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The Feasibility of Magnetic Resonance Imaging for Quantification of Liver, Pancreas, Spleen, Vertebral Bone Marrow, and Renal Cortex R2* and Proton Density Fat Fraction in Transfusion-Related Iron Overload

İlkay S. İdilman, Mithat Haliloğlu, Fatma Gümrük, Muşturay Karçaaltıncaba
2016 Turkish Journal of Hematology  
Objective: We aimed to evaluate the feasibility of quantification of liver, pancreas, spleen, vertebral bone marrow, and renal cortex R2* and magnetic resonance imaging-proton density fat fraction (MRI-PDFF  ...  Conclusion: High iron content of the liver, especially with a T2* value shorter than the first echo time can spoil the efficacy of PDFF calculation.  ...  Acknowledgments Muşturay Karçaaltıncaba was supported by the Turkish Academy of Sciences (TÜBA) in the framework of the Young Scientist Award Program (EA-TÜBA-GEBİP/2011).  ... 
doi:10.4274/tjh.2015.0142 pmid:26376710 pmcid:PMC4805342 fatcat:ouuycq6chzejzcmizjxn3wfrjy

Quantitative chemical shift-encoded MRI is an accurate method to quantify hepatic steatosis

Jens-Peter Kühn, Diego Hernando, Birger Mensel, Paul C. Krüger, Till Ittermann, Julia Mayerle, Norbert Hosten, Scott B. Reeder
2013 Journal of Magnetic Resonance Imaging  
Purpose-To compare the accuracy of liver fat quantification using a three-echo chemical shiftencoded magnetic resonance imaging (MRI) technique without and with correction for confounders with spectroscopy  ...  Results-The spectroscopic range of liver fat was 0.11%-38.7%. Excellent correlation between MRS-FF and MRI-FF was observed when using T2* correction (R 2 =0.96).  ...  Acknowledgments This work is part of the research project Greifswald Approach to Individualized Medicine (GANI_MED). The  ... 
doi:10.1002/jmri.24289 pmid:24123655 pmcid:PMC4276715 fatcat:ceb7i4psw5eqdevjv3zgzpimvm

Influence of the analysis technique on estimating hepatic iron content using MRI

El-Sayed H. Ibrahim, Ayman M. Khalifa, Ahmed K. Eldaly
2016 Journal of Magnetic Resonance Imaging  
Purpose: To investigate the effect of the analysis technique on estimating hepatic iron content using MRI Materials and Methods: We evaluated the influences of single-exponential (EXP), biexponential (  ...  In-vivo T2* values ranged from 3.1 to 53.6ms, depending on the amount of iron overload and implemented analysis method.  ...  It should be noted that besides T2* measurement, other MRI techniques, e.g. based on T2 measurements, have been developed for estimating iron overload in the liver, which are largely used in clinical practice  ... 
doi:10.1002/jmri.25317 pmid:27240936 fatcat:twa2s47upfde3owjzw27dllwqi

Letters to the Editor

Gavin Low, Guan Huang, Harini Dharmana, Zaahir Moloo, Winnie Fu
2015 Canadian Journal of Gastroenterology and Hepatology  
Coming from a radiology department in a tertiary referral institution for liver diseases, we would like to offer a perspective on the suitability of magnetic resonance imaging (MRI) for the investigation  ...  time influenced by magnetic field inhomogeneity (T2*) (1).  ... 
doi:10.1155/2015/523876 pmid:25855881 pmcid:PMC4399378 fatcat:ay6egcvm7bfkhejf4dsleexfny

Measurement of liver fat fraction and iron with MRI and MR spectroscopy techniques

Puneet Sharma, Maria Altbach, Jean Philippe Galons, Bobby Kalb, Diego R. Martin
2013 Diagnostic and Interventional Radiology  
The purpose of this review is to describe the current state-of-the-art methods for quantifying liver lipid and iron using magnetic resonance imaging and spectroscopy, including their implementation, benefits  ...  Metabolic iron manifests differently in magnetic resonance (MR) images.  ...  The use of magnetic resonance imaging as a front line tool for the robust assessment of diffuse liver disease is imminent.  ... 
doi:10.5152/dir.2013.13124 pmid:24047718 pmcid:PMC4463239 fatcat:rguffzcyo5cpri5wzl2hzksiha

Quantification of liver iron with MRI: State of the art and remaining challenges

Diego Hernando, Yakir S. Levin, Claude B. Sirlin, Scott B. Reeder
2014 Journal of Magnetic Resonance Imaging  
Iron overload can result in liver damage, with the eventual development of cirrhosis, liver failure and hepatocellular carcinoma.  ...  This article discusses the need for non-invasive assessment of liver iron, and reviews qualitative and quantitative methods with a particular emphasis on MRI.  ...  ACKNOWLEDGEMENTS We acknowledge the support of the NIH (R01 DK083380, R01 DK088925, RC1 EB010384, and R01 DK096169), the Wisconsin Alumni Research Foundation (WARF) Accelerator Program, and the University  ... 
doi:10.1002/jmri.24584 pmid:24585403 pmcid:PMC4308740 fatcat:24jpxog6xvdn5hnrphvwn65g2a

Magnetic Resonance Elastography and Other Magnetic Resonance Imaging Techniques in Chronic Liver Disease: Current Status and Future Directions

Cher Heng Tan, Sudhakar Kundapur Venkatesh
2016 Gut and Liver  
Advanced techniques may require additional postprocessing analysis. Liver iron quantification by MRI Iron overload leads to damage of hepatocytes and myocardium.  ...  Using the T2* relaxometry method, the estimated concentration of iron per dry weight of liver tissue was 10 mg/g, which is consistent with a moderately severe degree of hepatic iron overload.  ... 
doi:10.5009/gnl15492 pmid:27563019 pmcid:PMC5003189 fatcat:uoy7ux2omnfhxefpm5u3kw5roq

Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload

2017 Swiss Medical Weekly  
The assessment of liver iron concentration by liver biopsy or magnetic resonance imaging (MRI) may guide the further diagnostic and therapeutic workup.  ...  They summarise the standard practice in Switzerland on the use of liver iron concentration MRI as well as disease-specific guideline recommendations.  ...  Disclosure statement The first draft of the manuscript was written by the first author.  ... 
doi:10.4414/smw.2017.14550 pmid:29120023 fatcat:nqvjcdjsy5azjlayyh4d2haauy

Quantification of Hepatic Iron Concentration in Chronic Viral Hepatitis: Usefulness of T2-weighted Single-Shot Spin-Echo Echo-Planar MR Imaging

Tatsuyuki Tonan, Kiminori Fujimoto, Aliya Qayyum, Takumi Kawaguchi, Atsushi Kawaguchi, Osamu Nakashima, Koji Okuda, Naofumi Hayabuchi, Michio Sata, James Fung
2012 PLoS ONE  
The correlation between the liver-to-muscle signal intensity ratio, which was generated by regions of interest placed in the liver and paraspinous muscles of each sequence image, and the hepatic iron concentration  ...  Objective: To investigate the usefulness of single-shot spin-echo echo-planar imaging (SSEPI) sequence for quantifying mild degree of hepatic iron stores in patients with viral hepatitis.  ...  Therefore, it might be important to consider the influence of each factor in background liver tissue in the quantification of steatosis and iron stores using MR imaging.  ... 
doi:10.1371/journal.pone.0033868 pmid:22439008 pmcid:PMC3306306 fatcat:5cowcqwm7jblhaws63kgqxkleq

Impact of Iron Assessment by MRI

J. C. Wood
2011 Hematology ASH Education Program  
The use of magnetic resonance imaging (MRI) to estimate tissue iron was conceived in the 1980s, but has only become a practical reality in the last decade.  ...  The technique is most often used to estimate hepatic and cardiac iron in patients with transfusional siderosis and has largely replaced liver biopsy for liver iron quantification.  ...  The desire to replace liver biopsy with a noninvasive test drove the earliest studies on magnetic resonance imaging (MRI) iron quantification 6 .  ... 
doi:10.1182/asheducation-2011.1.443 pmid:22160072 fatcat:z5qzjbo7a5ctxaus4ouudc3id4

3D Multi-Echo Dixon technique for simultaneous assessment of liver steatosis and iron overload in patients with chronic liver diseases: a feasibility study

Fubi Hu, Ru Yang, Zixing Huang, Min Wang, Fang Yuan, Chunchao Xia, Yi Wei, Bin Song
2019 Quantitative Imaging in Medicine and Surgery  
feasibility of 3D ME Dixon technique for the simultaneous assessment of liver steatosis and iron overload using histopathologic findings as the reference standard.  ...  liver steatosis and iron overload in patients with CLDs, especially for quantification of liver steatosis.  ...  Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.  ... 
doi:10.21037/qims.2019.05.20 pmid:31367555 pmcid:PMC6629573 fatcat:qmp7dkz7rngfjpzdqcsitcr6xm

Imaging biomarkers of diffuse liver disease: current status

Bachir Taouli, Filipe Caseiro Alves
2020 Abdominal Radiology  
We have invited imaging experts to discuss various topics pertaining to diffuse liver disease, covering a vast array of imaging techniques including ultrasound (US), CT, MRI and new molecular imaging agents  ...  Below, we briefly discussed the current status, limitations, and future directions of imaging biomarkers of diffuse liver disease.  ...  Ghoz HM, Kroner PT, Stancampiano FF, Bowman AW, Vishnu P, Heckman MG, Diehl NN, McLeod E, Nikpour N, Palmer WC (2019) Hepatic iron overload identified by magnetic resonance imaging-based T2* is a predictor  ... 
doi:10.1007/s00261-020-02619-y pmid:32583139 fatcat:cyofegd36vexli6e4idzkue5sq

Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI

Manuela França, Ángel Alberich-Bayarri, Luis Martí-Bonmatí, Pedro Oliveira, Francisca Emanuel Costa, Graça Porto, José Ramón Vizcaíno, Javier Sanchez Gonzalez, Eduardo Ribeiro, João Oliveira, Helena Pessegueiro Miranda
2017 Abdominal Radiology  
Purpose: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload  ...  Proton density fat fraction (PDFF) was prospectively estimated using complexbased data reconstruction with multipeak fat modeling. Water R2* was used to estimate iron content.  ...  A previous report found no influence of iron overload [22] , if T2* correction was used. However, they did not have patients with R2* over 200 s -1 [22] .  ... 
doi:10.1007/s00261-017-1048-0 pmid:28110367 fatcat:nftbx2c7nbazblhphiyirlcsk4

Simultaneous R2* and Liver Fat-fraction Measurement Using Modulus and Real Multiple Gradient-echo with Low-field MRI

Tatsuhiko MATSUSHITA, Tosiaki MIYATI, Naoki OHNO, Tetsuo OGINO, Tomoyuki OKUAKI, Norio HAYASHI, Akihiro KITANAKA, Takashi HAMAGUCHI, Shigeki OHTAKE
2011 Medical Imaging and Information Sciences  
We evaluated the R2 * (iron content)and fat-fraction of liver tissue simultaneously using the modulus and real multiple gradient-echo(MRM-GRE)sequence at low-field MRI.  ...  Using a 0.4-Tesla open MRI, modulus images of 4 gradient-echoes (typically 8.9, 17.8, 26.7, and 35.6 ms)were obtained by MRM-GRE.  ...  In Vivo Human Study Fig. 3 illustrates the influence of fat-fraction on iron concentration of the liver.  ... 
doi:10.11318/mii.28.97 fatcat:2s6q6insnret7lzj52efgmlgnq

The role of magnetic resonance imaging in the evaluation of thalassemic syndromes: current practice and future perspectives

Sophie Mavrogeni, George Markousis-Mavrogenis, Genovefa Kolovou
2014 Thalassemia Reports  
Using magnetic resonance imaging, tissue iron is detected indirectly by the effects on relaxation times of ferritin and hemosiderin iron interacting with hydrogen nuclei.  ...  Currently, cardiovascular magnetic resonance using T2* is routinely used in many countries to identify patients with myocardial iron loading and guide chelation therapy, specifically tailored to the heart  ...  The role of magnetic resonance imaging in iron evaluation Magnetic resonance imaging (MRI) uses the magnetic properties of the human body to provide pictures of any tissue.  ... 
doi:10.4081/thal.2014.s1.1859 fatcat:ffvhfjesbbfhrnlj3hphstx7za
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