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Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Willemijn D. B. Warmink-Perdijk, Lilian L. Peters, Ettje F. Tigchelaar, Jackie A. M. Dekens, Soesma A. Jankipersadsing, Alexandra Zhernakova, Willem J. R. Bossers, Jan Sikkema, Ank de Jonge, Sijmen A. Reijneveld, Henkjan J. Verkade, Gerard H. Koppelman (+3 others)
2020 European Journal of Epidemiology  
The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design.  ...  It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern  ...  Acknowledgements We are grateful for the participation of all the mothers, fathers and children in Lifelines NEXT.  ... 
doi:10.1007/s10654-020-00614-7 pmid:32100173 fatcat:ohzu44cgq5gurncdjsnfm23bie

Range Management in the United States for the Next One to Three Generations

Marion Clawson
1972 Journal of range management  
One has only to recall the great changes that the past one to three generations have brought in every aspect of our lives; he would be wise to assume that the next one to three generations will bring equally  ...  But the course of economic and social development of the past three generations (at least) has been toward more and more waste products; we are growing increasingly restive that they should be dumped in  ... 
doi:10.2307/3896539 fatcat:5jnxa4hvbrbdhkp4dausucmlqu

General up to next-nearest-neighbour elasticity of triangular lattices in three dimensions

Cyril Dubus, Ken Sekimoto, Jean-Baptiste Fournier
2006 Proceedings of the Royal Society A  
We establish the most general form of the discrete elasticity of a 2D triangular lattice embedded in three dimensions, taking into account up to next-nearest neighbour interactions.  ...  the lattice.  ...  In this paper, we consider a triangular lattice embedded in three dimensions and we determine the most general expression of the harmonic elastic energy up to nextnearest neighbour interactions.  ... 
doi:10.1098/rspa.2006.1694 fatcat:pogv6mrkpre6djxzibajhfilzy

Science, Values and People: The Three Factors that Will Define the Next Generation of International Conservation Agreements

Alexander Gillespie
2011 Transnational Environmental Law  
The three issues are those related to the use of science to frame regimes; the use of philosophy to examine the values of what is trying to be achieved; and the use of politics to ensure that local communities  ...  AbstractThis paper is concerned with three emerging issues that define the way in which international conservation law moves forward in the coming decades.  ...  Rather, it seeks to draw out three issues which run through all conservation agreements.  ... 
doi:10.1017/s204710251100001x fatcat:2lkraotel5botcc2gr7ottwrta

Horizontal transmission of the ectoparasite Gyrodactylus arcuatus (Monogenea: Gyrodactylidae) to the next generation of the three-spined stickleback Gasterosteus aculeatus

Jaakko Lumme, Marek S. Zietara
2018 Folia Parasitologica  
To understand the transmission dynamics in a single location, the transmission of the parasite from adults to next generation sticklebacks was investigated in a northern Baltic brackish water location.  ...  In Baltic populations of the three-spined stickleback Gasterosteus aculeatus Linnaeus, the local mitochondrial diversity of Gyrodactylus arcuatus Bychowsky, 1933 is very high, and spatial differentiation  ...  The study was supported by The Finnish Academy (grants 63787 and 134592 to JL).  ... 
doi:10.14411/fp.2018.006 pmid:29743378 fatcat:q5qsza2aurag3ivrdhjanjadby

Reliable, robust and realistic: the three R's of next-generation land surface modelling

I. C. Prentice, X. Liang, B. E. Medlyn, Y.-P. Wang
2014 Atmospheric Chemistry and Physics Discussions  
We propose that the way forward for next-generation complex LSMs will include: (a) representations of biological and hydrological processes based on the implementation of multiple internal constraints;  ...  These "third-generation" LSMs respect the close coupling of the carbon and water cycles through plants, but otherwise tend to be under-constrained, and have not taken full advantage of robust hydrological  ...  The three R's of next-generation land surface modelling I. C. Prentice et al. Title Page Abstract Introduction Conclusions  ... 
doi:10.5194/acpd-14-24811-2014 fatcat:opwubqxdubgcbmdqyjklpde7ca

Reliable, robust and realistic: the three R's of next-generation land-surface modelling

I. C. Prentice, X. Liang, B. E. Medlyn, Y.-P. Wang
2015 Atmospheric Chemistry and Physics  
We propose that the way forward for next-generation complex LSMs will include: (a) representations of biological and hydrological processes based on the implementation of multiple internal constraints;  ...  These "third-generation" LSMs respect the close coupling of the carbon and water cycles through plants, but otherwise tend to be under-constrained, and have not taken full advantage of robust hydrological  ...  The three R's of next-generation land surface modelling I. C. Prentice et al. Title Page Abstract Introduction Conclusions  ... 
doi:10.5194/acp-15-5987-2015 fatcat:ax5afbacsbburaorp5cvis2z7i

Mentoring the next researcher generation: Reflections on three years of building VET research capacity and infrastructure

Llandis Barratt-Pugh
2012 International Journal of Training Research  
During those first three years more than 40 experienced VET researchers have been associated with the programme, mainly as mentors and facilitators.  ...  It traces the project development from the initial project dilemmas through to the completion and publication of papers.  ...  the next generation.  ... 
doi:10.5172/ijtr.2012.10.1.6 fatcat:hqppqttkandhli72eog4zbwfvq

Three Generations of Particles Are Necessary for Our Universe as Well as the Next Level of Matter

Vladimir Burdyuzha
2014 Journal of Modern Physics  
Dark matter from familons, existence of three generations of particles, existence of distinguished scales in the Universe, and fractal distribution of baryon structures are natural phenomenon in the preon  ...  The origin of the scale hierarchy in the baryon component is clarified because of this component owing to gravitation repeated dark matter structuring.  ...  For the very opportunity of structuring of the Universe at least three generations of particles are necessary (the first generation gives the observable baryon world, the second and third generations (  ... 
doi:10.4236/jmp.2014.517191 fatcat:cyhyymkjbrf2fpcti3r7lvfzta

Preclinical three-dimensional colorectal cancer model: The next generation of in vitro drug efficacy evaluation

Francesca Sensi, Edoardo D'Angelo, Sara D'Aronco, Roberto Molinaro, Marco Agostini
2018 Journal of Cellular Physiology  
In this review, we critically describe the most representative bioengineered models for anticancer drug screening in CRC from the conventional two-dimensional models to the new-generation three-dimensional  ...  in the later clinical phases.  ...  To identify new drugs, thus trying to shorten the in vitro test phase, the scientific community is evaluating the three-dimensional (3D) scaffold-based approach as a way to bridge the gap between the in  ... 
doi:10.1002/jcp.26812 pmid:30277557 fatcat:hcuqaah6yvcmrbbizmz5d3ypim

1 Targeted next generation sequencing (NGS) of the CFTR locus: Comparison of three technical approaches

P. Guéguen, M.-P. Audrézet, A. Despres, C. Le Maréchal, C. Férec
2013 Journal of Cystic Fibrosis  
in CF molecular diagnostics applying the next generation sequencing technologies M.D.  ...  Next Generation Sequencing (NGS) technologies have proven a high sensitivity to detect sequence variants, irrespectively of their frequency.  ... 
doi:10.1016/s1569-1993(13)60144-7 fatcat:dmmcf2gglvemhbdvyej5jnx2wa

What Is Left for Our Next Generation? Integrating Ecosystem Services into Regional Policy Planning in the Three Gorges Reservoir Area of China

Yang Xiao, Qinli Xiong, Kaiwen Pan
2018 Sustainability  
Three alternative scenarios in 2050 were modeled for the Three Gorges Reservoir Area watershed. The model GEOMOD was used to predict future LULC changes due to policy planning.  ...  This study highlights the observation that including ES in policy planning and has a great potential to generate opportunities to maximize ES.  ...  Acknowledgments: We thank Pinghan Liang for his help during the preparation of the manuscript.  ... 
doi:10.3390/su11010003 fatcat:xceeojaqt5af5oibo24tdb5ise

Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis

Nelson Montalvo, Ligia Redrobán, David Galarza
2019 Diagnostic Pathology  
The Ki-67 score was 46%. Using a next-generation sequencing assay, we documented genomic alterations in KRAS and CTNNB1, low tumor mutation burden (TMB), and an absence of microsatellite instability.  ...  Three years later, the patient presented pulmonary nodules in the lingula and left basal lobe that were resected by thoracotomy.  ...  DG conducted a thorough literature review and the differential diagnosis, and was the major contributor in writing the manuscript. All authors read and approved the final manuscript.  ... 
doi:10.1186/s13000-019-0847-8 pmid:31266530 pmcid:PMC6607580 fatcat:dcf5stncbzcbne4zc43sfevwsq

Detection of viromes of RNA viruses using the next generation sequencing libraries prepared by three methods

Yuan Qiu, Ji-Ming Chen, Tong Wang, Guang-Yu Hou, Qing-Ye Zhuang, Run Wu, Kai-Cheng Wang
2017 Virus Research  
Virome (viral megagenomics) detection using next generation sequencing has been widely applied in virology, but its methods remain complicated and need optimization.  ...  prepared by three methods.  ...  Acknowledgement This work was supported with the Innovation Fund of CAHEC (Number: 2015IF-0004FF).  ... 
doi:10.1016/j.virusres.2017.05.003 pmid:28501627 pmcid:PMC7111271 fatcat:x5rfasjn5bbcja7fvlodc75nua

Culture and Technology for the Next-Generation Image Production. Breakthrough for Image Production of Next Generation. Vedeo Input Systems. Three Dimensional Image to Interface beyond the Creaters' Intention
特集 次世代映像制作の文化と技術 次世代映像制作環境へのブレークスルー 映像入力 制作者の一意的な意図を越えて伝わる3次元映像

Kenji Taima
1994 The Journal of the Institute of Television Engineers of Japan  
Dimensional Image to Interface beyond the Creaters' Intention" by Kenji Taima (3D Project, Sanyo Electric Co., Ltd., Osaka) 1412(60) テ レ ビ ジ ョ ン 学 会 誌 Vol.48, No.11, pp.1412-1415 (1994) .  ...  ホ ロ グ ラ フ ィ に よ る 映 像 制 作 は,レ ー ザ 光 を直 接 被 写 体 に 当 て 撮 影 す る方 式 と,多 数 の2次 元 画 像 を集 約 す る ホ ロ グ ラ フ ィ ッ ク ス テ レ オ グ ラ ム と呼 ば れ る 方 式,さ ら に干 渉 縞 を計 算 機 で 作 成 す る計 算 機械 合 成 ホ ロ グ ラ ム(CGH,Computer Generated  ... 
doi:10.3169/itej1978.48.1412 fatcat:d7j2jlf2jzhvtkjmy2wnp254su
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