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Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus

Shenghua Li, Paul Brazhnik, Bruno Sobral, John J. Tyson, Jason A. Papin
2009 PLoS Computational Biology  
The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA.  ...  Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme.  ...  Acknowledgments The authors thank our many colleagues in the Tyson and Sobral research groups for valuable discussions of the model. We especially thank Dr.  ... 
doi:10.1371/journal.pcbi.1000463 pmid:19680425 pmcid:PMC2714070 fatcat:igeondrq4vazjixnvk3vwqnpmq

Proteolysis dependent cell cycle regulation in Caulobacter crescentus

Nida I Fatima, Khalid Majid Fazili, Nowsheen Hamid Bhat
2022 Cell Division  
Also, the proteolytic pathways of its candidate proteins are reported to play significant roles in regulating cell cycle and protein quality control.  ...  AbstractCaulobacter crescentus, a Gram-negative alpha-proteobacterium, has surfaced as a powerful model system for unraveling molecular networks that control the bacterial cell cycle.  ...  The facilities extended by University of Kashmir, Srinagar are also acknowledged.  ... 
doi:10.1186/s13008-022-00078-z pmid:35365160 pmcid:PMC8973945 fatcat:dqbwsuw7xrgw7ebh6glsqchtm4

Morphological and functional asymmetry in α-proteobacteria

Régis Hallez, Anne-Flore Bellefontaine, Jean-Jacques Letesson, Xavier De Bolle
2004 Trends in Microbiology  
It coordinates the cell cycle with an asymmetric division, which is part of the adaptation of Caulobacter to poor-nutrient environments.  ...  In this bacterium, the response regulator CtrA, which belongs to a complex regulatory network, acts as a molecular switch that allows the coordination of cell cycle progression and morphogenesis by controlling  ...  We also thank the 'Unité Interfacultaire de Microscopie Electronique' of the University of Namur. Régis Hallez is holding a fellowship from the F.R.I.A.  ... 
doi:10.1016/j.tim.2004.06.002 pmid:15276611 fatcat:5hq5h64oyfbmjkbnjv4jnnd5ym

Cell cycle control of cell morphogenesis in Caulobacter

J England
2001 Current Opinion in Microbiology  
Work in our laboratory is funded by a Public Health Service Grant GM48147 from the National Institutes of Health and a grant from the National Science Foundation MCB-9986127.  ...  In contrast, for the aquatic bacterium Caulobacter crescentus, morphogenesis is an intrinsic part of the cell cycle, in which every cell division yields a motile swarmer cell and a sessile stalked cell  ...  Jenal U: Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control. FEMS Microbiol Rev 2000, 24:177-191. 8.  ... 
doi:10.1016/s1369-5274(01)00268-5 pmid:11731319 fatcat:ritt2nvaeragrdx7vokjhnxkim

Caulobacter crescentus

Velocity Hughes, Chao Jiang, Yves Brun
2012 Current Biology  
Figure 1 . 1 The dimorphic cell cycle and asymmetric division of Caulobacter crescentus.  ...  It features regulated changes in cell shape and surface adhesion within the context of a dimorphic cell cycle that culminates in asymmetric cell division ( Figure 1 ).  ... 
doi:10.1016/j.cub.2012.05.036 pmid:22789993 fatcat:remkao6okbadtgu7a7uj7ay4m4

Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division

Jiahe Li, Pengcheng Bu, Kai-Yuan Chen, Xiling Shen
2013 Journal of Biomedical Science and Engineering  
This insight may shed light on the presence of similar phospho-switches in stem cell asymmetric division regulation.  ...  During asymmetric cell division, protein cell fate determinants asymmetrically localize to the opposite poles of a dividing cell to cause distinct cell fate.  ...  Overview of asymmetric cell division and spatial perturbation of cell fate proteins in C. crescentus. (a) The spatial and temporal dynamics of cell fate proteins in the bacterial cell cycle.  ... 
doi:10.4236/jbise.2013.62017 pmid:25750689 pmcid:PMC4350780 fatcat:jej6h7fbpvahvn76npqqnzjl7y

A Genetic Oscillator and the Regulation of Cell Cycle Progression inCaulobacter crescentus

Sean Crosson, Harley McAdams, Lucy Shapiro
2004 Cell Cycle  
of a cell cycle.  ...  Analyses of cell polarity, division, and differentiation in prokaryotes have identified several regulatory proteins that exhibit dramatic changes in expression and spatial localization over the course  ...  CELL CYCLE PROGRESSION AND DIMORPHISM IN CAULOBACTER CRESCENTUS In C. crescentus, a tightly orchestrated signaling network controls asymmetric cell division yielding two developmentally-distinct daughter  ... 
doi:10.4161/cc.3.10.1181 pmid:15467452 fatcat:3zlhkvexzrhnzoiu6agayao5im

Spatial complexity of mechanisms controlling a bacterial cell cycle

Patrick H Viollier, Lucy Shapiro
2004 Current Opinion in Microbiology  
Acknowledgements We thank Zemer Gitai and Sean Murray for critical reading of the manuscript.  ...  Keiler KC, Shapiro L: tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation.  ...  Finally, asymmetric cell division yields the distinct swarmer cell and stalked cell progeny. Here, we review mechanisms that control the cell cycle and are spatially confined in a bacterial cell.  ... 
doi:10.1016/j.mib.2004.10.005 pmid:15556028 fatcat:rcabjb7scvcszeoldg3a7qstfe

Signal transduction mechanisms in Caulobacter crescentus development and cell cycle control

U Jenal
2000 FEMS Microbiology Reviews  
The life cycle of the aquatic bacterium Caulobacter crescentus includes an asymmetric cell division and an obligate cell differentiation.  ...  This has been confirmed by the recent identification of signal transduction mechanisms, which are involved in temporal and spatial control of both development and cell cycle.  ...  Acknowledgements I would like to thank members of my group for critical reading of the manuscript and for helpful comments.  ... 
doi:10.1016/s0168-6445(99)00035-2 pmid:10717313 fatcat:aqcft6b3tnhyjiylefou2hifci

Regulation of cell cycle events in asymmetrically dividing cells: functions required for DNA initiation and chain elongation in Caulobacter crescentus

M A Osley, A Newton
1978 Journal of Bacteriology  
To study the regulation of cell cycle events after asymmetric cell division in Caulobacter crescentus, we have identified functions that are required for DNA synthesis in the stalked cell produced at division  ...  The characteristic pattern of DNA synthesis in C. crescentus appears to be controlled in part by the expression of these functions in the two stalked cells at different times after cell division.  ...  To study the regulation of cell cycle events after asymmetric cell division in Caulobacter crescentus, we have identified functions that are required for DNA synthesis in the stalked cell produced at division  ... 
pmid:670147 pmcid:PMC224754 fatcat:246furo5m5ffdjzu6obj72beei

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle

Jared M. Schrader, Lucy Shapiro
2015 Journal of Visualized Experiments  
In bacteria, studies of the cell cycle have focused largely on unsynchronized cells making it difficult to order the temporal events required for cell cycle progression, genome replication, and division  ...  , and to identify the establishment of polar signaling complexes required for asymmetric cell division.  ...  Acknowledgements The authors thank members of the Shapiro lab and Erin Schrader for comments on the manuscript.  ... 
doi:10.3791/52633 pmid:25938623 pmcid:PMC4541484 fatcat:nzqzmvgm6jbubckqx4hl4btu7i

Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

M. Christen, H. D. Kulasekara, B. Christen, B. R. Kulasekara, L. R. Hoffman, S. I. Miller
2010 Science  
Asymmetrical distribution of c-di-GMP in the progeny correlated with the time of cell division and polarization for Caulobacter crescentus and Pseudomonas aeruginosa.  ...  The apparent role of c-di-GMP in the cell cycle and the presence of many paralogous DGC, PDE, and PilZ proteins controlling diverse cellular functions indicate that there is likely tight spatial and temporal  ... 
doi:10.1126/science.1188658 pmid:20522779 pmcid:PMC3906730 fatcat:bd6lje2epvbubpkqpmdurxh2ui

An intracellular compass spatially coordinates cell cycle modules in Caulobacter crescentus

Keren Lasker, Thomas H Mann, Lucy Shapiro
2016 Current Opinion in Microbiology  
In this perspective, we highlight recent discoveries in Caulobacter crescentus asymmetric cell division to illuminate diverse mechanisms by which a cellular compass, composed of scaffolding and signaling  ...  Regulated timing of these cellular modules stems from global genetic circuits that allow precise temporal activation with respect to cell cycle progression and cell differentiation.  ...  The timing of divisome assembly and disassembly is controlled transcriptionally and posttranslationally to ensure that cell division occurs only upon completion of chromosome replication and segregation  ... 
doi:10.1016/j.mib.2016.06.007 pmid:27517351 pmcid:PMC5069156 fatcat:msk4ppdwuresrkzvxivectcywe

Signal transduction mechanisms inCaulobacter crescentusdevelopment and cell cycle control

Urs Jenal
2000 FEMS Microbiology Reviews  
The life cycle of the aquatic bacterium Caulobacter crescentus includes an asymmetric cell division and an obligate cell differentiation.  ...  This has been confirmed by the recent identification of signal transduction mechanisms, which are involved in temporal and spatial control of both development and cell cycle.  ...  Acknowledgements I would like to thank members of my group for critical reading of the manuscript and for helpful comments.  ... 
doi:10.1111/j.1574-6976.2000.tb00538.x pmid:10717313 fatcat:2fncrkctjbe2rpvia5vvxdwupi

Regulation of cellular differentiation in Caulobacter crescentus

J W Gober, M V Marques
1995 Microbiological reviews  
In Caulobacter crescentus, asymmetry is generated in the predivisional cell, resulting in the formation of two distinct cell types upon cell division: a motile swarmer cell and a sessile stalked cell.  ...  The genes encoding the flagellum are expressed under cell cycle control predominantly in the predivisional cell type.  ...  Research in our laboratory is supported by Public Health Service grant GM48417 from the National Institutes of Health and a Junior Faculty Research Award (JFRA-466) from the American Cancer Society to  ... 
pmid:7708011 pmcid:PMC239353 fatcat:xf4kizetvnccdezo65eitibb3e
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