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Tests for finding complex patterns of differential expression in cancers: towards individualized medicine

James Lyons-Weiler, Satish Patel, Michael J Becich, Tony E Godfrey
2004 BMC Bioinformatics  
provide a more complete portrait of differential expression in cancer.  ...  These tests and the gene expression pattern grid may be useful for the identification of therapeutic targets and diagnostic or prognostic markers that are present only in subsets of cancer patients, and  ...  Eleanor Feingold is thanked for her critical read of the manuscript and of the implementation of the PPST and ABA tests.  ... 
doi:10.1186/1471-2105-5-110 pmid:15307894 pmcid:PMC514539 fatcat:nzjn622xq5a7lm63fqhkhjzvtq

Central nervous system drug development: An integrative biomarker approach toward individualized medicine

B. Gomez-Mancilla, E. Marrer, J. Kehren, A. Kinnunen, G. Imbert, R. Hillebrand, M. Bergström, M. E. Schmidt
2005 NeuroRx  
The present review represent an effort to illustrate the integration of such technologies in drug development supporting the path of individualized medicine.  ...  Extensive clinical testing remains the core of registration of new compounds; however, traditional clinical trial methods are falling short in overcoming these development hurdles.  ...  radioligand for in vivo imaging before clinical testing of antagonists for this drug target. 59 Such an infusion of resources by a large pharmaceutical company, including compound libraries, medicinal  ... 
doi:10.1602/neurorx.2.4.683 pmid:16489375 pmcid:PMC1201325 fatcat:el6rrd4zabdwrgcrevkx72aovq

Racial and ethnic differences in response to medicines: towards individualized pharmaceutical treatment

Valentine J Burroughs, Randall W Maxey, Richard A Levy
2002 Journal of the National Medical Association  
These programs should be broad and flexible enough to enable rational choices and individualized treatment for all patients, regardless of race or ethnic origin.  ...  It is now well documented that substantial disparities exist in the quality and quantity of medical care received by minority Americans, especially those of African, Asian and Hispanic heritage.  ...  Toward Individualized Therapy Race or ethnicity is a risk factor that changes the probability that an individual will respond in the expected way to a given drug therapy.  ... 
pmid:12401060 pmcid:PMC2594139 fatcat:qeowxffvjvapvl6ztz424yemhm

Colorectal cancer

1993 Gut  
The analysis of proliferation state patterns in colorectal mucosa has been found to be a useful risk marker for colorectal cancer (CRC).  ...  Loss of expression of a2251 in moderate and poorly differentiated carcinomas in vivo and the observation that it is the key integrin that modulates differentiation in vitro are strong evidence for the  ...  The analysis of proliferation state patterns in colorectal mucosa has been found to be a useful risk marker for colorectal cancer (CRC).  ... 
doi:10.1136/gut.34.3_suppl.s14 fatcat:3lna44fdebaajobkgmbfowri4m

PPPM in Cancer

2011 The EPMA Journal  
Small comparative trials based on such biomarkers rather than large phase III trials may be preferable for testing efficacy of new drugs.  ...  Currently, whole tissue-proteome variations (protein expression; hormone isoforms; modifications) are studied in NF pituitary adenomas.  ...  This finding calls for further predictors of individual therapeutic responses in treated glioblastomas.  ... 
doi:10.1007/s13167-011-0119-5 fatcat:27xqatxq3nbr5pw4lmaebtihwu

Editorial: Using Cancer 'Omics' to Understand Cancer

Barbara K. Dunn, Daoud Meerzaman
2020 Frontiers in Oncology  
ACKNOWLEDGMENTS We thank Barbara Vann with assistance in preparation of this manuscript.  ...  across cancer genomic studies in support of precision medicine.  ...  They examined the gene expression patterns of transcription factors associated with GBM and identified four potential candidates based on their differential expression between tumor and adjacent tissue  ... 
doi:10.3389/fonc.2020.01201 pmid:32850349 pmcid:PMC7396572 fatcat:gv7gl32jtfatphgkyj3rar255e

Lung Cancer Genomic Signatures

M. Teresa Agulló-Ortuño, Fernando López-Ríos, Luis Paz-Ares
2010 Journal of Thoracic Oncology  
Lung cancer (LC) is the dominant cause of death by cancer in the world, being responsible for more than a million deaths annually.  ...  the enormous biologic complexity of this disease.  ...  To move toward a goal of individualized medicine with rationally targeted therapies, it is imperative to do more molecular profiling of treatmentsensitive and treatment-resistant tumors, to better understand  ... 
doi:10.1097/jto.0b013e3181f1900e pmid:20736853 fatcat:jb4zciwwhrdxfjvcsndtgbyeva

DNA Microarrays in Clinical Cancer Research

Raymond Wadlow, Sridhar Ramaswamy
2005 Current molecular medicine  
Complex information from tumor "expression profiling" studies can, in turn, be used to create novel molecular cancer diagnostics.  ...  In particular, DNA microarrays are powerful tools for obtaining global views of human tumor gene expression.  ...  Although clinical diagnostic tests have traditionally taken a backseat to therapeutic agents in cancer medicine, change is at hand.  ... 
doi:10.2174/1566524053152834 pmid:15720274 fatcat:fw7yaidow5d2jnv2ceyqlzwulu

Personalized Medicine in Cancer

Md Mizanur Rahman
2015 Journal of Bangladesh College of Physicians and Surgeons  
In particular, tests that predict the clinical outcome for patients on the basis of the genes expressed by their tumours are likely to increasingly affect patient management, heralding a new era of personalized  ...  In this review a brief discussion on definition and molecular aspects of personalized medicine and its practical application for the management of common solid cancers are highlighted.  ...  Table - I - List of Commercially Available Tests( few) Used for Personalized Medicine in CancerCRC-Colorectal cancer, NSCLC-Nonsmall cell lung cancer, CML-chronic myeloid leukaemia Test Cancer Type Test  ... 
doi:10.3329/jbcps.v32i3.26054 fatcat:yxx4gu4ib5cwziofczfc62dq7i

Clinical Cancer Genome and Precision Medicine

Dimitrios H. Roukos, Chee-Seng Ku
2012 Annals of Surgical Oncology  
In the pragmatic clinical world and in contrast to innovative research, is NGS-based clinical evidence sufficient for decision-making on tailoring the best available treatment to the individual cancer  ...  Revealing the whole landscape of causal somatic and inherited mutations underlying individual patient's cancer sample by whole-genome sequencing (WGS) and wholeexome sequencing (WES) can lead to not only  ...  In cancer, a deregulation of this differential circuit in concert with structural genome alterations lead to a dysfunction of the expression patterns a b FIG. 1 Current and emerging clinical cancer genome  ... 
doi:10.1245/s10434-012-2542-9 pmid:22851046 fatcat:ga52nnxswvduzcvd4vned62kmq

Cytosine methylation profiling of cancer cell lines

M. Ehrich, J. Turner, P. Gibbs, L. Lipton, M. Giovanneti, C. Cantor, D. van den Boom
2008 Proceedings of the National Academy of Sciences of the United States of America  
DNA-methylation changes in human cancer are complex and vary between the different types of cancer.  ...  Capturing this epigenetic variability in an atlas of DNA-methylation changes will be beneficial for basic research as well as translational medicine.  ...  Also, in concordance with expression data from another study, our findings for SN12C (renal CA), PC3 (prostate CA), and DU-145 (prostate CA) did not show tissue-specific patterns (5) .  ... 
doi:10.1073/pnas.0712251105 pmid:18353987 pmcid:PMC2290817 fatcat:poajle6uungmtfqdg3fyguvhx4

Precision medicine and future of cancer treatment

Chandrajit Lahiri, Shrikant Pawar, Rohit Mishra
2019 Precision Cancer Medicine  
Acknowledgments The authors acknowledge the support of Sunway University, Selangor, Malaysia for providing the computational facilities.  ...  strategy towards cancer precision medicines.  ...  Increased mutations and/or changes in the expression of these type of genes may also contribute to cancer multidrug resistance, thereby posing plausible hindrances towards the development of precision  ... 
doi:10.21037/pcm.2019.09.01 fatcat:6cstgyhbj5g5rkekdeusifaomq

The UnderstAnding of Enigmas Related to Cancer: Cancer Origin and Progression- A Review

MT Hasan
2021 Journal of Bio-Science  
Although having same responsible genes for metamorphosis of different organisms, the expression pattern of those genes varies in every species.  ...  Cancer can be called a disease of geometry which is also metastasize in human body maintain a developmental pathway.  ...  This model may work in: • Finding easiest path towards gaining rational control over biological shapes of cells, tissues, organs and perhaps for entire organisms. • Better understanding of histological  ... 
doi:10.3329/jbs.v29i0.54831 fatcat:n4qp45mebbdyfnaanw5j6h3nim

Functional genomics in translational cancer research: focus on breast cancer

I. G. Yulug, B. Gur-Dedeoglu
2008 Briefings in Functional Genomics & Proteomics  
Meta-analysis is an important tool for the identification and validation of differentially expressed genes to increase power in clinical and biological studies across different sets of data.  ...  in tumour development but also to compare the individual datasets to other cancer datasets to identify new sets of genes.  ...  Acknowledgements We would like to thank Bilkent University and the Scientific and Technical Research Council of Turkey for supporting work in our laboratory.  ... 
doi:10.1093/bfgp/eln009 pmid:18326545 fatcat:34spxeb5ivgz5lasnzlb5q2in4

Serum Protein Profiles to Identify Head and Neck Cancer

J. T. Wadsworth
2004 Clinical Cancer Research  
The purpose of this study was to determine whether a new proteomic technology could correctly identify protein expression profiles for cancer in patient serum samples.  ...  Experimental Design: Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry Protein-Chip system was used to screen for differentially expressed proteins in serum from 99 patients  ...  It seems probable that given the complexity of the genetic and molecular alterations that occur in HNSCC cells, the expression pattern of these complex changes may hold more vital information in screening  ... 
doi:10.1158/1078-0432.ccr-0297-3 pmid:15014013 fatcat:wwxoy4eq3fc4hmolstz6ycf4pq
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