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The microbiome revolution

Martin J. Blaser
2014 Journal of Clinical Investigation  
The gut in particular is a biological niche that is home to a diverse array of microbes that influence nearly all aspects of human biology through their interactions with their host; new technologies are  ...  The collection of bacteria, viruses, and fungi that live in and on the human body, collectively known as the microbiome, has recently emerged as an important factor in human physiology and disease.  ...  Also, without much evidence, we believed it to be homeostatic, such that when we would treat bacterial infections with antibiotics, we might perturb it a little, but that everything would just bounce back  ... 
doi:10.1172/jci78366 pmid:25271724 pmcid:PMC4191014 fatcat:4jmpezcz25bdtmr3sanu2u7yqe

Setting the agenda for social science research on the human microbiome

Beth Greenhough, Cressida Jervis Read, Jamie Lorimer, Javier Lezaun, Carmen McLeod, Amber Benezra, Sally Bloomfield, Tim Brown, Megan Clinch, Fulvio D'Acquisto, Anna Dumitriu, Joshua Evans (+15 others)
2020 Palgrave Communications  
Acknowledgements This project was organised and funded as part of the Oxford Interdisciplinary Microbiome Project (IMP) and supported by the John Fell Fund and the Economic and Social Research Council  ...  We have also witnessed a rapid growth in the number of products that see the human microbiome as a new way of defining a target market, including food and probiotic supplements designed to influence everything  ...  (AMR) (O'Neill, 2014) , there are also a growing number of initiatives focused on exploring what has been termed the 'new microbial frontier' (Microbiology Society, 2017) .  ... 
doi:10.1057/s41599-020-0388-5 fatcat:2r7dkj5qffh4fhelmjkr6hmd5i

The Microbiological Basis of Human Superorganism Freedom

Rodney R Dietert
2021 American Journal of Biomedical Science & Research  
This hypothesis stresses that lots of genetic variation within populations is a wonderful thing as it provides equal opportunity for success.  ...  It is the foundation of how earth organisms, especially humans, naturally operate. These views both reflected his research findings and helped to mold his world view.  ...  Acknowledgements The author thanks Janice Dietert for her editorial suggestions.  ... 
doi:10.34297/ajbsr.2021.13.001933 fatcat:ehgd3yd4jfb65lpxmv4ssi5bwy

The Challenge of Maintaining a Healthy Microbiome during Long-Duration Space Missions

Alexander A. Voorhies, Hernan A. Lorenzi
2016 Frontiers in Astronomy and Space Sciences  
The human microbiome is the collection of all microorganisms residing in and on a human host, and it plays an essential role in keeping humans healthy.  ...  Astronauts will face a host of challenges on long-duration space missions like a human expedition to Mars, including the difficulty of maintaining a balanced and healthy microbiome.  ...  The Human Microbiome Project found that while the collection of microbial taxa may change among subjects from a particular healthy human cohort, the metabolic pathways represented by those organisms tend  ... 
doi:10.3389/fspas.2016.00023 fatcat:uw2rcte6pnd4tnq324wguhovaq

Unsettling antibiosis: how might interdisciplinary researchers generate a feeling for the microbiome and to what effect?

Beth Greenhough, Andrew Dwyer, Richard Grenyer, Timothy Hodgetts, Carmen McLeod, Jamie Lorimer
2018 Palgrave Communications  
We argue that understanding and potentially generating different modes of relating to microbes-a feeling for the microbiome-offers opportunities for reconfiguring microbiopolitics and intervening into  ...  In reflecting on these findings we draw on work in animal geographies, environmental humanities and the social science of the microbiome.  ...  Thanks also go to the organisers and audience of the More-Than-Human Geographies of Empathy session at the RGS-IBG 2017 London meeting for useful feedback on an earlier draft of this paper.  ... 
doi:10.1057/s41599-018-0196-3 fatcat:ctmuomr3azdsbjb56t4jdhtz5u

Sick Individuals and Sick (Microbial) Populations: Challenges in Epidemiology and the Microbiome

Audrey Renson, Pamela Herd, Jennifer B. Dowd
2019 Annual Review of Public Health  
The human microbiome represents a new frontier in understanding the biology of human health.  ...  To rise to the challenge, we argue that epidemiology should capitalize on its population perspective as a critical complement to molecular microbiome research, allowing for the illumination of contextual  ...  ACKNOWLEDGMENTS The authors acknowledge support from the National Institute of Allergy and Infectious Diseases (R21AI121784-01) and the National Institute of Child Health and Development (5T32HD091058-  ... 
doi:10.1146/annurev-publhealth-040119-094423 pmid:31635533 fatcat:hxolebtoxfhebnibuoayae32se

Building the microbiome in health and disease: niche construction and social conflict in bacteria

Luke McNally, Sam P. Brown
2015 Philosophical Transactions of the Royal Society of London. Biological Sciences  
One contribution of 17 to a theme issue 'Within-host dynamics of infection: from ecological insights to evolutionary predictions'.  ...  By broad definitions, they are entirely overlapping 'theories of everything' that can describe all biological traits, in so far as all traits affect a focal organism, and other organisms via the inevitable  ...  (b) Case study 2: Pseudomonas aeruginosa dynamics in the cystic fibrosis lung microbiome Cystic fibrosis (CF) is a genetic condition that primarily affects the lung, leading to impaired airway clearance  ... 
doi:10.1098/rstb.2014.0298 pmid:26150664 pmcid:PMC4528496 fatcat:ak6hl5ejgvfnnj7rbopwf6ytyq

Methane matters: from blue-tinged moos, to boozy roos, and the health of humans too

Emily C. Hoedt, Páraic Ó Cuív, Mark Morrison
2016 Animal Frontiers  
For humans, these processes are also key, not just for the provision of nutrients (e.g., butyrate for  ...  by a suite of enzymes including glycoside hydrolases (cellulases and xylanases), esterases, lipases, and proteinases.  ...  to MM via CSIRO's Science Leader scheme and the University of Queensland Diamantina Institute.  ... 
doi:10.2527/af.2016-0029 fatcat:fe6x22x72zgsfjqnbzqcorclle

Ecology of Human Medical Enterprises: From Disease Ecology of Zoonoses, Cancer Ecology Through to Medical Ecology of Human Microbiomes

Zhanshan Sam Ma, Ya-Ping Zhang
2022 Frontiers in Ecology and Evolution  
(iii) Suggest that a unified medical ecology of human diseases is both necessary and feasible, but laissez-faire terminologies in other human medical enterprises may be preferred.  ...  (iv) Suggest that the evo-eco paradigm for cancer research can play a similar role of evo-devo in evolutionary developmental biology.  ...  AUTHOR CONTRIBUTIONS YPZ and ZSM conceived and outlined the review topics. ZSM wrote the draft. Both authors revised the draft and approved the submission.  ... 
doi:10.3389/fevo.2022.879130 fatcat:pbo7colv4jehncznjocaqtcevi

Distinct Oceanic Microbiomes From Viruses to Protists Located Near the Antarctic Circumpolar Current

Flavia Flaviani, Declan C. Schroeder, Karen Lebret, Cecilia Balestreri, Andrea C. Highfield, Joanna L. Schroeder, Sally E. Thorpe, Karen Moore, Konrad Pasckiewicz, Maya C. Pfaff, Edward P. Rybicki
2018 Frontiers in Microbiology  
To our knowledge, this is the first that a statistical difference in the microbiome (from viruses to protists) between the subtropical Indian and Southern Oceans.  ...  We also show that not all phylotypes can be found everywhere, and that meDNA is not a suitable resource for monitoring aquatic microbial diversity.  ...  on abiotic conditions that affect the presence of its hosts.  ... 
doi:10.3389/fmicb.2018.01474 pmid:30065704 pmcid:PMC6056678 fatcat:zsqnyoywnzfnrbkchq7fuuex7q

Human biome biotechnology and the personalization of odour profiles

Kenneth Timmis
2009 Microbial Biotechnology  
In this feature, leading researchers in the field of microbial biotechnology speculate on the technical and conceptual developments that will drive innovative research and open new vistas over the next  ...  Acknowledgements The opinions expressed above do not reflect the views of NCBI, National Library of Medicine, or the Intramural Research Program of the National Institutes of Health, which supports my  ...  Acknowledgements I thank Bernhard Hube for the helpful feedback and discussion on this issue.  ... 
doi:10.1111/j.1751-7915.2009.00090_18.x pmid:21261906 pmcid:PMC3815832 fatcat:ewqeqhk3dbgt3mlpt7yekdxv74

The Law of Self-Eating—Milk, Placenta, and Feces Consumption

Mathilde Cohen
2020 Law, Technology and Humans  
Second, it asks whether there is something different or specific about the way in which self-consumption (i.e., the consumption of human body materials by humans) is regulated compared to that of foods  ...  Humans have consumed nearly every human body part. Today, the consumption of milk, placenta, and feces, in particular, is on the rise.  ...  Thus, the drive toward cell-based, microbiome-based, and other therapies based on body materials offers a new frontier for the law to reach deeper into legal subjects.  ... 
doi:10.5204/lthj.v2i2.1490 fatcat:7hsk5qe7y5fl3l4oryg42b6lb4

Abstracts from the 52nd European Society of Human Genetics (ESHG) Conference: Oral Presentations

2019 European Journal of Human Genetics  
Funding: C.B. is supported by an ERC Starting Grant (n°6 79146) of the European Union and by a New Frontiers Group award of the Austrian Academy of Sciences. C. Bock: E.  ...  Wijmenga 1,4 , A. Zhernakova 1 , J. Fu 1, 2 Interaction between the human genome and gut microbiome is vital to human health.  ...  Functional studies confirmed that the variants c.3410C>T, located after the 3′ splice acceptor site (SAS), and c.4382G>A, predicted to introduce a novel SAS, do not affect splicing.  ... 
doi:10.1038/s41431-019-0492-4 fatcat:wuudroxpgfe6vfpv2ddzyr7vhi

Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?

Roman M. Stilling, Seth R. Bordenstein, Timothy G. Dinan, John F. Cryan
2014 Frontiers in Cellular and Infection Microbiology  
The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history.  ...  In particular, we explore the integration of human brain development with evolution, symbiosis, and RNA biology, which together represent a "social triangle" that drives human social behavior and cognition  ...  "MOST UNFORTUNATELY, IN THE LIVES OF PUPPETS THERE IS ALWAYS A BUT THAT SPOILS EVERYTHING."  ... 
doi:10.3389/fcimb.2014.00147 pmid:25401092 pmcid:PMC4212686 fatcat:apauk5ek55ehnezi5qppnkr3ea

Cover stories: Visualizing scientist migrations

2017 Science  
Investigating an unknown phylum "We are also working on a group of organisms, telonemids, that might be a phylum of their own.  ...  Induced Phenomena and New States of Matter at the Nanoscale PROCESSING AND MANUFACTURING PM1 Explore New Frontiers in Materials Design Using Plasmas-Synthesis, Processing and Characterization PM2 Advances  ... 
doi:10.1126/science.aan6494 pmid:28522469 fatcat:yxpbkn2bunbezlr2sqzebnaedy
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