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Digital Data Preservation for Scholarly Publications in Astronomy
2008
International Journal of Digital Curation
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Astronomy is similar to other scientific disciplines in that scholarly publication relies on the presentation and interpretation of data. But although astronomy now has archives for its primary research telescopes and associated surveys, the highly processed data that is presented in the peer-reviewed journals and is the basis for final analysis and interpretation is generally not archived and has no permanent repository. We have initiated a project whose goal is to implement an end-to-end
doi:10.2218/ijdc.v2i2.26
fatcat:d7e5ziny3nfrzogh4v5dhtrbiq
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... type system which, through a partnership of a professional society, that society's scholarly publications/publishers, research libraries, and an information technology substrate provided by the Virtual Observatory, will capture high-level digital data as part of the publication process and establish a distributed network of curated, permanent data repositories. The data in this network will be accessible through the research journals, astronomy data centers, and Virtual Observatory data discovery portals.
Toll-Like Receptor Stimulation Induces Higher TNF-α Secretion in Peripheral Blood Mononuclear Cells from Patients with Hyper IgE Syndrome
2008
International Archives of Allergy and Immunology
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Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory
doi:10.1159/000115886
pmid:18268386
fatcat:hso2uo5bzjauxd6tzau7weu46q
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... ytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-␣ and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome
2010
Journal of Allergy and Clinical Immunology
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The hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by infections of the lung and skin, elevated serum IgE, and involvement of the soft and bony tissues. Recently, HIES has been associated with heterozygous dominantnegative mutations in the signal transducer and activator of transcription 3 (STAT3) and severe reductions of T H 17 cells. Objective: To determine whether there is a correlation between the genotype and the phenotype of patients with HIES and to establish
doi:10.1016/j.jaci.2009.10.059
pmid:20159255
pmcid:PMC2878129
fatcat:tjsgbq5em5gflmcymta4wxz6lu
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... stic criteria to distinguish between STAT3 mutated and STAT3 wild-type patients. Methods: We collected clinical data, determined T H 17 cell numbers, and sequenced STAT3 in 100 patients with a strong clinical suspicion of HIES and serum IgE >1000 IU/mL. We explored diagnostic criteria by using a machine-learning approach to identify which features best predict a STAT3 mutation. Results: In 64 patients, we identified 31 different STAT3 mutations, 18 of which were novel. These included mutations at splice sites and outside the previously implicated DNA-binding and Src homology 2 domains. A combination of 5 clinical features predicted STAT3 mutations with 85% accuracy. T H 17 cells were profoundly reduced in patients harboring STAT3 mutations, whereas 10 of 13 patients without mutations had low (<1%) T H 17 cells but were distinct by markedly reduced IFN-g-producing CD4 1 T cells. Conclusion: We propose the following diagnostic guidelines for STAT3-deficient HIES. Possible: IgE >1000IU/mL plus a weighted score of clinical features >30 based on recurrent pneumonia, newborn rash, pathologic bone fractures, characteristic face, and high palate. Probable: These characteristics plus lack of T H 17 cells or a family history for definitive HIES. Definitive: These characteristics plus a dominant-negative heterozygous mutation in STAT3. (J Allergy Clin Immunol 2010;125:424-32.)
Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms
2018
Science Translational Medicine
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Recent evidence has revealed that oncogenic mutations may confer immune escape. A better understanding of how an oncogenic mutation affects immunosuppressive programmed death ligand 1 (PD-L1) expression may help in developing new therapeutic strategies. We show that oncogenic JAK2 (Janus kinase 2) activity caused STAT3 (signal transducer and activator of transcription 3) and STAT5 phosphorylation, which enhanced PD-L1 promoter activity and PD-L1 protein expression in JAK2 V617F -mutant cells,
doi:10.1126/scitranslmed.aam7729
pmid:29467301
fatcat:spbi3muotnc5rb7quymrhc4oma
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... ereas blockade of JAK2 reduced PD-L1 expression in myeloid JAK2 V617F -mutant cells. PD-L1 expression was higher on primary cells isolated from patients with JAK2 V617F -myeloproliferative neoplasms (MPNs) compared to healthy individuals and declined upon JAK2 inhibition. JAK2 V617F mutational burden, pSTAT3, and PD-L1 expression were highest in primary MPN patient-derived monocytes, megakaryocytes, and platelets. PD-1 (programmed death receptor 1) inhibition prolonged survival in human MPN xenograft and primary murine MPN models. This effect was dependent on T cells. Mechanistically, PD-L1 surface expression in JAK2 V617F -mutant cells affected metabolism and cell cycle progression of T cells. In summary, we report that in MPN, constitutive JAK2/STAT3/STAT5 activation, mainly in monocytes, megakaryocytes, and platelets, caused PD-L1-mediated immune escape by reducing T cell activation, metabolic activity, and cell cycle progression. The susceptibility of JAK2 V617F -mutant MPN to PD-1 targeting paves the way for immunomodulatory approaches relying on PD-1 inhibition.
In Memorium: Jonathan J. King (1949-1991)
1991
The AI Magazine
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I believe dIT Press
Robert Prior, Teresa Ehling
we can continue his quest for understanding ...
AAAI
What technical safeguards can we design into our inventions so that Robert Prior, Teresa Ehling, The hlIT Press
no individual is worse off because of them? ...
doi:10.1609/aimag.v12i2.893
dblp:journals/aim/Buchanan91
fatcat:6tfkwmpqbzfh5m3k3ameerddn4
Page 319 of Catholic Educational Review Vol. 29, Issue
[page]
1931
Catholic Educational Review
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Ehl: The Spiritual Direction of Sisters. New York: Benziger Brothers, 1931. Pp. xix+483.
Lyons, George N.: The King’s Steward. The True Story of George Schumann. ...
Tallon, Mother Mary Teresa: Family Meditations in Great Catholic Truths. 1930. Pp. xvii+304. Price, $2.00; The Parish Visitor Catechist. Conferences to the Parish Visitors of Mary Immaculate. 1930. ...
Author Index
2018
Journal of Veterinary Pharmacology and Therapeutics
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., 45
Ehling, S., 48
Ekstrand, C., 147
El Garch, F., 41, 87, 91
Elbadawy, M., 29, 138
Elgendy, R., 28, 29
Enemark, H., 98
Enevova, V., 104
Er, A., 158
Erdogan, E., 43
Evangelista, M.C ...
-F., 34
Taverne, F.J., 148
Taylor, P.M., 77
Tekin, K., 107
Teresa Capucchio, M., 44
Testa, C., 22
Thompson, C., 159
Tikhomirov, M., 58, 132
Tipold, A., 155
Tkaczyk, A., 145
Tolosi, ...
doi:10.1111/jvp.12663
fatcat:v5no2by62faufkdsrtkri2pme4
Page 5553 of Psychological Abstracts Vol. 85, Issue 12
[page]
1998
Psychological Abstracts
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K., 38297 King, Teresa, 38458 King, Valarie, 36637 Kingsbury, Anne, 37434 Kingstone, Alan, 35912 Kintsch, Walter, 36485 Kinzie, J. ...
., 37218
ehle, Thomas J., 37992, 38647
Kei zer, Fred A., 36208
Keil, Andreas, 37219
Keiley, Margaret K., 36816
Keith, Patricia B., 38686
Keith, Susan E., 37621
Keith, Timothy Z., 38686
Kell, Randi S., ...
Page 298 of PMLA. Publications of the Modern Language Association of America Vol. 75, Issue 2
[page]
1959
PMLA. Publications of the Modern Language Association of America
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., e Nilsson-Ehle. Voci ro- manesche. Aggiunte e commenti al Vocabolario romanesco Chiap pini-Rolandi. (SUVSL, No. 50.) Lunda: C. W. K. Gleerup, 1957.
7475. Cappello, Teresa. ...
A Pain Unit in a Developing Country: Epidemiology of Chronic Pain in Maputo, Mozambique
2014
Pain medicine (Malden, Mass.)
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J Pediatr 2000;
105:14-22.
8 Chermont AG, Falcão LFM, de Souza Silva EHL, et al.
Term newborn infants skin-to-skin contact and/or oral
25% dextrose for procedural pain relief. ...
KAREN DOS SANTOS FERREIRA, PhD,* MARIA TERESA SCHWALBACH, MD, † JOÃO SCHWALBACH, MD, † and JOSÉ GERALDO SPECIALI, PhD* *Department of Neurosciences and Behavioral Sciences, Division of Neurology, School ...
doi:10.1111/pme.12544
pmid:25220365
fatcat:eent2itgqfbcvfahfffpywzpze
Produção de cultivares de alface americana sob diferentes ambientes em condições tropicais
2016
Agro@mbiente On-line
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As cultivares de alface americana Teresa e Gloriosa são as mais indicadas para o cultivo em condições de alta temperatura, pois, entre as que apresentaram maior compacidade da cabeça, foram as que obtiveram ...
Nesse contexto, as cultivares Teresa e Graciosa foram as que apresentaram os melhores resultados, porém não demonstraram diferença significativa da cultivar Gloriosa. ...
CONCLUSÕES As cultivares Teresa e Gloriosa são indicadas para o cultivo em condições de alta temperatura em razão da maior compacidade da cabeça, menor comprimentos de caule e proporção da altura do caule ...
doi:10.18227/1982-8470ragro.v10i2.3200
fatcat:izwt363hfbbk7nxgpkcxp7mfam
Concussions and youth football: using a public health law framework to head off a potential public health crisis
2015
Journal of Law and the Biosciences
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See Baugh et al., supra note 25, at 307, 308. 34 Teresa B. Gibson et al., Analyzing the Effect of State Legislation on Health Care Utilization for Children With Concussion, 169 J. AM. MED. ...
Recognizing this, Professor Michelle Mello has set forth a series of criteria that she argues allow EHL research to positively influence policy decisions. 49 These factors include: (1) ... variation in ...
doi:10.1093/jlb/lsv023
pmid:27774206
pmcid:PMC5034378
fatcat:4dr3zexda5ag5i26blmezi7zg4
Does the presence of the palmaris longus tendon influence median nerve function?
2012
Muscle and Nerve
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Distal L5 muscles, such as TA, fibularis longus (FL), TP, and extensor hallucis longus (EHL), are sensitive in the EDx of L5 radiculopathy. ...
WERNER, MD, MS 1 and TERESA SPIEGELBERG, BS 2
1 Ann Arbor Veterans Health System, 2215 Fuller Road (117), Ann Arbor, Michigan 48105 USA
2 Department of Physical Medicine and Rehabilitation, University ...
doi:10.1002/mus.23323
pmid:22581546
fatcat:m6w7nt4xfnhb5c5kicszwcayke
Estudio biomecánico de la reconstrucción ligamentosa anatómica con autoinjerto en la inestabilidad lateral de tobillo
2020
Revista Española de Cirugía Ortopédica y Traumatología
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Inserción de plastia tendinosa de EHL en túnel ciego talar y posterior fijación con anclaje de 4,75 mm.
Figura 6 6 Tobillo derecho. ...
En este estudio empleamos el tendón EHL por varios motivos: su disponibilidad en la pieza anatómica, la fácil extracción del mismo y su diámetro en torno a 4,5 mm. ...
doi:10.1016/j.recot.2020.06.010
pmid:33334722
fatcat:6r52frcxlfah5fp3hsup4bwq3a
Untersuchungen über die Reaktion auf humanes und bovines Tuberkulin in der Kindheit
1913
European Journal of Pediatrics
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SehlieBlich ist noch ehl Faktor in Betracht zu ziehen: die M6glichkeit der Umwandlung des Tuberkelbacillus yon einem Typus in den anderen, je nachdem er die Umgebung wechselt. ...
Rattazzi, Teresa
Faniotto, Serafino
Tareri~ Maria
Riboni~ Cesare
MassiMetti, Giacomo
Poreri, Antonio
Bricio, Alfredo
De Capitani, Attilio
Baroni, Alessandro
Romanieri, Anita
Manzo~ Adolfo ...
doi:10.1007/bf02087638
fatcat:zav67dn74jdyxehhqgozxjellu
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