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Human Skin and Hair Xenografted on SCID Mouse. Usefulness as an in vivo Experimental Model

Toshiaki SAIDA
1997 Proceedings of The Japanese Society of Animal Models for Human Diseases  
To develop new in vivo study system of human skin and hair, our research group has tried to produce hu-skin/SCID mice model, that is, mice xenografted with human skin or hair suitable for in vivo experiments  ...  An isolated human hair follicle obtained by dissection of scalp skin was successfully transplanted onto SCID mice and used to identify localization of stem cells of hair follicles.  ... 
doi:10.1538/expanim1992.13.19 fatcat:vlxm4f3izjfltjjagpsq74idcq

The Abnormality of Vestibular Hair Cells and the Gene Transduction in Animal Model of Human Genetic Inner Ear Disease-Study of Vestibular Hair Cell Pathology in Shaker-2 Mouse and Waltzing Guinea Pig-
遺伝性内耳障害モデルにおける前庭形態異常と遺伝子導入の試み―shaker‐2マウス,waltzing guinea Pigの検討から―

Sho Kanzaki
2004 Equilibrium Research  
We reviewed the hair cell pathology of genetic hearing loss and circling behavior and discussed possibility of gene therapy in human genetic inner ear disease through genetic inner ear disease animal models  ...  Furthermore, we tested the possibility of gene transudation in shaker-2 mice, the model of DFNB3, i.e. human deafness, in order to treat the hair cell pathology including cytocaud.  ...  文 献 1) Ikezono T, Omori A, Ichinose S, et al: Identification of the protein product of the Coch gene (hereditary deafness gene) as the major com-ventional myosins and the genetics of hearing loss.  ... 
doi:10.3757/jser.63.81 fatcat:emk3k5j2vfd35gn6otog3wcnje

Urate Oxidase Activity and Copper Content in the Liver of Macular Mutant Mouse, a Model Animal for Human Congenital Copper Deficiency, Menkes' Kinky Hair Disease

Masahiko KOYAMA, Tetsuo ISHIDA, Kihachiro HORIIKE, Mitsuhiro NOZAKI, Morimi SHIMADA
1991 Journal of Nutritional Science and Vitaminology  
In spite of similarities in biochemical and histological features between human disease and model mice, there is a critical difference between the two.  ...  In human disease, many trials to improve the symptoms and save the life have been unsuc cessful (29, 30) , whereas the symptoms of the model mice can be significantly improved and the life span can be  ... 
doi:10.3177/jnsv.37.601 fatcat:u5l6zd47ybccvotulewsekq6cq

Positional Cloning of the shaker-1 Gene : A Myosin VII Involved in Sensory Hair Cell Development and Function

Steve D.M. BROWN, Tim SELF, Mary MAHONY, Jane FLEMING, Angela PEARCE, David HARVEY, Jo CABLE, Philomena MBURU, James WALSH, Fernando GIBSON, Anabel VARELA, Karen P. STEEL
1996 Proceedings of The Japanese Society of Animal Models for Human Diseases  
The other shaker=l mutations are all more severe in their effects on the cochlea and most show no signs of any cochlear responses at any stage of development.  ...  Finally, we have also shown that the human homologue of shaker=l is the gene affected in Usher syndrome type lb (Weil et al.: Nature, 374 60-61 (1995) ) in which progressive retinitis pigmentosa accompanies  ... 
doi:10.1538/expanim1992.12.2 fatcat:uffgbyq7kbbfpkxlklodsy47qu

SGK3 Plays Critical Roles in Murine Hair Follicle Morphogenesis and Hair Cycle Regulation

Taro OKADA, Kentaro MASUJIN, Yoshiyuki ISHII, Akira YASOSHIMA, Junichiro MATSUDA, Atsuo OGURA, Hiroyuki NAKAYAMA, Tetsuo KUNIEDA, Kunio DOI
2006 Proceedings of The Japanese Society of Animal Models for Human Diseases  
SGK3 Plays Critical Roles in Murine Hair Follicle Morphogenesis and Hair Cycle Regulation Taro OKADA1,6), Kentaro MASUJIN2), Yoshiyuki ISHII3), Akira YASOSHIMAI), Junichiro MATSUDA4), Atsuo OGURA5),  ...  The hair follicle length, which corresponds to the length from the base of the hair follicle bulb to the surface of the epidermis, represents the hair follicle cycling tological study on the skin and  ...  The hair follicle length, which corresponds to the length from the base of the hair follicle bulb to the surface of the epidermis, represents the hair follicle cycling pattern.  ... 
doi:10.1538/expanim1992.22.12 fatcat:lzabunfvyvavfo6tvhn67vacpq

Real Time Physical Force-Driven Hair Animation

Ahmad Hoirul Basori, Alaa Omran Almagrabi
2018 Zenodo  
This paper proposed physical forces of gravity and wind to be applied into hair animation in real time based on wisp model and verlet integration technique.  ...  The current technique still can be improved by apply tessellation technique to reduce excessive use of resources and not only straight-type hair model such as curly or frizzy.  ...  The authors, therefore, gratefully acknowledge the DSR technical and financial support.  ... 
doi:10.5281/zenodo.2550644 fatcat:horwqc746fffxdi6xtzrv3rvla

Evaluation of Animal Models Suitable for Hair Research and Regeneration [chapter]

Meda Sandra Orăsan, Andrei Coneac
2018 Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy  
The main reason for hair research on animal models relies on the similarities between human and animal skin biology.  ...  By using proper and well thought-out animal models, we aim to refine our knowledge on human hair diseases and hair regrowth.  ...  Hair regrowth studies in vivo The need of animal models Animals and humans are remarkably similar at physiological and anatomical levels.  ... 
doi:10.5772/intechopen.69698 fatcat:qhjcfn4a4rft7ifhz5qhz7xw5y

Performance Analysis of Virtual Human Bodies with Clothing and Hair from Images to Animation

Kulalvaimozhi. V. P., Germanus Alex. M, John Peter. S
2018 International Journal of Advanced Research in Computer Science and Software Engineering  
Virtual human bodies, clothing, and hair are widely used in a number of scenarios such as 3D animated movies, gaming, and online fashion.  ...  Machine learning can be used to construct data-driven 3D human bodies, clothing, and hair.  ...  Besides human body modeling, how to realistically represent clothing and hair is also on the top of the research agenda.  ... 
doi:10.23956/ijarcsse.v8i6.723 fatcat:rz3k6icm7fepdd5ztpnsw53faa

A Simple Physics Model to Animate Human Hair Modeled in 2D Strips in Real Time [chapter]

Chuan Koon Koh, Zhiyong Huang
2001 Eurographics  
A major difficulty in animating human hair results from the large number of individual hair strands in a hairstyle.  ...  This paper presents a simple Physics model to animate human hair modeled in 2D strips in real time.  ...  Introduction Hair modeling and animation are very challenging tasks in human animation due to the presences of a large number of hair, the complex interaction of light and shadow amongst them, and the  ... 
doi:10.1007/978-3-7091-6240-8_12 fatcat:n6l4hfjhencqpnyf54vt46hn3y

Evaluation of Animal Models for the Hair-Inducing Capacity of Cultured Human Dermal Papilla Cells

Keita Inoue, Harunosuke Kato, Takahiro Sato, Aki Osada, Noriyuki Aoi, Hirotaka Suga, Hitomi Eto, Koichi Gonda, Kotaro Yoshimura
2009 Cells Tissues Organs  
Conclusions: Although there is no significant difference in hair induction rate, the sandwich model using cultured hDPCs and the rat sole skin is more feasible than the chamber model using human cultured  ...  Results: Folliculoneogenesis was detected in both chamber and sandwich models, although the induction rate and maturity of the hair follicles varied among cell combination subgroups in each model.  ...  Acknowledgement This work was supported by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (contact grant No. B2-17390474).  ... 
doi:10.1159/000178021 pmid:19033718 fatcat:3bu3ywn7wjhnhmctgpvehpz56u

An Integrated System for Modeling, Animating and Rendering Hair

Agnes Daldegan, Nadia Magnenat Thalmann, Tsuneya Kurihara, Daniel Thalmann
1993 Computer graphics forum (Print)  
We present how hair styles may be designed with our HairStyler module. Then we survey the animation model and emphasize a method of collision processing.  ...  There are basically four problems to solve in order to produce realistic animated synthetic actors with hair: hair modeling and creation, hair motion, collision detection and hair rendering.  ...  Acknowledgments The authors would like to thank Dr. Geoff Wyvill for his useful remarks and discussion in hair rendering and hair interface problems.  ... 
doi:10.1111/1467-8659.1230211 fatcat:hgpz2mhp45emjkdewxq2fbbvp4

Research Problems for Creating Digital Actors [article]

Hyeong-Seok Ko, Kwang-Jin Choi, Min Gyu Choi, Seyoon Tak, Byoungwon Choe, Oh-Young Song
2003 Eurographics State of the Art Reports  
In particular, our research has been focused on components such as facial animation, hair animation, clothing animation, and body animation, which are crucial to the successful realization of digital actors  ...  This article summarizes the results of our research on those topics, reviews other approaches that have been taken in digital actor research, and outlines the challenges that must be overcome in this area  ...  This work was also partially supported by Automation and Systems Research Institute at Seoul National University, the Brain Korea 21 Project, and the Overhead Research Fund of Seoul National University  ... 
doi:10.2312/egst.20031088 fatcat:ldk5qnmbv5crbge5te55pec3uq

3D skin models in domestic animals

Laurent Souci, Caroline Denesvre
2021 Veterinary Research  
The development of these models benefited from the societal pressure to reduce animal experiments.  ...  Next, we describe the different 3D human skin models and their main applications. Finally, we review the available models for domestic animals and discuss the current and potential applications.  ...  Danielle Dhouailly for her expert comments on the manuscript. Authors' contributions LS and CD and wrote the manuscript. Both authors read and approved the final manuscript.  ... 
doi:10.1186/s13567-020-00888-5 pmid:33588939 fatcat:eijlaz7smbeifivnddj2s2l74m

Virtual humans: thirty years of research, what next?

Nadia Magnenat-Thalmann, Daniel Thalmann
2005 The Visual Computer  
To give a level of believable behavior, challenges are laid on generating on the fly flexible motion and complex behaviours of Virtual Humans inside their environments using a realistic perception of the  ...  At first, the issues of creating virtual humans with better skeleton and realistic deformable bodies are illustrated.  ...  Hair animation One of the many challenges in simulating believable virtual humans and animals has been to produce realistic looking hair.  ... 
doi:10.1007/s00371-005-0363-6 fatcat:66uenhkqv5citi5jss22wqxk7e

Animal models of vitiligo: Matching the model to the question

Kingsley I. Essien, John E. Harris
2014 Zhōnghuá Pífūkē Yīxué Zázhì  
Because of the complex pathogenesis of vitiligo, it is unlikely that any one single animal model will adequately reflect all factors implicated in the initiation, progression, and maintenance of the disease  ...  In this paper, we describe some of the available animal models that have been developed to study vitiligo.  ...  One key difference is the distribution of melanocytes in the skin. Human melanocytes reside in the hair follicles and in the epidermis of hair-bearing skin.  ... 
doi:10.1016/j.dsi.2014.09.008 fatcat:3koxosmb65cu3git2jh42tjsbq
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