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Collaborative Editing Support System for Cancer Information Distribution
2005
Japan Journal of Medical Informatics
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Using this system we have operate cancer information publication on the Web since October 2003. ...
Now we provide treatment information based on PDQ®(Physician Data Query from National Cancer Institute) ※1 , drug information, clinical trial information, and treatment result information. ...
tasks such as translation, HTML format checking, and drug database maintenance. ...
doi:10.14948/jami.25.297
fatcat:2jh35j4nengddkftip4j5ealga
Controlled Terminology for Clinical Research: A Collaboration between CDISC and NCI Enterprise Vocabulary Services
2007
Drug information journal
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Over the past decade, the Clinical Data Interchange Standards Consortium (CDISC) has developed international standards to improve the efficiency with which research data are collected, exchanged, and managed ...
The Study Data Tabulation Model (SDTM), used for regulatory submissions, is the most widely adopted CDISC standard to date. ...
Cimino stated: "Given this environment, information in one system cannot be easily recognized by other systems, hindering the ability to integrate component applications into larger systems" (6) . ...
doi:10.1177/009286150704100314
fatcat:optkcmsilfdkfe3rdsisp3bzim
Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia
2015
JAMA Oncology
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, or caregiver-administered oral 6MP during maintenance therapy; and (4) completion of at least 6 months of maintenance therapy at the time of study enrollment. ...
IMPORTANCE Variability in prescribed doses of 6-mercaptopurine (6MP) and lack of adherence to a 6MP treatment regimen could result in intra-individual variability in systemic exposure to 6MP (measured ...
6MP during maintenance therapy; and (4) completion of at least 6 months of maintenance therapy at the time of study enrollment. ...
doi:10.1001/jamaoncol.2015.0245
pmid:26181173
pmcid:PMC4561178
fatcat:z2msaw3m4jfxzmzx7h6n6r5fre
Understanding drug-related mortality in released prisoners: a review of national coronial records
2012
BMC Public Health
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Methods: A nationwide search of the Australian National Coroners Information System (NCIS) was conducted to identify reportable deaths among ex-prisoners from 2000 to 2007. ...
The majority of accidental drug-related deaths occurred in a home environment, and poly-substance use at or around the time of death was common, recorded in 72% of drugrelated deaths. ...
Acknowledgements The authors wish to thank Ms Jessica Wade ...
doi:10.1186/1471-2458-12-270
pmid:22475069
pmcid:PMC3464778
fatcat:p4yfe4zjdfgujasrasddc6hr4m
Page 2005 of Journal of Clinical Oncology Vol. 25, Issue 6
[page]
2007
Journal of Clinical Oncology
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infections for 6 months. infections (one or more infections per vent or within 6 months of the last dose. ...
The se reaction information from clinical trials does, however, provide a basis for identi- fying the adverse events that appear to be related to drug use and for approximating rates
ety data, except where ...
caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability
2008
Journal of Biomedical Informatics
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One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. ...
The caCORE infrastructure provides a mechanism to create interoperable biomedical information systems. ...
On the right is a class from a hypothetical data system that provides information about Drugs. ...
doi:10.1016/j.jbi.2007.03.009
pmid:17512259
pmcid:PMC2254758
fatcat:hwrj2dojvjc6xe244oakvwojfa
Cancer Pharmacogenomics and Pharmacoepidemiology: Setting a Research Agenda to Accelerate Translation
2010
Journal of the National Cancer Institute
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will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice. ...
To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting ...
information on prescription drug use. ...
doi:10.1093/jnci/djq390
pmid:20944079
pmcid:PMC2982809
fatcat:z6pcjmtt7ffgrbyarymsetm2yy
Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97
2009
Leukemia
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Importantly, the gradual reduction in central nervous system (CNS) irradiation led to a decreased incidence of brain tumours as a second malignancy. ...
compared with in vitro drug sensitivity testing. ...
We also thank all individuals who collaborated in the designated COALL trials in the past: Dr Pongratz ...
doi:10.1038/leu.2009.249
pmid:20016530
fatcat:3vbjdb4u7bbstgbbfg24mglwzy
Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity
2015
DNA Repair
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Based on this compendium of alterations, we determined which DNAR genomic alterations predicted drug response for 20,195 compounds present in the NCI-60 drug database. ...
Because the landscape of DNAR defects across numerous types of cancers and its relation with drug activity have not been systematically examined, we took advantage of the unique drug and genomic databases ...
Acknowledgments The authors wish to thank Dr. Agata Smogorzewska for kindly providing the FANCP cell lines, RA3331 and RA3331 complemented with WT SLX4. We thank Kurt W. Kohn ...
doi:10.1016/j.dnarep.2015.01.011
pmid:25758781
pmcid:PMC4385398
fatcat:7c5utrr4prh6lierufsnx6xrdi
Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia
2009
Leukemia
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A progressive improvement of results with reduction of isolated central nervous system relapse rate was obtained. ...
Treatment was characterized by progressive intensification of systemic therapy and reduction of cranial radiotherapy. ...
Acknowledgements We are grateful to all parents associations and charities, which continuously supported the clinical and research work. ...
doi:10.1038/leu.2009.250
pmid:20016536
fatcat:o46lgahcozck7ayynjquuqizd4
The Lexicon Builder Web service: Building Custom Lexicons from two hundred Biomedical Ontologies
2010
AMIA Annual Symposium Proceedings
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The Lexicon Builder Web service addresses this need and reduces the investment of time and effort involved in lexicon maintenance. ...
It is currently being evaluated for several use cases to establish its utility in biomedical information processing tasks. ...
Acknowledgments This work is supported by NIH grant U54 HG004028 in support of the National Center for Biomedical Ontology, one of the National Centers for Biomedical Computing. ...
pmid:21347046
pmcid:PMC3041331
fatcat:ssd6h5izpzcc3hplvttaf3vdjy
A Dual-Fluorescence High-Throughput Cell Line System for Probing Multidrug Resistance
2009
Assay and drug development technologies
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We describe the development of a dualfluorescent cell line system to allow multiplexing of drug-sensitive and Pgp-mediated MDR cell lines. ...
The parental OVCAR-8 human ovarian carcinoma cell line and the isogenic MDR NCI/ADR-RES subline, which stably expresses high levels of endogenous P-gp, were transfected to express the fluorescent proteins ...
This research was supported by the Intramural Research Program of the National Institutes of Health. K.R.B. was supported by a Center for Cancer Research/NCI training fellowship. ...
doi:10.1089/adt.2008.165
pmid:19548831
pmcid:PMC2814070
fatcat:72ktta2jsvcudcwpyzdrd6lrwy
India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base
2018
Journal of Global Oncology
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collate all information related to cancer research done in AYUSH systems. ...
tion of information on Indian systems of medi-
cine through collaborative research. ...
AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. ...
doi:10.1200/jgo.17.00099
pmid:30241135
pmcid:PMC6180779
fatcat:gbf533fnqffunlccor4pwiqjsi
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells
2012
Oncology Reports
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We investigated the effects of deguelin on DNA damage and associated gene expression in human lung cancer NCI-H460 cells in vitro. ...
DNA damage was assayed by using the comet assay and DNA gel electrophoresis and the results indicated that NCI-H460 cells treated with 0, 50, 250 and 500 nM deguelin led to a longer DNA migration smear ...
Acknowledgements This study was supported by grant 99-CCH-IRP-08 from the Changhua Christian Hospital, Changhua, Taiwan. ...
doi:10.3892/or.2012.1622
pmid:22227970
pmcid:PMC3583480
fatcat:cfkyc5diifb3fbl5n5bfpuiyty
Curing the Curable: Managing Low-Risk Acute Lymphoblastic Leukemia in Resource Limited Countries
2021
Journal of Clinical Medicine
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In treating childhood ALL, the key is risk stratification, which can be resource stratified. NCI standard-risk criteria (age 1–10 years, WBC < 50,000/uL) is simple yet highly effective. ...
Other key elements in low-toxicity protocol designs include: induction steroid type; high-dose versus low-dose escalating methotrexate; judicious use of anthracyclines; and steroid pulses during maintenance ...
Conflicts of Interest: The authors have no conflict of interest to disclose. ...
doi:10.3390/jcm10204728
pmid:34682851
fatcat:vmq2zn4aqven3pns3u35lnezvy
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