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Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review

Audrey P Fan, Hesamoddin Jahanian, Samantha J Holdsworth, Greg Zaharchuk
2016 Journal of Cerebral Blood Flow and Metabolism  
Although [ 15 O]-water has been used to study brain perfusion under normal and pathological conditions, it is not widely used in clinical settings due to the need for an on-site cyclotron, the invasive  ...  To date, the reference standard for cerebral blood flow measurements is considered to be positron emission tomography using injection of the [ 15 O]-water radiotracer.  ...  Declaration of conflicting interests The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr.  ... 
doi:10.1177/0271678x16636393 pmid:26945019 pmcid:PMC4853843 fatcat:kdn34nwrszbxpmqptf667puksq

A neuroradiologist's guide to arterial spin labeling MRI in clinical practice

M. Grade, J. A. Hernandez Tamames, F. B. Pizzini, E. Achten, X. Golay, M. Smits
2015 Neuroradiology  
In chronic cerebrovascular disease, the extent and severity of compromised cerebral perfusion can be visualised, which may be used to guide therapeutic or preventative intervention.  ...  In cerebrovascular disease, ASL is of particular interest owing to its quantitative nature and its capability to determine cerebral arterial territories.  ...  Acknowledgments This study is supported by the EU COST Action  ... 
doi:10.1007/s00234-015-1571-z pmid:26351201 pmcid:PMC4648972 fatcat:wbmxvor3pzdpjgs2jwh3z5c2ru

Abstracts

2012 Cerebrovascular Diseases  
attack est in the use of stroke imaging.  ...  Aim: In this work, we assess the use of susceptibility weighted Masafumi Ohtaki, Hiroshige Tsuda, Sounen Kin, phase imaging in three subject groups: normal (n = 5), sedation  ... 
doi:10.1159/000341759 pmid:22965283 fatcat:wixlchicxjh7plqfkkkqi65u7q

ECR 2015 Book of Abstracts - A - Postgraduate Educational Programme

2015 Insights into Imaging  
Both DSC and ASL can assess hypoperfusion and cerebrovascular reserve in chronic cerebrovascular disease.  ...  The normal distribution of radiotracers used in hybrid imaging technologies, such as PET/CT or PET/MRI, can vary due to a number of physiological, therapeutic, pathological and technical reasons.  ...  In this lecture, the principles and clinical significance of fractional flow reserve (FFR) and the technical background of FFR-CT will be reviewed.  ... 
doi:10.1007/s13244-015-0386-0 pmid:25708993 pmcid:PMC4349897 fatcat:m7eyvqcwojfpvf3lr5hy6dwjb4

ECR 2016 Book of Abstracts - A - Postgraduate Educational Programme

2016 Insights into Imaging  
Both DSC and ASL can assess hypoperfusion and cerebrovascular reserve in chronic cerebrovascular disease.  ...  The normal distribution of radiotracers used in hybrid imaging technologies, such as PET/CT or PET/MRI, can vary due to a number of physiological, therapeutic, pathological and technical reasons.  ...  In this lecture, the principles and clinical significance of fractional flow reserve (FFR) and the technical background of FFR-CT will be reviewed.  ... 
doi:10.1007/s13244-016-0474-9 pmid:26873353 pmcid:PMC4762839 fatcat:itxslbcacjhh3kixfkcwmdbt44

ECR 2013 Book of Abstracts - A - Postgraduate Educational Programme

2013 Insights into Imaging  
Both DSC and ASL can assess hypoperfusion and cerebrovascular reserve in chronic cerebrovascular disease.  ...  The normal distribution of radiotracers used in hybrid imaging technologies, such as PET/CT or PET/MRI, can vary due to a number of physiological, therapeutic, pathological and technical reasons.  ...  In this lecture, the principles and clinical significance of fractional flow reserve (FFR) and the technical background of FFR-CT will be reviewed.  ... 
doi:10.1007/s13244-013-0227-y pmid:23468009 pmcid:PMC3666656 fatcat:yitsk227mba2pl7wcypouf6tz4

ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme

2011 Insights into Imaging  
Both DSC and ASL can assess hypoperfusion and cerebrovascular reserve in chronic cerebrovascular disease.  ...  The normal distribution of radiotracers used in hybrid imaging technologies, such as PET/CT or PET/MRI, can vary due to a number of physiological, therapeutic, pathological and technical reasons.  ...  In this lecture, the principles and clinical significance of fractional flow reserve (FFR) and the technical background of FFR-CT will be reviewed.  ... 
doi:10.1007/s13244-011-0078-3 pmid:23100070 pmcid:PMC3533621 fatcat:qa3ln4hhvve2hhumgwwnmykgoe

Poster Viewing Session II

2017 Journal of Cerebral Blood Flow and Metabolism  
Hypoperfusion showed predominantly slow (<0.05 Hz) BOLD signal oscillations and was not identified using sICA or time shift analysis in the respiratory or cardiac frequency bands in any of the patients  ...  The spatial distributions of the power in the different frequency bands are also shown [3].  ...  Abstract Objectives: To investigate the feasibility of quantitative regional cerebral blood flow (rCBF) in healthy newborn subjects using PET with low-activity 15 O-water and an image derived input function  ... 
doi:10.1177/0271678x17695989 pmid:28366134 pmcid:PMC5441166 fatcat:no54qir44jemni3wacaipk5wxa

Oral Sessions. Thursday 28, May 2009

2009 Cerebrovascular Diseases  
people often ascribes cerebrovascular events to the experience of stress.  ...  We aimed to determine the proportion of people in primary care receiving secondary prevention measures.  ...  We validated CBF-, CBV-, MTTand rTTP-PWI on quantitative CBF measurement by 15O-water positron emission tomography (CBF-PET) with respect to penumbral flow (<20 ml/100g/min).  ... 
doi:10.1159/000221773 fatcat:spmsvafkifftze42l2loixdh64

ECR 2012 Book of Abstracts - A - Postergraduate Educational Programme

2012 Insights into Imaging  
Positron-emitting radionuclides for PET images, created in a cyclotron (18 F, 11C, 15O, 64Cu, 124I, 13N) or in a generator (68Ga), will be described.  ...  PET-MR produces images with excellent tissue contrast, dynamic and functional information. The simultaneous acquisition of PET and MR images allows temporary correction of dynamic PET studies.  ...  The choice between imaging techniques is often determined by local availability, expertise and technical details of these examinations which are also subject to considerable variation, which may affect  ... 
doi:10.1007/s13244-012-0153-4 pmid:22696127 pmcid:PMC3481066 fatcat:te6ctbtakzh5njsw43geghw3ta

Abstracts From the 4th World Stroke Congress

2000 Stroke  
Ependyma may be a good target of gene transfer to the brain. In the present study, we examined the effect of brain ischemia on adenovirusmediated gene transfer to the ependyma.  ...  Expression of the reporter gene at the lateral ventricle was scored semiquantitatively as 0 (null) to 3 (marked) at both hemispheres and averaged in 4 slices.  ...  We examined 34 patients with cerebrovascular disease using the ACZ-SPECT and PET.  ... 
doi:10.1161/01.str.31.11.2768 fatcat:xcy3ftmjq5djpfcczcpb4vgkh4

International TIA/ACVS Conference. Tokyo, Japan, November 15–16, 2013: Abstracts

2013 Cerebrovascular Diseases  
Cause of stroke was determined based on the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria.  ...  Furthermore, the timing of MRI can lead to under-detection of ischemic lesions using DWI.  ...  In order to clarify the mechanisms underlying the recurrence of subclinical lacunar infarcts, MR studies were carried out repeatedly in elderly subjects.  ... 
doi:10.1159/000356197 pmid:24247063 fatcat:ymnlju7rajgnbm6iuavqvrvbmq

Abstracts

2006 Cerebrovascular Diseases  
Statistical analysis was performed in both groups. The relationship between RLSh magnitude and stroke recurrence was determined through Cox regression analysis.  ...  Potentially, long term use of clopidogrel plus aspirin may lead to improvement in patient irrevocable adverse endpoints compared with aspirin alone.  ...  Using 15O-water PET, penumbral hypoperfusion was defined by CBF values below 20 ml/100g/min.  ... 
doi:10.1159/000093822 fatcat:zlkvlediy5ea3eepiunfetasjm

Abstracts

2019 Clinical Neuroradiology  
Conclusion: We report about a rare case of bilateral temporomesial polymicrogyria in a 28-year old female patient as cause for structural epilepsy.  ...  Quantitative Susceptibility Mapping (QSM) is a non-invasive alternative 1-2 to the gold standard 15O PET for measuring changes in the oxygenation and thus for studying such diseases in more detail.  ...  Clinical outcome was determined using modified Rankin Scale (mRS) score after 90 days. Edema formation was measured in admission and follow-up CT by net water uptake.  ... 
doi:10.1007/s00062-019-00826-9 fatcat:c6tdsym7jjc5dcduvvz7nxhcj4

Asia Pacific Stroke Conference 2016. Abstracts of the Annual Conference of theAsia Pacific Stroke Organization (APSO) Combined with Stroke Society of Australasia, Brisbane, Qld., Australia, July 14-17, 2016: Abstracts

2016 Cerebrovascular Diseases  
In this study we investigate the Gastrodia on the recovery of neurological function in rats of acute middle cerebral artery occlusion.  ...  This study aimed to determine the effect of SMART Arm training with or without outcome-triggered electrical stimulation compared with usual therapy in stroke survivors with subacute and severe arm disability  ...  Methods: 18F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using 15O-gas PET in 20 healthy subjects and 52 patients.  ... 
doi:10.1159/000447732 pmid:27409083 fatcat:npg6lu4kgzherj7oa5aaory3lq
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