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Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders

Wolf-Julian Neumann, Robert S. Turner, Benjamin Blankertz, Tom Mitchell, Andrea A. Kühn, R. Mark Richardson
2019 Neurotherapeutics  
improvements in the quality of life for movement disorders patients with DBS that ultimately could outperform traditional drug treatment.  ...  Deep brain stimulation is now an established therapeutic approach that robustly alleviates symptoms in patients with movement disorders, such as Parkinson's disease, essential tremor, and dystonia, who  ...  Pathophysiological Neural Activity in DBS Patients with Parkinson's Disease Beta Activity as Hallmark of Parkinsonian Bradykinesia and Rigidity The two most common DBS target sites for PD motor symptoms  ... 
doi:10.1007/s13311-018-00705-0 pmid:30607748 pmcid:PMC6361070 fatcat:iimt5tj5f5ejrpytjz4kdkoioa

Creating the Feedback Loop

Adam O. Hebb, Jun Jason Zhang, Mohammad H. Mahoor, Christos Tsiokos, Charles Matlack, Howard Jay Chizeck, Nader Pouratian
2014 Neurosurgery clinics of North America  
Neuronal oscillations may represent or facilitate the cooperative functioning of brain ensembles, and may provide critical information to customize neuromodulation therapy.  ...  The technology to record biosignals has outpaced our understanding of their relationship to the clinical state of the whole person.  ...  Investigations of LFP measured via electrocorticographic arrays in patients with Parkinson's disease have noted increased beta band activity and synchronization within the motor cortex in patients with  ... 
doi:10.1016/j.nec.2013.08.006 pmid:24262909 pmcid:PMC4058859 fatcat:cvxhliuwpzhlxoh3buyll62izu

Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review

J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
2020 Frontiers in Neurology  
Parkinson's disease (PD).  ...  One of the biggest unmet needs in the field is the identification of reliable biomarkers that can be construed from real walking scenarios to guide better treatments and validate medical and therapeutic  ...  throughout the motor network (2nd) Subthalamic neural entropy is a feature of freezing of gait in freely moving people with Parkinson's disease (30) STN activity comparison during stepping in  ... 
doi:10.3389/fneur.2020.571086 pmid:33240199 pmcid:PMC7683766 fatcat:weysy6cv6zauddjpvttqw6kehq

Local field potentials in Parkinson's disease: a frequency-based review

Zixiao Yin, Gaunyu Zhu, Baotian Zhao, Yutong Bai, Yin Jiang, Wolf-Julian Neumann, Andrea A. Kühn, Jianguo Zhang
2021 Neurobiology of Disease  
With direct access to the subcortical activity, LFP research has provided valuable insight into disease mechanisms and cognitive processes and inspired the advent of adaptive DBS for Parkinson's disease  ...  In the present review, we aim to highlight distinguishing features of frequency-specific activities, mainly within the motor domain, recorded from DBS electrodes in patients with PD.  ...  The power of low beta activity correlates with the disease severity of PD.  ... 
doi:10.1016/j.nbd.2021.105372 pmid:33932557 fatcat:4oh4mta62fgw3bzk62uh5son4e

Movement-related dynamics of cortical oscillations in Parkinson's disease and essential tremor

Efstathios D. Kondylis, Michael J. Randazzo, Ahmad Alhourani, Witold J. Lipski, Thomas A. Wozny, Yash Pandya, Avniel S. Ghuman, Robert S. Turner, Donald J. Crammond, R. Mark Richardson
2016 Brain  
activity in Parkinson's disease and essential tremor, with the greatest high-beta desynchronization occurring in Parkinson's disease and the greatest alpha desynchronization occurring in essential tremor  ...  Recent electrocorticography data have demonstrated excessive coupling of beta-phase to gamma-amplitude in primary motor cortex and that deep brain stimulation facilitates motor improvement by decreasing  ...  Funding The described project was supported by Grant Number UL1 TR0000005 from the National Center for Advancing Translational Sciences (NCATS), the Copeland Fund of the Pittsburgh Foundation and the University  ... 
doi:10.1093/brain/aww144 pmid:27329771 pmcid:PMC5022700 fatcat:vphavgdnwnfwfc2x2oretmh4ee

Statistical analysis of MER data of STN Neurons with DBS in Parkinson's movement disorders

Venkateshwarla Rama Raju, Computer Science & Engineering
2020 IP Indian Journal of Neurosciences  
Entropy was measured in all 12 patients (right hemisphere brain with DBS-ON = 1.4 ± 0.1; DBS-OFF: 1.4 ± 1.9; and left hemisphere brain ON: 1.5 ± 0.1 and OFF: 2.3 ± 1.2 for tremor complexity while root  ...  The goal of this study is to acquire and analyze LFP recordings within the map of Parkinson's environment of clinical-applications for significant-prognostics and this goal is achieved with frequency-analysis  ...  which reduces tremors and restores motor function in subjects (patients) with advanced idiopathic Parkinson's disease both unilateral and bilateral STN-DBS, and for many disorders.  ... 
doi:10.18231/j.ijn.2020.058 fatcat:bxvexkhrlnaolhembr3coo2hlq

Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

J. Lopez-Azcarate, M. Tainta, M. C. Rodriguez-Oroz, M. Valencia, R. Gonzalez, J. Guridi, J. Iriarte, J. A. Obeso, J. Artieda, M. Alegre
2010 Journal of Neuroscience  
We observed high-frequency oscillations (HFOs) in both the off and on motor states. In the off state, the amplitude of the HFOs was coupled to the phase of the abnormal beta activity.  ...  In Parkinson's disease (PD), the oscillatory activity recorded from the basal ganglia shows dopamine-dependent changes.  ...  Correlation with motor signs Recent studies have shown a positive correlation between the relative amplitude of the off subthalamic beta oscillations and the improvement in the bradykinesia/rigidity UPDRS  ... 
doi:10.1523/jneurosci.5459-09.2010 pmid:20463229 pmcid:PMC6632566 fatcat:gez6hudgrbe3zhznjyn5vnat5a

Approaches to closed-loop deep brain stimulation for movement disorders

Chao-Hung Kuo, Gabrielle A. White-Dzuro, Andrew L. Ko
2018 Neurosurgical Focus  
Most studies appear to focus on the treatment of Parkinson's disease.  ...  Although DBS provides effective treatment of the motor symptoms of diseases such as PD, side effects of therapy can include cognitive impairment and changes in speech, gait, and balance. 21 While most  ...  The link between beta-band power in the STN and motor state in PD has been demonstrated in a large cohort of patients, with correlation between 8-35 Hz band-limited power in the STN and UPDRS (United Parkinson's  ... 
doi:10.3171/2018.5.focus18173 pmid:30064321 fatcat:uryrxzyclrbx5n6wr2of7lnjuq

Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson's disease

2019 Brain  
Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment in Parkinson's disease, a plausible mechanism linking  ...  To this end we recorded local field potential activity in the subthalamic nucleus of 18 patients with Parkinson's disease as they executed cued upper and lower limb movements.  ...  Funding The research of P.B. is supported by the Medical Research Council (MC_UU_12024/1), NIHR Oxford Health Biomedical Research Centre and Rosetrees Trust.  ... 
doi:10.1093/brain/awz417 pmid:32040563 pmcid:PMC7009471 fatcat:ybi5ei2ttffhpohsfz3hrofaw4

Classification of pallidal oscillations with increasing parkinsonian severity

Allison T. Connolly, Alicia L. Jensen, Kenneth B. Baker, Jerrold L. Vitek, Matthew D. Johnson
2015 Journal of Neurophysiology  
The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp Neurol 215: 20 -28, 2009. Brown P.  ...  Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease. Exp Neurol 188: 480 -490, 2004. Buzsaki G, Anastassiou CA, Koch C.  ...  Parkinson's disease; machine learning; support vector machine; phase-amplitude coupling THE PATHOPHYSIOLOGY of Parkinson's disease (PD) has been associated with a diverse set of changes in firing rate  ... 
doi:10.1152/jn.00840.2014 pmid:25878156 pmcid:PMC4507953 fatcat:sw444cq3pbfj5olb4nxkgyzwvq

Improved Detection of Parkinsonian Resting Tremor with Feature Engineering and Kalman Filtering

Lin Yao, Peter Brown, Mahsa Shoaran
2019 Clinical Neurophysiology  
Accurate and reliable detection of tremor onset in Parkinson's disease (PD) is critical to the success of adaptive deep brain stimulation (aDBS) therapy.  ...  We analyzed the local field potential (LFP) recordings from the subthalamic nucleus region in 12 patients with PD (16 recordings).  ...  Declaration of Competing Interest None.  ... 
doi:10.1016/j.clinph.2019.09.021 pmid:31744673 pmcid:PMC6927801 fatcat:gqxya2eljrgltp7gobblcu7dye

Troubleshooting Gait Disturbances in Parkinson's Disease With Deep Brain Stimulation

Nicoló G. Pozzi, Chiara Palmisano, Martin M. Reich, Philip Capetian, Claudio Pacchetti, Jens Volkmann, Ioannis U. Isaias
2022 Frontiers in Human Neuroscience  
Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson's disease (PD) that yields a marked and lasting improvement of motor symptoms.  ...  In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic  ...  in PD patients with motor fluctuations (The Deep-Brain Stimulation for Parkinson's Disease Study Group, 2001; Deuschl et al., 2006; Follett et al., 2010; Schuepbach et al., 2013) .  ... 
doi:10.3389/fnhum.2022.806513 pmid:35652005 pmcid:PMC9148971 fatcat:uwtsovmfcjbc7b6qgka6gpvcne

MER based analysis of local field potentials with deep brain stimulation subthalamic nucleus in Parkinson\'s disease using coherence and entropy techniques

Venkateshwarla Rama Raju, Srinivas Konda, Kavitha Rani Balmuri, Anvesh Balabhadra, BSV Raju
2020 IP Indian Journal of Neurosciences  
insights in to Parkinson disease in particular with β -band oscillations.  ...  of neuronal cells in PD and LFP-STN contain electrophysiological footprints of motor sub types of Parkinson's disease 2 .  ... 
doi:10.18231/j.ijn.2020.041 fatcat:jhyjmhuarjh6ffsxte3ybb6r7q

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

Martin Jakobs, Anton Fomenko, Andres M Lozano, Karl L Kiening
2019 EMBO Molecular Medicine  
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such as Parkinson's disease, for more than 25 years and heralded the advent of electrical neuromodulation to treat diseases  ...  Specifically, we examine the electrical, cellular, molecular, and neurochemical mechanisms of DBS as applied to Parkinson's disease and other emerging applications.  ...  The injection of postsynaptic noise and the decoupling of the STN neurons has been shown to reduce the power of beta oscillations, reduce phase/amplitude coupling, and decrease the entropy in the firing  ... 
doi:10.15252/emmm.201809575 pmid:30862663 pmcid:PMC6460356 fatcat:kkplx6l5xvbjxirutc5jehamem

Analysis Methods of EEG Signals: A Review in EEG Application for Brain Disorder

Faridah Abd Rahman, Mohd Fauzi Othman, Nurul Aimi Shaharuddin
2015 Jurnal Teknologi  
It can be concluded that EEG plays its role as a detection tool to detect the disease in the early stage, rehabilitation, classification or as an assistive tool for the patient according to the needs of  ...  It can be concluded that EEG plays its role as a detection tool to detect the disease in the early stage, rehabilitation, classification or as an assistive tool for the patient according to the needs of  ...  Acknowledgement The authors would like to acknowledge Center for Artificial Intelligence & Robotics (CAIRO) and Malaysian-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia  ... 
doi:10.11113/jt.v72.3886 fatcat:2fny2c43gbf75cohofi4ryicwq
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