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Design and Implementation of a Middleware for Data Storage in Opportunistic Grids

Raphael Y. De Camargo, Fabio Kon
2007 Seventh IEEE International Symposium on Cluster Computing and the Grid (CCGrid '07)  
In this paper, we present the design and implementation of OppStore, a middleware that provides reliable distributed data storage using the free disk space from shared grid machines.  ...  The system utilizes a two-level peer-to-peer organization to connect grid machines in a scalable and faulttolerant way.  ...  with a replication factor of 2.  ... 
doi:10.1109/ccgrid.2007.37 dblp:conf/ccgrid/CamargoK07 fatcat:zxa5iiohdnccji6mmvjtfx4kpq

Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case–control study protocol for dimethyl fumarate-induced lymphopenia

Kaarina Kowalec, Elaine Kingwell, Robert Carruthers, Ruth Ann Marrie, Sasha Bernatsky, Anthony Traboulsee, Colin J D Ross, Bruce Carleton, Helen Tremlett
2017 BMJ Open  
data management The principal investigator (HT) and the study team will manage all the patient data for this study.  ...  Following the discovery of any genomic variants that reach the pre-determined statistical threshold of association with the ADR, a replication cohort will be identified and recruited.  ... 
doi:10.1136/bmjopen-2017-016276 pmid:28576902 pmcid:PMC5623385 fatcat:3vycb22opfehvhlioeuw2qz3ca

miR-625 reverses multidrug resistance in gastric cancer cells by directly targeting ALDH1A1

Xufei Gong, Baoli Xu, Li Zi, Xinrui Chen
2019 Cancer Management and Research  
The protein expression was determined by Western blot analysis, and the luciferase reporter assay was applied to confirm miR-625 regulation of the potential target.  ...  Moreover, miR-625 directly targets the aldehyde dehydrogenase 1A1 (ALDH1A1), and importantly, the restoration of ALDH1A1 expression rescues miR-625 effects on MDR in gastric cancer cells.  ...  Each column represents the mean value from 3 replicates.  ... 
doi:10.2147/cmar.s208708 pmid:31410057 pmcid:PMC6643062 fatcat:aosg5qwfgrgrhesgl72jtdlcd4

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King, Amanda McKenna, Niloufar Farzan, Susanne J. Vijverberg, Marc P. van der Schee, Anke H. Maitland-van der Zee, Lambang Arianto, Hans Bisgaard, Klaus BØnnelykke, Vojko Berce, Uroš Potočnik, Katja Repnik (+24 others)
2020 The Pharmacogenomics Journal  
Two of these polymorphisms were replicated within the paper, but none had external replication.  ...  Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria.  ...  The management of asthma is guided by national and international evidence based guidelines [4, 5] , but there is inter-individual variability in treatment response.  ... 
doi:10.1038/s41397-019-0140-y pmid:31949291 fatcat:dy3iklwtszh4howwjeszcawigi

Page 745 of Pharmacotherapy Vol. 26, Issue 6 [page]

2006 Pharmacotherapy  
Since this is the first large-scale study evaluating the impact of clinical pharmacy services on ADRs, these findings need to be replicated in future studies.  ...  which resulted in average settlements and judgments of $3.1 million/patient.* In hospitals with pharmacist- provided ADR management, the ADR rate was reduced by 34.90% (an average reduction of 22 ADRs/  ... 

Querying very large multi-dimensional datasets in ADR

Tahsin Kurc, Chialin Chang, Renato Ferreira, Alan Sussman, Joel Saltz
1999 Proceedings of the 1999 ACM/IEEE conference on Supercomputing (CDROM) - Supercomputing '99  
We have developed an infrastructure, called the Active Data Repository (ADR), that integrates storage, retrieval and processing of multi-dimensional datasets on distributed-memory parallel architectures  ...  In this paper we address efficient execution of range queries on distributed memory parallel machines within ADR framework.  ...  Dataset service manages the datasets stored on the ADR back-end and provides utility functions for loading datasets into the ADR back-end.  ... 
doi:10.1145/331532.331544 dblp:conf/sc/KurcCFSS99 fatcat:em7nbr3pcjbrbjnotaslsiq3bi

An adaptive data replication algorithm

Ouri Wolfson, Sushil Jajodia, Yixiu Huang
1997 ACM Transactions on Database Systems  
We show that the algorithm can be combined with the concurrency control and recovery mechanisms of a distributed database management system.  ...  The algorithm is adaptive in the sense that it changes the replication scheme of the object (i.e., the set of processors at which the object is replicated) as changes occur in the read-write pattern of  ...  replica-management protocols.  ... 
doi:10.1145/249978.249982 fatcat:rsqr6hxgb5bindqpef2hl5ptvy

Genome-Wide Association Study of Lithium-Induced Dry Mouth in Bipolar I Disorder

Lawrence Shih-Hsin Wu, Ming-Chyi Huang, Chih-Ken Chen, Chen-Yang Shen, Cathy Shen-Jang Fann, Chun-Yuan Lin, Chih-Chien Lin, Andrew Tai-Ann Cheng
2021 Journal of Personalized Medicine  
Dry mouth appeared to be the most prevalent (47.3%) ADR induced by lithium treatment.  ...  From the study patients, 921 were included in a genome-wide association study (GWAS), and replication was conducted in the remaining 321 patients.  ...  Conflicts of Interest: The authors declare no competing interest.  ... 
doi:10.3390/jpm11121265 pmid:34945737 pmcid:PMC8706003 fatcat:a5io4swhcnh6bhype3r6cer44e

Reliable management of checkpointing and application data in opportunistic grids

Raphael Y. de Camargo, Fernando Castor, Fabio Kon
2010 Journal of the Brazilian Computer Society  
Our evaluation shows that the proposed middleware promotes important improvements in grid data management reliability while imposing a low performance overhead.  ...  Besides computational power, these applications may also consume and generate large amounts of data, requiring an efficient data storage and management infrastructure.  ...  replication.  ... 
doi:10.1007/s13173-010-0016-0 fatcat:z3ygxivblfcp3aelx7pkkfd2je

IDENTIFICATION, ASSESSMENT AND REPORTING OF SUSPECTED ADVERSE DRUG REACTIONS (ADRS) TO ANTI-RETROVIRAL THERAPY (ART) AND ANTI-TUBERCULAR THERAPY (ATT) IN A COMMUNITY CARE CENTRE AT WARANGAL

K.S.ARUN KUMAR, KRANTHI YARLAGADDA, WASIM FEROZ
2019 World Journal of Current Medical and Pharmaceutical Research  
The findings of our study showed that a huge number of ADRs were experienced by the patients who are receiving ART and ATT which is a major cause for medication Noncompliance and discontinuation of the  ...  The ART regimen Stavudine+Lamivudine+Efavirenz (STV+LMV+EFV) was found to be most commonly involved in about 138 ADRs,whereas the regimen Zidovudine+Lamivudine+Nevirapine (ZDV+LMV+NVP) was found to be  ...  ACKNOWLEDGEMENTS The investigators thank the doctors and staff of the study site for permitting us to carry out our study and the cooperation extended by them throughout the study period.  ... 
doi:10.37022/wjcmpr.2019.01064 fatcat:mfloa6jbjndnnhtqu6wfzjbydi

Causality assessment of adverse drug reaction in Pulmonology Department of a Tertiary Care Hospital

Amer Khan, MirS Adil, K Nematullah, S Ihtisham, K Aamer, Syed Aamir
2015 Journal of Basic and Clinical Pharmacy  
Specific treatment for the management of suspected reaction was administered in 32.65% of ADR reports.  ...  Adverse drug reaction (ADR) is considered to be the sixth leading cause of death. The incidence rate estimates approximately 2% of hospital admissions are due to ADRs.  ...  S.A AzeezBasha, Principal, Deccan School of Pharmacy for necessary facilities, helping and motivating us during the project work. We also thank Dr.  ... 
doi:10.4103/0976-0105.160744 pmid:26229344 pmcid:PMC4513336 fatcat:4u357nbhnjf2bjnxxbc2hgli2u

Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions

Hang Tong, Nga V T Phan, Thanh T Nguyen, Dinh V Nguyen, Nam S Vo, Ly Le
2021 Pharmacogenomics and Personalized Medicine  
With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the  ...  Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome  ...  Disclosure The authors declare that they have no conflicts of interest.  ... 
doi:10.2147/pgpm.s290781 pmid:33469342 pmcid:PMC7812041 fatcat:rjhypew76zdg3ajp5j6n7772fq

Growth suppression of sandspur grass by cover crops1

Rodrigo Fonseca da Silva, Leandro Pereira Pacheco, Leandro dos Santos Soares, Wéverson Lima Fonseca, João Batista da Silva Oliveira, Adaniel Sousa dos Santos
2015 Pesquisa Agropecuária Tropical  
ABSTRACTSandspur grass has hindered the integrated weed management in the Brazilian crop systems.  ...  The first factor consisted of six cover crops (Pennisetum glaucum-ADR 7010 and ADR 300 cultivars, Crotalaria ochroleuca, Urochloa ruziziensis, Fagopyrum tataricum and Crambe abyssinica) and the second  ...  ACKNOWLEDGMENTS Authors are grateful to the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), for the scholarship granted to R.  ... 
doi:10.1590/1983-40632015v4534680 fatcat:7i3vsyzr55huxjzzokews3keda

Prevalence and Extent of Adverse Drug Reactions in Sudanese Patients in Highly Active Anti-retroviral Therapy Regimens

Bushra Mohamed Ibrahim Elnagar
2017 International Journal of Pharmacovigilance  
The WHO defines Pharmacovigilance as the science and activities relating to the detection, assessment, understanding and prevention of ADRs or any other possible drug related problems (4, 5).  ...  The aims of Pharmacovigilance according to WHO are: • Improve patient care and safety in relation to the use of medicines, • Improve public health and safety in relation to the use of medicines, • Contribute  ...  Acknowledgment The author would like to acknowledge all the colleagues at Sudan Pharmacovigilance Program -National Medicine and Poisons Board, the University of Medical Sciences and Technology and all  ... 
doi:10.15226/2476-2431/2/2/00118 fatcat:3hmohn6f75dddgfkrxogeynxsm

Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors

Seyed H. Mahmoudpour, Abirami Veluchamy, Moneeza K. Siddiqui, Folkert W. Asselbergs, Patrick C. Souverein, Catherine E. de Keyser, Albert Hofman, Chim C. Lang, Alexander S.F. Doney, Bruno H. Stricker, Anthonius de Boer, Anke H. Maitland-van der Zee (+1 others)
2017 Pharmacogenetics & Genomics  
However the direct relevance of our findings with ACE-inhibitor induced ADRs is not clear yet and needs to be further investigated, these findings, if replicated in other populations, can improve our understanding  ...  We acknowledge the support of the Health Informatics Centre, University of Dundee for managing and supplying the anonymised data and NHS Tayside, the original data owner.  ... 
doi:10.1097/fpc.0000000000000264 pmid:28030426 pmcid:PMC5289595 fatcat:v4f3ziukoveitgh56tl32eo4yi
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