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The Internal Dynamics of Fibrinogen and Its Implications for Coagulation and Adsorption

Stephan Köhler, Friederike Schmid, Giovanni Settanni, Russell F Doolittle
2015 PLoS Computational Biology  
It also explains the conformational variability of fibrinogen observed during its adsorption on inorganic surfaces and it is supposed to play a major role in the determination of the hydrodynamic properties  ...  In addition the simulations suggest how the dynamics of the D region of fibrinogen may contribute to the allosteric regulation of the blood coagulation cascade through a dynamic coupling between the a-and  ...  From the simulation results we construct a simplified representation of the internal flexibility of Fg and use it to fit and explain experimental data on conformational distribution of the molecule adsorbed  ... 
doi:10.1371/journal.pcbi.1004346 pmid:26366880 pmcid:PMC4569070 fatcat:7cadxdh4xjeirh6y3qnmip2qpi

Proteins, platelets, and blood coagulation at biomaterial interfaces

Li-Chong Xu, James W. Bauer, Christopher A. Siedlecki
2014 Colloids and Surfaces B: Biointerfaces  
Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution  ...  Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices.  ...  Avantika Golas for numerous discussions and technical assistance.  ... 
doi:10.1016/j.colsurfb.2014.09.040 pmid:25448722 pmcid:PMC5001692 fatcat:7s4uiwwdnja6fihd6senmamqqa

Protein adsorption steers blood contact activation on engineered cobalt chromium alloy oxide layers

Vincent Milleret, Stefano Buzzi, Peter Gehrig, Algirdas Ziogas, Jonas Grossmann, Katrin Schilcher, Annelies S. Zinkernagel, Arik Zucker, Martin Ehrbar
2015 Acta Biomaterialia  
It shows that modification of the surface oxide layer is a very attractive strategy to directly functionalize metallic implant surfaces and optimize their blood interaction for the desired orthopedic or  ...  Proteins associated with the coagulation cascade, platelet adhesion and neutrophil function correlated with the various blood surface activations observed.  ...  Acknowledgments The Commission for Technology and Innovation (CTI) is acknowledged for financial support. Armin W. Mäder is acknowledged for constructive discussions.  ... 
doi:10.1016/j.actbio.2015.06.020 pmid:26102336 fatcat:5uy773wdffbtrbym2437qgk7re

The fibrinolytic mechanism in haemostasis: A review

J. L. Stafford
1964 Journal of Clinical Pathology  
The work at St. George's Hospital referred to in this paper was made possible by grants from the Medical Research Council and from the St. George's Hospital Research Fund.  ...  PLASMIN In vitro this proteolytic enzyme has substrate specificity for both fibrinogen and fibrin (Ratnoff, 1953; Ambrus and Markus, 1960) : it will also digest certain protein components of the coagulation  ...  The dynamic interaction of protein molecules in solution, aided and abetted by ionic calcium, is clearly influenced by surface adsorption.  ... 
doi:10.1136/jcp.17.5.520 pmid:14207787 pmcid:PMC480809 fatcat:vqmrxfvckzcsncpwalghzvosqa

Protein Corona Composition and Dynamics on Carbon Nanotubes in Blood Plasma and Cerebrospinal Fluid [article]

Rebecca L. Pinals, Darwin Yang, Daniel J. Rosenberg, Tanya Chaudhary, Andrew R. Crothers, Anthony T. Iavarone, Michal Hammel, Markita P Landry
2020 bioRxiv   pre-print
Presence of the protein corona surrounding the nanoparticle has significant implications for applying nanotechnologies within biological systems, affecting outcomes such as biodistribution and toxicity  ...  Knowledge of the protein corona composition, dynamics, and structure informs translation of engineered nanoparticles from in vitro design to effective in vivo application.  ...  Acknowledgements Proteomic mass spectrometry data collection at the California Institute for Quantitative Biosciences (QB3)/College of Chemistry Mass Spectrometry Facility for LC-MS/MS was funded through  ... 
doi:10.1101/2020.01.13.905356 fatcat:y6mgk6am7vcitaazxwscbpesmy

Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions

Anne Strohbach, Raila Busch
2021 International Journal of Molecular Sciences  
Here, we review (i) the influence of biomaterials on complement and coagulation cascades, (ii) the significance of complement-coagulation interactions for the clinical success of cardiovascular implants  ...  The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on the host-initiated complement and coagulation cascade.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms222111390 pmid:34768821 pmcid:PMC8583792 fatcat:dnuterdkc5hbhbvbg5xsywjpd4

Zeolite Nanoparticles for Selective Sorption of Plasma Proteins

M. Rahimi, E.-P. Ng, K. Bakhtiari, M. Vinciguerra, H. Ali Ahmad, H. Awala, S. Mintova, M. Daghighi, F. Bakhshandeh Rostami, M. de Vries, M. M. Motazacker, M. P. Peppelenbosch (+2 others)
2015 Scientific Reports  
Moreover, a high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed.  ...  Recently, it was reported that the large pore EMT-type nanosized zeolite can adsorb fibrinogen and apolipoproteins while keeping the same amount of albumin in human plasma 12 .  ...  Importantly, a maximum concentration of fibrinogen is a guarantee for its strong adsorption to both zeolite nanoparticles.  ... 
doi:10.1038/srep17259 pmid:26616161 pmcid:PMC4663482 fatcat:7sxqbo6qube67efot7irvesqyi

Modelling and measurements of fibrinogen adsorption on positively charged microspheres

Zeliszewska, Bratek-Skicki, Adamczyk, Ciesla
2016 Condensed Matter Physics  
Adsorption of fibrinogen on positively charged microspheres was theoretically and experimentally studied.  ...  On the other hand, at pH=9.7, the maximum coverage of fibrinogen was larger, varying between 1.8 mg m^-2 and 3.4 mg m^-2 for 10^-2 and 0.15 M NaCl, respectively.  ...  Acknowledgements This work was financially supported by the NCN Grants: PRELUDIUM-2013/09/N/ST4/00320 and UMO-2012/07/B/ST4/00559.  ... 
doi:10.5488/cmp.19.13801 fatcat:6gt3qtohiveinaphuoo4lhujla

Corona exchange dynamics on carbon nanotubes by multiplexed fluorescence monitoring [article]

Rebecca L Pinals, Darwin Yang, Alison Lui, Wendy Cao, Markita P Landry
2019 bioRxiv   pre-print
Albumin and fibrinogen cause a 52.2% and 78.2% attenuation of the dopamine nanosensor response, coinciding with 0.5% and 3.7% desorption of (GT)6, respectively.  ...  Noncovalent adsorption of DNA on nanoparticles has led to their widespread implementation as gene delivery tools and optical probes.  ...  a key coagulation protein present in plasma but depleted from serum, and (iii) albumin and fibrinogen are known to be interfacially active proteins prone to surface-adsorption and are implicated in the  ... 
doi:10.1101/761296 fatcat:qr3v4vcbrjbdre4v52vauuqmna

Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

Dongwoo Khang, Yeon Kyung Lee, Eun-Ju Choi, Thomas J. Webster, Sang-Hyun Kim
2014 International Journal of Nanomedicine  
Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential  ...  use of nanostructured biomaterials for in vivo applications.  ...  Acknowledgments This research was supported by the National Research  ... 
doi:10.2147/ijn.s72998 pmid:25565807 pmcid:PMC4275058 fatcat:2uyo64f4hffhzg64fdx74j23he

Achieving Totally Local Anticoagulation on Blood Contacting Devices

Rana Gbyli, Anna Mercaldi, Harihara Sundaram, Kagya A. Amoako
2017 Advanced Materials Interfaces  
therapy for controlling blood coagulation on biomaterials.  ...  This review focuses on the remaining challenges in the context of biomaterial surface interaction with blood, biomaterial properties and their influence on coagulation, old and new surface anticoagulation  ...  For instance, the adsorbed fXII and fibrinogen constituents of this layer trigger the activation of the complement, and one of its components, C3 is prone to undergo conformational changes upon binding  ... 
doi:10.1002/admi.201700954 fatcat:ixueqpej6baddbizfocmmyzdlq

Anti-fouling strategies for central venous catheters

Alex Wallace, Hassan Albadawi, Nikasha Patel, Ali Khademhosseini, Yu Shrike Zhang, Sailendra Naidu, Grace Knuttinen, Rahmi Oklu
2017 Cardiovascular Diagnosis and Therapy  
Occlusion of a catheter renders the catheter unusable and is often treated by tissue plasminogen activator administration or replacement of the line.  ...  Prevention of this complication requires a thorough understanding of the mechanisms of platelet aggregation, signaling and cross-linking.  ...  A key component in thrombosis is fibrinogen and it is likely one of the first components to adsorb to artificial surfaces.  ... 
doi:10.21037/cdt.2017.09.18 pmid:29399528 pmcid:PMC5778515 fatcat:rrl53lpacjdtzcidhu7vkskgi4

Red blood cell aggregation in nephrotic syndrome

Patrick Ozanne, Robert B. Francis, Herbert J. Meiselman
1983 Kidney International  
The forces of aggregation due to macromolecular adsorption and bridging are countered by the forces of disaggregation due to mechanical shearing and electrostatic repulsion between the charged surfaces  ...  This investigation was thus designed to measure the dynamics and steady state extent of RBC aggregation for NS RBC in autologous plasma, NS RBC in an isotonic dextran solution known to produce cell aggregation  ...  Acknowledgments This work was supported by The National Institutes of Health research grants HL 15722, HL 15162, and American Heart Association-Greater Los Angeles Affiliate, Award 537 1G.  ... 
doi:10.1038/ki.1983.50 pmid:6842967 fatcat:zo7dgvgv3bhz3ie4wim2bw6z6e

Analysis of SiO2 nanoparticles binding proteins in rat blood and brain homogenate

Seong Soo A. An, Kyu Hwan Shim, John Hulme, Eun-Ho Meang, Myeong-Kon Kim
2014 International Journal of Nanomedicine  
for dynamic exclusion was 1, and its repeat duration (Seoul, South Korea).  ...  report differential adsorption onto the surface of nanoparticles, might have a lower affinity for ZnO, whereas it would have  ... 
doi:10.2147/ijn.s58203 pmid:25565838 pmcid:PMC4279766 fatcat:ircmjbc2qfeelgzyyhcak3snve

Normal and Abnormal Blood Coagulation: A Review

R. G. Macfarlane
1948 Journal of Clinical Pathology  
Introduction As one of the lesser problems of physiology, the nature of blood coagulation has received more than its share of investigation.  ...  There is now an insurmountable mass of literature dealing with its various aspects, contributed over the greater part of a century by some of the foremost experimentalists of their time, and embodying  ...  during storage, and it is not, at the moment, clear in its implications.  ... 
doi:10.1136/jcp.1.3.113 pmid:16810794 pmcid:PMC1023258 fatcat:ixx2s3mcm5eprjemnlbnusd5bu
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