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Different Forms of Helper Tolerance to Carcinoembryonic Antigen: Ignorance and Regulation

W. J. Pickford, A. J.M. Watson, R. N. Barker
2007 Clinical Cancer Research  
However, CEA elicited secretion of the Tr cytokine interleukin-10 (IL-10) in 23 of 50 donors, including 20 of 22 where no proliferation was induced.  ...  Purpose: Understanding the mechanisms of immune tolerance to tumor-associated antigens (TAA) is an important step in the design of cancer immunotherapy.  ...  ignorant'' in approximately half of the donors.  ... 
doi:10.1158/1078-0432.ccr-07-0721 pmid:17671139 fatcat:x5dwphojnnekbiyofh3wt5n2fa

CD8+T Cells Responding to Alveolar Self-Antigen Lack CD25 Expression and Fail to Precipitate Autoimmunity

Milena J. Tosiek, Sophie R. Bader, Achim D. Gruber, Jan Buer, Marcus Gereke, Dunja Bruder
2012 American Journal of Respiratory Cell and Molecular Biology  
We found that CD8 1 T cells remain ignorant in the steady state, whereas transient proliferation of self-reactive CD8 1 T cells is induced by forced maturation or licensing of dendritic cells, increases  ...  that allows the priming of previously ignorant T cells.  ...  Acknowledgments: The authors thank Silvia Prettin for excellent technical assistance and Lothar Gröbe for expert cell sorting.  ... 
doi:10.1165/rcmb.2011-0387oc pmid:22984087 fatcat:qhmxvgnoabfu3gxmtej5efwvy4

Page 190 of Business and Society Vol. 40, Issue 2 [page]

2001 Business and Society  
The mechanisms of diffusion and facilitation “grease the wheel” of the larger iterative process of proliferation and persistence.  ...  rule breaking by either passively ignoring it or more actively protecting rule breakers from the consequences of their actions.  ... 

Brain involvement in Duchenne muscular dystrophy: a role for dystrophin isoform Dp71 in cell migration and proliferation

A. Ash, L. Booth-Wynne, K. Anthony
2017 Neuromuscular Disorders  
Mounting evidence links these symptoms to the loss of dystrophin in the brain; yet central nervous system involvement in DMD has been largely ignored.  ...  The high risk of neuropsychiatric syndromes in Duchene warrants early intervention to achieve the best possible quality of life; our findings have significant potential to inform ongoing drug development  ...  Mounting evidence links these symptoms to the loss of dystrophin in the brain; yet central nervous system involvement in DMD has been largely ignored.  ... 
doi:10.1016/j.nmd.2017.06.085 fatcat:qjmckuhwenawneu26unona3kaq

Page 107 of Cancer Science Vol. 89, Issue 2 [page]

1998 Cancer Science  
Figures in parentheses are numbers of animals examined group in the present study can not be ignored, and the Although there have been no previous reports of SCCs possibility must be entertained that the  ...  Note the ductular lar proliferation in the submandibular gland of a female rat given proliferation and acinar atrophy, with extensive squamous meta- 1000 ppm KI in the water for 2 years.  ... 

Page 306 of English Journal Vol. 45, Issue 6 [page]

1956 English Journal  
In fact, one of the wonderful ironies of our culture is that on the one hand we proliferate an enormous and un- precedented popular art which is founded on the individual’s passion to remain ignorant of  ...  the facts of psychic and moral life; while on the other hand we proliferate an enormous and un- precedented family of professions sup- posed to supply us with self-knowledge —vocational counseling, marriage  ... 

Reversal of CD8+ T Cell Ignorance and Induction of Anti-Tumor Immunity by Peptide-Pulsed APC

N. Dalyot-Herman, O. F. Bathe, T. R. Malek
2000 Journal of Immunology  
Nguyen for technical assistance, and the Sylvester Comprehensive Cancer Center for support of the FACS facilities.  ...  We demonstrated that the naive OT-I T cells are functionally blind or ignorant of the OVA tumor Ag.  ...  The adoptively transferred OT-I T cells did not proliferate in lymphoid tissue of tumor-bearing mice and were not anergized by the tumor.  ... 
doi:10.4049/jimmunol.165.12.6731 pmid:11120791 fatcat:dzgz367ddndidmf6smy2pxifza

Page 36 of Journal of Systems Management Vol. 37, Issue 6 [page]

1986 Journal of Systems Management  
security of the system is endangered by this ignorance.  ...  The accuracy and integrity of data may well be affected by this ignorance.  ... 

B7+-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation

Hitoshi Yokoyama, Xinxiao Zheng, Terry B. Strom, Vicki Rubin Kelley
1994 Kidney International  
B7-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation.  ...  ignorance).  ...  Therefore, the role of Ia in autoimmune tissue injury is complex and the outcome (T cell anergy, ignorance or proliferation) is dependent on the presence or absence of costimulation by surface molecules  ... 
doi:10.1038/ki.1994.147 pmid:8007580 fatcat:pc7ao2hqqzf4ll4y2f66m3tcl4

Page 79 of American Society of Civil Engineers. Collected Journals Vol. 121, Issue 2 [page]

1995 American Society of Civil Engineers. Collected Journals  
The media seem to ignore any signs of real progress in environmental protection.  ...  The proliferation of environmental programs by various disciplines has obscured the origins of environmental engineering in traditional civil engineering programs.  ... 

Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction

Christian Kurts, Jacques F.A.P. Miller, Rathan M. Subramaniam, Francis R. Carbone, William R. Heath
1998 Journal of Experimental Medicine  
This represents the first in vivo evidence that cellular destruction can enhance access of exogenous antigens to the cross-presentation pathway.  ...  To activate naive T cells, foreign antigens must traffic from the site of infection to the draining lymph nodes, where they can be presented by professional antigen presenting cells.  ...  damage based on the lack of proliferation found in Fig. 4 G , and no later than day 6 given the proliferation shown in Fig. 4 C.  ... 
doi:10.1084/jem.188.2.409 pmid:9670054 pmcid:PMC2212442 fatcat:sqfxgfrf4vfwhpwbixtaqgzore

Three Kinds of Event Nominal Negation in Russian [chapter]

Anna Pazelskaya
2009 Lecture Notes in Computer Science  
distinction of simple event nominals (SENs) and complex event nominals (CENs) will be ignored: as has been shown (see A.  ...  'non-proliferations' b. nerasprostranenie 'non-proliferation' -* nerasprostranenija 'non-proliferations' c. mnogoletnee nerasprostranenie 'non-proliferation lasting for many years' d. dlitel'noe nevmeshatel'stvo  ... 
doi:10.1007/978-3-642-00665-4_3 fatcat:nllhroh3sjhivalyprmln7erru

High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model

Asmae Gassa, Halime Kalkavan, Fu Jian, Vikas Duhan, Vishal Khairnar, Namir Shaabani, Nadine Honke, Alexander Carpinteiro, Lacramioara Botezatu, Pietro Crivello, Sebastian Dolff, Stanislav Ferencik (+8 others)
2016 Cellular Physiology and Biochemistry  
Lang share authorship. host inflammatory response could break antigen ignorance. Introducing the GP33 antigen into BM cells led to deletion of anti-host reactive CD8 + T cells.  ...  This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (, applicable to the online version of  ...  Disclosure Statement The authors of this manuscript have no conflicts of interest to disclose as described by the journal of Cellular Physiology and Biochemistry.  ... 
doi:10.1159/000443078 pmid:27007114 fatcat:cgwh2pfg7ncqleef6k3lj5bosq

Lack of ignorance to tumor antigens: evaluation using nominal antigen transfection and T-cell receptor transgenic lymphocytes in Lyons-Parish analysis--implications for tumor tolerance

B W Robinson, B M Scott, R A Lake, P A Stumbles, D J Nelson, S Fisher, A L Marzo
2001 Clinical Cancer Research  
system, a failure of the tumor-specific immune response largely attributable to "ignorance."  ...  These data suggest that ignorance is not an explanation for the failure of the host immune system to respond to tumor antigens.  ...  Sherman from Scripps Medical Research Institute for the provision of the TCR transgenic mice.  ... 
pmid:11300477 fatcat:73ehfajlsbehpcvetk5weinrby

Study of Cancer Hallmarks Relevance Using a Cellular Automaton Tumor Growth Model [chapter]

José Santos, Ángel Monteagudo
2012 Lecture Notes in Computer Science  
Here we focus on the relevance of each hallmark in the progression of the first avascular phase of tumor growth and in representative situations.  ...  Additionally, these hallmarks are associated with a series of parameters, and depending on their values and the activation of the hallmarks in each of the cells, the system can evolve to different dynamics  ...  This paper has been funded by the Ministry of Science and Innovation of Spain (project TIN2011-27294).  ... 
doi:10.1007/978-3-642-32937-1_49 fatcat:rl2uoqctkrebbegynsi7m4esaa
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