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In this study, we conducted a stage loading consolidation test with varying load increment ratio and investigated its effect. By adjusting the primary consolidation ratio of one-dimensional consolidation analysis with secondary consolidation taken into account, it is possible to reproduce the consolidation amount-time curve affected by the load increment ratio.doi:10.1051/matecconf/201819202029 fatcat:3tj5zldtgfhjxohzktutr4g4mi
Various superconducting detector solenoids for particle physics have been developed in the world. The key technology is the aluminum-stabilized superconducting conductor for almost all the detector magnets in particle physics experiments. With the progress of the conductor, the coil fabrication technology has progressed as well, such as the inner coil winding technique, indirect cooling, transparent vacuum vessel, quench protection scheme using pure aluminum strips and so on. The detectorarXiv:2203.07799v1 fatcat:v43ocqmwmvcmzkpehmkm5g6nqm
more »... ids design study is in progress for future big projects in Japan and Europe, that is, ILC, FCC and CLIC, based on the technologies established over many years. The combination of good mechanical properties and keeping a high RRR is a key point for the development of Al-stabilized conductor. The present concern for the detector solenoid development is to have been gradually losing the key technologies and experiences, because large-scale detector magnets with Al-stabilized conductor has not been fabricated after the success of CMS and ATLAS-CS in LHC. Complementary efforts are needed to resume an equivalent level of expertise, to extend the effort on research and to develop these technologies and apply them to future detector magnet projects. Especially, further effort is necessary for the industrial technology of Al-stabilized superconductor production. The worldwide collaboration with relevant institutes and industries will be critically important to re-realize and validate the required performances. Some detector solenoids for mid-scale experiment wound with conventional copper-stabilized Nb-Ti conductor require precise control of magnetic field distribution. The development efforts are on-going in terms of the magnetic field design technology with high precision simulation, coil fabrication technology and control method of magnetic field distribution.
2006 IEEE Asian Solid-State Circuits Conference
This paper describes an 800-µW H.264 baselineprofile motion estimation processor for portable video applications. It features a VLSI-oriented block partitioning strategy, a reconfigurable SIMD/systolic-array datapath architecture and a power-efficient novel SRAM circuit with a segmentation-free and horizontal/vertical accessibility. The proposed architecture can reconfigure datapath to either an SIMD or systolic array depending on processing flow. The segmentation-free access means concurrentdoi:10.1109/asscc.2006.357861 fatcat:6ngo2bup2nfmhkbnqjdpyd3uuy
more »... cessibility to arbitrary consecutive pixels. The processor supports all the seven kinds of block modes, and can handle three reference frames for a VGA (640 × 480) 30-fps to QCIF (176 × 144) 15fps sequences with a quarter-pixel accuracy. It integrates 3.3 million transistors, and occupies 2.8 × 3.1 mm 2 in a 130-nm CMOS technology. The proposed processor achieves a power of 800 µW for QCIF 15-fps with one reference picture.
Donor organ damage caused by cold preservation is a major problem affecting liver transplantation. Cold preservation most easily damages liver sinusoidal endothelial cells (LSECs), and information about the molecules modulating LSECs function can provide the basis for new therapeutic strategies. Adrenomedullin (AM) is a peptide known to possess anti-apoptotic and anti-inflammatory properties. AM is abundant in vascular endothelial cells, but levels are comparatively low in liver, and little isdoi:10.1016/j.peptides.2010.01.011 pmid:20132855 fatcat:kuhnbnrbp5eg7dcstrc46xudde
more »... nown about its function there. In this study, we demonstrated both AM and its receptors are expressed in LSECs. AM treatment reduced LSECs loss and apoptosis under cold treatment. AM also downregulated cold-induced expression of TNF, IL1, IL6, ICAM1 and VCAM1. AM reduced apoptosis and expression of ICAM1 and VCAM1 in an in vivo liver model subjected to cold storage. Conversely, apoptosis was exacerbated in livers from AM and RAMP2 (AM receptor activity-modifying protein) knockout mice. These results suggest that AM expressed in LSECs exerts a protective effect against cold-organ damage through modulation of apoptosis and inflammation.
doi:10.1620/tjem.209.163 pmid:16707859 fatcat:wrzzr2rqurcunkt3yxbwf5i7wq
https://doi.org/10.1172/JCI33022. Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular diseases and in circulatory homeostasis. The high-affinity AM receptor is composed of receptor activity-modifying protein 2 or 3 (RAMP2 or -3) and the GPCR calcitonin receptorlike receptor. Testing our hypothesis that RAMP2 is a key determinant of the effects of AM on the vasculature, we generated and analyzed mice lacking RAMP2. Similar to AM -/embryos, RAMP2 -/embryos died indoi:10.1172/jci33022 pmid:18097473 pmcid:PMC2147670 fatcat:jyszxlgdnfh6xekhk7u2dywthi
more »... utero at midgestation due to vascular fragility that led to severe edema and hemorrhage. Vascular ECs in RAMP2 -/embryos were severely deformed and detached from the basement membrane. In addition, the abnormally thin arterial walls of these mice had a severe disruption of their typically multilayer structure. Expression of tight junction, adherence junction, and basement membrane molecules by ECs was diminished in RAMP2 -/embryos, leading to paracellular leakage and likely contributing to the severe edema observed. In adult RAMP2 +/mice, reduced RAMP2 expression led to vascular hyperpermeability and impaired neovascularization. Conversely, ECs overexpressing RAMP2 had enhanced capillary formation, firmer tight junctions, and reduced vascular permeability. Our findings in human cells and in mice demonstrate that RAMP2 is a key determinant of the effects of AM on the vasculature and is essential for angiogenesis and vascular integrity. Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular diseases and in circulatory homeostasis. The high-affinity AM receptor is composed of receptor activity-modifying protein 2 or 3 (RAMP2 or -3) and the GPCR calcitonin receptor-like receptor. Testing our hypothesis that RAMP2 is a key determinant of the effects of AM on the vasculature, we generated and analyzed mice lacking RAMP2. Similar to AM -/embryos, RAMP2 -/embryos died in utero at midgestation due to vascular fragility that led to severe edema and hemorrhage. Vascular ECs in RAMP2 -/embryos were severely deformed and detached from the basement membrane. In addition, the abnormally thin arterial walls of these mice had a severe disruption of their typically multilayer structure. Expression of tight junction, adherence junction, and basement membrane molecules by ECs was diminished in RAMP2 -/embryos, leading to paracellular leakage and likely contributing to the severe edema observed. In adult RAMP2 +/mice, reduced RAMP2 expression led to vascular hyperpermeability and impaired neovascularization. Conversely, ECs overexpressing RAMP2 had enhanced capillary formation, firmer tight junctions, and reduced vascular permeability. Our findings in human cells and in mice demonstrate that RAMP2 is a key determinant of the effects of AM on the vasculature and is essential for angiogenesis and vascular integrity. Results Generation of RAMP2-null mice. We initially analyzed the expression of AM and its related genes during midgestational development (E11.5-E14.5), Nonstandard abbreviations used: AGM, aorta-gonad-mesonephros; AM, adrenomedullin; CDN5, claudin 5; CGRP, calcitonin gene-related peptide; CRLR, calcitonin receptor-like receptor; RAMP, receptor activity-modifying protein; RAMP2O/E, RAMP2-overexpressing (cell); ZO-1, zona occludens-1. Conflict of interest: The authors have declared that no conflict of interest exists. Citation for this article:
For super-parallel video processing, we proposed a power-and area-efficient SRAM core architecture with a segmentation-free access, which means accessibility to arbitrary consecutive pixels, and horizontal/vertical access. To achieve these flexible accesses, a spirally-connected localwordline select signal and multi-selection scheme in wordlines are proposed, so that extra X-decoders in the conventional multi-division SRAM can be eliminated. Consequently, the proposed SRAM reduces an area anddoi:10.1109/vlsisoc.2006.313232 dblp:conf/vlsi/MiyakoshiMHIIKYM06 fatcat:7asthg5dyndbxm3l4lxgdv7odu
more »... wer by 69% and 59%, respectively, when it is applied to a 128 parallel architecture. The proposed 160-kbit SRAM with 16-read ports (eightdivision and 2-read port SRAM) is implemented to a search window buffer for an H.264 motion estimation processor core which dissipates 800 µW for QCIF 15-fps in a 130-nm technology.
This paper describes an H.264/AVC MP@L4.1 quarter-pel motion estimation processor core for a low power video encoder. It supports macro block adaptive frame field (MBAFF) encoding and bi-directional prediction for a resolution of 1920 × 1080 pixels at 30 fps which haven't been realized by conventional methods yet. The proposed processor consists of four modules for low power consumption: a module for an integer-pel motion estimation, a segmentation-free rectangle-access search window buffer, adoi:10.1109/icecs.2008.4675069 dblp:conf/icecsys/MizunoMMHIIYLKY08 fatcat:keat3ubfb5eu5alusabhy5oaou
more »... odule for quarter-pel motion estimation, and a module reducing candidate motion vectors. We propose an adaptive algorithm that reduces a workload and power in quarter-pel motion estimation. The algorithm and architecture for the candidate motion vectors reduction suppress a workload of the following process. The processor core has been designed in a 90 nm CMOS technology. The core size is 6.0 × 6.0 mm 2 . With this core, two reference frame can be handled, and 160.1 mW is consumed at 1.0 V. I.
Copyright: Takano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT A primary tumor can create a premetastatic niche in distant organs to facilitate the development of metastasis. The mechanism by which tumor cells communicate with host cells to develop premetastatic niches isdoi:10.18632/oncotarget.20009 pmid:29108252 pmcid:PMC5667985 fatcat:cqqwisytvvfgnor6oaujbs2cia
more »... ear. We focused on the role of microRNA (miR) signaling in promoting metastasis. Here, we identified miR-203 as a signaling molecule between tumors and monocytes in metastatic colorectal cancer (CRC) patients. Notably, high expression of serum exosomal miR-203, a major form in circulation, was associated with distant metastasis and an independent poor prognostic factor, whereas low expression in tumor tissues was a poor prognostic factor in CRC patients. We also found that exosomes carrying miR-203 from CRC cells were incorporated into monocytes and miR-203 could promote the expression of M2 markers in vitro, suggesting miR-203 promoted the differentiation of monocytes to M2-tumor-associated macrophages (TAMs). In a xenograft mouse model, miR-203transfected CRC cells developed more liver metastasis compared to control cells. In conclusion, serum exosomal miR-203 expression is a novel biomarker for predicting metastasis, possibly via promoting the differentiation of monocytes to M2-TAMs in CRC. Furthermore, we propose the concept of site-dependent functions for miR-203 in tumor progression.
This paper describes a sub 100-mW H.264/AVC MP@L4.1 integer-pel motion estimation processor core for a low power video encoder. It supports macro block adaptive frame field (MBAFF) encoding and bi-directional prediction for a resolution of 1920 × 1080 pixels at 30 fps which haven't been realized by conventional methods. The proposed processor core features a novel hierarchical algorithm, a reconfigurable ring-connected systolic array architecture, and a segmentationfree rectangle-accessdoi:10.1109/iscas.2008.4541551 dblp:conf/iscas/MurachiMMHIIYLKKY08 fatcat:amjzntjg6vhqzigrknv7z32hea
more »... arch window buffer. The processor core has been designed in a 90 nm CMOS technology, and its core size is 2.5 × 2.5 mm 2 . With one core, one reference frame can be handled, and 48 mW is consumed at 1 V. Two-core configuration dissipates 96 mW for two reference frames.
Liquid biomarkers for the early detection of resistance to chemotherapy are important for improving prognosis. This study investigated the usefulness of plasma exosomal microRNA-125b (ex-miRNA-125b) for the early detection of resistance to modified fluorouracil, leucovorin and oxaliplatin (mFOLFOX6)-based first-line chemotherapy in patients with advanced or recurrent (advanced/recurrent) colorectal cancer (CRC). First, ex-miRNAs associated with resistance to mFOLFOX6-based chemotherapy weredoi:10.3892/mco.2019.1911 pmid:31497299 pmcid:PMC6719252 fatcat:blglri5qabdbrgunrx7j4jupwi
more »... iled via miRNA microarray analysis. In this analysis, ex-miR-125b exhibited the greatest upregulation in patients with progressive disease (PD) compared with the findings for patients with stable disease (SD) and healthy controls. Next, another 55 patients with advanced/recurrent CRC who received mFOLFOX6-based first-line chemotherapy underwent a validation study of ex-miR-125b. Blood samples were collected before and during treatment until tumor progression. Ex-miRNA levels were measured via TaqMan microRNA assays. Patients with CRC had significantly higher ex-miR-125b levels than healthy controls. In patients with partial responses, ex-miR-125b levels at the Response Evaluation Criteria in Solid Tumors (RECIST) judgment point were significantly lower than those measured before treatment. In patients with SD, ex-miR-125b levels did not differ before and during treatment. In patients with PD, ex-miR-125b levels at the RECIST judgment point were significantly higher than those measured before treatment. These changes in ex-miR-125b levels were significantly different between groups even 1 month after the initiation of chemotherapy. Progression-free survival (PFS) was significantly worse in patients with high baseline ex-miR-125b levels than in those with low levels. In the Cox analysis, baseline ex-miR-125b levels and KRAS mutation were indicated to be independent prognostic factors for PFS. The present results suggest that plasma ex-miR-125b levels may be useful for the early detection of resistance to mFOLFOX6-based first-line chemotherapy. Furthermore, ex-miR-125b before chemotherapy is a predictive biomarker for PFS in patients with advanced/recurrent CRC.
The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)
The stability of the water surface movement mechanism of the water strider is higher than that of the ship etc. Moreover ,doi:10.1299/jsmermd.2006._2p1-a18_1 fatcat:r33lbeo3yrf5bfdaouzwcoryjq
The details of the postseismic displacement's spatiotemporal variation are presented in a companion paper by Iinuma et al. (2008) . ...doi:10.1186/bf03353140 fatcat:45dlnxp7zrdmbdpf44nusvsab4
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