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The EORTC New Drug Development Office (NDDO)
1996
Annals of Oncology
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NCI, EORTC and CRC The agreement between NCI, EORTC and CRC on collaboration in new drug development, originally signed in 1986, has been updated recently. ...
A brief description and an overview of recent progress and future plans is given below. ...
doi:10.1093/annonc/7.suppl_1.7
fatcat:m5a3ljctdvazrjimcepmsm7tk4
NCI Image-Guided Drug Delivery Summit
2011
Cancer Research
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On April 17, 2010, scientists from academia, the National Cancer Institute (NCI), and the Food and Drug Administration (FDA) assembled at "The NCI Image Guided Drug Delivery Summit," in Washington D.C. ...
Speakers discussed potential challenges to clinical translation of nano-based drug delivery systems including in vivo characterization of nanocarriers, preclinical validation of targeting and delivery, ...
Acknowledgment The authors thank Paula Jacobs, PhD, Cancer Imaging Program, NCI. ...
doi:10.1158/0008-5472.can-10-2629
pmid:21224356
pmcid:PMC3075539
fatcat:ssudweu7p5blfhqvzefong6zri
An overview of the NCI precision medicine trials-NCI MATCH and MPACT
2015
Chinese Clinical Oncology
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To this end, the United States National Cancer Institute (NCI) has launched precision-based medicine trials to address this question. ...
NCI Molecular Analysis for Therapy Choice (MATCH), a genomic pre-screening study, was designed to explore the efficacy of using targeted agents to target specific molecular aberrations and whether these ...
Footnote
Conflicts of Interest: The authors have no conflicts of interest to declare. ...
doi:10.3978/j.issn.2304-3865.2015.08.01
pmid:26408298
fatcat:neviso72ebgoro5khw4o2dwanq
Cancer and Leukemia Group B Clinical Research Associates Committee
2006
Clinical Cancer Research
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In addition, CRAs may also be responsible for writing reports, grant, and budget development and the development of protocols, forms, and informed consent documents. ...
; prepare and submit timely adverse event experience reports; maintain case report forms and drug accountability records; educate other health care professionals, patients, and families regarding clinical ...
Institute (NCI) drug accountability, audit preparation and procedures, and organizational and interpersonal skills. ...
doi:10.1158/1078-0432.ccr-06-9014
pmid:16740800
fatcat:vcnumoznengmjmd6pz7a3kzmru
In vivoModels for Experimental Therapeutics Relevant to Human Cancer
2004
Cancer Research
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Giovanni Melillo (Science Applications International Corporation-Frederick, NCI-Frederick, Frederick, MD) shared information on his in vivo models for the evaluation of hypoxia-inducible factor (HIF)-1 ...
Robert Shoemaker (DTP, NCI, Bethesda, MD) opened the meeting with an overview of the evolution of animal models for experimental therapeutics, from transplantable syngeneic mouse tumor models to more complex ...
Giovanni Melillo (Science Applications International Corporation-Frederick, NCI-Frederick, Frederick, MD) shared information on his in vivo models for the evaluation of hypoxia-inducible factor (HIF)-1 ...
doi:10.1158/0008-5472.can-04-2057
pmid:15548722
fatcat:diea2cmjijczpkjtesxebncrky
India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base
2018
Journal of Global Oncology
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collate all information related to cancer research done in AYUSH systems. ...
tion of information on Indian systems of medi-
cine through collaborative research. ...
AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. ...
doi:10.1200/jgo.17.00099
pmid:30241135
pmcid:PMC6180779
fatcat:gbf533fnqffunlccor4pwiqjsi
Evidence-Based Network Approach to Recommending Targeted Cancer Therapies
2020
JCO Clinical Cancer Informatics
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For the 2 categories that use pathway information, we include an interactive Sankey visualization built on top of d3.js that also provides links to PubChem. ...
DailyMed), pathways for specific cancer types (from Kyoto Encyclopedia of Genes and Genomes [KEGG]), gene-drug connections (from DrugBank), and oncogene information (from KEGG). ...
Removing 1 or both of the last 2 checkboxes expands the range of therapies in categories 3 and 4 beyond US Food and Drug Administration (FDA)-approved drugs and FDA-approved targeted cancer drugs, respectively ...
doi:10.1200/cci.19.00097
pmid:31990579
pmcid:PMC6995264
fatcat:mgnukv25wvhjlpnvgd5alhdkiy
Evaluation of the Efficacy of Cancer Drugs by Using the Second Largest Eigenvalue of Metabolic Cancer Pathways
2018
Journal of computer science and systems biology
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This research was (partially) supported by the European Regional Development
The authors want to thank the following organizations and institutions National Cancer Institute for making NCI-60 Human ...
Drugbank for making the drug structures free to use. Kanehisa Labs for allowing KEGG cancer pathways free to use (under the copyright permission) in academic publications. ...
Specific boxes may exist providing additional information (Figure 1 ). ...
doi:10.4172/jcsb.1000280
fatcat:ovbga752kvfg5nxy34hazzhjli
Patient-Reported Outcomes Assessment in Cancer Trials: Evaluating and Enhancing the Payoff to Decision Making
2007
Journal of Clinical Oncology
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other diseases, through the Patient Reported Out- comes Measurement Information System (PROMIS).* As a Na- tional Institutes of Health Roadmap initiative, PROMIS will provide clinical research communities ...
US Food and Drug Administration: Patient-reported outcome measures: Use in medical product development to support labeling claims. Accessed August 1, 2007. ...
doi:10.1200/jco.2007.14.5888
pmid:17991919
fatcat:hwnqam44bbhk3g7laibybaak4i
Spotlight on molecular profiling: "Integromic" analysis of the NCI-60 cancer cell lines
2006
Molecular Cancer Therapeutics
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Acknowledgments Past and present staff of the NCI DTP deserve the research community's gratitude for establishing and conducting the NCI-60 screen over the years. ...
I also want to thank our many collaborators and other scientists around the world for the molecular profile databases they've generated on the NCI-60. ...
Figure 1 . 1 Schematic overview of the NCI-60 databases. ...
doi:10.1158/1535-7163.mct-06-0640
pmid:17088435
fatcat:6dv5uaeaejeq7pxk5uuxfjh5qe
Drug sensitivity in cancer cell lines is not tissue-specific
2015
Molecular Cancer
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Conclusions: To get the most out of cell line panels, it will be necessary to look into their molecular characteristics, and integrate them into systems biology frameworks. ...
We find that cancer-specific drugs do not show higher efficacies in cell lines representing the respective tissues. ...
Acknowledgements We would like to thank all the IRB Barcelona PIs, specially E. Giralt and A.R. ...
doi:10.1186/s12943-015-0312-6
pmid:25881072
pmcid:PMC4359490
fatcat:6n7peovvvnhffp7w6cm6ncckzm
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge
2010
Nucleic Acids Research
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In order to facilitate an overview of existing and supporting information, a series of novel information connections have been established. ...
During the development of methods for cancer diagnosis and treatment, a vast amount of information is generated. ...
ACKNOWLEDGEMENTS The authors like to thank Bjo¨rn Gru¨ning for the development of the initial database and Ilona Gawronska and Ulrike Schmidt for manual validation of cancer-relevant drug-target relations ...
doi:10.1093/nar/gkq910
pmid:20952398
pmcid:PMC3013779
fatcat:kca5ezc63vgdll6yee4ijgwtrq
Interpretable Drug Synergy Prediction with Graph Neural Networks for Human-AI Collaboration in Healthcare
[article]
2021
arXiv
pre-print
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The experimental results demonstrated that 1) IDSP can learn from the underlying molecular mechanism to make prediction without additional drug chemical information while achieving highly comparable performance ...
mechanisms of synergy (MoS) for the human-AI collaboration in healthcare systems. ...
Since information aggregation through different interactions are processed with different weight matrix ( ! (,) " (,) ), such
Figure 2 : 2 An overview of the proposed architecture. ...
arXiv:2105.07082v1
fatcat:a7kqfdzi5bfipn6csnzs3wzkze
Precision Oncology—The Quest for Evidence
2019
Journal of Personalized Medicine
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on drug resistance/response, patient survival, and/or quality of life. ...
We conclude that, as increasing volumes of clinico-molecular outcomes data become available, in future, we will begin to transition away from expert systems for treatment decision support (TDS), towards ...
Acknowledgments: We would like to thank the reviewers for their comments.
Conflicts of Interest: The authors are employees of Molecular Health GmbH. ...
doi:10.3390/jpm9030043
pmid:31492009
pmcid:PMC6789813
fatcat:22gsr4jiifg4fa4m76gkvbxakq
Overview and Utilization of the NCI Thesaurus
2004
Comparative and Functional Genomics
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The NCI Thesaurus is produced by the Enterprise Vocabulary Services project, a collaborative effort between the NCI Center for Bioinformatics and the NCI Office of Communications, and is part of the caCORE ...
The NCI Thesaurus is a reference terminology covering areas of basic and clinical science, built with the goal of facilitating translational research in cancer. ...
It arose out of the need to have an institute-wide common terminology in order to integrate the diverse data systems in use throughout the NCI [10] . ...
doi:10.1002/cfg.445
pmid:18629178
pmcid:PMC2447470
fatcat:robajpfvwfhvddmapd3crthzpm
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