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Vascular stasis, intestinal hemorrhage, and heightened vascular permeability complicate acute portal hypertension in cd39-null mice

Xiaofeng Sun, Andrés Cárdenas, Yan Wu, Keichi Enjyoji, Simon C. Robson
2009 American Journal of Physiology - Gastrointestinal and Liver Physiology  
Vascular stasis, intestinal hemorrhage, and heightened vascular permeability complicate acute portal hypertension in cd39-null mice.  ...  ACKNOWLEDGMENTS The authors thank Dr. Juan G. Abraldes for insightful comments. GRANTS  ...  This relative failure to generate adenosine within the vasculature results in decreased type-1 purinergic/adenosine receptor activation and disordered vascular inflammatory responses in the Cd39-null mouse  ... 
doi:10.1152/ajpgi.90703.2008 pmid:19520738 pmcid:PMC2724088 fatcat:w6hgygd4gzd5jbrb6jsptmpp7e

Smad3 Deficiency Counteracts Hepatocyte Apoptosis and Portal Fibrogenesis Induced By Bile Duct Ligation

Misako Sato, Kathleen C Flanders
2014 Journal of Liver  
Results: Here we found that mice lacking Smad3 are protected against cholestatic liver injury induced by BDL as evidenced by the absence of hepatocyte apoptosis and portal fibroproliferative responses,  ...  Smad3-null mice are also shown to reverse the hepatic TGF-β1 upregulation after BDL.  ...  Acknowledgements We are very grateful to the late Dr. Anita B. Roberts for her suggestions and encouragement. We also thank Mario Anzano for his help with the Smad3-null mice.  ... 
doi:10.4172/2167-0889.1000145 fatcat:5hrzs5htwjftpakbz2r2nr3c4m

Extracting Duplicate Georeferences from Herbarium Specimen Data [article]

Katelin D. Pearson
2021 Zenodo  
portal).  ...  The user must then clean the output file so it results in one row per specimen record.  ...  duplicates, one record in the target dataset may result in several records/rows in the output dataset.  ... 
doi:10.5281/zenodo.4637000 fatcat:6myagvh2azbn5mp5dhuy3gdpe4

Bile duct proliferation in liver-specificJag1conditional knockout mice: Effects of gene dosage

Kathleen M. Loomes, Pierre Russo, Matthew Ryan, Anthony Nelson, Lara Underkoffler, Curtis Glover, Hong Fu, Thomas Gridley, Klaus H. Kaestner, Rebecca J. Oakey
2007 Hepatology  
When Jag1 conditional mice were crossed with mice carrying the Jag1 null allele, the adult progeny exhibited striking bile duct proliferation.  ...  Conclusion: These results indicate that Notch signaling in the liver is sensitive to Jag1 gene dosage and suggest a role for the Notch pathway in postnatal growth and morphogenesis of bile ducts.  ...  in the Jag1 conditional/null mice might be a result of decreased overall Notch signaling.  ... 
doi:10.1002/hep.21460 pmid:17366661 fatcat:rjkn2nrdgrhztjks5ugnx3ho4m

Page 603 of Annals of Internal Medicine Vol. 55, Issue 4 [page]

1961 Annals of Internal Medicine  
.: Assessment of the results of surgical treatment in portal hypertension. Gastroenterology 38: 142, 1960. We tcu, C. S., Ramos, A.  ...  .: Results of porta caval shunts in the treatment of portal hyper tension. Surgery 41: 756, 1957. Fercuson, D. J.: Experience with surgery for portal hypertension. J. Lancet 77: 426, 1957  ... 

Tryptophan Residues in the Portal Protein of Herpes Simplex Virus 1 Critical to the Interaction with Scaffold Proteins and Incorporation of the Portal into Capsids

K. Yang, J. D. Baines
2009 Journal of Virology  
of the portal protein precluded this coimmunoprecipitation.  ...  In contrast, the W27A mutation precluded portal-scaffold interactions in infected cell lysates, reduced the solubility of pU L 6, decreased incorporation of the portal into capsids, and abrogated viral-DNA  ...  ACKNOWLEDGMENTS These studies were supported by R01 grant GM50740 from the National Institutes of Health. We thank Elizabeth Wills for reading the manuscript.  ... 
doi:10.1128/jvi.01463-09 pmid:19740984 pmcid:PMC2772705 fatcat:ooqtsqorbfbshfouxfsog2covi

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis

Linda Feldbrügge, Z. Gordon Jiang, Eva Csizmadia, Shuji Mitsuhashi, Stephanie Tran, Eric U. Yee, Sonja Rothweiler, Kahini A. Vaid, Jean Sévigny, Moritz Schmelzle, Yury V. Popov, Simon C. Robson
2017 Purinergic Signalling Purinergic Signalling  
Liver regeneration after partial hepatectomy is not substantively impaired in global Entpd2 null mice. NTPDase2 protects from liver fibrosis resulting from hepatocellular injury induced by CCl 4 .  ...  In injured livers, NTPDase2 expression extends from the portal areas to fibrotic septae in pan-lobular (CCl 4 -induced) liver fibrosis; the same pattern was observed, albeit to a lesser extent in biliary-type  ...  This ecto-enzyme is primarily an ATPase with minimal ADPase activity, which results in the accumulation of ADP in the extracellular milieu [10] .  ... 
doi:10.1007/s11302-017-9590-3 pmid:29134411 pmcid:PMC5842151 fatcat:gryuud45kzg3tpixoaw7gc4wpy

The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing

Fabien Delaere, Adeline Duchampt, Lourdes Mounien, Pascal Seyer, Céline Duraffourd, Carine Zitoun, Bernard Thorens, Gilles Mithieux
2013 Molecular Metabolism  
From these results we propose a finely tuned dual mechanism for portal glucose sensing that responds to different physiological conditions.  ...  A similar response of Trpm5-null mice and portal infusions of sweeteners also excluded sugar taste receptors.  ...  Then we used Trpm5-null mice in the same paradigm as GLUT2-null mice.  ... 
doi:10.1016/j.molmet.2012.11.003 pmid:24024129 pmcid:PMC3757661 fatcat:qk5jr6k7rfedjl47mead7crpce

Metrics for Outpatient Portal Use Based on Log File Analysis: Algorithm Development

Gennaro Di Tosto, Ann Scheck McAlearney, Naleef Fareed, Timothy R Huerta
2020 Journal of Medical Internet Research  
facilitate the adoption of behavioral metrics that enable the measurement of patient engagement based on the outpatient portal use.  ...  Of the 2607 patients in our sample, 2511 were active users of the patients portal where the median number of sessions was 94 (IQR 207).  ...  Acknowledgments This work was supported by the Agency for Healthcare Research and Quality grants R01 HS024091-01, R21 HS024349-01, and P30-HS024379.  ... 
doi:10.2196/16849 pmid:32530435 pmcid:PMC7320309 fatcat:ytk4mhi4mvfezdcjum4xmcisau

Development of the web portal for research support in the area of electrical impedance tomography

Grayr Aleksanyan, Andrey Katsupeev, Andrey Sulyz, Stanislav Pyatnitsin, Danil Peregorodiev
2019 Eastern-European Journal of Enterprise Technologies  
Acknowledgements The study is carried out as part of the federal target program "Research and Development in Priority Directions for the Development of the Russian Science and Technology Complex for 2014  ...  -2020", with financial support from the Ministry of Science and Higher Education (agreement No. 05.607.21.0305).  ...  Discussion of experimental results of EIT web portal research The obtained timing results of the web portal work for various matrix dimensions, presented in Table 6 , allow to calculate the conduction  ... 
doi:10.15587/1729-4061.2019.184318 fatcat:uhggq4iwyvh53jlfcqr6k7fr4u

Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance

Keval Chandarana, Cigdem Gelegen, Elaine E. Irvine, Agharul I. Choudhury, Chloé Amouyal, Fabrizio Andreelli, Dominic J. Withers, Rachel L. Batterham
2013 Molecular Metabolism  
ACKNOWLEDGMENTS This work was funded by the Rosetrees Trust. K.C., E.I.E., A.I.C., and D.J.W were funded by the MRC. K.C. researched data and wrote the article.  ...  ., F.A researched data and reviewed the article. D.J.W. researched data, contributed to discussion, and reviewed the article. R.L.B. researched data and wrote the article.  ...  The common bile duct was clamped and a Liberase solution (Roche, UK) solution was injected into the pancreatic duct resulting in pancreatic disruption.  ... 
doi:10.1016/j.molmet.2013.03.001 pmid:24049729 pmcid:PMC3773824 fatcat:jrltyxpt2ngcrk3g2ga4nd6jte

Cryo-electron tomography of the herpesvirus procapsid reveals interactions of the portal with the scaffold and a shift on maturation [article]

Michael H C Buch, J Bernard Heymann, William W Newcomb, Dennis C Winkler, Alasdair C Steven
2020 bioRxiv   pre-print
The portal is embedded in the underlying scaffold, consistent with assembly initiating on a portal-scaffold complex.  ...  The portal is located on the interior surface with its narrower end facing outwards in contact with the capsid shell.  ...  Tomograms were 410 binned 2-fold, resulting in a final pixel size of 3.66 Å for UL25-null A-capsids and 3.61 Å for 411 procapsids.  ... 
doi:10.1101/2020.09.30.320457 fatcat:xyziyv4pmzcaxkbd3zo6fvb3he

Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption

M. Miyata, Y. Matsuda, M. Nomoto, Y. Takamatsu, N. Sato, M. Hamatsu, P. A. Dawson, F. J. Gonzalez, Y. Yamazoe
2008 Drug Metabolism And Disposition  
Fecal bile acid excretion was also increased in Fxr-null mice fed the CA؉Chol versus CA diet.  ...  Cholic acid (CA) feeding of farnesoid X receptor (Fxr)-null mice results in markedly elevated hepatic bile acid levels and liver injury.  ...  The portal blood bile acid concentration was approximately 11-fold higher in Fxr-null mice fed the CA diet compared with Fxr-null mice fed the control diet (Fig. 4) .  ... 
doi:10.1124/dmd.108.022590 pmid:18988759 pmcid:PMC2680521 fatcat:pljnwn4fkne7jkjmqgj6ec3mhy

Page 33 of None Vol. 12, Issue 1 [page]

1985 None  
RESULTS The pattern of variation of plasma glucose, IRI, IRG, and SRIF across the clock time in portal blood of four 1 6s PORTAL n=2 1600r gs 1400 1 1 oS 8888 8s 88 8 E37 normal dogs, sampled every 7.5  ...  A two-factor analysis of variance was then performed on the obtained components using the F dis- tribution and rejecting the null hypothesis of equivalent mean frequencies among the two classifications  ... 

Portal m-Da'wah using Wireless Application Protocol

Daru Prasetyawan, Ahmad Subhan Yazid, Agus Mulyanto
2013 IJID (International Journal on Informatics for Development)  
The test results show that the application meets the functionality requirements and is suitable for use.  ...  The study method used in this study is system development, which is an experiment for the design of the m-da'wah portal that can be accessed via a cellphone or PDA.  ...  The results will be displayed on the screen of the device being used. D.  ... 
doi:10.14421/ijid.2013.02105 doaj:54ef23c74e0e4e868e0e316675babcb5 fatcat:s7zwkqanubggfp4ahgukulzqmi
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