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Seeing Theranostic Nano-Carriers by Freeze-Fracture Electron Microscopy

Brigitte Papahadjopoulos-Sternberg
2011 Biophysical Journal  
Microarrays can contain tens of thousands of antigens or antibodies on a 1"x3" chemically functionalized glass slide, matching the required throughput.  ...  The formation of the nanocomplexes was confirmed by zeta-potential analysis. The morphologies of the complexes were examined by electron microscopy.  ...  Microarrays can contain tens of thousands of antigens or antibodies on a 1''x3'' chemically functionalized glass slide, matching the required throughput.  ... 
doi:10.1016/j.bpj.2010.12.1922 fatcat:xgbnqsa6yrgwxkd4bxe4zvxsta

Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis

M. DIEUDÉ, M.-A. GILLIS, J.-F. THÉORÊT, E. THORIN, G. LAJOIE, J. S. LEVINE, Y. MERHI, J. RAUCH
2009 Journal of Thrombosis and Haemostasis  
We hypothesized that anti-HSP60 autoantibodies could potentiate thrombosis, and evaluated the effect of anti-murine HSP60 antibodies in a ferric chloride (FeCl 3 )-induced murine model of carotid artery  ...  Non-injured contralateral arteries of anti-HSP60 IgG-treated mice were also affected, exhibiting abnormal endothelial cell morphology and significantly greater von Willebrand factor (VWF) and P-selectin  ...  Acknowledgments The authors are grateful to J. Correa for performing the statistical analysis on the blood flow data, to D. Lauzier, M.-H. Clavet-Lanthier and J.-F.  ... 
doi:10.1111/j.1538-7836.2009.03305.x pmid:19192108 pmcid:PMC3429411 fatcat:jjar42utjnbvzdeuwxrndozebi

Simultaneous Real-Time Measurements of 10,000 Antibody-Antigen Reactions Using a Label-Free Scanning Ellipsometric Microscope

James P. Landry, Xiangdong Zhu
2011 Biophysical Journal  
Microarrays can contain tens of thousands of antigens or antibodies on a 1"x3" chemically functionalized glass slide, matching the required throughput.  ...  The formation of the nanocomplexes was confirmed by zeta-potential analysis. The morphologies of the complexes were examined by electron microscopy.  ...  Microarrays can contain tens of thousands of antigens or antibodies on a 1''x3'' chemically functionalized glass slide, matching the required throughput.  ... 
doi:10.1016/j.bpj.2010.12.1921 fatcat:hb4kz53jwbayvapcamf2qwmppu

Single-Cell Oxygen Consumption Measurements in Bacteria Using a Microobservation Chamber

Michael C. Konopka, David S. Ojala, Samuel Levine, Sarah C. McQuaide, Ekaterina Latypova, Marina G. Kalyuzhnaya, Mary E. Lidstrom
2011 Biophysical Journal  
Microarrays can contain tens of thousands of antigens or antibodies on a 1"x3" chemically functionalized glass slide, matching the required throughput.  ...  The formation of the nanocomplexes was confirmed by zeta-potential analysis. The morphologies of the complexes were examined by electron microscopy.  ...  Microarrays can contain tens of thousands of antigens or antibodies on a 1''x3'' chemically functionalized glass slide, matching the required throughput.  ... 
doi:10.1016/j.bpj.2010.12.1920 fatcat:o5gmehl57nd3potv6shr6cowze

Ellagic Acid Nanotubular and Poly-Cationic Conjugates as Nano-Carriers for Delivery into Mammalian Cells

Stacey N. Barnaby, Karl R. Fath, Areti Tsiola, Ipsita A. Banerjee
2011 Biophysical Journal  
Microarrays can contain tens of thousands of antigens or antibodies on a 1"x3" chemically functionalized glass slide, matching the required throughput.  ...  The formation of the nanocomplexes was confirmed by zeta-potential analysis. The morphologies of the complexes were examined by electron microscopy.  ...  Microarrays can contain tens of thousands of antigens or antibodies on a 1''x3'' chemically functionalized glass slide, matching the required throughput.  ... 
doi:10.1016/j.bpj.2010.12.1919 fatcat:5ru4334f6be7njkm4w2wapraaq

Adsorption-induced fibronectin aggregation and fibrillogenesis

Delphine Pellenc, Hugues Berry, Olivier Gallet
2006 Journal of Colloid and Interface Science  
In the context of bone biology, little is known about the influence of the mineral surface on fibronectin supramolecular assembly.  ...  The addition of a non-ionic surfactant during adsorption tends to promote aggregation with respect to fibrillation.  ...  Effect of a non-ionic surfactant on fibronectin morphological state occurrence on HA with respect to the ionic strength in the bulk Tween20 was added to each adsorption buffer (a) T50N0, (b) T50N20 or  ... 
doi:10.1016/j.jcis.2005.11.059 pmid:16375913 fatcat:abrqpojbyvakdfsuaoef477gtu

Page 263 of Journal of Molecular Recognition: JMR Vol. 7, Issue 4 [page]

1994 Journal of Molecular Recognition: JMR  
Since nucleation is a ‘one-shot’ event that requires only minute amounts of molecules to trigger a_ self- amplifying chain of events, the nucleation assay proved to be a sensitive method for the detection  ...  The prevailing direction of the morphological effect shows that adsorption of protein takes place preferentially on the more hydro- phobic faces, presumably due to interaction with aro- matic groups.  ... 

Self transglutaminase-based rapid coeliac disease antibody detection by a lateral flow method

T. RAIVIO, K. KAUKINEN, E. NEMES, K. LAURILA, P. COLLIN, J. B. KOVACS, M. MAKI, I. R. KORPONAY-SZABO
2006 Alimentary Pharmacology and Therapeutics  
The test recognized the disappearance of tissue transglutaminase antibodies on a gluten-free diet.  ...  When tested on site the results were concordant in 96.7% of cases compared with endomysium and tissue transglutaminase antibody results.  ...  Self tissue transglutaminase-based rapid coeliac antibody detection The self tTG-based coeliac antibody detection was based on our innovation utilizing endogenous tTG found in the red blood cells. 11  ... 
doi:10.1111/j.1365-2036.2006.02957.x pmid:16803613 fatcat:mvxc67fwijeyxcnivud43cmpfq

Effect of a feeder layer composed of mouse embryonic and human foreskin fibroblasts on the proliferation of human embryonic stem cells

HUA YANG, YING QIU, XIANGHUI ZENG, YAN DING, JIANYE ZENG, KEHUAN LU, DONGSHENG LI
2016 Experimental and Therapeutic Medicine  
The aim of the present study was to investigate the effects of feeder layers composed of various ratios of mouse embryonic fibroblasts (MEFs) and human foreskin fibroblasts (hFFs) on the growth of human  ...  The differences in the cellular morphology of the hESCs were observed using microscopy, and the expression levels alkaline phosphatase (AKP) and octamer-binding transcription factor 4 (OCT-4) were detected  ...  Acknowledgements The present study was supported by the Scientific and Technological Project of Guangxi Province (grant no. 0993003A-23) and the Major Science and Technology of Nanning (grant no. 200801024C  ... 
doi:10.3892/etm.2016.3204 pmid:27313670 pmcid:PMC4888025 fatcat:vydzi4leqvgfvnzwvn6pcq5g2u

Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells

Xiong Zhang, Calvin Simerly, Carrie Hartnett, Gerald Schatten, Thomas E. Smithgall
2014 Stem Cell Research  
Previous work has implicated the Src family of non-receptor protein-tyrosine kinases in mouse ES cell self-renewal and differentiation.  ...  Remarkably, human ES cells maintained in the presence of the potent Src-family kinase inhibitor A-419259 retained the morphology of domed, pluripotent colonies and continued to express the self-renewal  ...  Acknowledgments This work was supported in part by National Institutes of Health grants GM077629 to T.E.S. and HD047675 to G.S. Appendix A.  ... 
doi:10.1016/j.scr.2014.09.007 pmid:25305536 pmcid:PMC4252886 fatcat:ulutjonbhvfcnexzwk7daz2hii

Self-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses

Syed Rahin Ahmed, Éva Nagy, Suresh Neethirajan
2017 RSC Advances  
Nanoengineered chiral gold nanoparticles and quantum dots for ultrasensitive chiroptical sensing of viruses in blood samples.  ...  The authors thank Professor Rod Merrill of the Molecular and Cell Biology department of the University of Guelph for providing access to the circular dichroism equipment. Notes and references  ...  Acknowledgements The authors sincerely thank the Natural Sciences and Engineering Research Council of Canada (400705) for funding this study.  ... 
doi:10.1039/c7ra07175b fatcat:7fik2hg7gvhe3jyfeb3xtlr47e

Peroxisome Proliferator-activated Receptor γ-mediated Regulation of Neural Stem Cell Proliferation and Differentiation

Koichiro Wada, Atsushi Nakajima, Kazufumi Katayama, Chiho Kudo, Atsuhito Shibuya, Naoto Kubota, Yasuo Terauchi, Masashi Tachibana, Hiroyuki Miyoshi, Yoshinori Kamisaki, Tadanori Mayumi, Takashi Kadowaki (+1 others)
2006 Journal of Biological Chemistry  
Here, we show that PPAR␥ mediates the proliferation and differentiation of murine NSCs via upregulation of the epidermal growth factor receptor and activation of the ERK pathway.  ...  In contrast, activation of PPAR␥ by agonists inhibited the differentiation of NSCs into neurons. The inhibition of differentiation was associated with an activation of STAT3.  ...  Effect of PPAR␥ agonists, rosiglitazone (closed circle) or pioglitazone (open circle), on morphological changes (A) and cell growth rates (B) of NSCs cultured in non-coated bottles for 3 days.  ... 
doi:10.1074/jbc.m513786200 pmid:16524877 fatcat:2rtbov222zcudk375kp3z3yn5i

Common Mechanisms of Pathogenesis of Tissue-Specific Autoimmune Diseases: The Edited Model to Illustrate Those for IDDM and Multiple Sclerosis [chapter]

S. A., A. V., D. S., D. A., S. V.
2013 Genes and Autoimmunity - Intracellular Signaling and Microbiome Contribution  
Such a response, resulting from activation of self-specific lymphocytes, is an inevitable side effect of the work of the immune system.  ...  Prognostic use of antibodies is based on the fact that correlation can be made between types of main determinants and antibodies and prognosis/ clinical stage of the disease.  ... 
doi:10.5772/53597 fatcat:wi7voxruqrb63eshpb3iddat7q

3-Dimensional Laser Structured Scaffolds Improve Macrophage Adherence and Antigen-specific Response

I. Zerva, C. Simitzi, A. Ranella, E. Stratakis, C. Fotakis, I. Athanassakis
2013 Procedia Engineering  
Biomaterial surface properties are determined by the synergistic effect of the morphology and chemistry.  ...  The aim of the study was to investigate whether 3D micro and submicron laser textured transplantable Si scaffolds with tunable morphology and chemistry could support macrophage adherence, antigen presentation  ...  Acknowledgements These and the Reference headings are in bold but have no numbers. Text below continues as normal.  ... 
doi:10.1016/j.proeng.2013.05.113 fatcat:6qx4kvzar5av5bif76aweitxru

Field Effect Transistor Biosensor Using Antigen Binding Fragment for Detecting Tumor Marker in Human Serum

Shanshan Cheng, Kaori Hotani, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Masahiro Hashimoto, Yasuro Mori, Tetsuya Osaka
2014 Materials  
Here, we investigated the effect of probe molecule size on the detection of a tumor marker, α-fetoprotein (AFP) using a FET biosensor.  ...  Therefore, the use of a small Fab probe molecule instead of a whole antibody is shown to be effective for improving the sensitivity of AFP detection in FET biosensors.  ...  Innovation and Entrepreneurship Program), both from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.  ... 
doi:10.3390/ma7042490 pmid:28788579 pmcid:PMC5453370 fatcat:vybz3y4m4zd77htnxcp3ysbatu
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