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CORTICAL PLASTICITY AND ITS IMPLICATIONS FOR FOCAL HAND DYSTONIA

Robert Opavsky, Petr Hlustik, Petr Kanovsky
2006 Biomedical Papers of the Faculty of Medicine of Palacky University  
Conclusions: The emerging theory presumes that a maladaptive plasticity of brain cortex with abnormal sensorimotor intergration can evolve in predisposed individuals.  ...  English-language articles were identified using the following keywords: focal hand dystonia or writer's cramp and cortical plasticity, sensorimotor, imaging.  ...  With the help of PAS, significantly higher excitability of the motor cortex with a decreased specificity of individual finger representations was detected in patients with writer's cramp.  ... 
doi:10.5507/bp.2006.031 pmid:17426782 fatcat:jqqcpn24ujdlrbocdcduok4vba

Novel nonpharmacologic perspectives for the treatment of task-specific focal hand dystonia

Filippo Cogiamanian, Sergio Barbieri, Alberto Priori
2009 Journal of Hand Therapy  
.”° found improvement in dystonia using a sensorimotor retraining method designed specifically for patients with writer’s cramp.  ...  Siebner et al.*” evaluated the effect of low-frequency (1 Hz) stimulation of the primary motor cortex in 16 patients with writer’s cramp.  ... 
doi:10.1016/j.jht.2008.11.008 pmid:19278828 fatcat:qmbv4yrrbfdbffnskuh6fbs2ey

Sensory Abnormalities in Focal Hand Dystonia and Non-Invasive Brain Stimulation

Angelo Quartarone, Vincenzo Rizzo, Carmen Terranova, Demetrio Milardi, Daniele Bruschetta, Maria Felice Ghilardi, Paolo Girlanda
2014 Frontiers in Human Neuroscience  
of plasticity within somatosensory loop.  ...  These findings provide support for the role of excessive plasticity in FHD.  ...  Since, Stefan et al. (2000) have shown that plastic changes occur at the level of the motor cortex, our findings indicate an increased modifiability of the motor cortex in patients with writer's cramp  ... 
doi:10.3389/fnhum.2014.00956 pmid:25538594 pmcid:PMC4257013 fatcat:agae3pe7znfkfdhicrhohgdt7y

Somatosensory cortical remodelling after rehabilitation and clinical benefit of in writer's cramp

J. P. Bleton, M. Vidailhet, F. Bourdain, A. Ducorps, D. Schwartz, C. Delmaire, S. Lehericy, B. Renault, L. Garnero, S. Meunier
2010 Journal of Neurology, Neurosurgery and Psychiatry  
These authors contributed equally* ABSTRACT In order to explore the pathophysiological basis of a new rehabilitation therapy in writer's cramp (WC), healthy controls, untreated WC and WC who recovered  ...  In the cortex controlling the dystonic limb, the size of the hand representation in the trained patients was similar to that of healthy controls, and significantly different from that of untrained patients  ...  We are indebted to Drs Sangla and Trocello for patient recruitment and to Pr. Dormont for his help in MRI acquisitions.  ... 
doi:10.1136/jnnp.2009.192476 pmid:20562399 fatcat:tnqt3i47k5e6vjw7otckhakmye

Defective cerebellar control of cortical plasticity in writer's cramp

Cecile Hubsch, Emmanuel Roze, Traian Popa, Margherita Russo, Ammu Balachandran, Salini Pradeep, Florian Mueller, Vanessa Brochard, Angelo Quartarone, Bertrand Degos, Marie Vidailhet, Asha Kishore (+1 others)
2013 Brain  
The loss of cerebellar control over sensorimotor plasticity might also lead to building up an incorrect motor program to specific adaptation tasks such as writing.  ...  Cerebellum and writer's cramp Brain  ...  CR-ICM for their invaluable support with the experiments.  ... 
doi:10.1093/brain/awt147 pmid:23801734 pmcid:PMC3692031 fatcat:nhfayjq7qvdthhpar24pfg6mfi

Motor and Sensory Dysfunction in Musician's Dystonia

Florence C.F. Chang, Steven J. Frucht
2013 Current Neuropharmacology  
Musicians' dystonia is a task-specific and painless loss of motor control in a previously well-executed task. It is increasingly recognized in the medical and musical community.  ...  To date, a deranged cortical plasticity leading to abnormal sensorimotor integration, combined with reduced inhibition across several levels of the motor pathway are likely mechanisms.This paper reviews  ...  ACKNOWLEDGEMENTS We thank the Dystonia Medical Research Foundation and Glen Estrin for their untiring efforts to help musicians affected with dystonia over the last decade.  ... 
doi:10.2174/157015913804999531 pmid:23814536 pmcid:PMC3580790 fatcat:6fwxbxwucreprcoo2niwhkiuei

Reduced Motor Cortex Deactivation in Individuals Who Suffer from Writer's Cramp

Yi-Jhan Tseng, Rou-Shayn Chen, Wan-Yu Hsu, Fu-Jung Hsiao, Yung-Yang Lin, Robert Chen
2014 PLoS ONE  
In conclusion, a motor dependent dysregulation of the sensorimotor network seems to be involved in the functional impairment of patients with writer's cramp.  ...  This study investigated the neuromagnetic activities of self-paced finger lifting task and electrical median nerve stimulation in ten writer's cramp patients and fourteen control subjects.  ...  As writer's cramp is a task-specific dystonia, only writing or similar motor activities induces the symptoms.  ... 
doi:10.1371/journal.pone.0097561 pmid:24831291 pmcid:PMC4022529 fatcat:jsun6vdujna63hkt3qgim7a4ti

Silent event-related fMRI reveals deficient motor and enhanced somatosensory activation in orofacial dystonia

Christian Dresel, Bernhard Haslinger, Florian Castrop, Afra M. Wohlschlaeger, Andrés O. Ceballos-Baumann
2005 Brain  
We used a whistling task and silent event-related fMRI to investigate functional changes in patients with blepharospasm and patients with a combination of blepharospasm and oromandibular dystonia (Meige's  ...  Compared with healthy controls, both forms of orofacial dystonia had increased activation of bilateral somatosensory areas and the caudal supplementary motor area (SMA) in common.  ...  Ilg at the Department of Neurology for their help in recruiting patients and to the technical staff at the Department of Radiology for their assistance.  ... 
doi:10.1093/brain/awh665 pmid:16280353 fatcat:kmc54lzavjfxbamhxqmqf6flcq

Retuning the misfiring brain

R. J. Nudo
2003 Proceedings of the National Academy of Sciences of the United States of America  
This idea gained support from transcranial magnetic imaging studies of patients with dystonia demonstrating increased excitability in motor cortex (21) .  ...  Similar findings have been found in neuroimaging studies of somatosensory cortex in human subjects with focal hand dystonia (15, 16) .  ... 
doi:10.1073/pnas.1533210100 pmid:12810942 pmcid:PMC164600 fatcat:6u2ukblqljhstmeqfymz2qtwdu

Differences in Physical Characteristics and Response to Rehabilitation for Patients with Hand Dystonia: Musicians' Cramp Compared to Writers' Cramp

Alison L. McKenzie, Sarah Goldman, Cindy Barrango, Maria Shrime, Tricia Wong, Nancy Byl
2009 Journal of Hand Therapy  
Task-specific plasticity of somatosensory cortex in patients with writer’s cramp. Neuroimage. 2003;20:1329-38. . Byl N, Wilson F, Merzenich M, et al.  ...  Temporal discrimina- tion of two passive movements in writer’s cramp. Mov Dis- ord. 2006;21:1131-5. . Weise D, Schramm A, Stefan K, et al. The two sides of associa- tive plasticity in writer’s cramp.  ... 
doi:10.1016/j.jht.2008.12.006 pmid:19389604 fatcat:5vf4ya2um5ei3nbf7nlv4v7efi

Research Priorities in Limb and Task-Specific Dystonias

Sarah Pirio Richardson, Eckart Altenmüller, Katharine Alter, Ron L. Alterman, Robert Chen, Steven Frucht, Shinichi Furuya, Joseph Jankovic, H. A. Jinnah, Teresa J. Kimberley, Codrin Lungu, Joel S. Perlmutter (+2 others)
2017 Frontiers in Neurology  
In the limbs, focal dystonia can occur in either the upper or lower limbs and may be task-specific causing abnormal motor performance for only a specific task, such as in writer's cramp, runner's dystonia  ...  The pathophysiology of focal limb dystonia shares some commonalities with other dystonias with a loss of inhibition in the central nervous system and a loss of the normal regulation of plasticity, called  ...  In addition to examining motor cortical plasticity, studies have also measured somatosensory-evoked potentials and found increased LTP-like plasticity in the somatosensory cortex in patients with focal  ... 
doi:10.3389/fneur.2017.00170 pmid:28515706 pmcid:PMC5413505 fatcat:f6jazmmm5fehvjqqksfj5o4pa4

Dystonia Arising from Occupations: The Clinical Phenomenology and Therapy [chapter]

Criscely L., Raymond L.
2012 Dystonia - The Many Facets  
The task specific focal hand dystonia arising from occupations (i.e. occupational cramp) include variants like writer's cramp, musician's cramp and sports' cramp (e.g. golfer's cramp).  ...  Patients with writer's cramp may also benefit from training individual fingers not involved in the dystonia (38) (39) .  ... 
doi:10.5772/38957 fatcat:o4d36ljwwzebtebgu3t66g6uzq

The functional neuroanatomy of dystonia

Vladimir K. Neychev, Robert E. Gross, Stephane Lehéricy, Ellen J. Hess, H.A. Jinnah
2011 Neurobiology of Disease  
Transcranial stimulation methods that probe mechanisms of synaptic plasticity in the motor cortex show an abnormal modifiability of sensorimotor circuits in patients with writer's cramp, probably because  ...  Focal hand dystonia may be task specific, as is the case with writer's cramp. In early stages, task specificity can be so specific that it may be mistaken for a psychogenic movement disorder.  ...  In contrast, neither form of cTBS over PMd had any significant effect on MEPs, while cTBS600 increased effectiveness of SICI and RI and improved writing in patients with writer's cramp.  ... 
doi:10.1016/j.nbd.2011.01.026 pmid:21303695 pmcid:PMC3478782 fatcat:rjype3rmqbentfzvqvql2dtuhy

Changing the Brain through Therapy for Musicians' Hand Dystonia

V. CANDIA
2005 Annals of the New York Academy of Sciences  
Furthermore, we observed differences in abnormal tactile acuity between patients with musician's cramp and those with writer's cramp: Using twopoint finger discrimination, dystonic musicians showed perceptual  ...  asymmetry between hands, while writer's cramp patients did not.  ...  ), the National Institutes of Health (RO1MH60734, RO1EY12091, K24 RR018875), and the Goldberg Foundation.  ... 
doi:10.1196/annals.1360.028 pmid:16597783 fatcat:63t3hmxk6bfdjmakyds2i7onau

Is writer's cramp caused by a deficit of sensorimotor integration?

Thomas Schenk, Norbert Mai
2001 Experimental Brain Research  
We compared the grip force and handwriting performance of writer's cramp patients with that of control subjects and with that of a stroke patient suffering a purely somatosensory deficit of his dominant  ...  Writer's cramp is a highly specific movement disorder in which handwriting is impaired while most other manual skills are often unaffected.  ...  We wish to thank all patients and subjects who took part in the study. We also thank Ms. Judy Benson for copy-editing the manuscript.  ... 
doi:10.1007/s002210000599 pmid:11243474 fatcat:uad6j2ancrcrlkyxcknbweaede
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