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Long-Term Neuroanatomical Consequences of Childhood Maltreatment: Reduced Amygdala Inhibition by Medial Prefrontal Cortex

Roman Kessler, Simon Schmitt, Torsten Sauder, Frederike Stein, Dilara Yüksel, Dominik Grotegerd, Udo Dannlowski, Tim Hahn, Astrid Dempfle, Jens Sommer, Olaf Steinsträter, Igor Nenadic (+2 others)
2020 Frontiers in Systems Neuroscience  
history of affective disorders or a personal history of childhood maltreatment.  ...  We assigned a genetic risk if subjects had a first-degree relative with an affective disorder and an environmental risk if subjects experienced childhood maltreatment.  ...  This work is part of the German multicenter consortium ''Neurobiology of Affective Disorders.  ... 
doi:10.3389/fnsys.2020.00028 pmid:32581732 pmcid:PMC7283497 fatcat:wpsshwrvhnh6tptvwbud3eji6m

Brain structural connectivity, anhedonia, and phenotypes of major depressive disorder: A structural equation model approach

Julia‐Katharina Pfarr, Katharina Brosch, Tina Meller, Kai Gustav Ringwald, Simon Schmitt, Frederike Stein, Susanne Meinert, Dominik Grotegerd, Katharina Thiel, Hannah Lemke, Alexandra Winter, Lena Waltemate (+9 others)
2021 Human Brain Mapping  
Our findings provide evidence for a differential impact of state and trait variables of MDD on brain connectivity and cognition.  ...  Aberrant brain structural connectivity in major depressive disorder (MDD) has been repeatedly reported, yet many previous studies lack integration of different features of MDD with structural connectivity  ...  Quality assurance methods included several aspects: First, we used an ongoing quality assurance protocol covering all MRI scans obtained in the FOR2107 study (Vogelbacher et al., 2018) Andersson, Jenkinson  ... 
doi:10.1002/hbm.25600 pmid:34302413 pmcid:PMC8449111 fatcat:hpsee4sykjaqvmlh5qdagsjgda

Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder

Jonathan Repple, Marco Mauritz, Susanne Meinert, Siemon C. de Lange, Dominik Grotegerd, Nils Opel, Ronny Redlich, Tim Hahn, Katharina Förster, Elisabeth J. Leehr, Nils Winter, Janik Goltermann (+16 others)
2019 Molecular Psychiatry  
Major depressive disorder (MDD) is associated to affected brain wiring.  ...  Human white matter network ("connectome") analysis via network science is a suitable tool to investigate the association between affected brain connectivity and MDD.  ...  This cooperation has no relevance to the work that is covered in the manuscript. The other authors declare no conflict of interest.  ... 
doi:10.1038/s41380-019-0603-1 pmid:31758093 fatcat:zhwpdnvbu5h2rirpnky7auen6q

Systematic Misestimation of Machine Learning Performance in Neuroimaging Studies of Depression [article]

Claas Flint, Micah Cearns, Nils Opel, Ronny Redlich, David M. A. Mehler, Daniel Emden, Nils R. Winter, Ramona Leenings, Simon B. Eickhoff, Tilo Kircher, Axel Krug, Igor Nenadic (+6 others)
2021 arXiv   pre-print
and healthy control (HC) based on neuroimaging data.  ...  We currently observe a disconcerting phenomenon in machine learning studies in psychiatry: While we would expect larger samples to yield better results due to the availability of more data, larger machine  ...  for Clinical Research (IZKF) of the medical faculty of Münster (grant Dan3/012/17 to UD).  ... 
arXiv:1912.06686v2 fatcat:pabizhpcnzeh5b67hhm5aw6asa

Development of quality standards for multi-center, longitudinal magnetic resonance imaging studies in clinical neuroscience

Christoph Vogelbacher, Jansen, Andreas (Prof. Dr.), Medizin
In the first part a study-specific QA-protocol was developed for a large multicenter MRI-study, FOR2107.  ...  In addition to the development of parameters for the characterization of MRI-data, the used QA-protocols were improved during the study.  ...  For the first question a gel phantom was used to monitor the temporal stability of the MRIscanners in the Marburg-Münster Affective Disorders Cohort Study (, MACS).  ... 
doi:10.17192/z2020.0151 fatcat:agxhg2qe5za3pbukdi5qwyiclu

Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Basel, 30.09.–04.10. 2011, pp 1-89

2011 Onkologie (Basel)  
Techniques for neuroimaging including advanced MR imaging and PET imaging will be covered.  ...  These systems always have to meet competently the increasing challenges of routine practice and provide data for internal and external quality assurance.  ...  Introduction: Immunosuppression in the context of organ transplantation increases the risk for a variety of cancer types including the group of posttransplant lymphoproliferative disorders (PTLD).  ... 
doi:10.1159/000333299 fatcat:ciesjvjdxzds5fgtsxclqaovde

ESICM LIVES 2016: part three

T. Velasquez, G. Mackey, J. Lusk, U. G. Kyle, T. Fontenot, P. Marshall, L. S. Shekerdemian, J. A. Coss-Bu, A. Nishigaki, T. Yatabe, T. Tamura, K. Yamashita (+2609 others)
2016 Intensive Care Medicine Experimental  
The results suggest that AM could be useful for LCOS prediction. More data are necessary to confirm the role in the prediction of relevant outcomes.  ...  This new formula combine 2 parameters, DTF*RSBI, as a good parameter for extubation.  ...  Demographic and clinical data were retrieved from a quality assurance data base.  ... 
doi:10.1186/s40635-016-0100-7 fatcat:ymmv7gxkdjdq5jq3idaxr46knu

Connectivity models in the neural face perception domain – interfaces to understand the human brain in health and disease?

Roman Kessler, Jansen, Andreas (Prof. Dr.), Medizin
In the present dissertation, so-called Dynamic Causal Models are applied in the field of neural face processing. In a first study a clinical context is used.  ...  A prerequisite for clinical application is the reliability of the modeling method. Thus, results of models should be generalizable and not depend on certain nuances of the modeling.  ...  The marburg-münster affective disorders cohort study (MACS): a quality assurance protocol for MR neuroimaging data.  ... 
doi:10.17192/z2022.0319 fatcat:eby6nnngxzgnviv32qnojxi4pe