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Subjecting Elite Athletes to Inspiratory Breathing Load Reveals Behavioral and Neural Signatures of Optimal Performers in Extreme Environments

Martin P. Paulus, Taru Flagan, Alan N. Simmons, Kristine Gillis, Sante Kotturi, Nathaniel Thom, Douglas C. Johnson, Karl F. Van Orden, Paul W. Davenport, Judith L. Swain, Alejandro Lucia
2012 PLoS ONE  
The process of computing a body prediction error involves the insular cortex, which is important for interoception, i.e. the sense of the physiological condition of the body.  ...  Thus, optimal performance may be related to efficient minimization of the body prediction error.  ...  Thus, greater activation and possibly a larger body prediction error might predict sub-optimal performance.  ... 
doi:10.1371/journal.pone.0029394 pmid:22276111 pmcid:PMC3261851 fatcat:scbk5pb3hfdsrk6hc66h6tubhm

Interoception and drug addiction

Martin P. Paulus, Jennifer L. Stewart
2014 Neuropharmacology  
It is proposed that interoception contributes to drug addiction by incorporating an "embodied" experience of drug uses together with the individual's predicted versus actual internal state to modulate  ...  The insular cortex is the central nervous system hub to process and integrate these signals.  ...  In comparison, greater anterior insula activation is associated with an aversive prediction error relative to an appetitive prediction error (Jensen et al., 2007) as well as rewards that are more highly  ... 
doi:10.1016/j.neuropharm.2013.07.002 pmid:23855999 pmcid:PMC3858461 fatcat:mz7ymjtldbe2rpv7anto7hvtbm

Neural correlates of error awareness

Tilmann A. Klein, Tanja Endrass, Norbert Kathmann, Jane Neumann, D. Yves von Cramon, Markus Ullsperger
2007 NeuroImage  
et al., 2001 , Endrass et al., 2005 : modulation of the error positivity (Pe) by error awareness -a normal Pe was found in case of an aware error, a diminished Pe was observed in case of an unaware error  ...  ; the error related negativity (ERN) was present on aware and unaware errors • Behavioural: post-error slowing (PES) only after an aware error • Rostral cingulate zone (RCZ; most probable generator of  ... 
doi:10.1016/j.neuroimage.2006.11.014 pmid:17185003 fatcat:jys3qavfcrgixeegbeozohcqne

Disruption of Anterior Insula Modulation of Large-Scale Brain Networks in Schizophrenia

Lauren V. Moran, Malle A. Tagamets, Hemalatha Sampath, Alan O'Donnell, Elliot A. Stein, Peter Kochunov, L. Elliot Hong
2013 Biological Psychiatry  
The strength of right anterior insula modulation of these networks predicted cognitive performance.  ...  patients with schizophrenia and 44 healthy control subjects, we used seed-based resting state functional connectivity functional magnetic resonance imaging analysis to examine connectivity between right insular  ...  Red arrows denote positive paths (activity in source predicts subsequent increases in target activity) and blue arrows denote negative paths (source predicts subsequent decreases in target).  ... 
doi:10.1016/j.biopsych.2013.02.029 pmid:23623456 pmcid:PMC3735654 fatcat:2w4sdigvyzfpzhgdf3gcksowku

The Anterior Insular Cortex Represents Breaches of Taste Identity Expectation

M. G. Veldhuizen, D. Douglas, K. Aschenbrenner, D. R. Gitelman, D. M. Small
2011 Journal of Neuroscience  
Connectivity analyses confirmed that expectation enhanced network interactions, with IPS and VS influencing insular responses.  ...  greater activation to unexpected versus expected stimuli occurred in areas related to taste (thalamus, anterior insula), reward [ventral striatum (VS), orbitofrontal cortex], and attention [anterior cingulate  ...  We predicted enhanced response to unexpected compared with expected taste in insular taste cortex.  ... 
doi:10.1523/jneurosci.1502-11.2011 pmid:21994389 pmcid:PMC3221736 fatcat:bw6ow3mn6vflnn43qef7gib4um

Anterior insular cortex and emotional awareness

Xiaosi Gu, Patrick R. Hof, Karl J. Friston, Jin Fan
2013 Journal of Comparative Neurology  
This paper reviews the foundation for a role of the human anterior insular cortex (AIC) in emotional awareness, defined as the conscious experience of emotions.  ...  Using empathy, the awareness and understanding of other people's emotional states, as a test case, we then present evidence to demonstrate: 1) AIC and anterior cingulate cortex (ACC) are commonly coactivated  ...  Anterior insular cortex (AIC) serves two major processes in this model (center): 1) integrating bottom-up interoceptive prediction errors with top-down predictions from high-order brain regions such as  ... 
doi:10.1002/cne.23368 pmid:23749500 pmcid:PMC3999437 fatcat:a3svkizso5gsbfuaqf63lj6upu

Insula and drug cravings

Hugh Garavan
2010 Brain Structure and Function  
An important role for the insula in craving is supported by evidence of insular activity changing with satiety and with the top-down cognitive modulation of cravings.  ...  A regression analysis, however, revealed that other prefrontal, temporal and posterior cingulate regions proved to be better predictors of outcome.  ...  Although the task, a colour-word STROOP task did produce insular activity, this activity did not predict outcome.  ... 
doi:10.1007/s00429-010-0259-8 pmid:20512373 fatcat:6komot6hejhlnnlajs7bu2muy4

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

Lena Palaniyappan
2012 Journal of Psychiatry & Neuroscience  
The anterior cingulate cortex (ACC) and insula together constitute the salience network, an intrinsic large-scale network showing strong functional connectivity.  ...  The insular cortex is one of the brain regions that show consistent abnormalities in both structural and functional neuroimaging studies of schizophrenia.  ...  In particular, insular activity is often seen with prediction error coding. Prediction error refers to a discrepancy between an expectation and its occurrence.  ... 
doi:10.1503/jpn.100176 pmid:21693094 pmcid:PMC3244495 fatcat:r5ajljnmanep3a4kahqsvqhyai

Temporal decision-making: insights from cognitive neuroscience

Christian Luhmann
2009 Frontiers in Behavioral Neuroscience  
Taken as a whole, this body of work illustrates the progress made in understanding temporal choice behavior.  ...  Decisions frequently have consequences that play out over time and these temporal factors can exert strong influences on behavior.  ...  When subjects learn to make sequences of actions to acquire monetary rewards, anterior and inferior portions of insular cortex appear to be differentially involved in producing reward-prediction error  ... 
doi:10.3389/neuro.08.039.2009 pmid:19898688 pmcid:PMC2773702 fatcat:vhxyyyg46ffxxfkuuqs2wr3hmu

Neuroanatomical substrates for the volitional regulation of heart rate

Catherine L. Jones, Ludovico Minati, Yoko Nagai, Nick Medford, Neil A. Harrison, Marcus Gray, Jamie Ward, Hugo D. Critchley
2015 Frontiers in Psychology  
Biofeedback enhanced activity within occipito-temporal cortices, but there was no significant interaction with task conditions.  ...  Participants achieved appropriate changes in heart rate, without significant modulation of respiratory rate, and were overall not influenced by the presence of visual feedback.  ...  Caudate activity, alongside insula and dorsal cingulate, predicts heart rate changes to emotional stimuli and at a network level, the connectivity between caudate, cingulate, insula, and midbrain is coupled  ... 
doi:10.3389/fpsyg.2015.00300 pmid:25992711 pmcid:PMC4373272 fatcat:xx27pcu2rzdfritqtqndoxvioa

Brain network dysfunction in youth with obsessive-compulsive disorder induced by simple uni-manual behavior: The role of the dorsal anterior cingulate cortex

Amy L. Friedman, Ashley Burgess, Karthik Ramaseshan, Phil Easter, Dalal Khatib, Asadur Chowdury, Paul D. Arnold, Gregory L. Hanna, David R. Rosenberg, Vaibhav A. Diwadkar
2017 Psychiatry Research : Neuroimaging  
Across conditions, OCD were characterized by hyper-modulation by the dACC, with loci alternatively observed as both condition-general and condition-specific.  ...  Here we focus on network interactions of the dorsal anterior cingulate cortex (dACC) during simple unimanual behavior in youth with OCD.  ...  mechanisms for optimizing prediction error in OCD.  ... 
doi:10.1016/j.pscychresns.2016.12.005 pmid:27992792 pmcid:PMC5302006 fatcat:3fgbl2dlvjgaperinyhdhxxvb4

Mesocorticolimbic Interactions Mediate fMRI-Guided Regulation of Self-Generated Affective States

Andrea Caria
2020 Brain Sciences  
Mesencephalic regions not only control autonomic responses but also participate in the modulation of autonomic, emotional, and motivational responses.  ...  Neuroimaging studies grounding on appraisal models of emotion emphasize a major role of prefrontal cortex in modulating emotion-related cortical and subcortical regions but usually neglect the contribution  ...  In this context, ascending dopaminergic prediction error signals [100, 101] would be highly relevant for emotion regulation [10] .  ... 
doi:10.3390/brainsci10040223 pmid:32276411 fatcat:yhpzhzfqvnhpta4mv766ypx72u

Imaging how attention modulates pain in humans using functional MRI

Susanna J. Bantick, Richard G. Wise, Alexander Ploghaus, Stuart Clare, Stephen M. Smith, Irene Tracey
2002 Brain  
Abbreviations: ACC = anterior cingulate cortex; BA = Brodmann area; BOLD = blood oxygen level-dependent; fMRI = functional MRI; GLM = general linear model; RT = reaction time ã  ...  When subjects were distracted during painful stimulation, brain areas associated with the affective division of the anterior cingulate cortex (ACC) and orbitofrontal regions showed increased activation  ...  Perigenual cingulate Our study found a relative increase in activity in the perigenual cingulate compared with what would be predicted by adding the signal increases in the pain and the Stroop condition  ... 
doi:10.1093/brain/awf022 pmid:11844731 fatcat:fawymwrbyzdf5fjfyvkjn3nvem

Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response

Nick Medford, Hugo D. Critchley
2010 Brain Structure and Function  
There is now a wealth of evidence that anterior insular and anterior cingulate cortices have a close functional relationship, such that they may be considered together as input and output regions of a  ...  representation of the feeling state to be modulated by cingulate activity.  ...  Phillips et al. (2003) studied responses to oesophageal distention coupled with the viewing of neutral or fearful facial expressions, designed to provide an emotional context that would modulate sensory  ... 
doi:10.1007/s00429-010-0265-x pmid:20512367 pmcid:PMC2886906 fatcat:xdzs4m6mj5hhnjsmthboc5turi

Anterior insula coordinates hierarchical processing of tactile mismatch responses

Micah Allen, Francesca Fardo, Martin J. Dietz, Hauke Hillebrandt, Karl J. Friston, Geraint Rees, Andreas Roepstorff
2016 NeuroImage  
These results suggest that the AIC coordinates hierarchical processing of tactile prediction error.  ...  Further, participants who rated stimulus changes as easier to detect showed stronger modulation of descending PFC to AIC connections by deviance.  ...  In terms of predictive coding, this linking is likely to be mediated by modulating the precision of ascending prediction errors so that they exert greater influence on higher-level processing.  ... 
doi:10.1016/j.neuroimage.2015.11.030 pmid:26584870 pmcid:PMC4758822 fatcat:ictxwi4g25c6tpwwd6iwu4nn6q
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