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NCI Image-Guided Drug Delivery Summit

Pushpa Tandon, Keyvan Farahani
2011 Cancer Research  
On April 17, 2010, scientists from academia, the National Cancer Institute (NCI), and the Food and Drug Administration (FDA) assembled at "The NCI Image Guided Drug Delivery Summit," in Washington D.C.  ...  Speakers discussed potential challenges to clinical translation of nano-based drug delivery systems including in vivo characterization of nanocarriers, preclinical validation of targeting and delivery,  ...  Acknowledgment The authors thank Paula Jacobs, PhD, Cancer Imaging Program, NCI.  ... 
doi:10.1158/0008-5472.can-10-2629 pmid:21224356 pmcid:PMC3075539 fatcat:ssudweu7p5blfhqvzefong6zri

An overview of the NCI precision medicine trials-NCI MATCH and MPACT

Khanh Do, Geraldine O'Sullivan Coyne, Alice P Chen
2015 Chinese Clinical Oncology  
To this end, the United States National Cancer Institute (NCI) has launched precision-based medicine trials to address this question.  ...  NCI Molecular Analysis for Therapy Choice (MATCH), a genomic pre-screening study, was designed to explore the efficacy of using targeted agents to target specific molecular aberrations and whether these  ...  Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.  ... 
doi:10.3978/j.issn.2304-3865.2015.08.01 pmid:26408298 fatcat:neviso72ebgoro5khw4o2dwanq

Cancer and Leukemia Group B Clinical Research Associates Committee

K. C. Price
2006 Clinical Cancer Research  
In addition, CRAs may also be responsible for writing reports, grant, and budget development and the development of protocols, forms, and informed consent documents.  ...  ; prepare and submit timely adverse event experience reports; maintain case report forms and drug accountability records; educate other health care professionals, patients, and families regarding clinical  ...  Institute (NCI) drug accountability, audit preparation and procedures, and organizational and interpersonal skills.  ... 
doi:10.1158/1078-0432.ccr-06-9014 pmid:16740800 fatcat:vcnumoznengmjmd6pz7a3kzmru

In vivoModels for Experimental Therapeutics Relevant to Human Cancer

Miriam S. Gitler, Edward A. Sausville, Melinda Hollingshead, Robert Shoemaker
2004 Cancer Research  
Giovanni Melillo (Science Applications International Corporation-Frederick, NCI-Frederick, Frederick, MD) shared information on his in vivo models for the evaluation of hypoxia-inducible factor (HIF)-1  ...  Robert Shoemaker (DTP, NCI, Bethesda, MD) opened the meeting with an overview of the evolution of animal models for experimental therapeutics, from transplantable syngeneic mouse tumor models to more complex  ...  Giovanni Melillo (Science Applications International Corporation-Frederick, NCI-Frederick, Frederick, MD) shared information on his in vivo models for the evaluation of hypoxia-inducible factor (HIF)-1  ... 
doi:10.1158/0008-5472.can-04-2057 pmid:15548722 fatcat:diea2cmjijczpkjtesxebncrky

India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base

Jeffrey D. White, Barry R. O'Keefe, Jitendra Sharma, Ghazala Javed, Vid Nukala, Aniruddha Ganguly, Ikhlas A. Khan, Nagi B. Kumar, Hasan Mukhtar, Guido F. Pauli, Larry Walker, Sudha Sivaram (+2 others)
2018 Journal of Global Oncology  
collate all information related to cancer research done in AYUSH systems.  ...  tion of information on Indian systems of medi- cine through collaborative research.  ...  AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated.  ... 
doi:10.1200/jgo.17.00099 pmid:30241135 pmcid:PMC6180779 fatcat:gbf533fnqffunlccor4pwiqjsi

Evidence-Based Network Approach to Recommending Targeted Cancer Therapies

Jayaram Kancherla, Shruti Rao, Krithika Bhuvaneshwar, Rebecca B. Riggins, Robert A. Beckman, Subha Madhavan, Héctor Corrada Bravo, Simina M. Boca
2020 JCO Clinical Cancer Informatics  
For the 2 categories that use pathway information, we include an interactive Sankey visualization built on top of d3.js that also provides links to PubChem.  ...  DailyMed), pathways for specific cancer types (from Kyoto Encyclopedia of Genes and Genomes [KEGG]), gene-drug connections (from DrugBank), and oncogene information (from KEGG).  ...  Removing 1 or both of the last 2 checkboxes expands the range of therapies in categories 3 and 4 beyond US Food and Drug Administration (FDA)-approved drugs and FDA-approved targeted cancer drugs, respectively  ... 
doi:10.1200/cci.19.00097 pmid:31990579 pmcid:PMC6995264 fatcat:mgnukv25wvhjlpnvgd5alhdkiy

Evaluation of the Efficacy of Cancer Drugs by Using the Second Largest Eigenvalue of Metabolic Cancer Pathways

Drasko Tomic, Karolj Skala, Lado Kranjcevic, Boris Pirkic, Sanja Stifter, Iva Smit
2018 Journal of computer science and systems biology  
This research was (partially) supported by the European Regional Development The authors want to thank the following organizations and institutions National Cancer Institute for making NCI-60 Human  ...  Drugbank for making the drug structures free to use. Kanehisa Labs for allowing KEGG cancer pathways free to use (under the copyright permission) in academic publications.  ...  Specific boxes may exist providing additional information (Figure 1 ).  ... 
doi:10.4172/jcsb.1000280 fatcat:ovbga752kvfg5nxy34hazzhjli

Patient-Reported Outcomes Assessment in Cancer Trials: Evaluating and Enhancing the Payoff to Decision Making

Steven B. Clauser, Patricia A. Ganz, Joseph Lipscomb, Bryce B. Reeve
2007 Journal of Clinical Oncology  
other diseases, through the Patient Reported Out- comes Measurement Information System (PROMIS).* As a Na- tional Institutes of Health Roadmap initiative, PROMIS will provide clinical research communities  ...  US Food and Drug Administration: Patient-reported outcome measures: Use in medical product development to support labeling claims. Accessed August 1, 2007.  ... 
doi:10.1200/jco.2007.14.5888 pmid:17991919 fatcat:hwnqam44bbhk3g7laibybaak4i

Spotlight on molecular profiling: "Integromic" analysis of the NCI-60 cancer cell lines

J. N. Weinstein
2006 Molecular Cancer Therapeutics  
Acknowledgments Past and present staff of the NCI DTP deserve the research community's gratitude for establishing and conducting the NCI-60 screen over the years.  ...  I also want to thank our many collaborators and other scientists around the world for the molecular profile databases they've generated on the NCI-60.  ...  Figure 1 . 1 Schematic overview of the NCI-60 databases.  ... 
doi:10.1158/1535-7163.mct-06-0640 pmid:17088435 fatcat:6dv5uaeaejeq7pxk5uuxfjh5qe

Drug sensitivity in cancer cell lines is not tissue-specific

Samira Jaeger, Miquel Duran-Frigola, Patrick Aloy
2015 Molecular Cancer  
Conclusions: To get the most out of cell line panels, it will be necessary to look into their molecular characteristics, and integrate them into systems biology frameworks.  ...  We find that cancer-specific drugs do not show higher efficacies in cell lines representing the respective tissues.  ...  Acknowledgements We would like to thank all the IRB Barcelona PIs, specially E. Giralt and A.R.  ... 
doi:10.1186/s12943-015-0312-6 pmid:25881072 pmcid:PMC4359490 fatcat:6n7peovvvnhffp7w6cm6ncckzm

CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge

Jessica Ahmed, Thomas Meinel, Mathias Dunkel, Manuela S. Murgueitio, Robert Adams, Corinna Blasse, Andreas Eckert, Saskia Preissner, Robert Preissner
2010 Nucleic Acids Research  
In order to facilitate an overview of existing and supporting information, a series of novel information connections have been established.  ...  During the development of methods for cancer diagnosis and treatment, a vast amount of information is generated.  ...  ACKNOWLEDGEMENTS The authors like to thank Bjo¨rn Gru¨ning for the development of the initial database and Ilona Gawronska and Ulrike Schmidt for manual validation of cancer-relevant drug-target relations  ... 
doi:10.1093/nar/gkq910 pmid:20952398 pmcid:PMC3013779 fatcat:kca5ezc63vgdll6yee4ijgwtrq

Interpretable Drug Synergy Prediction with Graph Neural Networks for Human-AI Collaboration in Healthcare [article]

Zehao Dong, Heming Zhang, Yixin Chen, Fuhai Li
2021 arXiv   pre-print
The experimental results demonstrated that 1) IDSP can learn from the underlying molecular mechanism to make prediction without additional drug chemical information while achieving highly comparable performance  ...  mechanisms of synergy (MoS) for the human-AI collaboration in healthcare systems.  ...  Since information aggregation through different interactions are processed with different weight matrix ( ! (,) " (,) ), such Figure 2 : 2 An overview of the proposed architecture.  ... 
arXiv:2105.07082v1 fatcat:a7kqfdzi5bfipn6csnzs3wzkze

Precision Oncology—The Quest for Evidence

Soldatos, Kaduthanam, Jackson
2019 Journal of Personalized Medicine  
on drug resistance/response, patient survival, and/or quality of life.  ...  We conclude that, as increasing volumes of clinico-molecular outcomes data become available, in future, we will begin to transition away from expert systems for treatment decision support (TDS), towards  ...  Acknowledgments: We would like to thank the reviewers for their comments. Conflicts of Interest: The authors are employees of Molecular Health GmbH.  ... 
doi:10.3390/jpm9030043 pmid:31492009 pmcid:PMC6789813 fatcat:22gsr4jiifg4fa4m76gkvbxakq

Overview and Utilization of the NCI Thesaurus

Gilberto Fragoso, Sherri de Coronado, Margaret Haber, Frank Hartel, Larry Wright
2004 Comparative and Functional Genomics  
The NCI Thesaurus is produced by the Enterprise Vocabulary Services project, a collaborative effort between the NCI Center for Bioinformatics and the NCI Office of Communications, and is part of the caCORE  ...  The NCI Thesaurus is a reference terminology covering areas of basic and clinical science, built with the goal of facilitating translational research in cancer.  ...  It arose out of the need to have an institute-wide common terminology in order to integrate the diverse data systems in use throughout the NCI [10] .  ... 
doi:10.1002/cfg.445 pmid:18629178 pmcid:PMC2447470 fatcat:robajpfvwfhvddmapd3crthzpm
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