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Digital Data Preservation for Scholarly Publications in Astronomy

Sayeed Choudhury, Tim DiLauro, Alex Szalay, Ethan Vishniac, Robert Hanisch, Julie Steffen, Robert Milkey, Teresa Ehling, Ray Plante
2008 International Journal of Digital Curation  
Astronomy is similar to other scientific disciplines in that scholarly publication relies on the presentation and interpretation of data. But although astronomy now has archives for its primary research telescopes and associated surveys, the highly processed data that is presented in the peer-reviewed journals and is the basis for final analysis and interpretation is generally not archived and has no permanent repository. We have initiated a project whose goal is to implement an end-to-end
more » ... type system which, through a partnership of a professional society, that society's scholarly publications/publishers, research libraries, and an information technology substrate provided by the Virtual Observatory, will capture high-level digital data as part of the publication process and establish a distributed network of curated, permanent data repositories. The data in this network will be accessible through the research journals, astronomy data centers, and Virtual Observatory data discovery portals.
doi:10.2218/ijdc.v2i2.26 fatcat:d7e5ziny3nfrzogh4v5dhtrbiq

Toll-Like Receptor Stimulation Induces Higher TNF-α Secretion in Peripheral Blood Mononuclear Cells from Patients with Hyper IgE Syndrome

Mehdi Yeganeh, Philipp Henneke, Nima Rezaei, Stephan Ehl, Doerte Thiel, Nuria Matamoros, Cristina Pietrogrande, Teresa Espanol, Jiri Litzman, Jose L. Franco, Ozden Sanal, Sara S. Kilic (+7 others)
2008 International Archives of Allergy and Immunology  
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory
more » ... ytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-␣ and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.
doi:10.1159/000115886 pmid:18268386 fatcat:hso2uo5bzjauxd6tzau7weu46q

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

Cristina Woellner, E. Michael Gertz, Alejandro A. Schäffer, Macarena Lagos, Mario Perro, Erik-Oliver Glocker, Maria C. Pietrogrande, Fausto Cossu, José L. Franco, Nuria Matamoros, Barbara Pietrucha, Edyta Heropolitańska-Pliszka (+35 others)
2010 Journal of Allergy and Clinical Immunology  
The hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by infections of the lung and skin, elevated serum IgE, and involvement of the soft and bony tissues. Recently, HIES has been associated with heterozygous dominantnegative mutations in the signal transducer and activator of transcription 3 (STAT3) and severe reductions of T H 17 cells. Objective: To determine whether there is a correlation between the genotype and the phenotype of patients with HIES and to establish
more » ... stic criteria to distinguish between STAT3 mutated and STAT3 wild-type patients. Methods: We collected clinical data, determined T H 17 cell numbers, and sequenced STAT3 in 100 patients with a strong clinical suspicion of HIES and serum IgE >1000 IU/mL. We explored diagnostic criteria by using a machine-learning approach to identify which features best predict a STAT3 mutation. Results: In 64 patients, we identified 31 different STAT3 mutations, 18 of which were novel. These included mutations at splice sites and outside the previously implicated DNA-binding and Src homology 2 domains. A combination of 5 clinical features predicted STAT3 mutations with 85% accuracy. T H 17 cells were profoundly reduced in patients harboring STAT3 mutations, whereas 10 of 13 patients without mutations had low (<1%) T H 17 cells but were distinct by markedly reduced IFN-g-producing CD4 1 T cells. Conclusion: We propose the following diagnostic guidelines for STAT3-deficient HIES. Possible: IgE >1000IU/mL plus a weighted score of clinical features >30 based on recurrent pneumonia, newborn rash, pathologic bone fractures, characteristic face, and high palate. Probable: These characteristics plus lack of T H 17 cells or a family history for definitive HIES. Definitive: These characteristics plus a dominant-negative heterozygous mutation in STAT3. (J Allergy Clin Immunol 2010;125:424-32.)
doi:10.1016/j.jaci.2009.10.059 pmid:20159255 pmcid:PMC2878129 fatcat:tjsgbq5em5gflmcymta4wxz6lu

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David O'Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach (+37 others)
2018 Science Translational Medicine  
Recent evidence has revealed that oncogenic mutations may confer immune escape. A better understanding of how an oncogenic mutation affects immunosuppressive programmed death ligand 1 (PD-L1) expression may help in developing new therapeutic strategies. We show that oncogenic JAK2 (Janus kinase 2) activity caused STAT3 (signal transducer and activator of transcription 3) and STAT5 phosphorylation, which enhanced PD-L1 promoter activity and PD-L1 protein expression in JAK2 V617F -mutant cells,
more » ... ereas blockade of JAK2 reduced PD-L1 expression in myeloid JAK2 V617F -mutant cells. PD-L1 expression was higher on primary cells isolated from patients with JAK2 V617F -myeloproliferative neoplasms (MPNs) compared to healthy individuals and declined upon JAK2 inhibition. JAK2 V617F mutational burden, pSTAT3, and PD-L1 expression were highest in primary MPN patient-derived monocytes, megakaryocytes, and platelets. PD-1 (programmed death receptor 1) inhibition prolonged survival in human MPN xenograft and primary murine MPN models. This effect was dependent on T cells. Mechanistically, PD-L1 surface expression in JAK2 V617F -mutant cells affected metabolism and cell cycle progression of T cells. In summary, we report that in MPN, constitutive JAK2/STAT3/STAT5 activation, mainly in monocytes, megakaryocytes, and platelets, caused PD-L1-mediated immune escape by reducing T cell activation, metabolic activity, and cell cycle progression. The susceptibility of JAK2 V617F -mutant MPN to PD-1 targeting paves the way for immunomodulatory approaches relying on PD-1 inhibition.
doi:10.1126/scitranslmed.aam7729 pmid:29467301 fatcat:spbi3muotnc5rb7quymrhc4oma

In Memorium: Jonathan J. King (1949-1991)

Bruce G. Buchanan
1991 The AI Magazine  
I believe dIT Press Robert Prior, Teresa Ehling we can continue his quest for understanding  ...  AAAI What technical safeguards can we design into our inventions so that Robert Prior, Teresa Ehling, The hlIT Press no individual is worse off because of them?  ... 
doi:10.1609/aimag.v12i2.893 dblp:journals/aim/Buchanan91 fatcat:6tfkwmpqbzfh5m3k3ameerddn4

Page 319 of Catholic Educational Review Vol. 29, Issue [page]

1931 Catholic Educational Review  
Ehl: The Spiritual Direction of Sisters. New York: Benziger Brothers, 1931. Pp. xix+483. Lyons, George N.: The King’s Steward. The True Story of George Schumann.  ...  Tallon, Mother Mary Teresa: Family Meditations in Great Catholic Truths. 1930. Pp. xvii+304. Price, $2.00; The Parish Visitor Catechist. Conferences to the Parish Visitors of Mary Immaculate. 1930.  ... 

Author Index

2018 Journal of Veterinary Pharmacology and Therapeutics  
., 45 Ehling, S., 48 Ekstrand, C., 147 El Garch, F., 41, 87, 91 Elbadawy, M., 29, 138 Elgendy, R., 28, 29 Enemark, H., 98 Enevova, V., 104 Er, A., 158 Erdogan, E., 43 Evangelista, M.C  ...  -F., 34 Taverne, F.J., 148 Taylor, P.M., 77 Tekin, K., 107 Teresa Capucchio, M., 44 Testa, C., 22 Thompson, C., 159 Tikhomirov, M., 58, 132 Tipold, A., 155 Tkaczyk, A., 145 Tolosi,  ... 
doi:10.1111/jvp.12663 fatcat:v5no2by62faufkdsrtkri2pme4

Page 5553 of Psychological Abstracts Vol. 85, Issue 12 [page]

1998 Psychological Abstracts  
K., 38297 King, Teresa, 38458 King, Valarie, 36637 Kingsbury, Anne, 37434 Kingstone, Alan, 35912 Kintsch, Walter, 36485 Kinzie, J.  ...  ., 37218 ehle, Thomas J., 37992, 38647 Kei zer, Fred A., 36208 Keil, Andreas, 37219 Keiley, Margaret K., 36816 Keith, Patricia B., 38686 Keith, Susan E., 37621 Keith, Timothy Z., 38686 Kell, Randi S.,  ... 

Page 298 of PMLA. Publications of the Modern Language Association of America Vol. 75, Issue 2 [page]

1959 PMLA. Publications of the Modern Language Association of America  
., e Nilsson-Ehle. Voci ro- manesche. Aggiunte e commenti al Vocabolario romanesco Chiap pini-Rolandi. (SUVSL, No. 50.) Lunda: C. W. K. Gleerup, 1957. 7475. Cappello, Teresa.  ... 

A Pain Unit in a Developing Country: Epidemiology of Chronic Pain in Maputo, Mozambique

Karen dos Santos Ferreira, Maria Teresa Schwalbach, João Schwalbach, José Geraldo Speciali
2014 Pain medicine (Malden, Mass.)  
J Pediatr 2000; 105:14-22. 8 Chermont AG, Falcão LFM, de Souza Silva EHL, et al. Term newborn infants skin-to-skin contact and/or oral 25% dextrose for procedural pain relief.  ...  KAREN DOS SANTOS FERREIRA, PhD,* MARIA TERESA SCHWALBACH, MD, † JOÃO SCHWALBACH, MD, † and JOSÉ GERALDO SPECIALI, PhD* *Department of Neurosciences and Behavioral Sciences, Division of Neurology, School  ... 
doi:10.1111/pme.12544 pmid:25220365 fatcat:eent2itgqfbcvfahfffpywzpze

Produção de cultivares de alface americana sob diferentes ambientes em condições tropicais

Jucimar Ferreira Neves Ferreira Neves, Ivan David Ehle Nodari, Santino Seabra Júnior, Leonardo Diogo Ehle Dias, Leandro Batista Da Silva, Rivanildo Dallacort
2016 Agro@mbiente On-line  
As cultivares de alface americana Teresa e Gloriosa são as mais indicadas para o cultivo em condições de alta temperatura, pois, entre as que apresentaram maior compacidade da cabeça, foram as que obtiveram  ...  Nesse contexto, as cultivares Teresa e Graciosa foram as que apresentaram os melhores resultados, porém não demonstraram diferença significativa da cultivar Gloriosa.  ...  CONCLUSÕES As cultivares Teresa e Gloriosa são indicadas para o cultivo em condições de alta temperatura em razão da maior compacidade da cabeça, menor comprimentos de caule e proporção da altura do caule  ... 
doi:10.18227/1982-8470ragro.v10i2.3200 fatcat:izwt363hfbbk7nxgpkcxp7mfam

Concussions and youth football: using a public health law framework to head off a potential public health crisis

Christine M. Baugh, Zachary E. Shapiro
2015 Journal of Law and the Biosciences  
See Baugh et al., supra note 25, at 307, 308. 34 Teresa B. Gibson et al., Analyzing the Effect of State Legislation on Health Care Utilization for Children With Concussion, 169 J. AM. MED.  ...  Recognizing this, Professor Michelle Mello has set forth a series of criteria that she argues allow EHL research to positively influence policy decisions. 49 These factors include: (1) ... variation in  ... 
doi:10.1093/jlb/lsv023 pmid:27774206 pmcid:PMC5034378 fatcat:4dr3zexda5ag5i26blmezi7zg4

Does the presence of the palmaris longus tendon influence median nerve function?

Robert A. Werner, Teresa Spiegelberg
2012 Muscle and Nerve  
Distal L5 muscles, such as TA, fibularis longus (FL), TP, and extensor hallucis longus (EHL), are sensitive in the EDx of L5 radiculopathy.  ...  WERNER, MD, MS 1 and TERESA SPIEGELBERG, BS 2 1 Ann Arbor Veterans Health System, 2215 Fuller Road (117), Ann Arbor, Michigan 48105 USA 2 Department of Physical Medicine and Rehabilitation, University  ... 
doi:10.1002/mus.23323 pmid:22581546 fatcat:m6w7nt4xfnhb5c5kicszwcayke

Estudio biomecánico de la reconstrucción ligamentosa anatómica con autoinjerto en la inestabilidad lateral de tobillo

María Ángela Mellado-Romero, Francisco Guerra-Pinto, José Guimarães-Consciência, Enrique J. Sánchez-Morata, Elena Vacas-Sánchez, Marta Arroyo-Hernández, Ana Abarquero-Diezhandino, M. Teresa Vázquez Osorio, Luis Ramos-Pascua, Jesús Vilá-Rico
2020 Revista Española de Cirugía Ortopédica y Traumatología  
Inserción de plastia tendinosa de EHL en túnel ciego talar y posterior fijación con anclaje de 4,75 mm. Figura 6 6 Tobillo derecho.  ...  En este estudio empleamos el tendón EHL por varios motivos: su disponibilidad en la pieza anatómica, la fácil extracción del mismo y su diámetro en torno a 4,5 mm.  ... 
doi:10.1016/j.recot.2020.06.010 pmid:33334722 fatcat:6r52frcxlfah5fp3hsup4bwq3a

Untersuchungen über die Reaktion auf humanes und bovines Tuberkulin in der Kindheit

Cesare Cattaneo
1913 European Journal of Pediatrics  
SehlieBlich ist noch ehl Faktor in Betracht zu ziehen: die M6glichkeit der Umwandlung des Tuberkelbacillus yon einem Typus in den anderen, je nachdem er die Umgebung wechselt.  ...  Rattazzi, Teresa Faniotto, Serafino Tareri~ Maria Riboni~ Cesare MassiMetti, Giacomo Poreri, Antonio Bricio, Alfredo De Capitani, Attilio Baroni, Alessandro Romanieri, Anita Manzo~ Adolfo  ... 
doi:10.1007/bf02087638 fatcat:zav67dn74jdyxehhqgozxjellu
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