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Temporary disruption of the rat blood–brain barrier with a monoclonal antibody: A novel method for dynamic manganese-enhanced MRI

Hanbing Lu, Steven Demny, Yantao Zuo, William Rea, Leiming Wang, Svetlana I. Chefer, D. Bruce Vaupel, Yihong Yang, Elliot A. Stein
2010 NeuroImage  
Opening the BBB such that a sufficient amount of Mn(2+) enters the extracellular space is a critical step for dynamic manganese-enhanced magnetic resonance imaging (ME-MRI) experiments.  ...  Manganese (Mn(2+)) has limited permeability through the blood-brain barrier (BBB).  ...  Eckhaus, V.M.D, chief of Pathology Service at the Division of Veterinary Resources, ORS, OD, National Institutes of Health for performing pathological examinations; we would also like to  ... 
doi:10.1016/j.neuroimage.2009.12.053 pmid:20026228 pmcid:PMC2819608 fatcat:ac6kxwznmbbsfbdxx52cp64gqm

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

Raluca Ioana Teleanu, Manuela Daniela Preda, Adelina-Gabriela Niculescu, Oana Vladâcenco, Crina Ioana Radu, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu
2022 Pharmaceutics  
The bloodbrain barrier (BBB) has shown to be a significant obstacle to brain medication delivery.  ...  The BBB in a healthy brain is a diffusion barrier that prevents most substances from passing from the blood to the brain; only tiny molecules can pass across the BBB.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/pharmaceutics14050987 fatcat:tssrroy4m5cwxfqcrc3wl5l3f4

Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment

Ko-Ting Chen, Kuo-Chen Wei, Hao-Li Liu
2019 Frontiers in Pharmacology  
Recent research has shown that, under burst-type energy exposure with the presence of microbubbles, this modality can transiently permeate the blood-brain barrier (BBB).  ...  Focused Ultrasound (FUS) in combination with gaseous microbubbles has emerged as a potential new means of effective drug delivery to the brain.  ...  Identifier NCT03608553, Evaluate Temporary Blood Brain Barrier Disruption in Patients with Parkinson's Disease Dementia.  ... 
doi:10.3389/fphar.2019.00086 pmid:30792657 pmcid:PMC6374338 fatcat:odrgmkvfevap7booygwotatytq

Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy?

Babak Kateb, Katherine Chiu, Keith L. Black, Vicky Yamamoto, Bhavraj Khalsa, Julia Y. Ljubimova, Hui Ding, Rameshwar Patil, Jose Antonio Portilla-Arias, Mike Modo, David F. Moore, Keyvan Farahani (+7 others)
2011 NeuroImage  
suited for the diagnosis and treatment of a variety of diseases.  ...  Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nanoimmunochemotherapy, for patients with cancer.  ...  Chiu provided care for the uninsured, handicapped, and disabled and was an advocate for the people of Taiwan. His life's work was to ensure a better future for his children and the people of Taiwan.  ... 
doi:10.1016/j.neuroimage.2010.01.105 pmid:20149882 pmcid:PMC3524337 fatcat:6mibn2venjaobcbmrng7ps2jge

Proceedings of the World Molecular Imaging Congress 2020, October 7-9, 2020: General Abstracts

2022 Molecular Imaging and Biology  
Conclusion: Tumor specific uptake of pan800 provided remarkable contrast and a flexible imaging window for fluorescence-guided identification of HGGs despite modest EGFR expression.  ...  Results: In HGG xenografts, intratumoral distribution of pan800 correlated with the EGFR expression and the fluorescence signal.  ...  We believe that our miniature microscope will herald a new era in preclinical brain disease research by enabling novel insights into the dysfunction of multiple neurobiological variables over the disease  ... 
doi:10.1007/s11307-021-01691-0 pmid:34982363 pmcid:PMC8725637 fatcat:ipn7hwekzzh6nbsk6dr2mzuhhm

Review on the Third International Neuroinflammation Congress and Student Festival of Neuroscience in Mashhad University of Medical Sciences

Mostafa Modarres Mousavi, Sajad Sahab Negah, Ali Gorji, Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran, a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Epilepsy Research Center, Department of Neurology and Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany
2019 The Neuroscience Journal of Shefaye Khatam  
Conclusion: Through a comprehensive scientific program with a broad basic and clinical aspects, we discussed the basic aspects of neuroinflammation and neurodegeneration up to the s tate-of-the-art treatments  ...  Neuroinflammation congress was the third in a series of annual events aimed to facilitate the inves tigative and analytical discussions on a range of neuroinflammatory diseases.  ...  1 The Study of How to Articulate the Expression of Key Genes in Alzheimer،s Disease (AD) Bioinformatics Approaches and Analyzing Pathways Involved in Them  ... 
doi:10.29252/shefa.7.3.111 fatcat:zh35i4tf7jc55bzs53kz3tiine

Emerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A 2021 Update

Noha A. Gouda, Ahmed Elkamhawy, Jungsook Cho
2022 Biomedicines  
Moreover, preclinical studies and clinical trials evaluating the efficacy of novel and repurposed therapeutic agents and their pragmatic applications with encouraging outcomes are summarized.  ...  In addition, we address the novel innovative therapeutic targets for PD therapy, including α-synuclein, autophagy, neurodegeneration, neuroinflammation, and others.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/biomedicines10020371 pmid:35203580 pmcid:PMC8962417 fatcat:k5paoi6jdvcofogfvekljiyeuu

Vascular targeting of nanoparticles for molecular imaging of diseased endothelium

Prabhani U. Atukorale, Gil Covarrubias, Lisa Bauer, Efstathios Karathanasis
2017 Advanced Drug Delivery Reviews  
Thus, the remodeled endothelium provides a wide range of targets for nanoparticles and molecular imaging.  ...  To demonstrate the potential of molecular imaging, we present a variety of nanoparticles designed for molecular imaging of cancer or atherosclerosis using different imaging modalities.  ...  L.B. was supported by a fellowship from the National Cancer Institute Training Program in Cancer Pharmacology (R25CA148052).  ... 
doi:10.1016/j.addr.2016.09.006 pmid:27639317 pmcid:PMC5352558 fatcat:mo2b2zsu5ja5dhsfxdmdgc4upm

Abstracts for the 13th Turkish Neuroscience Congress April 30th 2015 to May 3rd 2015, Konya, Turkey

2015 Anatomy (International Journal of Experimental and Clinical Anatomy)  
The phylogenic, ontogenic, histogenic, angiogenic, endocrinogenic and immunogenic defined compartments of the CNS present a unique macro-and microarchitecture along the spinal cord, brain stem, diencephalon  ...  The visualization of living ultra-micro-structures is a great accomplishment, a culmination of centuries of scientific endeavors.In contrast, the phylogenic aspects of vascular, neoplastic, degenerative  ...  Recent studies point to blood-brain barrier (BBB) dysfunction in the development of epileptic seizures and epileptogenesis is associated with the loss of control by endothelial cells over the passage of  ... 
doi:10.2399/ana.15.001s fatcat:cc6uyz2r2ve2fcomz3f5ptr5re

Kimdaejung Convention Center

2019 2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)  
We have demonstrated how this PRS platform can determine the optimal drug-dose combination and dynamically adjust the doses for about 30 different disease models.  ...  Hence, the AI-PRS platform can quantitatively determine the optimal drug-dose combination for treating a specific patient or a population of patients.  ...  By comparison to the eyes and the ears, the skin is a relatively underexplored sensory interface for VR/AR technology that could, nevertheless, greatly enhance experiences, at a qualitative level, with  ... 
doi:10.1109/nanomed49242.2019.9130603 fatcat:wlmmq4uwyjablibepjnazw4fp4

XXVIIth Meeting of the Canadian Congress of Neurological Sciences -corrected - Program and Abstracts

1992 Canadian Journal of Neurological Sciences  
Patients with ZS had a cavum septum pellucidum and vergae evident on US (2), CT (5), and MRI (2); subependymal cysts on US (6), CT (2), and MRI (1).  ...  The neuroradiological and clinical features of patients with Zellweger Syndrome (10 ZS), Infantile Refsum's Disease (3 IRD), and Rhizomelic Chondrodysplasia Punctata (1 RCP) are reported.  ...  Radionuclide scanning showed early focal uptake suggestive of a disruption of the blood-brain barrier. In conclusion, early diagnosis of HSVE is essential to optimize neurologic outcome.  ... 
doi:10.1017/s0317167100042359 fatcat:b2dhx6n4vzg2bpgohz6gojyhca

Multiple Dynamics in Tumor Microenvironment Under Radiotherapy [chapter]

Jie Huang, Jian Jian Li
2020 Advances in Experimental Medicine and Biology  
With the potential clinical benefits, interests in RT combined with immunotherapy (IT) are intensified with a large scale of clinical trials underway for an array of cancer types.  ...  enhancing the benefit of RT-IT modality.  ...  Yang-Xin Fu at the University of Texas Southwestern for their invaluable inputs and discussions on radiation-associated tumor immunoregulation.  ... 
doi:10.1007/978-3-030-44518-8_10 pmid:32588328 fatcat:mtbq4fvq55dltprqw5dqlqk3ju


2021 European Journal of Clinical Investigation  
SESSION 4 55ASM-0284 S1 PC2 | Measuring the impact of microbiome metabolites on mitochondrial function using the Agilent Seahorse XF analyser A.  ...  We have developed a simple assay technology that enables measurement of the substrates used by eukaryotic cells and by their mitochondria to produce energy.  ...  Introduction: Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases, such as Alzheimer's and Huntington's.  ... 
doi:10.1111/eci.13567 fatcat:casumfo4afhklgo42swkednpya

Poster Session 2, Monday 27 September

2010 European Journal of Neurology  
P2336 Exposure of manganese nanoparticles induce blood-brain barrier disruption, brain pathology and cognitive and motor dysfunctions in rats P2341 Emotional deficit as an early marker of Alzheimer's  ...  migration through the blood brain barrier.  ...  If the initial CT scan shows SAH, brain contusion and primary hematoma with brain swelling, an earlier and dynamic CT scan should be performed for detection of PHI as early as possible and the medical  ... 
doi:10.1111/j.1468-1331.2010.03233.x fatcat:lsellp2xyvc77c7gr7qbzu6coi

Oral Presentations

2000 Stroke  
Background and Purpose: We looked at the ability of quantitative cerebral blood flow (qCBF) to act as a physiologic marker for the identification of patients (pts.) at high risk for symptomatic hemorrhagic  ...  All pretreatment CT scans were prospectively evaluated blind to clinical information by 2 methods of quantifying middle cerebral artery territory (MCA) early CT change: (1) a novel 10 point CT score (Alberta  ...  the diagnostic efficacy of contrast-enhanced transcranial color coded duplexsonography (CE-TCCD) for noninvasive evaluation of collateral pathways through the Circle of Willis in patients with limited  ... 
doi:10.1161/01.str.31.1.275 fatcat:kzhua4mnzjcp3pqzu4rdidt3qu
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