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Health—exploring complexity: an interdisciplinary systems approach HEC2016

Eva Grill, Martin Müller, Ulrich Mansmann
2016 European Journal of Epidemiology  
a BM ontology that drives the BM decision support to physicians and BM strategy adherence monitoring and messaging to patients.  ...  The key contribution of our approach is the modeling of BM knowledge and then operationalizing the BM model to generate personalized BM strategies for diabetes patients to self-manage their condition.  ...  In this context, a focused crawler uses techniques from the field of machine learning to estimate the relevance of a webpage for the domain of interest [5,6].  ... 
doi:10.1007/s10654-016-0183-1 pmid:27522353 fatcat:dcl3nbpygvh5fg7keri74h55ie

A Roadmap for Big Model [article]

Sha Yuan, Hanyu Zhao, Shuai Zhao, Jiahong Leng, Yangxiao Liang, Xiaozhi Wang, Jifan Yu, Xin Lv, Zhou Shao, Jiaao He, Yankai Lin, Xu Han (+88 others)
2022 arXiv   pre-print
With the rapid development of deep learning, training Big Models (BMs) for multiple downstream tasks becomes a popular paradigm.  ...  At present, there is a lack of research work that sorts out the overall progress of BMs and guides the follow-up research.  ...  To further consider the contextual information from both directions, bidirectional LM was proposed to model the input text with two LMs: a forward left-to-right LM and a backward right-to-left LM.  ... 
arXiv:2203.14101v4 fatcat:rdikzudoezak5b36cf6hhne5u4

Models and applications for measuring the impact of health research: update of a systematic review for the Health Technology Assessment programme

James Raftery, Steve Hanney, Trish Greenhalgh, Matthew Glover, Amanda Blatch-Jones
2016 Health Technology Assessment  
BackgroundThis report reviews approaches and tools for measuring the impact of research programmes, building on, and extending, a 2007 review.Objectives(1) To identify the range of theoretical models and  ...  empirical approaches for measuring the impact of health research programmes; (2) to develop a taxonomy of models and approaches; (3) to summarise the evidence on the application and use of these models  ...  In terms of the accuracy of the data from surveys of researchers, several studies report that, in general, the findings from users were similar to those from researchers, for example Guinea et al. 64  ... 
doi:10.3310/hta20760 pmid:27767013 fatcat:4xucv6wrkfg4bn2sxz5obiv4le

The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei [article]

Anish Das, Tong Liu, Hong Li, Seema Husain
2021 bioRxiv   pre-print
In this report, we present a systematic analysis of an essential RNA-binding protein, RBP42, in the mammalian-infective slender bloodstream form of African trypanosome, and we show that RBP42 is a key  ...  of RBP42 as a positive regulator of target mRNA translation.  ...  The reporter ion-based quantification workflow was chosen for data analysis; the CID spectra in MS2 was used for peptide identification and the HCD spectra in MS3 was used for iTRAQ quantitation.  ... 
doi:10.1101/2021.04.14.439849 fatcat:gbjh22zfmvacriqnfulyrt46ay

Full Issue PDF

2020 JACC: Basic to Translational Science  
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors'  ...  Nevertheless, Fioretta et al. (2) raised an important warning with respect to issues that need to be addressed throughout the whole lifecycle of poly- SUMMARY This study sought to investigate whether  ...  The results were compared with nonseeded TEHVs from a previous report (5) , which served as the control group for the current study.  ... 
doi:10.1016/s2452-302x(19)30443-7 fatcat:l2pyhklx4bg2vcubacesfrqrti

Abstract Book: ISEV2017

2017 Journal of Extracellular Vesicles  
Immunocytochemistry analysis revealed that tunicamycin changed AZU1 cellular localisation from golgi apparatus to throughout the cell.  ...  The content of EVs shed by cancer cells differ from normal cells, but the correlation with tumour characteristics and clinical data remains unknown.  ...  We found that PQS export phenotypes are independent of growth phase and stable throughout the lifecycle of the bacterial culture.  ... 
doi:10.1080/20013078.2017.1310414 pmid:29046763 pmcid:PMC5637785 fatcat:ejbhnmhfqbeuronzsj47flas6u

Biology of Trypanosoma Cruzi

Z Brener
1973 Annual Review of Microbiology  
He is a member of several scientific societies as well as academies of science and medicine. He is also a member of the editorial board of several international journals in the area of parasitology.  ...  Contents Preface XIII Section 1 Basic Biology Chapter 1 Introductory Chapter: Biology of Trypanosoma cruzi by Wanderley de Souza Chapter 2 Life Cycle of Trypanosoma cruzi in the Invertebrate and the Vertebrate  ...  Multidisciplinary studies are needed to identify novel key molecules in T. cruzi in order to increase trypanocidal activity and reduce mammalian toxicity, ensuring the development of novel drugs for Chagas  ... 
doi:10.1146/annurev.mi.27.100173.002023 pmid:4201691 fatcat:25mrmypq35huhasi7ckjdolxdi

ELIXIR Scientific Programme 2019-2023 [article]

from biomedical research to healthcare will bring new challenges.  ...  biomedical research data.  ...  With special thanks to all of those who contributed to the development of the ELIXIR 2019-23 Scientific Programme, most notably Heads of Nodes, Platform and Community Leaders, Technical and Training Coordinators  ... 
doi:10.7490/f1000research.1117352.1 fatcat:aaocjeqix5dfbgwxvkfazdjcsi

Enabling the Reuse of Electronic Health Record Data through Data Quality Assessment and Transparency

Nicole Gray Weiskopf
On the basis of these results, we developed and evaluated a dynamic guideline for data quality measures in order to help researchers choose data quality measures and methods appropriately within the context  ...  This dissertation documents the development of a data quality assessment framework and guideline for clinical researchers engaged in the secondary use of electronic health record data for retrospective  ...  The third expert comes from a strong background in ontological science, and therefore felt that the guideline needed to be more ontologically coherent.  ... 
doi:10.7916/d8rf5ss2 fatcat:jda4d25cvfdwppi7hqe6oaitly

Using 1H-NMR based metabolomics to investigate the pathological consequences of mitochondrial disease and human rabies infection

Stacey N Reinke
Metabolomics is the systematic study of metabolites and is a powerful approach to understanding disease.  ...  These model systems provide the opportunity to study mitochondrial disease in a well-defined genetic background under controlled environmental conditions.  ...  Data Analysis Metabolomic studies generate a substantial amount of data; as with any study, The projection approach There are several methods for modelling metabolomic data; however, the projection  ... 
doi:10.7939/r36361 fatcat:xblxt27nsbasthmxpnmkoo5ooa

MITE (mariner insect transposon-like element, miniature inverted-repeat transposable element) [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
In the procedural system of modeling, the focus is on the steps from the data to the conclusion.  ...  In the next step, the validity of the M model is tested by the maximum likelihood estimation regarding its fit to the data available.  ...  In a mouse model, isolated neural precursor cells from the mouse brain was injected into the blood or the spinal fluid.  ... 
doi:10.1007/978-1-4020-6754-9_10520 fatcat:tj67vdv34vc63hlfupk6xahu24

Mitochondrial Import [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
In the procedural system of modeling, the focus is on the steps from the data to the conclusion.  ...  In the next step, the validity of the M model is tested by the maximum likelihood estimation regarding its fit to the data available.  ...  In a mouse model, isolated neural precursor cells from the mouse brain was injected into the blood or the spinal fluid.  ... 
doi:10.1007/978-1-4020-6754-9_10535 fatcat:kablmiledvdx3lxxk4j3tsicca

Discovery and characterization of a novel class of metabolic regulators in the malaria parasite Plasmodium falciparum

Ann Marie Guggisberg
J.P. performed protein expression, crystallization, data collection, and structure solution, enzyme assays, and wrote the manuscript. I generated the catalytically active PfHAD1 mutant,  ...  PREFACE The following work was performed by Jooyoung Park, myself, Audrey R. Odom, and Niraj H. Tolia.  ...  HAD2 is expressed throughout the parasite intraerythrocytic lifecycle To determine if HAD2 was functional during a specific stage of the parasite lifecycle, we evaluated HAD2 expression throughout intraerythrocytic  ... 
doi:10.7936/k7h41pv4 fatcat:7hypvafszfhpbcavstgxfpxlpi

Parasite factors, prognostic markers and epidemiological aspects in babesia canis babesiosis

Ramon Marc Eichenberger
We gratefully acknowledge the assistance of the local veterinary practitioners for the reports on Babesia cases and to encourage their clients to participate in the study.  ...  The authors disclose no conflict of interests. Acknowledgements We thank the animal keepers, A. Rüdemann and B. Brändle, for their support throughout the study.  ...  Ticks submitted from dogs and cats throughout the two study years.  ... 
doi:10.5167/uzh-151591 fatcat:34uh3c4wvba33nd744pbvgtx54