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Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene

C. Wan, Y. La, H. Zhu, Y. Yang, L. Jiang, Y. Chen, G. Feng, H. Li, H. Sang, X. Hao, G. Zhang, L. He
2006 Amino Acids  
The positive APPs are schizophrenic related proteins, with the highly concordant results on four positive APPs.  ...  With the relatively high number of samples for 2-DE work, we found that four proteins in the family of positive APPs were all up-regulated in patients.  ...  Acknowledgements This work was supported by grants from the national 973 and 863 Programs of China, the National Natural Science Foundation of China, the Ministry of Education, PRC and the Shanghai Municipal  ... 
doi:10.1007/s00726-005-0292-8 pmid:16897611 fatcat:htc5qotayffw3g56cng3k6tdci

On the Formal Verification of Middleware Behavioral Properties

Jérôme Hugues, Thomas Vergnaud, Laurent Pautet, Yann Thierry-Mieg, Soheib Baarir, Fabrice Kordon
2005 Electronical Notes in Theoretical Computer Science  
Then we present the tools and techniques deployed to actually verify the behavioral properties of our model: Petri nets, temporal logic and advanced algorithms to reduce the size of the state space.  ...  In this paper, we present our work on middleware modeling and the verification of its behavioral properties; the study is applied to our middleware architecture: PolyORB.  ...  typical workstations.  ... 
doi:10.1016/j.entcs.2004.08.062 fatcat:dbuonb77mzek3lijar7oyozzge

Neuropsychological and cerebral morphometric aspects of negative symptoms in schizophrenia: negative symptomatology is associated with specific mnestic deficits in schizophrenic patients

Tobias Hornig, Gabi Valerius, Bernd Feige, Emanuel Bubl, Hans M Olbrich, Ludger Tebartz van Elst
2014 BMC Psychiatry  
After dividing the schizophrenic group in patients with high and low SANS scores almost all of these deficits were restricted to the former group.  ...  The prevalence of negative symptoms in schizophrenic patients seems to be an important indicator for treatment response and prognosis.  ...  This work was supported by a grant from the Ministry of Science, Research and the Arts of Baden-Württemberg AZ: 23-7532.22-11/1 to Dr. Tebartz van Elst.  ... 
doi:10.1186/s12888-014-0326-4 pmid:25420531 pmcid:PMC4247219 fatcat:3taza7llx5gevcc2jcusqamb2q

DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients - support for the glutamate hypothesis of schizophrenias

A. J. Fallgatter, A.-C. Ehlis, M. J. Herrmann, C. Hohoff, A. Reif, C. M. Freitag, J. Deckert
2010 Genes, Brain and Behavior  
In the present study, we investigated the influence of seven dysbindin gene variants on the NGA in a group of 44 schizophrenic patients.  ...  This is the first report on a role of DTNBP1 gene variation for prefrontal functioning at a basic neurophysiological level in schizophrenic patients.  ...  Preparation of the polymerase chain reaction (PCR) reaction mixtures was performed by Genesis Workstation RSP 150 (Tecan, Crailsheim, Germany).  ... 
doi:10.1111/j.1601-183x.2010.00574.x pmid:20180862 fatcat:rf5si4osizbirkjotwes66yeoy

Volumetric Measure of the Frontal and Temporal Lobe Regions in Schizophrenia

Michael Sanfilipo, Todd Lafargue, Henry Rusinek, Luigi Arena, Celia Loneragan, Andrew Lautin, Deborah Feiner, John Rotrosen, Adam Wolkin
2000 Archives of General Psychiatry  
This study was supported by the Department of Veterans Affairs, Washington, DC.  ...  We also thank Douglas Harris, Julius Perry, and John Asarian for their assistance with acquiring the magnetic resonance imaging scans.  ...  MR IMAGING SCAN ANALYSIS Magnetic resonance imaging scans were loaded on a personal computer system workstation (Sun, Mountain View, head circumference also was not different for these 2 groups, schizophrenic  ... 
doi:10.1001/archpsyc.57.5.471 pmid:10807487 fatcat:hi2h6lct55eqtaifenoo5yj7bi

Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study

Cynthia G Wible, Jane Anderson, Martha E Shenton, Ashley Kricun, Yoshio Hirayasu, Shin Tanaka, James J Levitt, Brian F O'Donnell, Ron Kikinis, Ferenc A Jolesz, Robert W McCarley
2001 Psychiatry Research : Neuroimaging  
These results underscore the importance of temporal᎐prefrontal pathways in the symptomatology of schizophrenia, and they suggest an association between prefrontal abnormalities and negative symptoms.  ...  Wible et al. r Psychiatry Research: Neuroimaging 108 2001 65᎐78 66 schizophrenic subjects with mostly positive symptoms.  ...  Acknowledgements This research was supported by the National Institute of Mental Health through a National Ž . Research Service Award MH 16259 JA , a K02  ... 
doi:10.1016/s0925-4927(01)00109-3 pmid:11738541 pmcid:PMC2845854 fatcat:mhhri2d2hzepbipqgo6qhgumri

Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter

Chandlee C Dickey, Robert W McCarley, Martina M Voglmaier, Margaret A Niznikiewicz, Larry J Seidman, Yoshio Hirayasu, Iris Fischer, Eng Kaet Teh, Richard Van Rhoads, Marianna Jakab, Ron Kikinis, Ferenc A Jolesz (+1 others)
1999 Biological Psychiatry  
In addition, differences between groups may suggest which are the brain structures of schizophrenics that contribute to the development of psychosis.  ...  Interpretation of research studies involving schizophrenics may be complicated by the effects of exposure to neuroleptics and chronic illness.  ...  Images were acquired on a 1.5 Tesla MRI system (GE Medical Systems, Milwaukee, WI), the same scanner used for the previous schizophrenia study, although there was an upgrade of the gradient coil and some  ... 
doi:10.1016/s0006-3223(99)00030-x pmid:10356620 pmcid:PMC2832794 fatcat:qe5elyaxsjbfdhnnvtbfyrqimq

Functional neuroimaging of word priming in males with chronic schizophrenia

S. Duke Han, Paul G. Nestor, Magdalena Hale-Spencer, Adam Cohen, Margaret Niznikiewicz, Robert W. McCarley, Cynthia G. Wible
2007 NeuroImage  
Word-priming studies have suggested that the associative disturbance of schizophrenia may reflect aberrant spread of activation through the lexicon of the brain.  ...  The patients did not display left frontal and temporal activation as a function of the degree of word connectivity as seen in healthy controls.  ...  A single schizophrenic subject and a single control subject from the present study were the focus of a recent Grand Rounds article .  ... 
doi:10.1016/j.neuroimage.2006.11.029 pmid:17215145 pmcid:PMC1852450 fatcat:q24jqegnorg57cydjywoqrvqcy

Sch-net: a deep learning architecture for automatic detection of schizophrenia

Jia Fu, Sen Yang, Fei He, Ling He, Yuanyuan Li, Jing Zhang, Xi Xiong
2021 BioMedical Engineering OnLine  
Methods This work designs a novel Sch-net neural network based on a convolutional neural network, which is the first work for end-to-end schizophrenic speech detection using deep learning techniques.  ...  The literature about schizophrenic speech detection was mainly based on feature engineering, in which effective feature extraction is difficult because of the variability of speech signals.  ...  The MFCCs and GTCCs are computed using a series of filters that are designed according to the frequency response characteristics of the human auditory system.  ... 
doi:10.1186/s12938-021-00915-2 pmid:34344372 pmcid:PMC8336375 fatcat:a2qxyvtel5hw3elgsu722xxmgq

Digital Technologies for Innovative Mental Health Rehabilitation

Rui Pedro Lopes, Bárbara Barroso, Leonel Deusdado, André Novo, Manuel Guimarães, João Paulo Teixeira, Paulo Leitão
2021 Electronics  
schizophrenic patients.  ...  A clinical trial is also planned for assessing the effectiveness of the system among negative symptoms in schizophrenia patients.  ...  Study Design The main purpose of the work described in this paper is the development of a rehabilitation system based on VR and serious games.  ... 
doi:10.3390/electronics10182260 fatcat:lsew6gmqyrf7rdriltw6aflzou

Multimodality image quantification using the Talairach grid

Manuel Desco, Javier Pascau, Santiago Reig, Juan D. Gispert, Andres Santos, Carlos Benito, Vicente Molina, Pedro Garcia-Barreno, Milan Sonka, Kenneth M. Hanson
2001 Medical Imaging 2001: Image Processing  
We present an application of the widely accepted anatomical reference of the Talairach atlas as a system for semiautomatic segmentation and analysis of MRI and PET images.  ...  schizophrenic patients and 24 healthy volunteers.  ...  ACKNOWLEDGMENTS This work was supported in part by the Spanish National research funding programs TIC99 #1085-C02 and FIS #00/0036; Comunidad de Madrid III-PRICYT and CM#08.1/0049/98; and by 'Fundación  ... 
doi:10.1117/12.431018 dblp:conf/miip/DescoPRGSBMG01 fatcat:od5pap6fvjbpfmrhyhq56lymqy

The Effect of Clozapine on Caudate Nucleus Volume in Schizophrenic Patients Previously Treated with Typical Antipsychotics

F Scheepers
2001 Neuropsychopharmacology  
Br J Psychiatry 135:360-362 Rapoport JL (1996): Childhood-onset schizophrenia: Brain MRI rescan after 2 years of clozapine maintenance treatment.  ...  Am J Psychiatry 153:564-566 Friston KJ, Liddle PF, Frith CD, Hirsch SR, Frackowiak RSJ (1992): The left medial temporal region and schizophrenia. Brain 115:367-382  ...  The MRI data were processed on a Unix 9000 series workstation.  ... 
doi:10.1016/s0893-133x(00)00172-x pmid:11106875 fatcat:oqrzkvpexffyzlgi7debacdwqq

A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia

James J. Levitt, Marek Kubicki, Paul G. Nestor, Hal Ersner-Hershfield, C-F Westin, Jorge L. Alvarado, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley, Martha E. Shenton
2010 Psychiatry Research : Neuroimaging  
Methods-16 chronic schizophrenics and 19 male, normal controls group matched for handedness, age, and parental SES, underwent DTI on a 1.5 Tesla GE system.  ...  The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal capsule (AL-IC).  ...  MR scans were performed with a quadrature head coil on a 1.5-T GE Echospeed system (General Electric Medical Systems, Milwaukee), which permits maximum gradient amplitudes of 40 mT/meter.  ... 
doi:10.1016/j.pscychresns.2010.08.004 pmid:21055906 pmcid:PMC4043632 fatcat:ljqavdjtozgr5ehb2bpjocdqxy

Magnetic Resonance Imaging of the Thalamic Mediodorsal Nucleus and Pulvinar in Schizophrenia and Schizotypal Personality Disorder

William Byne, Monte S. Buchsbaum, Eileen Kemether, Erin A. Hazlett, Akbar Shinwari, Vivian Mitropoulou, Larry J. Siever
2001 Archives of General Psychiatry  
The importance of neuronal interactions in development, the cortical dependence of many thalamic nuclei, and the phenomenon of transsynaptic degeneration suggest possible abnormalities in thalamic nuclei  ...  The MDN and pulvinar were rendered visible by means of a Sobel intensity-gradient filter.  ...  The MDN, via its projection from the dentate of the cerebellum, has been proposed as a potential substrate for schizophrenic thought disorder. 5 That proposal is based on analogy to the motor system  ... 
doi:10.1001/archpsyc.58.2.133 pmid:11177115 fatcat:qeobxay3kjdvzbqrvtkwssqqom

Smoking Severity and Functional MRI Results In Schizophrenia: A Case-Series

Zsuzsa Szombathyne Meszaros
2014 Journal of Addiction Research & Therapy  
There are very few studies published on non-smoking schizophrenic patients [1, 2] .  ...  Objective Although the majority of patients with schizophrenia smoke, assessment of smoking severity is usually ignored in fMRI studies [1].  ...  The sponsor was not involved in the study design, interpretation of data or writing of the report.  ... 
doi:10.4172/2155-6105.1000189 fatcat:7jp6etrqm5byhbsjo4s6xfj5lq
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