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Management of iron deficiency anemia in hemodialysis patients based on mean corpuscular volume

Kumiko Onda, Teruo Koyama, Sanae Kobayashi, Yoji Ishii, Kazuo Ohashi
2021 Renal Replacement Therapy  
Background To manage the anemic status in hemodialysis (HD) patients, a well-balanced combination therapy based on the use of erythropoiesis-stimulating agents (ESAs) and iron supplementation is essential. Serum ferritin level and transferrin saturation rate (TSAT) are the current standard tests for screening iron deficiency status. However, these are not included in frequently checked regular blood measurements in many HD centers. Other parameters that could predict a hemoglobin (Hb) increase
more » ... esponse from iron supplementation have yet to be established. To determine a frequently checked and regularly measured biomarker for predicting iron deficiency status, this study investigated the value of mean corpuscular volume (MCV) as a clinical parameter for HD patients receiving intravenous iron supplementation (Fe-IV) therapy. Methods and results One hundred thirty four HD patients, 88 non-HD patients with anemia, and 50 HD patients on Fe-IV therapy from the Nozatomon clinic were assessed. Comparison of MCV values of anemic HD patients and anemic non-chronic kidney disease (CKD) patients showed that anemic HD patients had significantly higher MCV values (93.9 ± 7.3 fL) compared with anemic non-CKD patients (82.8 ± 8.8fL). Fifty HD patients, who received Fe-IV therapy at ten consecutive HD sessions (inclusion criteria: Hb ≤ 12.0 g/dL, TSAT < 20%, and serum ferritin < 100 ng/mL) showed a rapid increase during the Fe-IV period in MCV, Hb, and TSAT levels. After the completion of the Fe-IV therapy, MCV persisted at the increased levels, whereas Hb levels further increased and peaked at 1 month with a gradual decline after, largely influenced by ESA dosage reductions. The 50 patients were divided into three groups according to the MCV levels obtained immediately prior to the Fe-IV therapy (MCV ≤ 85 fL, 85 fL < MCV ≤ 90 fL, MCV > 90 fL), and Hb changes at 50 days after the initiation of the Fe-IV therapy were compared. All the patients in the MCV ≤ 85 fL group and most of the patients in the 85 fL < MCV ≤ 90 fL group showed linear and consistent Hb increase during the 50-day period. In marked contrast, patients in the MCV > 90 fL group showed dispersed trends in their Hb increase. The present study also revealed that successful ESA dosage reduction could be achieved after the Fe-IV therapy in both the MCV ≤ 85 fL and 85 fL < MCV ≤ 90 fL groups. Conclusions The present study underscored the value of MCV in perceiving iron deficiency status as well as predicting iron-based therapeutic response in HD patients.
doi:10.1186/s41100-021-00327-x fatcat:lk6m5224fvhk3bzcizacs4zzsu

Extracting Elementary Terms from Dictionaries

1995 Proceedings of Annual Conference Japan Society of Information and Knowledge  
Because many of Japa 皿 ese terms in variety fields ca 皿 be regarded as co 皿 posite ter 皿 s , decomPosing ter 皿 s into elementary ter 皿 s see 皿 s to be helpful to understand about ter 皿 8 . 1》 eco 皿 Posing terms , iセ is neccessary to decide a basic set of elemelltary terms . In this
doi:10.2964/jsikproc.3.0_25 fatcat:qo53scwu4fdqtcoy3d25tpi3qa

Dispersion Hardening of Cu–Al–Ti Alloys by Internal Oxidation

Teruo Takahashi, Yasuhiko Hashimoto, Shinichiro Omori, Koichiro Koyama
1985 Transactions of the Japan Institute of Metals  
*calculated mass ratio Fig.9 Effect of internally oxidizing temperature on the Teruo Takahashi, Yasuhiko Hashimoto, Shinichiro Omori and Koichiro Koyama especially for the improvement  ... 
doi:10.2320/matertrans1960.26.271 fatcat:5veqat7wwvgpraankj6v5fmqse


1996 Biomedical research  
To evaluate the diacylglycerol (DG) concentration that may induce the membrane fusion, we examined the formation of the inverted hexagonal (H11) structure in the multilamellar vesicles comprised of bovine brain phosphatidylcholine (BBPC), bovine brain phosphatidylethanolamine (BBPE) and cholesterol (1 : 1: 1 molar ratio) in the absence or presence of a small amount of dioleoylglycerol (DOG). These lipid layers are considered as the model system for the secreting cell membranes. The formation of
more » ... the HM structure was detected using "P-NMR and fluorescence techniques. The fluorescent probe used was N-(dimethylaminonaphthalene-5-
doi:10.2220/biomedres.17.287 fatcat:5hd4wy75f5ctxovjyr4advylva

Stractural Analysis of Japanese Medical Terms

Teruo KOYAMA, Kazuhiko OHE
1994 Proceedings of Annual Conference Japan Society of Information and Knowledge  
doi:10.2964/jsikproc.2.0_17 fatcat:mttrgk3zjbg2nbra5mgfjam7oq

Deverbal compound noun analysis based on lexical conceptual structure

Koichi Takeuchi, Kyo Kageura, Teruo Koyama
2003 Proceedings of the 41st Annual Meeting on Association for Computational Linguistics - ACL '03  
This paper proposes a principled approach for analysis of semantic relations between constituents in compound nouns based on lexical semantic structure. One of the difficulties of compound noun analysis is that the mechanisms governing the decision system of semantic relations and the representation method of semantic relations associated with lexical and contextual meaning are not obvious. The aim of our research is to clarify how lexical semantics contribute to the relations in compound nouns
more » ... since such nouns are very productive and are supposed to be governed by systematic mechanisms. The results of applying our approach to the analysis of noun-deverbal compounds in Japanese and English show that lexical conceptual structure contributes to the restrictional rules in compounds.
doi:10.3115/1075178.1075211 dblp:conf/acl/TakeuchiKK03 fatcat:2xmnshl7mbhe5psm73qxdrxwjy

Unexpected Impingement Corrosion of Aluminum Brass Condenser Tubes

Hiroshi Yamamoto, Hiroshi Kunieda, Teruo Koyama, Naomichi Nishijima
1979 Corrosion engineering digest  
Some discussions about the mechanism of the unexpected severe impingement corrosion of condenser tubes were made in relation to hydrotalcite. It was elucidated experimentally that hydrotalcite is the initial corrosion product of Aluminum Brass in the natural sea water. Even if iron rich protective films are formed on hydrotalcite, they will be broken quite easily by the collision of foreign bodies with smaller energy in the sea water. This will increase the possibility of corrosion. The most
more » ... ortant countermeasure is to supress the initial corrosion of condenser tubes by the effective ferrous ion dosing and to prevent hydrotalcite formation. It was pointed out that more attension should be paid to hydrotalcite from the standpoint of corrosion engineering of condenser tubes.
doi:10.3323/jcorr1974.28.9_485 fatcat:j3mytejrizckbm6vgjslom4j7m

Creep damage evaluation of boiler tubes

Takashi SATO, Teruo KOYAMA, Masataka NOMURA, Shigekatsu SUGAI
1990 Journal of the Society of Materials Science Japan  
doi:10.2472/jsms.39.483 fatcat:op2mywgfe5hj3hz4abj6uxnyoe

健常人におけるRU 28965の吸収, 代謝及び排泄に関する研究

1988 Chemotherapy  
doi:10.11250/chemotherapy1953.36.supplement4_164 fatcat:bxc5e5pl4fc3pnymnb3a6h7j34

Monophasic primary renal synovial sarcoma accompanied with a hemorrhagic cyst

Takeshi Nishida, Teruo Inamoto, Hiroshi Uehara, Naokazu Ibuki, Kohei Koyama, Kazumasa Komura, Yutaka Fujisue, Yoshitake Kurisu, Motomu Tsuji, Haruhito Azuma, Yoji Katsuoka
2011 Urology Journal  
pmid:21910108 fatcat:tvralhxsznhiljiphexa5blgua

A pheochromocytoma of urinary bladder treated with neoadjuvant chemotherapy

Naokazu Ibuki, Kazumasa Komura, Kouhei Koyama, Teruo Inamoto, Naoki Segawa, Keiji Tanimoto, Motomu Tuji, Haruhito Azuma, Yoji Katsuoka
2009 Hinyokika kiyo. Acta urologica Japonica  
A 69-year-old female presented with hypertension and a solid mass in the bladder on ultrasonography. Cystoscopy revealed a submucosal tumor in the right lateral wall of the bladder. A transurethral resection was performed. Histologically, pathologic examination revealed a malignant pheochromocytoma. She refused surgical therapy and radiation therapy. She had no treatment for two years. She suddenly complained of gross hematuria. T2-weighted magnetic resonance imaging showed a bladder tumor of
more » ... gh intensity and extra-bladder invasion. She was treated with chemotherapy (CVD) for 26 cycles. Since the tumor size was reduced, she was referred to our hospital for operative indication. Partial cystectomy was performed. Histologically, the tumor was a pheochromocytoma of the urinary bladder. Ten months after the operation, she has no clinical evidence of recurrence.
pmid:20048562 fatcat:yny2ldctufdvhj3v25ipbw5pjq

Microscopic Origin of Interfacial Dzyaloshinskii-Moriya Interaction [article]

Sanghoon Kim, Kohei Ueda, Gyungchoon Go, Peong-Hwa Jang, Kyung-Jin Lee, Abderrezak Belabbes, Aurelien Manchon, Motohiro Suzuki, Yoshinori Kotani, Tetsuya Nakamura, Kohji Nakamura, Tomohiro Koyama (+5 others)
2017 arXiv   pre-print
Chiral spin textures at the interface between ferromagnetic and heavy nonmagnetic metals, such as Neel-type domain walls and skyrmions, have been studied intensively because of their great potential for future nanomagnetic devices. The Dyzaloshinskii-Moriya interaction (DMI) is an essential phenomenon for the formation of such chiral spin textures. In spite of recent theoretical progress aiming at understanding the microscopic origin of the DMI, an experimental investigation unravelling the
more » ... ics at stake is still required. Here, we experimentally demonstrate the close correlation of the DMI with the anisotropy of the orbital magnetic moment and with the magnetic dipole moment of the ferromagnetic metal. The density functional theory and the tight-binding model calculations reveal that asymmetric electron occupation in orbitals gives rise to this correlation.
arXiv:1704.02900v1 fatcat:m4lsku64mjhbpkqmnmlgiwuj5y

Study of Autoanalyzing Electrocardiograph for Rats and Mice

Hiroto NAITO, Teruo YOSHII, Hisao FUKUDA, Tomiya UCHINO, Rie KANO, Hidekazu KOYAMA, Shigekatsu MOTOYOSHI
1989 Advances in Animal Cardiology  
The authors have developed a restraining device which allows the operator to record electrocardiograms (ECGs) of the rat under the non-anesthetic condition.
doi:10.11276/jsvc1984.22.16 fatcat:5vaw7enwpbetxnu7377mwal2ai

Phase and Morphology of ZrO2 in Internally Oxidized Dilute Cu–Zr Alloys

Teruo Takahashi, Yasuhiko Hashimoto, Shinichiro Omori, Koichiro Koyama
1986 Transactions of the Japan Institute of Metals  
Teruo Takahashi et al. nal oxidation decreased with the concentration of alloying element(1). The maximum values of microvickers hardness shown in Fig. 9 ap- peared near 1173 K.  ... 
doi:10.2320/matertrans1960.27.552 fatcat:5yuu7fislva75eopcnxyphmoj4

A Study on Air-jet Looms

Minoru Uno, Kaoru Yamawaki, Teruo Ishida, Kenji Matsui, Taichi Arakawa, Hiroshi Aoyama, Yoshio Kimura, Takao Shinkai, Syoichi Koyama, Koichi Tamada
1961 Journal of the Textile Machinery Society of Japan  
Injection of the weft by air-jet into the free air or shed has been studied with the aid of several experimental devices. The main results obtained from this study are: 2. Laval tubes are unfit for weft propulsion. 3. The air speed drops sharply near the nozzle, and is exceeded, in the middle of the shed, by the running speed of the weft. 4. How to remove the point (whene the air speed is exceeded by the running speed of the weft as far as possible from the nozzle with the least possible
more » ... nal comsumption of horsepower for air compression is a problem which awaits further inquiry. 1.
doi:10.4188/jte1955.7.28 fatcat:sdzzyylsmndafgzxa33uzpmtzq
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