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Electronic health record design and implementation for pharmacogenomics: a local perspective

Josh F. Peterson, Erica Bowton, Julie R. Field, Marc Beller, Jennifer Mitchell, Jonathan Schildcrout, William Gregg, Kevin Johnson, Jim N. Jirjis, Dan M. Roden, Jill M. Pulley, Josh C. Denny
2013 Genetics in Medicine  
Purpose-The design of electronic health records (EHR) to translate genomic medicine into clinical care is crucial to successful introduction of new genomic services, yet there are few published guides  ...  Methods-The design, implemented features, and evolution of a locally developed EHR that supports a large pharmacogenomics program at a tertiary care academic medical center was tracked over a 4-year development  ...  Its contents are solely the responsibility of the authors and do not necessarily represent official views of the Centers for Disease Control and Prevention or the National Institutes of Health.  ... 
doi:10.1038/gim.2013.109 pmid:24009000 pmcid:PMC3925979 fatcat:b434s65vtbczlitbmfhzhygi64

Multidisciplinary model to implement pharmacogenomics at the point of care

Pedro J. Caraballo, Lucy S. Hodge, Suzette J. Bielinski, A. Keith Stewart, Gianrico Farrugia, Cloann G. Schultz, Carolyn R. Rohrer-Vitek, Janet E. Olson, Jennifer L. St. Sauver, Veronique L. Roger, Mark A. Parkulo, Iftikhar J. Kullo (+4 others)
2016 Genetics in Medicine  
Purpose: Despite potential clinical benefits, implementation of pharmacogenomics (PGx) faces many technical and clinical challenges.  ...  Results : Between August 2012 and June 2015, 21 specific druggene interactions were reviewed and 18 of them were implemented in the electronic medical record as PGx-CDS interventions.  ...  ACKNOWLEDGMENTS We acknowledge the support of the Center for Individualized Medicine, the Clinical Decision Support Program, and the Office of Information and Knowledge Management of the Mayo Clinic.  ... 
doi:10.1038/gim.2016.120 pmid:27657685 pmcid:PMC5362352 fatcat:33vysgnaj5dvfk4fzrvenrpmxi

Integrating pharmacogenomics into electronic health records with clinical decision support

J. K. Hicks, H. M. Dunnenberger, K. F. Gumpper, C. E. Haidar, J. M. Hoffman
2016 American Journal of Health-System Pharmacy  
Informatics, especially clinical decision support (CDS) in the electronic health record (EHR), is a critical tool for the integration of pharmacogenomics into routine patient care.  ...  clinical decision support in the EHR.  ...  of pharmacogenomic orientated electronic health record (EHR) informatics, using computerized health records to maintain awareness of pharmacogenomic results to guide drug selection and dosing.  ... 
doi:10.2146/ajhp160030 pmid:27864204 pmcid:PMC5117634 fatcat:i2y4q3olg5bpzmrhbax2sgs3uy

Personalized medicine: challenges and opportunities for translational bioinformatics

Casey Lynnette Overby, Peter Tarczy-Hornoch
2013 Personalized Medicine  
Two US President's Council of Advisors on Science and Technology reports illustrate challenges in personalized medicine (in a 2008 report) and in use of health information technology (in a 2010 report)  ...  Translational bioinformatics is a field that can help address these challenges and is defined by the American Medical Informatics Association as "the development of storage, analytic and interpretive methods  ...  CL Overby was supported in part by Columbia University Training in Biomedical Informatics (NIH NLM T15 LM007079), the University of Washington Informatics research training grant (NIH NLM T15 LM07442)  ... 
doi:10.2217/pme.13.30 pmid:24039624 pmcid:PMC3770190 fatcat:6bafa4ln6jcdtdnjirdipstyui

Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good

Kristi Krebs, Lili Milani
2019 Human Genomics  
Despite the progress in the field of pharmacogenomics, its implementation into routine care has been slow due to several barriers.  ...  This review focuses on some of the challenges faced by these initiatives, the solutions and different approaches for testing that they suggest, and the evidence that they provide regarding the benefits  ...  Acknowledgements We appreciate the assistance of our colleagues, particularly Dr. Jana Lass, for carefully reading this manuscript and offering valuable advice.  ... 
doi:10.1186/s40246-019-0229-z pmid:31455423 pmcid:PMC6712791 fatcat:wcmfsltznzhyzm5eajjpzkgwoa

Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable

S. P. David, S. G. Johnson, A. C. Berger, W. G. Feero, S. F. Terry, L. A. Green, R. L. Phillips, G. S. Ginsburg
2015 Annals of Family Medicine  
Genomic medicine may have the greatest impact on health care if it is integrated into primary care, where most health care is received and where evidence supports the value of personalized medicine grounded  ...  national experience to implement genomic medicine in a patient-centered, learning health care system.  ...  , and Russell Glasgow, MS, PhD, from the University of Colorado, Denver, Colorado, for their thoughtful reviews and insights.  ... 
doi:10.1370/afm.1772 pmid:26195686 pmcid:PMC4508182 fatcat:pn2jdrdx7bcuvann6ugczr2lbq

Genomics and electronic health record systems

Lucila Ohno-Machado, Jihoon Kim, Rodney A Gabriel, Grace M Kuo, Michael A Hogarth
2018 Human Molecular Genetics  
Several reviews and case reports have described how information derived from the analysis of genomes are currently included in electronic health records (EHRs) for the purposes of supporting clinical decisions  ...  In addition, we include discussions on open issues and a vision for the next generation systems that integrate whole genome sequencing and EHRs in a seamless fashion.  ...  Introduction Genome analysis is relatively new to the practicing clinician, and thus its inclusion in electronic health records (EHRs) is not yet standardized.  ... 
doi:10.1093/hmg/ddy104 pmid:29741693 fatcat:72pc5zcxgbcihkp7wz5pov32me

The IGNITE network: a model for genomic medicine implementation and research

Kristin Wiisanen Weitzel, Madeline Alexander, Barbara A. Bernhardt, Neil Calman, David J. Carey, Larisa H. Cavallari, Julie R. Field, Diane Hauser, Heather A. Junkins, Phillip A. Levin, Kenneth Levy, Ebony B. Madden (+16 others)
2015 BMC Medical Genomics  
center, was established in 2013 to support the development, investigation and dissemination of genomic medicine practice models that seamlessly integrate genomic data into the electronic health record  ...  Methods: To address these challenges, the National Institutes of Health-funded IGNITE (Implementing GeNomics In pracTicE; www.ignite-genomics.org) Network, comprised of six projects and a coordinating  ...  of test results with the electronic health record (EHR) and clinical decision support (CDS) tools  ... 
doi:10.1186/s12920-015-0162-5 pmid:26729011 pmcid:PMC4700677 fatcat:cg3vi5onmbhjrjorcsp5gvzpne

Stakeholder engagement: a key component of integrating genomic information into electronic health records

Andrea Hartzler, Catherine A. McCarty, Luke V. Rasmussen, Marc S. Williams, Murray Brilliant, Erica A. Bowton, Ellen Wright Clayton, William A. Faucett, Kadija Ferryman, Julie R. Field, Stephanie M. Fullerton, Carol R. Horowitz (+6 others)
2013 Genetics in Medicine  
Integrating genomic information into clinical care and the electronic health record can facilitate personalized medicine through genetically guided clinical decision support.  ...  development of effective clinical decision support (CDS) tools within the electronic health record (EHR). 6, 7 Stakeholder engagement-involving those affected by changes in policy in the development of  ...  Integrating genomic information into clinical care and the electronic health record can facilitate personalized medicine through genetically guided clinical decision support.  ... 
doi:10.1038/gim.2013.127 pmid:24030437 pmcid:PMC3909653 fatcat:73b224qht5hshdayc7pensdjrq

Semantically enabling pharmacogenomic data for the realization of personalized medicine

Matthias Samwald, Adrien Coulet, Iker Huerga, Robert L Powers, Joanne S Luciano, Robert R Freimuth, Frederick Whipple, Elgar Pichler, Eric Prud'hommeaux, Michel Dumontier, M Scott Marshall
2012 Pharmacogenomics (London)  
A lack of actionable patient data in electronic health record systems (or lack of such systems altogether).  ...  and deployment of genetic data in clinical decision-making (established clinical rules that can be implemented in decision support systems).  ... 
doi:10.2217/pgs.11.179 pmid:22256869 pmcid:PMC3957334 fatcat:q7o2vfijn5hmlasoaskcjjopkq

Genomic Information for Clinicians in the Electronic Health Record: Lessons Learned From the Clinical Genome Resource Project and the Electronic Medical Records and Genomics Network

Marc S. Williams, Casey Overby Taylor, Nephi A. Walton, Scott R. Goehringer, Samuel Aronson, Robert R. Freimuth, Luke V. Rasmussen, Eric S. Hall, Cynthia A. Prows, Wendy K. Chung, Alexander Fedotov, Jordan Nestor (+5 others)
2019 Frontiers in Genetics  
Utilizing the electronic health record to present information to support the use of genomic medicine in clinical care to improve outcomes represents a tremendous opportunity.  ...  The electronic health record working groups of the Electronic Medical Records and Genomics (eMERGE) Network and the Clinical Genome Resource (ClinGen) project, along with other groups, have been defining  ...  1 Requirements, Available Standards, Challenges, and Resources to Support Clinician Education in the Electronic Health Record. eMERGE, Electronic Medical Records and Genomics Network; ClinGen, Clinical  ... 
doi:10.3389/fgene.2019.01059 pmid:31737042 pmcid:PMC6830110 fatcat:gclp4ndqlbddncpmxv5yelzauq

Challenges in Cardiovascular Pharmacogenomics Implementation: A viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy

E F Magavern, J C Kaski, R M Turner, H Drexel, A Janmohamed, A Scourfield, D Burrage, C N Floyd, E Adeyeye, J Tamargo, B S Lewis, Keld Per Kjeldsen (+9 others)
2021 European Heart Journal - Cardiovascular Pharmacotherapy  
Differences in healthcare delivery across Europe present a challenge, but also opportunities to collaborate on PGx implementation.  ...  It is important that widespread implementation serves to narrow rather than widen any existing gaps in health equality between populations.  ...  M.P. is an Emeritus NIHR Senior Investigator, and wishes to thank the MRC Centre for Drug Safety Science and Wolfson Centre for Personalised Medicine for infrastructure support.  ... 
doi:10.1093/ehjcvp/pvab063 pmid:34463331 fatcat:2r4ieamf3rcwrcqsceoqwrq7ca

Advances in Sharing Multi-sourced Health Data on Decision Support Science 2016-2017

Nick Anderson, Prabhu Shankar
2018 IMIA Yearbook of Medical Informatics  
Objective: Evaluate key advances and challenges of accessing, sharing, and managing data from multiple sources for development and implementation of Clinical Decision Support (CDS) systems in 2016-2017  ...  Conclusion: Partnerships with Electronic Health Record and commercial CDS vendors, policy makers, standards development agencies, clinicians, and patients are needed to see CDS deployed in the evolving  ...  Acknowledgments This work was supported in part by NCATS grant UL1TR001860 from the National Institutes of Health (USA).  ... 
doi:10.1055/s-0038-1641215 pmid:30157504 fatcat:4vekturoffhp7jdvbc7osqynyu

The impact of genomics on the future of medicine and health

John S Mattick, Marie A Dziadek, Bronwyn N Terrill, Warren Kaplan, Allan D Spigelman, Frank G Bowling, Marcel E Dinger
2014 Medical Journal of Australia  
part of a patient's electronic health record Components of a clinical decision support database for genomic medicine Global genome knowledge databasedata from experimental studies, clinical research  ...  Inevitably, personal genome sequences, likely obtained at birth, will become an integral part of a patient's electronic health record (EHR), where this information will be integrated with other clinical  ... 
doi:10.5694/mja13.10920 pmid:24999876 fatcat:ktzxievinzf6xonv7jcedpn43u

Empowering Mayo Clinic Individualized Medicine with Genomic Data Warehousing

Iain Horton, Yaxiong Lin, Gay Reed, Mathieu Wiepert, Steven Hart
2017 Journal of Personalized Medicine  
To address this need, the Center for Individualized Medicine at Mayo Clinic has implemented a genomic data warehouse and a workflow management system to bring data from institutional electronic health  ...  Individualized medicine enables better diagnoses and treatment decisions for patients and promotes research in understanding the molecular underpinnings of disease.  ...  Project Timeline TRC was first implemented at Mayo in 2012 ( Figure 1 .Figure 2 . 12 Mayo Clinic genomic data warehouse architecture. EHR: electronic health records VCF: Variant Call Format2.2.  ... 
doi:10.3390/jpm7030007 pmid:28829408 pmcid:PMC5618153 fatcat:es2rfye7bzha3g5btqaia6dr7q
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