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The LIFEdb database in 2006

A. Mehrle
2006 Nucleic Acids Research  
New features of LIFEdb include (i) an updated user interface with enhanced query capabilities, (ii) a configurable output table and the option to download search results in XML, (iii) the integration of  ...  data from cell-based screening assays addressing the influence of protein-overexpression on cell proliferation and (iv) the display of the relative expression ('Electronic Northern') of the genes under  ...  ACKNOWLEDGEMENTS This work was supported by National Genome Research Network grants 01GR0101 and 01GR0420 by the Bundesministerium für Bildung und Forschung (BMBF), and in part by EU grant 503438 (TRANSFOG  ... 
doi:10.1093/nar/gkj139 pmid:16381901 pmcid:PMC1347501 fatcat:l3gyagrirzhsxearcs2k6ielpm

The GOA database in 2009--an integrated Gene Ontology Annotation resource

D. Barrell, E. Dimmer, R. P. Huntley, D. Binns, C. O'Donovan, R. Apweiler
2009 Nucleic Acids Research  
Annotations created by the project are collated with annotations from external databases to provide an extensive, publicly available GO annotation resource.  ...  Over the last five years, the group has augmented the number and coverage of their electronic pipelines and a number of new manual annotation projects and collaborations now further enhance this resource  ...  that help enrich the data set.  ... 
doi:10.1093/nar/gkn803 pmid:18957448 pmcid:PMC2686469 fatcat:6rr3sdg375fdharxpzr6xjia6i

LOCATE: a mouse protein subcellular localization database

J. L. Fink
2006 Nucleic Acids Research  
We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set.  ...  data for 40% of the mouse proteome.  ...  The work was supported by funds from the Australian Research Council (ARC) and by  ... 
doi:10.1093/nar/gkj069 pmid:16381849 pmcid:PMC1347432 fatcat:q6iwxmmuhbdldfiq7mmwudpimi

High-Content Screening Microscopy Identifies Novel Proteins With a Putative Role in Secretory Membrane Traffic

V. Starkuviene
2004 Genome Research  
This work has been supported by a grant to R.P. from the Verbundforschung Baden-Wuerttemberg (No. 24-720.431-1-2/2) and grants from the BMBF 01KW0013 (R.P.) and NGFN 01GR1001 (R.P. and S.W.), DHGP 01KW0012  ...  We also thank Olympus, Olympus BioSystems, and Perkin Elmer for continuous support throughout the project.  ...  d Clone IDs used by http://gfp-cdna.embl.de/ (upper line) and http://www.dkfz-heidelberg.de/LIFEdb (lower line) databases, respectively. e Average value and f standard error value derived from independent  ... 
doi:10.1101/gr.2658304 pmid:15466293 pmcid:PMC524419 fatcat:pfki7lmas5dolbxoux2daysbl4

MITOCHONDRIAL PROTEIN PROFILE AND ITS ROLE IN PATHOLOGIC PROCESSES

Ye. A. Kosterina, I. I. Kozenkov, V. A. Kasymov, P. A. Kamensky, I. N. Dominova, Yu. A. Korolyova, V. Ye. Patrusheva, R. S. Bogachev, L. S. Litvinova, S. V. Babak, Ye. M. Moiseeva, Ye. A. Bogdanov (+4 others)
2013 Bûlleten' Sibirskoj Mediciny  
In this review we discuss a recent data in the field of mitochondrial proteomics.  ...  Mitochondria import hundreds of different precursor proteins from the cytosol, and only 13 proteins are encoded by mtDNA itself.  ...  The LIFEdb database in 2006 // Nucleic Acids Res. 2006. 34. D415-18. 20 years of human mtDNA patho- logic point mutations: carefully reading the pathogenicity criteria // Biochim. Biophys.  ... 
doi:10.20538/1682-0363-2013-3-5-17 fatcat:mvyjotj6yja6vjislzjvo5fydm

Automated Subcellular Location Determination and High-Throughput Microscopy

Estelle Glory, Robert F. Murphy
2007 Developmental Cell  
Examples include the organism-specific genome databases and LIFEdb (Localization, Interaction, Functional assays and Expression of Proteins) (http:// www.LIFEdb.de).  ...  in detail in a recent review (Giepmans et al., 2006) .  ... 
doi:10.1016/j.devcel.2006.12.007 pmid:17199037 fatcat:xklrrwtxazg67awsyvtrlx4354

Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold

B. A. Manjasetty
2006 Protein Science  
Acknowledgments We thank Anja Koch, Thomas Grund, Dinh-Trung Pham, and Janett Tischer for technical assistance, and Ulrich Harttig for help in selecting DKFZ targets.  ...  ), and by the Fonds der Chemischen Industrie.  ...  The sub-cellular location of PTD012 was revealed as predominantly nuclear by an automatic phenotyping approach (Conrad et al. 2004 ); see LIFEdb database (Bannasch et al. 2004) .  ... 
doi:10.1110/ps.052037006 pmid:16522806 pmcid:PMC2242484 fatcat:njocmpxxijeb7pe7x6omuddk7m

DILIMOT: discovery of linear motifs in proteins

V. Neduva, R. B. Russell
2006 Nucleic Acids Research  
Motifs are then found in the remaining sequence and ranked according to a statistic that measure over-representation and conservation across homologues in related species.  ...  Discovery of protein functional motifs is critical in modern biology. Small segments of 3-10 residues play critical roles in protein interactions, posttranslational modifications and trafficking.  ...  The authors thank Toby Gibson (EMBL) for the critical reading of the manuscript. Funding to pay the Open Access publication charges for this article was provided by EMBL.  ... 
doi:10.1093/nar/gkl159 pmid:16845024 pmcid:PMC1538856 fatcat:ympr6a7fcfci5narge4rrxhgse

Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport

Chelsi J. Snow, Ashraf Dar, Anindya Dutta, Ralph H. Kehlenbach, Bryce M. Paschal
2013 Journal of Cell Biology  
This set included proteins with welldescribed nuclear localization pathways (GFP-Jun and GFPtelomerase), as well as proteins from the LIFEdb (life database) library (Bannasch et al., 2004; Mehrle et al  ...  et al., 2006) .  ... 
doi:10.1083/jcb.201212117 pmid:23649804 pmcid:PMC3653351 fatcat:hu5huaak6rbp3kn3t4cl3uuysy

Deciphering the function of G protein-coupled receptor 30 [article]

Jörg Isensee, Humboldt-Universität Zu Berlin, Humboldt-Universität Zu Berlin
2017
chief cells in the stomach, (iv) cells in the intermediate and anterior pituitary, and (v) chromaffin cells in the adrenal glands.  ...  In conclusion, this study provides a cellular basis for the function of Gpr30 in vivo.  ...  www.inet.dkfz-heidelberg.de/LIFEdb).  ... 
doi:10.18452/15964 fatcat:7tumal5iivhtdnuy4pesqpiilm

Development and application of a high throughput cell based assay to identify apoptosis inducing proteins, and functional characterization of the candidate Vacuole Membrane Protein 1 (Vmp1)

Mamatha Sauermann
2006
The data generated from these assays and the subcellular localization of the proteins would be integrated into a database (LIFEdb).  ...  The data generated from all the assays as well as the subcellular localization of the proteins [4] would be integrated into a database, LIFEdb [5] .  ... 
doi:10.11588/heidok.00006858 fatcat:6cdtevgqmndmvi4fmykzmz5imq