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The Human Connectome Project: A Retrospective

Jennifer Stine Elam, Matthew F. Glasser, Michael P. Harms, Stamatios N. Sotiropoulos, Jesper L.R. Andersson, Gregory C. Burgess, Sandra W. Curtiss, Robert Oostenveld, Linda J. Larson-Prior, Jan-Mathijs Schoffelen, Michael R. Hodge, Eileen A. Cler (+6 others)
2021 NeuroImage  
The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study  ...  We conclude with a look forward at opportunities and challenges facing the human neuroimaging field from the perspective of the HCP consortium.  ...  ( HCP-A: Mapping the Human  ... 
doi:10.1016/j.neuroimage.2021.118543 pmid:34508893 fatcat:qzxs43vy7reavhdqkn2f5yhw6u

Advances in diffusion MRI acquisition and processing in the Human Connectome Project

Stamatios N. Sotiropoulos, Saad Jbabdi, Junqian Xu, Jesper L. Andersson, Steen Moeller, Edward J. Auerbach, Matthew F. Glasser, Moises Hernandez, Guillermo Sapiro, Mark Jenkinson, David A. Feinberg, Essa Yacoub (+4 others)
2013 NeuroImage  
The Human Connectome Project (HCP) is a collaborative 5-year effort to map human brain connections and their variability in healthy adults.  ...  In this overview, we focus on diffusion MRI (dMRI) and the structural connectivity aspect of the project.  ...  Acknowledgments We acknowledge support from the Human Connectome Project (1U54MH091657-01), from the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, plus grants  ... 
doi:10.1016/j.neuroimage.2013.05.057 pmid:23702418 pmcid:PMC3720790 fatcat:3e3hkqbzdjcmtnx4anwqp3swvi

The Human Connectome Project's neuroimaging approach

Matthew F Glasser, Stephen M Smith, Daniel S Marcus, Jesper L R Andersson, Edward J Auerbach, Timothy E J Behrens, Timothy S Coalson, Michael P Harms, Mark Jenkinson, Steen Moeller, Emma C Robinson, Stamatios N Sotiropoulos (+4 others)
2016 Nature Neuroscience  
This paper presents an integrated approach to data acquisition, analysis, and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP).  ...  Non-invasive human neuroimaging has yielded many exciting discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption.  ...  We thank the other investigators and staff members of the Human Connectome Project consortium for invaluable contributions to data acquisition, analysis, and sharing.  ... 
doi:10.1038/nn.4361 pmid:27571196 fatcat:wwg4h7gmw5eshc5bc3zsmt6zmy

Imaging human connectomes at the macroscale

R Cameron Craddock, Saad Jbabdi, Chao-Gan Yan, Joshua T Vogelstein, F Xavier Castellanos, Adriana Di Martino, Clare Kelly, Keith Heberlein, Stan Colcombe, Michael P Milham
2013 Nature Methods  
At macroscopic scales, the human connectome is composed of anatomically distinct brain areas, the structural pathways connecting them, and their functional interactions.  ...  Successful annotation of phenotypic associations with variation in the connectome and cataloguing of neurophenotypes promise to transform our understanding of the human brain.  ...  J.T.V. receives funding from the London Institute for Mathematical Sciences HDTRA1-11-1-0048 and NIH R01ES017436. Additional support provided by a gift from Joseph P.  ... 
doi:10.1038/nmeth.2482 pmid:23722212 pmcid:PMC4096321 fatcat:ahp5n642fzahpdjl2nke67dwxq

Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission

Vincent Gras, Benedikt A. Poser, Xiaoping Wu, Raphaël Tomi-Tricot, Nicolas Boulant
2019 NeuroImage  
The Human Connectome Project (HCP) has a 7T component that aims to study the human brain's organization and function with high spatial and temporal resolution fMRI and diffusion-weighted acquisitions.  ...  Validation in five healthy adults shows that the proposed technique achieves a flip angle homogeneity comparable to that of a clinical 3 T system.  ...  Acknowledgements The research leading to these results has received funding from the  ... 
doi:10.1016/j.neuroimage.2019.03.040 pmid:30923027 fatcat:dqtoiagdbrbvlefq7hqfe275aq

Optimizing transcranial direct current stimulation (tDCS) electrode position, size, and distance doubles the on-target cortical electric field: Evidence from 3000 Human Connectome Project models [article]

Kevin A. Caulfield, Mark S. George
2021 bioRxiv   pre-print
Here, we computed 3000 MRI-based electric field models in 200 Human Connectome Project (HCP) participants, finding that the largely unexamined variables of electrode position, size, and between-electrode  ...  At the same scalp stimulation intensity, smaller electrodes surrounding the neural target deliver more than double the on-target cortical electric field while stimulating only a fraction of the off-target  ...  We show here, with extensive modeling in 200 Human Connectome Project (HCP) brains (35) , that tDCS researchers have wrongly assumed where maximal stimulation effects are induced and thus have inefficiently  ... 
doi:10.1101/2021.11.21.469417 fatcat:iincv7f5zvce3jl33jxohm674q

Heritability of the human connectome: A connectotyping study

Oscar Miranda-Dominguez, Eric Feczko, David S. Grayson, Hasse Walum, Joel T. Nigg, Damien A. Fair
2018 Network Neuroscience  
" or "connectotype" for the human brain-in both children and adults.  ...  AUTHOR SUMMARY By using machine learning and two independent datasets, this report shows that the brain's individualized functional connectome or connectotype is familial and heritable.  ...  methods in a larger sample taken from the Human Connectome Project (HCP).  ... 
doi:10.1162/netn_a_00029 pmid:30215032 pmcid:PMC6130446 fatcat:pn7wxnhpujcxjahqutwmeufetq

The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants

Sean P. Fitzgibbon, Samuel J. Harrison, Mark Jenkinson, Luke Baxter, Emma C. Robinson, Matteo Bastiani, Jelena Bozek, Vyacheslav Karolis, Lucilio Cordero Grande, Anthony N. Price, Emer Hughes, Antonios Makropoulos (+15 others)
2020 NeuroImage  
The developing Human Connectome Project (dHCP) aims to create a detailed 4-dimensional connectome of early life spanning 20 to 45 weeks post-menstrual age.  ...  We provide a detailed description and evaluation of the pipeline which includes integrated slice-to-volume motion correction and dynamic susceptibility distortion correction, a robust multimodal registration  ...  We are grateful to the families who generously supported this trial. The work was supported by the NIHR Biomedical Research Centres at Guys and St Thomas NHS Trust. The Wellcome Centre for Integrative  ... 
doi:10.1016/j.neuroimage.2020.117303 pmid:32866666 pmcid:PMC7762845 fatcat:f2xibrg5snfczhvwe2rruhd5cm

The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants [article]

Sean Patrick Fitzgibbon, Samuel J Harrison, Mark Jenkinson, Luke Baxter, Emma Claire Robinson, Matteo Bastiani, Jelena Bozek, Vyacheslav Karolis, Lucilio Cordero Grande, Anthony N Price, Emer Hughes, Antonios Makropoulos (+15 others)
2019 bioRxiv   pre-print
The developing Human Connectome Project (dHCP) aims to create a detailed 4-dimensional connectome of early life spanning 20 to 45 weeks post-menstrual age.  ...  We provide a detailed description and evaluation of the pipeline which includes integrated slice-to-volume motion correction and dynamic susceptibility distortion correction, a robust multimodal registration  ...  Kenneth Pope for assistance with the neonatal HRF. The research leading to these results has received funding from the European Research Council under the European Union Seventh  ... 
doi:10.1101/766030 fatcat:j6xg3n7lfjhrrfujmpqf7juv54

An fMRI investigation of the relations between Extraversion, internalizing psychopathology, and neural activation following reward receipt in the Human Connectome Project sample

Courtland S. Hyatt, Emily S. Hallowell, Max M. Owens, Brandon M. Weiss, Lawrence H. Sweet, Joshua D. Miller
2020 Personality Neuroscience  
In the current study, we used data from the Human Connectome Project (N = 1050) to investigate neural activation following receipt of a reward during an fMRI task as one shared mechanism that may be related  ...  We also conducted exploratory analyses on the links between neural activation following reward receipt and the other Five-Factor Model personality traits, as well as separate analyses by gender.  ...  Acknowledgments and Conflicts of Interest Declaration The data used in this project are from the Human Connectome Project, WU-Minn Consortium (  ... 
doi:10.1017/pen.2020.11 pmid:33354651 pmcid:PMC7737192 fatcat:jpgzssw4wfatjey5cy3vmnawsy

Disruptions of the Human Connectome Associated With Hemispatial Neglect

Sadhvi Saxena, Zafer Keser, Chris Rorden, Leonardo Bonilha, Julius Fridriksson, Alexandra Walker, Argye Elizabeth Hillis
2022 Neurology  
and ObjectivesHemispatial neglect is a heterogeneous and complex disorder that can be classified by frame of reference for "left" vs "right," including viewer-centered neglect (VCN, affecting the contralesional  ...  We performed a linear association analysis between network connectivity strength and continuous measures of neglect to identify lesion-induced disconnections associated with the presence or severity of  ...  Acknowledgment The authors thank the study participants and the NIH for support. The content is solely the responsibility of the authors and does not necessarily represent the views of the NIH.  ... 
doi:10.1212/wnl.0000000000013050 pmid:35263271 pmcid:PMC8762585 fatcat:3dmoweg5prhofozxu2mg4lkihu

Novel Primary Immunodeficiency Candidate Genes Predicted by the Human Gene Connectome

Yuval Itan, Jean-Laurent Casanova
2015 Frontiers in Immunology  
We first identified the top 1% of human genes predicted by the human genes connectome to be biologically close to the 229 known PID genes.  ...  It is thus a major challenge to select only a few candidate disease-causing variants for experimental testing.  ...  YI was supported in part by grant # UL1 TR000043 from the National Center for Advancing Translational  ... 
doi:10.3389/fimmu.2015.00142 pmid:25883595 pmcid:PMC4381650 fatcat:j5dwevogfnffrhlzgj2gzitvje

Function in the human connectome: Task-fMRI and individual differences in behavior

Deanna M. Barch, Gregory C. Burgess, Michael P. Harms, Steven E. Petersen, Bradley L. Schlaggar, Maurizio Corbetta, Matthew F. Glasser, Sandra Curtiss, Sachin Dixit, Cindy Feldt, Dan Nolan, Edward Bryant (+8 others)
2013 NeuroImage  
The primary goal of the Human Connectome Project (HCP) is to delineate the typical patterns of structural 35 and functional connectivity in the healthy adult human brain.  ...  The HCP data 38 will be a critical stepping-off point for future studies that will examine how variation in human structural 39 and functional connectivity play a role in adult and pediatric neurological  ...  221 sortium, and the preferences of the NIH Human Connectome Project 222 Team, as voiced by the NIH Scientific Officer of the project, Dr.  ... 
doi:10.1016/j.neuroimage.2013.05.033 pmid:23684877 pmcid:PMC4011498 fatcat:ve7jooajlje5viahrk46xy66b4

The human gene connectome as a map of short cuts for morbid allele discovery

Y. Itan, S.-Y. Zhang, G. Vogt, A. Abhyankar, M. Herman, P. Nitschke, D. Fried, L. Quintana-Murci, L. Abel, J.-L. Casanova
2013 Proceedings of the National Academy of Sciences of the United States of America  
The work was funded in part by the National Center for Research Resources and the National Center for Advancing Sciences (NCATS), National Institutes of Health (NIH) Grant 8 UL1 TR000043.  ...  We thank Aric Hagberg (43) , which provided the initial inspiration for the HGC concept. Y.I. was funded by an AXA Research Fund postdoctoral fellowship.  ...  Just as the Human Connectome Project (26, 27) aims to identify the set of connections in the human brain, the HGC project aims to describe the connections between human genes, Fig. 3 .  ... 
doi:10.1073/pnas.1218167110 pmid:23509278 pmcid:PMC3619280 fatcat:jbryxbnra5eg7i5go2ocgwr7c4

Validating atlas-based lesion disconnectomics in multiple sclerosis: a retrospective multi-centric study [article]

Veronica Ravano, Michaela Andelova, Mario Joao Fartaria, Mazen Fouad A-Wali Mahdi, Benedicte Marechal, Reto Meuli, Tomas Uher, Jan Krasensky, Manuela Vaneckova, Dana Horakova, Tobias Kober, Jonas Richiardi
2021 medRxiv   pre-print
Second, tractography quality is highly dependent on the acquisition parameters of diffusion sequences, leading to a trade-off between acquisition time and tractography precision.  ...  A graph embedding technique followed by dimensionality reduction found a topological organization that mirrored disability.  ...  We also thank Dimitri Van De Ville for gracefully hosting this project and providing useful feedback and discussion.  ... 
doi:10.1101/2021.05.03.21256161 fatcat:uqbphsjxfvglxcoz5fy6iz67pe
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