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Collaborative Editing Support System for Cancer Information Distribution

Takashi Fukushima, Kotone Matsuyama, Keiko Murata, Masanori Fukushima
2005 Japan Journal of Medical Informatics  
Using this system we have operate cancer information publication on the Web since October 2003.  ...  Now we provide treatment information based on PDQ®(Physician Data Query from National Cancer Institute) ※1 , drug information, clinical trial information, and treatment result information.  ...  tasks such as translation, HTML format checking, and drug database maintenance.  ... 
doi:10.14948/jami.25.297 fatcat:2jh35j4nengddkftip4j5ealga

Controlled Terminology for Clinical Research: A Collaboration between CDISC and NCI Enterprise Vocabulary Services

Margaret W. Haber, Bron W. Kisler, Mary Lenzen, Lawrence W. Wright
2007 Drug information journal  
Over the past decade, the Clinical Data Interchange Standards Consortium (CDISC) has developed international standards to improve the efficiency with which research data are collected, exchanged, and managed  ...  The Study Data Tabulation Model (SDTM), used for regulatory submissions, is the most widely adopted CDISC standard to date.  ...  Cimino stated: "Given this environment, information in one system cannot be easily recognized by other systems, hindering the ability to integrate component applications into larger systems" (6) .  ... 
doi:10.1177/009286150704100314 fatcat:optkcmsilfdkfe3rdsisp3bzim

Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia

Smita Bhatia, Wendy Landier, Lindsey Hageman, Yanjun Chen, Heeyoung Kim, Can-Lan Sun, Nancy Kornegay, William E. Evans, Anne L. Angiolillo, Bruce Bostrom, Jacqueline Casillas, Glen Lew (+7 others)
2015 JAMA Oncology  
, or caregiver-administered oral 6MP during maintenance therapy; and (4) completion of at least 6 months of maintenance therapy at the time of study enrollment.  ...  IMPORTANCE Variability in prescribed doses of 6-mercaptopurine (6MP) and lack of adherence to a 6MP treatment regimen could result in intra-individual variability in systemic exposure to 6MP (measured  ...  6MP during maintenance therapy; and (4) completion of at least 6 months of maintenance therapy at the time of study enrollment.  ... 
doi:10.1001/jamaoncol.2015.0245 pmid:26181173 pmcid:PMC4561178 fatcat:z2msaw3m4jfxzmzx7h6n6r5fre

Understanding drug-related mortality in released prisoners: a review of national coronial records

Jessica Y Andrews, Stuart A Kinner
2012 BMC Public Health  
Methods: A nationwide search of the Australian National Coroners Information System (NCIS) was conducted to identify reportable deaths among ex-prisoners from 2000 to 2007.  ...  The majority of accidental drug-related deaths occurred in a home environment, and poly-substance use at or around the time of death was common, recorded in 72% of drugrelated deaths.  ...  Acknowledgements The authors wish to thank Ms Jessica Wade  ... 
doi:10.1186/1471-2458-12-270 pmid:22475069 pmcid:PMC3464778 fatcat:p4yfe4zjdfgujasrasddc6hr4m

Page 2005 of Journal of Clinical Oncology Vol. 25, Issue 6 [page]

2007 Journal of Clinical Oncology  
infections for 6 months. infections (one or more infections per vent or within 6 months of the last dose.  ...  The se reaction information from clinical trials does, however, provide a basis for identi- fying the adverse events that appear to be related to drug use and for approximating rates ety data, except where  ... 

caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability

George A. Komatsoulis, Denise B. Warzel, Francis W. Hartel, Krishnakant Shanbhag, Ram Chilukuri, Gilberto Fragoso, Sherri de Coronado, Dianne M. Reeves, Jillaine B. Hadfield, Christophe Ludet, Peter A. Covitz
2008 Journal of Biomedical Informatics  
One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system.  ...  The caCORE infrastructure provides a mechanism to create interoperable biomedical information systems.  ...  On the right is a class from a hypothetical data system that provides information about Drugs.  ... 
doi:10.1016/j.jbi.2007.03.009 pmid:17512259 pmcid:PMC2254758 fatcat:hwrj2dojvjc6xe244oakvwojfa

Cancer Pharmacogenomics and Pharmacoepidemiology: Setting a Research Agenda to Accelerate Translation

Andrew N. Freedman, Leah B. Sansbury, William D. Figg, Arnold L. Potosky, Sheila R. Weiss Smith, Muin J. Khoury, Stefanie A. Nelson, Richard M. Weinshilboum, Mark J. Ratain, Howard L. McLeod, Robert S. Epstein, Geoffrey S. Ginsburg (+16 others)
2010 Journal of the National Cancer Institute  
will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice.  ...  To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting  ...  information on prescription drug use.  ... 
doi:10.1093/jnci/djq390 pmid:20944079 pmcid:PMC2982809 fatcat:z6pcjmtt7ffgrbyarymsetm2yy

Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97

G Escherich, M A Horstmann, M Zimmermann, G E Janka-Schaub
2009 Leukemia  
Importantly, the gradual reduction in central nervous system (CNS) irradiation led to a decreased incidence of brain tumours as a second malignancy.  ...  compared with in vitro drug sensitivity testing.  ...  We also thank all individuals who collaborated in the designated COALL trials in the past: Dr Pongratz  ... 
doi:10.1038/leu.2009.249 pmid:20016530 fatcat:3vbjdb4u7bbstgbbfg24mglwzy

Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity

Fabricio G. Sousa, Renata Matuo, Sai-Wen Tang, Vinodh N. Rajapakse, Augustin Luna, Chris Sander, Sudhir Varma, Paul H.G. Simon, James H. Doroshow, William C. Reinhold, Yves Pommier
2015 DNA Repair  
Based on this compendium of alterations, we determined which DNAR genomic alterations predicted drug response for 20,195 compounds present in the NCI-60 drug database.  ...  Because the landscape of DNAR defects across numerous types of cancers and its relation with drug activity have not been systematically examined, we took advantage of the unique drug and genomic databases  ...  Acknowledgments The authors wish to thank Dr. Agata Smogorzewska for kindly providing the FANCP cell lines, RA3331 and RA3331 complemented with WT SLX4. We thank Kurt W. Kohn  ... 
doi:10.1016/j.dnarep.2015.01.011 pmid:25758781 pmcid:PMC4385398 fatcat:7c5utrr4prh6lierufsnx6xrdi

Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia

V Conter, M Aricò, G Basso, A Biondi, E Barisone, C Messina, R Parasole, G De Rossi, F Locatelli, A Pession, N Santoro, C Micalizzi (+9 others)
2009 Leukemia  
A progressive improvement of results with reduction of isolated central nervous system relapse rate was obtained.  ...  Treatment was characterized by progressive intensification of systemic therapy and reduction of cranial radiotherapy.  ...  Acknowledgements We are grateful to all parents associations and charities, which continuously supported the clinical and research work.  ... 
doi:10.1038/leu.2009.250 pmid:20016536 fatcat:o46lgahcozck7ayynjquuqizd4

The Lexicon Builder Web service: Building Custom Lexicons from two hundred Biomedical Ontologies

Gautam K Parai, Clement Jonquet, Rong Xu, Mark A Musen, Nigam H Shah
2010 AMIA Annual Symposium Proceedings  
The Lexicon Builder Web service addresses this need and reduces the investment of time and effort involved in lexicon maintenance.  ...  It is currently being evaluated for several use cases to establish its utility in biomedical information processing tasks.  ...  Acknowledgments This work is supported by NIH grant U54 HG004028 in support of the National Center for Biomedical Ontology, one of the National Centers for Biomedical Computing.  ... 
pmid:21347046 pmcid:PMC3041331 fatcat:ssd6h5izpzcc3hplvttaf3vdjy

A Dual-Fluorescence High-Throughput Cell Line System for Probing Multidrug Resistance

Kyle R. Brimacombe, Matthew D. Hall, Douglas S. Auld, James Inglese, Christopher P. Austin, Michael M. Gottesman, King-Leung Fung
2009 Assay and drug development technologies  
We describe the development of a dualfluorescent cell line system to allow multiplexing of drug-sensitive and Pgp-mediated MDR cell lines.  ...  The parental OVCAR-8 human ovarian carcinoma cell line and the isogenic MDR NCI/ADR-RES subline, which stably expresses high levels of endogenous P-gp, were transfected to express the fluorescent proteins  ...  This research was supported by the Intramural Research Program of the National Institutes of Health. K.R.B. was supported by a Center for Cancer Research/NCI training fellowship.  ... 
doi:10.1089/adt.2008.165 pmid:19548831 pmcid:PMC2814070 fatcat:72ktta2jsvcudcwpyzdrd6lrwy

India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base

Jeffrey D. White, Barry R. O'Keefe, Jitendra Sharma, Ghazala Javed, Vid Nukala, Aniruddha Ganguly, Ikhlas A. Khan, Nagi B. Kumar, Hasan Mukhtar, Guido F. Pauli, Larry Walker, Sudha Sivaram (+2 others)
2018 Journal of Global Oncology  
collate all information related to cancer research done in AYUSH systems.  ...  tion of information on Indian systems of medi- cine through collaborative research.  ...  AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated.  ... 
doi:10.1200/jgo.17.00099 pmid:30241135 pmcid:PMC6180779 fatcat:gbf533fnqffunlccor4pwiqjsi

Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells

BIN-CHUAN JI, CHIEN-CHIH YU, SU-TSO YANG, TE-CHUN HSIA, JAI-SING YANG, KUANG-CHI LAI, YANG-CHING KO, JEN-JYH LIN, TUNG-YUAN LAI, JING-GUNG CHUNG
2012 Oncology Reports  
We investigated the effects of deguelin on DNA damage and associated gene expression in human lung cancer NCI-H460 cells in vitro.  ...  DNA damage was assayed by using the comet assay and DNA gel electrophoresis and the results indicated that NCI-H460 cells treated with 0, 50, 250 and 500 nM deguelin led to a longer DNA migration smear  ...  Acknowledgements This study was supported by grant 99-CCH-IRP-08 from the Changhua Christian Hospital, Changhua, Taiwan.  ... 
doi:10.3892/or.2012.1622 pmid:22227970 pmcid:PMC3583480 fatcat:cfkyc5diifb3fbl5n5bfpuiyty

Curing the Curable: Managing Low-Risk Acute Lymphoblastic Leukemia in Resource Limited Countries

Bernice L. Z. Oh, Shawn H. R. Lee, Allen E. J. Yeoh
2021 Journal of Clinical Medicine  
In treating childhood ALL, the key is risk stratification, which can be resource stratified. NCI standard-risk criteria (age 1–10 years, WBC < 50,000/uL) is simple yet highly effective.  ...  Other key elements in low-toxicity protocol designs include: induction steroid type; high-dose versus low-dose escalating methotrexate; judicious use of anthracyclines; and steroid pulses during maintenance  ...  Conflicts of Interest: The authors have no conflict of interest to disclose.  ... 
doi:10.3390/jcm10204728 pmid:34682851 fatcat:vmq2zn4aqven3pns3u35lnezvy
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