Filters








65 Hits in 17.0 sec

The HIV Mutation Browser: A Resource for Human Immunodeficiency Virus Mutagenesis and Polymorphism Data

Norman E. Davey, Venkata P. Satagopam, Salvador Santiago-Mozos, Carlos Villacorta-Martin, Tanmay A. M. Bharat, Reinhard Schneider, John A. G. Briggs, Alan Rein
2014 PLoS Computational Biology  
The HIV mutation browser provides a valuable new resource for the research community. The HIV mutation browser is available at: http://hivmut.org.  ...  We have applied computational text-mining techniques to parse and map mutagenesis and polymorphism information from the HIV literature, have enriched the data with ancillary information and have developed  ...  Acknowledgments We would like to thank members of the Schneider and Briggs groups, and Aino I Jä rvelin for their helpful comments on the manuscript.  ... 
doi:10.1371/journal.pcbi.1003951 pmid:25474213 pmcid:PMC4256008 fatcat:z3xyysbegbacdketnunitk3oom

The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms

Kimberly Walker, Divya Kalra, Rebecca Lowdon, Guangyi Chen, David Molik, Daniela C. Soto, Fawaz Dabbaghie, Ahmad Al Khleifat, Medhat Mahmoud, Luis F Paulin, Muhammad Sohail Raza, Susanne P. Pfeifer (+47 others)
2022 F1000Research  
Repositories for the projects that participated in the hackathon are available at https://github.com/collaborativebioinformatics.  ...  The goal of the hackathon was to advance research on structural variants (SVs) by prototyping and iterating on open-source software.  ...  We'd like to thank Richard Gibbs and the Baylor College of Medicine Human Genome Sequencing Center for hosting the hackathon.  ... 
doi:10.12688/f1000research.110194.1 fatcat:2yqiygmc7fdhzk3dhwcvvyuwmi

Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein

Vinita R. Joshi, Ruchi M. Newman, Melissa L. Pack, Karen A. Power, James B. Munro, Ken Okawa, Navid Madani, Joseph G. Sodroski, Aaron G. Schmidt, Todd M. Allen, Guido Silvestri
2020 PLoS Pathogens  
These data contribute to our understanding of gp41 residues involved in membrane fusion and identify a mechanism by which host factors can alleviate a viral defect.  ...  We demonstrate that Q563R reduces viral infection by disrupting formation of the gp41 six-helix bundle required for virus-cell membrane fusion.  ...  Acknowledgments We would like to acknowledge the participants in the MGH Acute HIV Cohort and the HIV Negative Cohort as well as Dr. Eric Rosenberg, Dr.  ... 
doi:10.1371/journal.ppat.1008577 pmid:32392227 fatcat:pcxqfheqgng2hkgpnnxapqpizy

The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness [article]

Elena Sugrue, Arthur Wickenhagen, Nardus Mollentze, Muhamad Afiq Aziz, Vattipally B Sreenu, Sven Truxa, Lily Tong, Ana da Silva Filipe, David L Robertson, Joseph Hughes, Suzannah J Rihn, Sam J Wilson
2021 bioRxiv   pre-print
To identify the specific molecular defences that make CC viruses more susceptible to the IFN-induced ′antiviral state′ than TF viruses, we established a pair of fluorescent GFP-IRES-Nef TF and CC viruses  ...  HIV-1 transmission via sexual exposure is a relatively inefficient process.  ...  The HIV 2003;77(3):2174-81. mutation browser: a resource for human immunodeficiency 71.  ... 
doi:10.1101/2021.12.18.473292 fatcat:um5fqgpauffcbc26buoua6n2ui

Proceedings of the Frontiers of Retrovirology Conference 2016

Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov (+639 others)
2016 Retrovirology  
Viral subtyping was done using online tools and drug resistannce mutations were screened using the Stanford University HIV Drug Resistance Database for Interpretation and the International AIDS Society-USA  ...  Our 205 cohort samples with a viral load above 2000 copies/ml were amplified by PCR and sequenced.  ...  Human Immunodeficiency Virus, HIV-1).  ... 
doi:10.1186/s12977-016-0294-5 fatcat:4oldvixbkjfkdfkl3ouqlrrxka

Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor

Nicole Espy, Beatriz Pacheco, Joseph Sodroski
2017 Virology  
The binding of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ((gp120/gp41) 3 ) to the receptors CD4 and CCR5 triggers virus entry into host cells.  ...  Cf2Th cells expressing human CD4 constitutively and human CCR5 in a Tet-regulated manner (Fig. 1) were incubated with the HIV-1 NL4.3(JR-FL) virus and then passaged. By three Espy et al.  ...  This study was supported by the National Institutes of Health (AI24982, GM56550 and AI100645) and the late William F. McCarty-Cooper.  ... 
doi:10.1016/j.virol.2017.04.033 pmid:28521215 pmcid:PMC5516540 fatcat:sgl26mxsanfrfdy2qnk3mcpnii

Dead Cas Systems: Types, Principles, and Applications [chapter]

Sergey Brezgin, Anastasiya Kostyusheva, Dmitry Kostyushev, Vladimir Chulanov
2020 Prime Archives in Molecular Biology  
The gene editing tool CRISPR-Cas has become the foundation for developing numerous molecular systems used in research and, increasingly, in medical practice.  ...  We conclude with comments on the state-of-art in the CRISPR field and future directions.  ...  block replication and protein synthesis of viruses including HIV, HBV, human papilloma virus, and Epstein-Barr virus.  ... 
doi:10.37247/pamb.1.2020.14 fatcat:hjttxkolwne2dbnaatgxcofbv4

Dead Cas Systems: Types, Principles, and Applications

Sergey Brezgin, Anastasiya Kostyusheva, Dmitry Kostyushev, Vladimir Chulanov
2019 International Journal of Molecular Sciences  
The gene editing tool CRISPR-Cas has become the foundation for developing numerous molecular systems used in research and, increasingly, in medical practice.  ...  We conclude with comments on the state-of-art in the CRISPR field and future directions.  ...  block replication and protein synthesis of viruses including HIV, HBV, human papilloma virus, and Epstein-Barr virus.  ... 
doi:10.3390/ijms20236041 pmid:31801211 pmcid:PMC6929090 fatcat:ysmnrmvogrcifjk7zp7xof4woa

Anaerob [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
A6: Agrobacterium tumefaciens strain with a Ti plasmid coding for octopine production in the plant cell.  ...  If the two genes encoding these two enzymes are transformed into plants, they provide resistance against RNA viruses.  ...  Acquired Immunodeficiency Syndrome (AIDS): Caused apparently by the HIV-1 (HTLV-III) and HIV-2 (human immunodeficiency virus [lentivirus]), retroviruses.  ... 
doi:10.1007/978-1-4020-6754-9_723 fatcat:hc7wmrns4nhydondy7l3kkltde

Auxins [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
A6: Agrobacterium tumefaciens strain with a Ti plasmid coding for octopine production in the plant cell.  ...  If the two genes encoding these two enzymes are transformed into plants, they provide resistance against RNA viruses.  ...  Acquired Immunodeficiency Syndrome (AIDS): Caused apparently by the HIV-1 (HTLV-III) and HIV-2 (human immunodeficiency virus [lentivirus]), retroviruses.  ... 
doi:10.1007/978-1-4020-6754-9_1408 fatcat:k6mgbxvlkndzbp66zjgpgjyle4

Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference

2021 Journal of Clinical Immunology  
Published literature on human immunodeficiency virus (HIV) shows that OIs are associated with significant morbidity and mortality, but data are lacking from patients with non-HIV associated CD4+ lymphopenia  ...  Our data suggest that HSV, CMV, EBV and human parvo virus B19 do not trigger the disease onset in the context of CTLA-4 innsufficiency.  ...  We are interested in improving detection and management of immunodeficiency in premature infants, both for primary immunodeficiency disorders and PRID.  ... 
doi:10.1007/s10875-021-01001-x pmid:33822308 fatcat:tzh42i7r5re5vidhzflbwfstfa

A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles

Diego Forni, Rachele Cagliani, Uberto Pozzoli, Marta Colleoni, Stefania Riva, Mara Biasin, Giulia Filippi, Luca De Gioia, Federica Gnudi, Giacomo P. Comi, Nereo Bresolin, Mario Clerici (+1 others)
2013 Immunity  
Data from the 1000 Genomes Project and from the HGDP resource were integrated and we considered genes to represent selection targets if they showed significant results in the same population for at least  ...  loci has a potential impact on the development of immunodeficiencies, autoimmune and inflammatory conditions, and cancer.  ... 
doi:10.1016/j.immuni.2013.04.008 pmid:23707475 fatcat:xnxkjswllvgvhp4efcllxaxox4

HGM 2010 Programme / Abstract

2010 The HUGO Journal  
The identification of an EYS mutation in a dog affected with retinal progressive atrophy would provide a useful model for establishing future therapies for retinitis pigmentosa.  ...  Conclusion: Heterozygous patients in the two families studied may carry an intronic EYS mutation causing exon skipping.  ...  mutagenesis and gene manipulation.  ... 
doi:10.1007/s11568-010-9143-0 fatcat:oykxd6u7snfi5o7m6tst7wi6yq

H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage

Luke F. Pennington, Abdulaziz Alouffi, Evaristus C. Mbanefo, Debalina Ray, David M. Heery, Theodore S. Jardetzky, Michael H. Hsieh, Franco H. Falcone, Judith A. Appleton
2017 Infection and Immunity  
by site-directed mutagenesis and green fluorescent protein (GFP) tagging.  ...  Although the function of M-IPSE is unknown, its ability to translocate to the nuclei of host cells and bind DNA suggests a possible role in immune modulation of host cell tissues.  ...  The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.  ... 
doi:10.1128/iai.00301-17 pmid:28923894 pmcid:PMC5695104 fatcat:6efa65tbczdyrouw5b24dsmhia

International Society of Protistologists 57thAnnual Meeting 20?24 June 2006 Lisbon, Portugal (80A?175A)

2007 Journal of Eukaryotic Microbiology  
We used sitedirected mutagenesis to change individual polymorphic amino acids creating MsgC3A/C9A chimeric molecules (93-1 and 93-2), and have analyzed the effect of the mutations on antibody recognition  ...  synthase (DHPS) mutations and HIV-associated Pneumocystis pneumonia (PcP).  ... 
doi:10.1111/j.1550-7408.2006.00235.x fatcat:m5exruc4svcxteytixg6kp5pjm
« Previous Showing results 1 — 15 out of 65 results