Ponnaluri, James N. Weiss, Zhilin Qu, William S. Klug, Daniel B. Ennis, Alan Garfinkel, Alexander V. Panfilov
2014 PLoS ONE  
We describe a sequence of methods to produce a partial differential equation model of the electrical activation of the ventricles.  ...  We are particularly concerned with the validation of the various methods used in our model and, in this regard, propose a series of validation criteria that we consider essential.  ...  General features of the observed activation are 1. Early activation in the septum 2. Epicardial breakthrough in the RV first, followed by the LV 3.  ... 
doi:10.1371/journal.pone.0114494 pmid:25493967 pmcid:PMC4262432 fatcat:fv63vajlhng77j63py4o6ykoz4

Circulation Editors' Picks: Most Read Articles in Imaging

2011 Circulation  
These data suggest that the contractile pattern itself may play a role in prognosis after myocardial infarction independently of global and regional contractile function.  ...  Conclusion: Left ventricular dyssynchrony is independently associated with increased risk of death or heart failure after myocardial infarction, suggesting that contractile pattern may play a role in post-myocardial  ... 
doi:10.1161/circulationaha.111.077586 fatcat:2b2ipz5ghrgldcrlbho6guogiy

Computational Modeling of Cardiac Growth and Remodeling in Pressure Overloaded Hearts — Linking Microstructure to Organ Phenotype

Justyna A. Niestrawska, Christoph M. Augustin, Gernot Plank
2020 Acta Biomaterialia  
the progression of disease in the clinic.  ...  Cardiac growth and remodeling (G&R) refers to structural changes in myocardial tissue in response to chronic alterations in loading conditions.  ...  As the active myocardial state changes due to G&R, he link between active and passive mechanics should be modelled in future models as well.  ... 
doi:10.1016/j.actbio.2020.02.010 pmid:32058078 pmcid:PMC7311197 fatcat:futt7moxmveepjd4l6r5hcrtim
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