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Hyperhidrosis
2009
Deutsches Ärzteblatt International
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Tanja Schlereth, Marianne Dieterich, Frank Birklein
SUMMARY
Background: Basically two types of sweating exist:
thermoregulatory and emotional sweating. ...
REVIEW ARTICLE
Hyperhidrosis-Causes and Treatment of Enhanced Sweating Tanja Schlereth, Marianne Dieterich, Frank Birklein FIGURE 1 1 FIGURE 1 Therapeutic algorithm for axillary hyperhidrosis (adapted ...
doi:10.3238/arztebl.2009.0032
pmid:19564960
pmcid:PMC2695293
fatcat:5qyogrmw7fbb3mzmxj5zfpknyi
Mast Cells
2012
Anesthesiology
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Tanja Schlereth, M.D., Frank Birklein, M.D., Ph.D., Department of Neurology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. schleret@uni-mainz.de
Fig. 1 . 1 Proposed ...
doi:10.1097/aln.0b013e31824bb143
pmid:22314295
fatcat:24chr5pghjgt5e6f4643thmzb4
Complex regional pain syndrome—significant progress in understanding
2015
Pain
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Schlereth · 156 (2015) S94-S103 PAIN ®
What do rodent models tell us? It is crucial to prove hypotheses in animal models. ...
Schlereth · 156 (2015) S94-S103 PAIN ® the implantation of an intrathecal pump for baclofen must be restricted to specialized centers. ...
doi:10.1097/01.j.pain.0000460344.54470.20
pmid:25789441
fatcat:xqj4mxtakzcqliyapafpd5dg4a
Inflammation in CRPS: Role of the sympathetic supply
2014
Autonomic Neuroscience: Basic & Clinical
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., 2004; A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT CGRP and SP -Schlereth et al. 6 et al., 2012) which constitute a major part of the cellular immune system in the skin and are an important ...
A small uncontrolled trial found improvement of pain by the use of phenoxybenzamine, which induces a noncompetitive
A C C E P T E D M A N U S C R I P T
ACCEPTED MANUSCRIPT CGRP and SP -Schlereth et ...
doi:10.1016/j.autneu.2013.12.011
pmid:24411269
fatcat:54osmxkjt5cdzaddq5nqgfhtii
Clonidine induces nitric oxide- and prostaglandin-mediated vasodilation in healthy human skin
2005
Journal of applied physiology
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Birklein. Clonidine induces nitric oxide-and prostaglandin-mediated vasodilation in healthy human skin. Sustained sympathetic activation not only leads to vasoconstriction but also might induce paradox vasodilation. This study was performed to explore whether and how ␣ 2-receptor stimulation mediates this vasodilation. We investigated 11 healthy subjects in 33 dermal microdialysis (MD) sessions. After nerve trunk blockade, MD fibers were inserted and perfused with physiological saline until
doi:10.1152/japplphysiol.00271.2005
pmid:16037407
fatcat:tiarbc6fircj7nwmtl2efkrfvi
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... trauma-related vasodilation subsided. Thereafter, fibers were perfused with either clonidine solutions (10 Ϫ3 , 5 ϫ 10 Ϫ4 , 10 Ϫ4 mol/l), N Gmonomethyl-l-arginine (L-NMMA; nitric oxide synthase blocker), acetylsalicylic acid (ASA; cyclooxygenase blocker), or combinations of these. Laser-Doppler scanning of the investigated skin revealed that clonidine not only induces vasoconstriction but subsequently also vasodilation with higher concentrations (P Ͻ 0.001). In contrast, both L-NMMA and ASA induced vasoconstriction (P Ͻ 0.001). By coapplication of 10 Ϫ3 mol/l clonidine with L-NMMA or ASA, vasodilation was partially prevented (P Ͻ 0.001). Our results demonstrate that sustained ␣ 2-receptor stimulation induces vasodilation in a dosedependent way, which is mediated by nitric oxide and prostaglandin mechanisms in human skin. dermal microdialysis; sympathetic nervous system; alpha-adrenoreceptors; laser-Doppler imaging
Development of a severity score for CRPS
2010
Pain
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The clinical diagnosis of Complex Regional Pain Syndrome (CRPS) is a dichotomous (yes/no) categorization necessary for clinical decision-making. However, such dichotomous diagnostic categories do not convey an individual's subtle and temporal gradations in severity of the condition, and have poor statistical power when used as an outcome measure in research. This study evaluated the validity and potential utility of a continuous type score to index severity of CRPS. Psychometric and medical
doi:10.1016/j.pain.2010.09.031
pmid:20965657
fatcat:mieuo54jzngsre6r3djx3tfvfi
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... uations were conducted in 114 CRPS patients and 41 non-CRPS neuropathic pain patients. Based on the presence/absence of 17 clinically-assessed signs and symptoms of CRPS, an overall CRPS Severity Score (CSS) was derived. The CSS discriminated well between CRPS and non-CRPS patients (p<.001), and displayed strong associations with dichotomous CRPS diagnoses using both IASP diagnostic criteria (Eta=0.69) and proposed revised criteria (Eta=0.77-0.88). Higher CSS was associated with significantly higher clinical pain intensity, distress, and functional impairments, as well as greater bilateral temperature asymmetry and thermal perception abnormalities (p's<.05). In an archival prospective dataset, increases in anxiety and depression from pre-surgical baseline to 4 weeks post-knee arthroplasty were found to predict significantly higher CSS at 6- and 12-month follow-up (p's<.05). Results indicate the CSS corresponds with and complements currently accepted dichotomous diagnostic criteria for CRPS, and support its validity as an index of CRPS severity. Its utility as an outcome measure in research studies is also suggested, with potential statistical advantages over dichotomous diagnostic criteria.
Guideline "diagnosis and non interventional therapy of neuropathic pain" of the German Society of Neurology (deutsche Gesellschaft für Neurologie)
2020
Neurological Research and Practice
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Schlereth Neurological Research and Practice(2020) 2:16 Page 6 of 19
Schlereth Neurological Research and Practice (2020) 2:16 Page 7 of 19
Schlereth Neurological Research and Practice(2020) 2 ...
:16
Schlereth Neurological Research and Practice(2020) 2:16 Page 9 of 19 ...
doi:10.1186/s42466-020-00063-3
pmid:33324922
pmcid:PMC7650069
fatcat:hixcfz6bjnf7ncfafqahyfpmra
Activation of Cutaneous Immune Responses in Complex Regional Pain Syndrome
2014
Journal of Pain
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The pathogenesis of complex regional pain syndrome (CRPS) is unresolved, but tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are elevated in experimental skin blister fluid from CRPS-affected limbs, as is tryptase, a marker for mast cells. In the rat fracture model of CRPS, exaggerated sensory and sympathetic neural signaling stimulate keratinocyte and mast cell proliferation, causing the local production of high levels of inflammatory cytokines leading to pain behavior. The
doi:10.1016/j.jpain.2014.01.490
pmid:24462502
pmcid:PMC4011956
fatcat:wipicp35ora2xdydkzp3mbvney
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... investigation used CRPS patient skin biopsies to determine whether keratinocyte and mast cell proliferation occur in CRPS skin and to identify the cellular source of the up-regulated TNF-α, IL-6, and tryptase observed in CRPS experimental skin blister fluid. Skin biopsies were collected from the affected skin and the contralateral mirror site in 55 CRPS patients and the biopsy sections were immunostained for keratinocyte, cell proliferation, mast cell markers, TNF-α, and IL-6. In early CRPS, keratinocytes were activated in the affected skin, resulting in proliferation, epidermal thickening, and up-regulated TNF-α and IL-6 expression. In chronic CRPS, there was reduced keratinocyte proliferation, leading to epidermal thinning in the affected skin. Acute CRPS patients also had increased mast cell accumulation in the affected skin, but there was no increase in mast cell numbers in chronic CRPS.
The Rodent Tibia Fracture Model: A Critical Review and Comparison With the Complex Regional Pain Syndrome Literature
2018
Journal of Pain
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Bruehl S, Maihofner C, Stanton-Hicks M, Perez RS, Vatine JJ, Brunner F, Birklein F, Schlereth T,
Mackey S, Mailis-Gagnon A, Livshitz A, Harden RN. ...
Birklein F, Drummond PD, Li W, Schlereth T, Albrecht N, Finch PM, Dawson LF, Clark JD,
Kingery WS. Activation of cutaneous immune responses in complex regional pain syndrome. ...
doi:10.1016/j.jpain.2018.03.018
pmid:29684510
pmcid:PMC6163066
fatcat:gwipndqupjgwxhqf4hui5sfnoi
Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome
2018
Journal of Neuroinflammation
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Both dysfunctional neuropeptide signaling and immune system activation are characteristic of complex regional pain syndrome (CRPS). Unknown is whether substance P (SP) or calcitonin gene-related peptide (CGRP) support autoantibody production and, consequently, nociceptive sensitization. Methods: These experiments involved the use of a well-characterized tibia fracture model of CRPS. Mice deficient in SP expression (Tac1 −/− ) and CGRP signaling (RAMP1 −/− ) were used to probe the neuropeptide
doi:10.1186/s12974-018-1145-1
pmid:29642930
pmcid:PMC5896028
fatcat:udxa4ce4hvealfdr6byra433iu
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... pendence of post-fracture sensitization and antibody production. The deposition of IgM in the spinal cord, sciatic nerves, and skin was followed using Western blotting, as was expression of the CRPS-related autoantigen cytokeratin 16 (Krt16). Passive serum transfer to B-cell-deficient muMT mice was used to assess the production of functional autoantibodies in CRPS model mice. The use of immunohistochemistry allowed us to assess neuropeptide-containing fiber distribution and Langerhans cell abundance in mouse and human CRPS patient skin, while Langerhans cell-deficient mice were used to assess the functional contributions of these cells. Results: Functional SP and CGRP signaling were required both for the full development of nociceptive sensitization after fracture and the deposition of IgM in skin and neural tissues. Furthermore, the passive transfer of serum from wildtype but not neuropeptide-deficient mice to fractured muMT mice caused enhanced allodynia and postural unweighting. Langerhans cells were increased in number in the skin of fracture mice and CRPS patients, and those increases in mice were reduced in neuropeptide signaling-deficient animals. Unexpectedly, Langerhans cell-deficient mice showed normal nociceptive sensitization after fracture. However, the increased expression of Krt16 after tibia fracture was not seen in neuropeptide-deficient mice. Conclusions: Collectively, these data support the hypothesis that neuropeptide signaling in the fracture limb of mice is required for autoantigenic IgM production and nociceptive sensitization. The mechanism may be related to neuropeptide-supported autoantigen expression.
Osteoprotegerin: A new biomarker for impaired bone metabolism in complex regional pain syndrome?
2014
Pain
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Osteoprotegerin (OPG) is important for bone remodeling and may contribute to complex regional pain syndrome (CRPS) pathophysiology. We aimed to assess the value of OPG as a biomarker for CRPS and a possible correlation with radiotracer uptake in 3-phase bone scintigraphy (TPBS). OPG levels were analyzed in 23 CRPS patients (17 women; mean age 50±9.0 years; disease duration: 12 weeks [IQR 8-24]), 10 controls (6 women; mean age 58±9.6 years) and 21 patients after uncomplicated fractures (12
doi:10.1016/j.pain.2014.01.014
pmid:24447513
fatcat:v2gwjlxdq5eshe2bowmeqks5ba
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... mean age: 43±15 years; time after fracture: 15 weeks [IQR: 6-22]). The CRPS and control patients also underwent TPBS. OPG in CRPS patients was significantly increased by comparison with both control groups (P=0.001; Kruskal-Wallis test; CRPS patients: 74.1 pg/mL [IQR: 47.1-100.7]; controls: 46.7 pg/mL [IQR: 35.5-55.0]; P=0.004; fracture patients: 45.9 pg/mL [IQR: 37.5-56.7]; P=0.001). As a diagnostic test for CRPS, OPG had a sensitivity of 0.74, specificity of 0.80, positive predictive value of 68% and negative predictive value of 84%. Receiver operating characteristic curve analysis showed an area under the curve of 0.80 (CI: 0.68-0.91). For the CRPS-affected hand, a significant correlation between OPG and TPBS region of interest analysis in phase III was detected (carpal bones; r=0.391; P=0.03). The persistent OPG increase in CRPS indicates enhanced osteoblastic activity shown by increased radiotracer uptake in TPBS phase III. A contribution of bone turnover to CRPS pathophysiology is likely. OPG might be useful as a biomarker for CRPS.
In vivorelease of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin
2006
British Journal of Pharmacology
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., 2003; Schlereth et al., 2005) . ...
Schlereth et alAcetylcholine release by dermal microdialysis ...
doi:10.1038/sj.bjp.0706451
pmid:16273117
pmcid:PMC1615863
fatcat:m4emgefh3fchxplxty37fp4vfq
Page 3769 of Psychological Abstracts Vol. 88, Issue 9
[page]
2001
Psychological Abstracts
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., 26219 Schlereth, Tanja , 26087 Schlicht, Christian, 28301 Schliebner, Scott D., 26355 Schmechel, Donald E., 2 Schmeidler, James, 2 Schmidt, Louis A., 26500 Schmidt, Lyle, 25918 Schmidt, Martin H., 27373 ...
Thank you to our reviewers 2016
2017
BMJ Open
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Grimes
Tammy Clifford
Tammy Hoffmann
Tania Huedo-Medina
Tania King
Tanja Roy
Tanja Schlereth
Tanya Murphy
Tara Gomes
Tara Mills
Tarang Sharma
Tasha Stanton
Tasneem Motiwala
Tatjana Rundek ...
doi:10.1136/bmjopen-2017-reviewers
fatcat:aq6ur6zrmvdm7irf2amzehyyey
Page 209 of Psychological Abstracts Vol. 88, Issue Author Index
[page]
Psychological Abstracts
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., 20548, 36720
Schlereth, Tanja , 26087
Schlesinger, Mark, 23962
Schlesinger, Matthew, 17036
Schlesser, Michael, 23860
Schlicht, Christian, 28301
Schlicht, Jeffrey
Schlichter, Lyanne, 1354
Schlidt, Andrea ...
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