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Temporal representation of care trajectories of cancer patients using data from a regional information system: an application in breast cancer

Gautier Defossez, Alexandre Rollet, Olivier Dameron, Pierre Ingrand
2014 BMC Medical Informatics and Decision Making  
We developed an algorithm for extracting temporally represented care trajectories from coded information collected routinely by the general cancer Registry in Poitou-Charentes region, France.  ...  The present work aimed to assess the performance of this algorithm on real-life patient data in the setting of non-metastatic breast cancer, using measures of similarity.  ...  Acknowledgments The authors would like to thanks all the all the pathologists, departments of medical data processing in public and private hospitals, oncologists, and medical practitioners for their valuable  ... 
doi:10.1186/1472-6947-14-24 pmid:24690482 pmcid:PMC3983896 fatcat:kulc2f4i5bd2nkvm6j6zmtzlvq

Systems Biology of Cancer Metastasis

Yasir Suhail, Margo P. Cain, Kiran Vanaja, Paul A. Kurywchak, Andre Levchenko, Raghu Kalluri, Kshitiz
2019 Cell Systems  
We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.  ...  The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease.  ...  Nancy Boudreau from the National Cancer Institutes for providing constructive criticisms in support in writing the manuscript.  ... 
doi:10.1016/j.cels.2019.07.003 pmid:31465728 pmcid:PMC6716621 fatcat:gxyvneow5jf3xflyrxd3hycczm

An information model for computable cancer phenotypes

Harry Hochheiser, Melissa Castine, David Harris, Guergana Savova, Rebecca S. Jacobson
2016 BMC Medical Informatics and Decision Making  
of cancer care.  ...  Methods: Reviews of existing ontologies and interviews with cancer researchers were used to inform iterative development of a cancer phenotype information model.  ...  The use of the HL7 FHIR data model bridges the gap between two key applications of patient data: data resulting from direct clinical care and secondary use of clinical data for research purposes.  ... 
doi:10.1186/s12911-016-0358-4 pmid:27629872 pmcid:PMC5024416 fatcat:5az7amhx4zgwjph74cmcdd64d4

Human-Centered Text Mining: A New Software System [chapter]

Jonas Poelmans, Paul Elzinga, Alexei A. Neznanov, Guido Dedene, Stijn Viaene, Sergei O. Kuznetsov
2012 Lecture Notes in Computer Science  
In this paper we introduce a novel human-centered data mining software system which was designed to gain intelligence from unstructured textual data.  ...  At the core of the system are concept lattices which can be used to interactively explore the data.  ...  Jonas Poelmans is Aspirant of the "Fonds voor Wetenschappelijk Onderzoek -Vlaanderen" (FWO) or Research Foundation -Flanders.  ... 
doi:10.1007/978-3-642-31488-9_21 fatcat:dlmifsydgfd4vl6obdrbtuhmrm

Modeling human eye behavior during mammographic scanning: preliminary results

K. Preston White, T.L. Hutson, T.E. Hutchinson
1997 IEEE transactions on systems, man and cybernetics. Part A. Systems and humans  
the promise of eventual adaptation as a source of diagnostic information in clinical practice.  ...  Understanding how people acquire information from pictures-radiographs, maps, charts, photographs, drawings, and other static images-can be an important component in understanding, aiding, and eventually  ...  (See [37] for an excellent and readable summary of the epidemiology of breast cancer). Mammography is a means of imaging breast tissue using X-rays.  ... 
doi:10.1109/3468.594915 fatcat:hslng2owwne5beoflbwhufdnni

Mathematical models of breast and ovarian cancers

Dana-Adriana Botesteanu, Stanley Lipkowitz, Jung-Min Lee, Doron Levy
2016 Wiley Interdisciplinary Reviews: Systems Biology and Medicine  
from a systems biology perspective are needed.  ...  Human breast cancers In 2016, it is estimated that 246,660 new cases of breast cancer with an estimated 40,450 deaths related to the disease will occur in the US, for a calculated 4:25 death to incidence  ...  ACKNOWLEDGEMENTS Funding: The work was supported by the Intramural Research Program of the National Institutes of Health, Center for Cancer Research, National Cancer Institute as part of a seed grant from  ... 
doi:10.1002/wsbm.1343 pmid:27259061 pmcid:PMC4911289 fatcat:fhlkj6j3rfbcnfwsvud23tfnbe

Contextualizing the Young Adult Female Breast Cancer Experience: Developmental, Psychosocial, and Interpersonal Influences

Cameron Froude, Sandra Rigazio-DiGilio, Laura Donorfio, Keith Bellizzi
2017 The Qualitative Report  
Future studies should explore the ways in which medical providers attend to these systems across the breast cancer trajectory.  ...  Using a phenomenological approach, 23 breast cancer survivors were interviewed using a semi-structured interview.  ...  the breast cancer trajectory, as well as the potential avenues for reconciling patient care and needs.  ... 
doi:10.46743/2160-3715/2017.2596 fatcat:4kjos6733vbthhy2rp6cz5sw74

Cancer systems immunology

Nathan E Reticker-Flynn, Edgar G Engleman
2020 eLife  
While in its infancy, the field of 'Cancer Systems Immunology' has already influenced our understanding of tumor immunology and immunotherapy.  ...  These advances have coincided with an exponential growth in the development of –omics technologies.  ...  The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Additional information  ... 
doi:10.7554/elife.53839 fatcat:xx4k5vorbraqlkvzjbrjhjw5py

Development and validation of clinical prediction models for breast cancer incidence and mortality: a protocol for a dual cohort study

Ashley Kieran Clift, Julia Hippisley-Cox, David Dodwell, Simon Lord, Mike Brady, Stavros Petrou, Gary S. Collins
2022 BMJ Open  
It will evaluate a set of modelling approaches to predict the risk of developing breast cancer within the next 10 years, the 'combined' risk of developing a breast cancer and then dying from it within  ...  10 years, and the risk of breast cancer mortality within 10 years of diagnosis.  ...  This project will involve data derived from patient-level information collected by the NHS, as part of the care and support of cancer patients.  ... 
doi:10.1136/bmjopen-2021-050828 pmid:35351695 pmcid:PMC8961149 fatcat:nukps6cgjnbjzcn55nxv3vtqjy

A contribution to the discovery of multidimensional patterns in healthcare trajectories

Elias Egho, Nicolas Jay, Chedy Raïssi, Dino Ienco, Pascal Poncelet, Maguelonne Teisseire, Amedeo Napoli
2014 Journal of Intelligent Information Systems  
We introduce a case-study on real-world data from a regional healthcare system and we point out the usefulness of the extracted patterns.  ...  Sequential pattern mining is aimed at extracting correlations among temporal data.  ...  Acknowledgments The authors would like to thank the French institution "Institut National du Cancer (INCa)" for its financial support.  ... 
doi:10.1007/s10844-014-0309-4 fatcat:bxabwtksz5b5dgsglvelccf55y

Integrated care pathway for breast cancer: a relational and geographical approach

Laurent Mériade, Corinne Rochette
2020 Social Science and Medicine  
minutes, in-depth interviews) and quantitative data relating to the mobility and geographical location of a cohort of 1798 patients treated in this centre.  ...  This inseparability is constructed from the proposal of a method for mapping the integrated care pathways in their territories.  ...  After a few background information on the French health care system and cancer care, we present the case study.  ... 
doi:10.1016/j.socscimed.2020.113658 pmid:33421916 fatcat:zcgifd6ob5ar7ogsjfn3hdkbai

Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine

Emma Kurnat-Thoma, Ancha Baranova, Pat Baird, Elia Brodsky, Atul J. Butte, Amrita K. Cheema, Feixiong Cheng, Shuchismita Dutta, Christina Grant, James Giordano, Anke H. Maitland-van der Zee, Douglas B. Fridsma (+30 others)
2020 Systems Medicine  
Topics ranged from: Systems and Network Medicine in Clinical Practice; the role of -omics technologies in Health Care; the role of Education and Ethics in Clinical Practice, Systems Thinking, and Rare  ...  The conference served as a unique nexus for interdisciplinary discovery and dialogue and fostered formation of new insights and possibilities for health care systems advances.  ...  Maddipatla, Baby A. Satravada, Bharath K.  ... 
doi:10.1089/sysm.2020.0001 pmid:32226924 pmcid:PMC7099876 fatcat:4acs6ozyxjdrxhwya735k6k5wm

Health—exploring complexity: an interdisciplinary systems approach HEC2016

Eva Grill, Martin Müller, Ulrich Mansmann
2016 European Journal of Epidemiology  
the risks and matters of patients not under care and an increase in time to collect information from the computer before starting patient care.  ...  The template was evaluated by an application system expert and through conducting a first test mapping of real-world data from one of the systems.  ...  In this context, a focused crawler uses techniques from the field of machine learning to estimate the relevance of a webpage for the domain of interest [5,6].  ... 
doi:10.1007/s10654-016-0183-1 pmid:27522353 fatcat:dcl3nbpygvh5fg7keri74h55ie

Abstracts From the 22nd Annual Health Care Systems Research Network Conference, April 13–16, 2016, Atlanta, Georgia

2016 Journal of Patient-Centered Research and Reviews  
of human health, the care of the individual patient, and the care of populations.  ...  Conclusion: Anesthesia exposure was not associated with an increased risk of dementia or AD in older adults.  ...  A5-3: Universal Screen for Lynch Syndrome in an  ... 
doi:10.17294/2330-0698.1413 fatcat:dvytsofskrh5bb7r2atlpyogmm

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman (+32 others)
2018 Journal of Alzheimer's Disease  
The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems  ...  dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in  ...  applied to breast cancer patients to determine their risk of reappearance, can be used in prostate cancer as well for predicting which individual may take advantage from early initiation of post-operative  ... 
doi:10.3233/jad-179932 pmid:29562524 pmcid:PMC6008221 fatcat:j3u6gkzfqbg47kv4o2hpkjadn4
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