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Optical measurements reveal nature of intercellular coupling across ventricular wall
2005
American Journal of Physiology. Heart and Circulatory Physiology
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Optical measurements reveal nature of intercellular coupling across ventricular wall. ...
The paraffinized blocks were then sectioned from epicardial to midmyocardial to endocardial layers every 2 mm, allowing for selective quantification of fiber orientation for each layer. ...
A: summary data for all experiments demonstrate that coupling in the longitudinal direction on the epicardial surface is significantly different from coupling transverse and transmural to epicardial fibers ...
doi:10.1152/ajpheart.01245.2004
pmid:15863452
fatcat:m5rwcupi5bbrjn37fl62ouve5a
Electrophysiological Consequences of Cardiac Fibrosis
2021
Cells
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The impact of fibrosis on propagation depends on exactly how the patterns of electrical connections between myocytes are altered. ...
Finally, we will discuss a histological quantification of fibrosis. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/cells10113220
pmid:34831442
pmcid:PMC8625398
fatcat:oy2ybdaborfqjc4lns47qv74xi
Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure
2005
Magnetic Resonance in Medicine
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The method was applied to the ex vivo reconstruction of the fiber architecture of seven canine hearts. ...
of the diffusion tensor (DT) defines the sheet normal. ...
Studies of electrical activation patterns have shown that current propagates most rapidly in the direction of the longitudinal fiber axis, and that spatial change of fiber orientation influences conduction ...
doi:10.1002/mrm.20622
pmid:16149057
pmcid:PMC2396270
fatcat:7pzjkaw5y5hyjjasafefdo52um
Surgical Reinforcement Alters Collagen Alignment and Turnover in Healing Myocardial Infarcts
2018
American Journal of Physiology. Heart and Circulatory Physiology
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We found that collagen in healing infarcts aligned parallel to regional strain and perpendicular to the preinfarction muscle and collagen fiber direction, strongly supporting our hypothesis that mechanical ...
Previous studies have suggested that the composition and global mechanical properties of the scar tissue that forms after a myocardial infarction (MI) are key determinants of long-term survival, and emerging ...
ACKNOWLEDGMENTS The authors thank the group at the Institute for Sports Medicine Copenhagen for assistance establishing the microdialysis method in our laboratory.
GRANTS ...
doi:10.1152/ajpheart.00088.2018
pmid:30028201
fatcat:q6vxcsoa2nd6blhuax4mbetygu
Modern Imaging Techniques in Cardiomyopathies
2017
Circulation Research
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The new catchphrase in the evaluation of cardiomyopathies is multimodality imaging, which is purported to be the efficient integration of various methods of cardiovascular imaging to improve the ability ...
In contemporary cardiology practice, echocardiography and cardiac magnetic resonance imaging are widely used to provide a basic framework in the evaluation and management of cardiomyopathies. ...
Services for editorial preparation of the article. ...
doi:10.1161/circresaha.117.309600
pmid:28912188
fatcat:zrtfpo4bwjbk5kq3qatzwqmnry
Therapeutic Targets in Heart Failure
2014
Journal of the American College of Cardiology
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These capabilities may provide a mechanistic platform to advance understanding of the role of the ECM, foster the development of novel therapeutics, and target specific disease-modifying pathways intrinsic ...
Improved left ventricular characterization permits the identification and targeting of the intrinsic fundamental disease-modifying pathways that culminate in HF. ...
Acknowledgment The authors are grateful for the expertise of Peter Kellman, PhD, from the National Heart, Lung, and Blood Institute, who provided invaluable assistance in creating Figure 3 . ...
doi:10.1016/j.jacc.2014.01.068
pmid:24657693
fatcat:f2nwrkrh6vhbfcj3qszfeuejae
Multiphysics Modeling of the Atrial Systole under Standard Ablation Strategies
2017
Cardiovascular Engineering and Technology
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for the choice of the ablation concept in the future. ...
We found that our computational model is able to detect the differences in the left atrial contractility and ejection fraction for various electrical activation sequences resulting from different ablation ...
ACKNOWLEDGMENTS The authors would like to thank the Centers for Radiology of Klinikum rechts der Isar and German Heart Center, Munich, for image data used in this work. ...
doi:10.1007/s13239-017-0308-z
pmid:28512679
fatcat:h3iglnfc2zfxnceg7nrtbstfnu
Uncertainty in cardiac myofiber orientation and stiffnesses dominate the variability of left ventricle deformation response
2019
International Journal for Numerical Methods in Biomedical Engineering
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In this study, we apply UQ in computational heart mechanics to study uncertainty both in material parameters characterizing global myocardial stiffness and in the local muscle fiber orientation that governs ...
In addition, in order to study variability in the muscle fiber architecture, we model the uncertainty in orientation of the fiber field as an approximated random field using a truncated Karhunen-Loéve ...
Modelling uncertainty in the input parameters for the LDRB algorithm examines only one aspect of the influence of randomness in myocardial fiber architecture. ...
doi:10.1002/cnm.3178
pmid:30632711
pmcid:PMC6618163
fatcat:2j7b3zkjrrasjpzmgvc63hrqe4
Predicting the cardiac toxicity of drugs using a novel multiscale exposure–response simulator
2018
Computer Methods in Biomechanics and Biomedical Engineering
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Torsadogenic risk has traditionally been associated with blockage of a specific potassium channel and an increased recovery period in the electrocardiogram. ...
Here we establish a computational model to explore how drug-induced effects propagate from the single channel, via the single cell, to the whole heart level. ...
Acknowledgements This research received the Hyperion Innovation Excellence Award and the HPC Wire Editors' Choice Award for Best Use ...
doi:10.1080/10255842.2018.1439479
pmid:29493299
fatcat:2lv2rvhemvhsbom45izg3rl2ue
Computational Modeling for Cardiac Resynchronization Therapy
2018
Journal of Cardiovascular Translational Research
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In the future, once these technical challenges are overcome, biophysically based models of the heart have the potential to become a clinical tool to aid in the diagnosis and treatment of HF. ...
Cardiac modeling of the electrophysiology, electromechanics, and hemodynamics of the heart has been used to study mechanisms behind HF pathology and CRT response. ...
[67] investigated the role of myocardial properties in the activation sequence on the LV endocardial surface and the ECG morphology in HF patients. ...
doi:10.1007/s12265-017-9779-4
pmid:29327314
pmcid:PMC5908824
fatcat:kaphptosk5d35aglppwv4q6z7u
2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias
2019
Heart Rhythm
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Further sections provide a practical synopsis of the various techniques and of the specific ventricular arrhythmia sites and substrates encountered in the electrophysiology lab. ...
Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. ...
Purkinje and myocardial fibers located in the pap-
illary muscles (S2.2.4.53). ...
doi:10.1016/j.hrthm.2019.03.002
pmid:31085023
pmcid:PMC8453449
fatcat:s4tb4vmbhreebb7trwrfq76zeq
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity
2003
Physiological Reviews
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pattern of the peripheral Purkinje fiber network has yet to be established (202, 384) . ...
Role of epicardial mesothelial cells in the modification of phenotype and function of adult rat ventricular myocytes in primary coculture. Circ Res 71: 40 -50, 1992. 138. ...
doi:10.1152/physrev.00017.2002
pmid:12506127
fatcat:lcbvm5gilbdbbbggl4rgjggbku
Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology
2014
PLoS ONE
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We describe a sequence of methods to produce a partial differential equation model of the electrical activation of the ventricles. ...
We are particularly concerned with the validation of the various methods used in our model and, in this regard, propose a series of validation criteria that we consider essential. ...
General features of the observed activation are 1. Early activation in the septum 2. Epicardial breakthrough in the RV first, followed by the LV 3. ...
doi:10.1371/journal.pone.0114494
pmid:25493967
pmcid:PMC4262432
fatcat:fv63vajlhng77j63py4o6ykoz4
Circulation Editors' Picks: Most Read Articles in Imaging
2011
Circulation
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These data suggest that the contractile pattern itself may play a role in prognosis after myocardial infarction independently of global and regional contractile function. ...
Conclusion: Left ventricular dyssynchrony is independently associated with increased risk of death or heart failure after myocardial infarction, suggesting that contractile pattern may play a role in post-myocardial ...
doi:10.1161/circulationaha.111.077586
fatcat:2b2ipz5ghrgldcrlbho6guogiy
Computational Modeling of Cardiac Growth and Remodeling in Pressure Overloaded Hearts — Linking Microstructure to Organ Phenotype
2020
Acta Biomaterialia
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2020 pre-print arXiv:2003.00776v1 fatcat:ynzlcgqwmbc3fmvmhokydx7lji
the progression of disease in the clinic. ...
Cardiac growth and remodeling (G&R) refers to structural changes in myocardial tissue in response to chronic alterations in loading conditions. ...
As the active myocardial state changes due to G&R, he link between active and passive mechanics should be modelled in future models as well. ...
doi:10.1016/j.actbio.2020.02.010
pmid:32058078
pmcid:PMC7311197
fatcat:futt7moxmveepjd4l6r5hcrtim
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