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International collaboration in drug discovery and development: the NCI experience

Gordon M. Cragg, M. R. Boyd, Rita Khanna, Robert Kneller, T. D. Mays, K. D. Mazan, D. J. Newman, E. A. Sausville
1999 Pure and Applied Chemistry  
The past century, however, has seen an increasing role played by micro-organisms in the production of antibiotics and other drugs for the treatment of diseases, ranging from bacterial infections to cardiovascular  ...  Over the millennia, natural products, mainly of plant origin, have been used for the treatment of diseases, and an impressive number of modern drugs have been isolated from natural sources based on their  ...  and India [4] .  ... 
doi:10.1351/pac199971091619 fatcat:mtdxtgt7e5h3tjsblbchzdkoyy

SWOG Cooperative Group Biorepository Resource: Access for Scientific Research Studies

Carolyn J. Hoban, Wilbur Franklin, Kenneth J. Kopecky, Laurence H. Baker
2011 Clinical Cancer Research  
By collecting, storing, and distributing the specimens, SWOG provides the framework for translational scientists to complete the feedback loop from "bedside to bench."  ...  This article provides an overview of the group's biospecimen resources and guidelines for gaining access to them.  ...  Acknowledgments The authors would like to thank patients contributing specimens in the spirit of advancing cancer treatment and research; the staff of the SWOG Grant Support This article was supported  ... 
doi:10.1158/1078-0432.ccr-10-3138 pmid:21555374 fatcat:nnzamy6oenglddbyr7nftkwpv4

Supporting the development of biobanks in low and medium income countries

Tomas Klingstrom, Maimuna Mendy, Dominique Meunier, Anouk Berger, Jane Reichel, Alan Christoffels, Hocine Bendou, Carmen Swanepoel, Lemoene Smit, Campbell Mckellar-Basset, Erik Bongcam-Rudloff, Jonas Soderberg (+6 others)
2016 2016 IST-Africa Week Conference  
The B3Africa consortium is based on these conclusions and set up to support biobank based research by creating a cost efficient Laboratory Information Management System (LIMS) for developing biobanks and  ...  The technical platform called the eB3Kit is open source and consists of a LIMS and a bioinformatics module based on the eBiokit that allow researchers to take control over the analysis of their own data  ...  Shipping is related to the whole chain of custody and storage inventory and the sample access management.  ... 
doi:10.1109/istafrica.2016.7530672 fatcat:sx7at2gs2bci3jysyhkbi3bt4m

Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor

J Berlin, K D Tutsch, P Hutson, J Cleary, R P Rago, R Z Arzoomanian, D Alberti, C Feierabend, G Wilding
1997 Journal of Clinical Oncology  
Treatment Plan The Investigational Drug Branch of the NCI received CAI (NSC 609974; Merck L-651582; chemical name: 1H-1,2,3-triazole-4- carboxamide, 5-amino-|-[[3,5-dichloro-4(4-chlorobenzoyl)phenyl]-  ...  Patients had to be = 18 years of age and were required to be able to give informed consent with understanding of the investi- gational nature of the treatment and its potential risks.  ... 
doi:10.1200/jco.1997.15.2.781 pmid:9053505 fatcat:ef7kohy7fzfwndxpsjzm6kvbsm

Education for future biobankers - The state-of-the-art and outlook

Judita Kinkorová
2021 The EPMA Journal  
The importance of biobanks for multitasking research, personalised treatment, and health care systems was emphasised by many scientists and health care experts.  ...  interested groups, emerging technologies and innovations as well as current and future requirements of health care systems.  ...  16 members mainly EU states and 4 observers) [24] .  ... 
doi:10.1007/s13167-021-00234-5 pmid:33717371 pmcid:PMC7943331 fatcat:jgztin53pvc43owgfnspz5ktsq

Informatic system for a global tissue–fluid biorepository with a graph theory–oriented graphical user interface

William E. Butler, Nadia Atai, Bob Carter, Fred Hochberg
2014 Journal of Extracellular Vesicles  
The informatic system provides specimen inventory tracking with bar codes assigned to specimens and containers and projects, is hosted on globalized cloud computing resources, and embeds a suite of shared  ...  Clinical data are recorded in relation to molecular EV attributes and may be tagged with terms drawn from a network of externally maintained ontologies thus offering expansion of the system as the field  ...  Acknowledgements Ryan Kim, Sarada Sivaraman, and Lin Dan Zhu provided essential feedback as early users of the system. We acknowledge the editorial help of Dr. C.J.F. Van Noorden.  ... 
doi:10.3402/jev.v3.24247 pmid:25317275 pmcid:PMC4172698 fatcat:uxt2ogejxrctjgm4dlxhsxzr3u

Depression, Immunity, and Survival in Patients With Hepatobiliary Carcinoma

Jennifer L. Steel, David A. Geller, T. Clark Gamblin, Marion C. Olek, Brian I. Carr
2007 Journal of Clinical Oncology  
28 9 24 2-3 drinks per day 10 4 9 = 4 drinks per day 31 57 37 No information 4 4 3 Drug use 9 22 12 Tobacco use 37 35 Comorbid substance use Alcohol (= 2 drinks per day) 22 and drug use Alcohol (> 2 drinks  ...  '”""* At this time, the predominant theory explain- ing the link between depressive symptoms and survival is modulation of the immune system.  ... 
doi:10.1200/jco.2006.06.4592 pmid:17557953 fatcat:b6db5pcqrbfvxoue5d4kslzvra

The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer

Jennifer Permuth, Kaleena Dezsi, Shraddha Vyas, Karla Ali, Toni Basinski, Ovie Utuama, Jason Denbo, Jason Klapman, Aamir Dam, Estrella Carballido, Dae Kim, Jose Pimiento (+44 others)
2021 Cancers  
Methods: We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer  ...  Results: The FPC consists of multidisciplinary teams from fifteen Florida medical institutions.  ...  Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.  ... 
doi:10.3390/cancers13040809 pmid:33671939 fatcat:7ruyu5l3rrg4rgz674on5hjsea

The Florida Pancreas Collaborative Next-Generation Biobank: State-wide Infrastructure to Reduce Disparities and Improve Survival for a Racially and Ethnically Diverse Cohort of Patients with Pancreatic Cancer [article]

Jennifer B Permuth, Kaleena B Dezsi, Shraddha Vyas, Karla N. Ali, Toni L Basinski, Ovie A Utuama, Jason W. Denbo, Jason Klapman, Aamir Dam, Estrella Carballido, DaeWon Kim, Jose M Pimiento (+41 others)
2020 biorxiv/medrxiv   pre-print
This report describes the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective longitudinal cohort study and biorepository specifically designed to address the higher  ...  Methods: We describe rationale for establishing the FPC and provide an overview of key stakeholders; study eligibility and design; ascertainment and recruitment strategies; and standard operating procedures  ...  Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.  ... 
doi:10.1101/2020.10.10.20209247 fatcat:xqs2wd5k6jextivivrdhpsxcce

Scientific Frontiers

B.J. Baum, J.R. Yates, S. Srivastava, D.T.W. Wong, J.E. Melvin, D.T.W. Wong
2011 Advances in Dental Research  
This systemic communicative capability of exosomes has been recently revealed, since they have been shown to be released from many different cell types to be important modulators of the immune system as  ...  To achieve this goal, a definitive Food and Drug Administration(FDA)level clinical salivary biomarker development and validation study for systemic disease detection must be performed.  ... 
doi:10.1177/0022034511420433 pmid:21917746 pmcid:PMC3172997 fatcat:vz4lueepjngktb2elemo26bh44

A phase I study of pazopanib in combination with escalating doses of 131I in patients with well-differentiated thyroid carcinoma borderline refractory to radioiodine

Laura Q. Chow, Rafael Santana-Davila, Austin Pantel, Mara Roth, Leslie N. Anderson, Alan Failor, Robert Doot, David Mankoff, Robert K Hills
2017 PLoS ONE  
Hypothesis: The combined actions of the multi-targeted anti-angiogenic tyrosine kinase inhibitor (TKI), pazopanib, and concurrent 131 I radioiodine will have additively or synergistically overcome therapeutic  ...  Objectives Primary Objectives:  To determine the safety, tolerability and feasibility of administrating escalating doses of 131 I in combination with concurrent pazopanib therapy in order to define the  ...  Upon written notification, the Principal Investigator will ship unused investigational drug according to instructions provided by GSK Pharmaceuticals, Inc.  ... 
doi:10.1371/journal.pone.0178325 pmid:28662033 pmcid:PMC5490965 fatcat:xouv2l76drdlfigwtgy6mklxey

News briefs

1992 Journal of Research of the National Institute of Standards and Technology  
detectors, modulators, switches, long-haul systems, LANs, subscriber loops, field and laboratory instrumentation, and standards.  ...  The publication, AMMTAP: Sample Inventory and Results of Selected Samples for Organic and Trace Elements (NISTIR 4731), is available from the National Technical Information Service, Springfield, VA 22161  ...  The product is a bottled sample of human hair in powdered form that contains known amounts of each of four different drugs: cocaine, morphine, codeine, and benzoylecgonine.  ... 
doi:10.6028/jres.097.011 fatcat:5loccc45t5gk3dqt4ublav6oii

The AIDS and Cancer Specimen Resource: Role in HIV/AIDS scientific discovery

Leona W Ayers, Sylvia Silver, Michael S McGrath, Jan M Orenstein
2007 Infectious Agents and Cancer  
The ACSR was established as a cooperative agreement between the NCI (Office of the Director, Division of Cancer Treatment and Diagnosis) and regional consortia, University of California, San Francisco  ...  The available biological samples with clinical data and the application process are described on the ACSR web site.  ...  In addition, the inventory contains donations from the AIDS epidemics in developing countries outside the United States.  ... 
doi:10.1186/1750-9378-2-7 pmid:17335575 pmcid:PMC1851770 fatcat:ow5nq2ygajaitlld66pevtd23a

A Modified SMO Algorithm for SVM Regression and Its Application in Quality Prediction of HP-LDPE [chapter]

Hengping Zhao, Jinshou Yu
2005 Lecture Notes in Computer Science  
TRI -Toxic Chemical Release Inventory TRI -Toxic Release Inventory TRIANA -Triana Medical Claims Information System TRIP -Toxic Release Inventory Program TRIP -Transboundary Resource Inventory  ...  System CHIEF -Clearinghouse for Inventories and Emission Factors CHIP -Chemical Hazard Information Profile CHIPS -Chemical Hazard Information Profile System CHLOREP -A mutual aid group of shippers  ... 
doi:10.1007/11539087_79 fatcat:ydvvlhkkh5grhh7r6rv66y2tia

Direct estrogen receptor (ER) / HER family crosstalk mediating sensitivity to lumretuzumab and pertuzumab in ER+ breast cancer

Denis Collins, Wolfgang Jacob, Juan Miguel Cejalvo, Maurizio Ceppi, Ian James, Max Hasmann, John Crown, Andrés Cervantes, Martin Weisser, Birgit Bossenmaier, Daniele Santini
2017 PLoS ONE  
inventory and reconciled against the documentation of quantity shipped, dispensed, returned, destroyed and provided that adequate storage and integrity of drug has been confirmed.  ...  investigational products(s)Accurate records of all IMPs received at, dispensed from, returned to and disposed of by the study site should be recorded on the Drug Inventory Log.  ...  For SAEs, the following must be assessed and recorded on the AE eform of the eCRF: intensity, relationship to study drug, action taken, and outcome to date.  ... 
doi:10.1371/journal.pone.0177331 pmid:28493933 pmcid:PMC5426757 fatcat:zg34usp7kbbmpckmlqe5jptp3u
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