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Home Polysomnography Reveals a First-Night Effect in Patients With Low Sleep Bruxism Activity
2018
Journal of Clinical Sleep Medicine (JCSM)
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Home PSG First Night Effect and Sleep Bruxism
T Miettinen, K Myllymaa, T Hukkanen, et al.Home PSG First Night Effect and Sleep Bruxism ...
57.4 14 28 F Yes 1.8 0.4 0.8 1.0 72.1 15 47 F Yes 0.2 0.5 1.0 0.6 71.3 16 41 F Yes 0.3 1.1 0.6 0.7 60.6
Journal of Clinical Sleep Medicine, Vol. 14, No. 8 August 15, 2018 T Miettinen, K Myllymaa, T Hukkanen ...
doi:10.5664/jcsm.7278
pmid:30092900
pmcid:PMC6086957
fatcat:m2z24lq5yng7tei2ohw35vnj7a
Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study
2016
PLoS ONE
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and Aims Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD). We tested whether second-harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) microscopy, detecting fibrillar collagen and fat in a label-free manner, might allow automated and sensitive quantification of early fibrosis in NAFLD. Methods We analyzed 32 surgical biopsies from patients covering histological fibrosis
doi:10.1371/journal.pone.0147804
pmid:26808140
pmcid:PMC4726624
fatcat:jitxrpr3ezeuppwksol6cwnbyi
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... es 0-4, using multimodal label-free microscopy. Native samples were visualized by SHG and CARS imaging for detecting fibrillar collagen and fat. Furthermore, we developed a method for quantitative assessment of early fibrosis using automated analysis of SHG signals. Results We found that the SHG mean signal intensity correlated well with fibrosis stage and the mean CARS signal intensity with liver fat. Little overlap in SHG signal intensities between fibrosis stages 0 and 1 was observed. A specific fibrillar SHG signal was detected in the liver parenchyma outside portal areas in all samples histologically classified as having no fibrosis. This signal correlated with immunohistochemical location of fibrillar collagens I and III. Conclusions This study demonstrates that label-free SHG imaging detects fibrillar collagen deposition in NAFLD more sensitively than routine histological staging and enables observer-independent quantification of early fibrosis in NAFLD with continuous grading.
Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups
2019
Sleep and Breathing
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To determine the accuracy of scoring masticatory muscle activity (MMA) events in seven different polysomnography (PSG) setups. Nineteen volunteers (13 females, 6 males, age 31.1 ± 12.9 years, 12 self-proclaimed bruxers) attended one-night PSG recording, supplemented with audio, video, and a separate frontal electroencephalography electrode set (FES). The same examiner scored the MMA events with seven different setups, with varying number of channels available: (1) one, (2) two, and (3) four EMG
doi:10.1007/s11325-019-01915-2
pmid:31402440
fatcat:syzev4rmpzfszkynrn3yekgsxe
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... channels, (4) PSG without audio or video (PSG-N), (5) home PSG with FES and audio (FES-A), (6) PSG with audio (PSG-A), and (7) PSG with audio and video (PSG-AV). A subset (n = 10) of recordings was scored twice to determine intra-scorer reliability. MMA indices and accuracy of scoring the events in different setups were compared against PSG-AV. The intra-class correlation coefficient (ICC) between PSG-AV and PSG-A was high (0.940, p < 0.001) as well as for FES-A (0.927, p < 0.001), whereas for PSG-N, it was lower (0.835, p < 0.001); for setups with only EMG channels, coefficients were very low (ICC < 0.100 for all). Intra-examiner reliability was high (ICC > 0.939 for all setups), with the exception of PSG-N (ICC = 0.764, p = 0.002). When comparing against the MMA events scored in PSG-AV, the sensitivity of MMA event recognition for PSG-A was 78.5% and specificity 95.5%, which were substantially higher than sensitivity (52.0%) and specificity (87.2%) of PSG-N. MMA event scoring accuracy with PSG-A or FES-A is almost comparable to PSG-AV. Since precise event recognition is essential for accurate MMA scoring, it is evident that one cannot rely exclusively on EMG.
Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress
2014
Redox Biology
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We thank Taina Vihavainen and Taija Hukkanen for the skillful technical assistance. ...
doi:10.1016/j.redox.2014.10.003
pmid:25462062
pmcid:PMC4225528
fatcat:ygai7xzgj5g7tmwkdfsbpi2cli
Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits
2012
PLoS ONE
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Satu Marttila, Taina Vihavainen and Taija Hukkanen provided skilful technical assistance.
Author Contributions ...
doi:10.1371/journal.pone.0051635
pmid:23284729
pmcid:PMC3524224
fatcat:yg2a6rlh4ncg7bwnaeqx34y56q
Common Genetic Variation in the IGF1 Associates with Maximal Force Output
2011
Medicine & Science in Sports & Exercise
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Satu Marttila, Taina Vihavainen, and Taija Hukkanen provided skillful technical assistance. Elina Kokkonen is thanked for the statistical assistance. The authors report no conflict of interest. ...
doi:10.1249/mss.0b013e3182220179
pmid:21552154
fatcat:j2ytutdunnhllaz2sfeitzyfsi
Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain
2009
Journal of applied physiology
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ACKNOWLEDGMENTS We thank Taija Hukkanen, Satu Marttila and Taina Vihavainen for technical assistance. ...
doi:10.1152/japplphysiol.91252.2008
pmid:19074570
fatcat:5rgjjdfltzbjfbgkfd5foz2qjy
Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils
[article]
2019
bioRxiv
pre-print
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We thank Mikko Kettunen and Kimmo Jokivarsi for help in MRI and Taina Vihavainen, Taija Hukkanen, Satu Marttila, Eija Rahunen, Shabana Azmy, Juha Niskanen for skillful technical help. ...
doi:10.1101/783704
fatcat:yr2o4zootjcwfcq2t32vbkrs7m
High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils
2020
Biological Procedures Online
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We thank Mikko Kettunen and Kimmo Jokivarsi for help in MRI and Taina Vihavainen, Taija Hukkanen, Satu Marttila, Eija Rahunen, Shabana Azmy, Juha Niskanen for skillful technical help. ...
doi:10.1186/s12575-020-00118-4
pmid:32190011
pmcid:PMC7073015
fatcat:76fmjifqhvbe7dmsfaqokfdxbe
SISÄLTÖ ESIPUHE 5 ASTE-PROJEKTI 7 TYÖPROSESSIEN KEHITTÄMINEN 12 Turun ammattikorkeakoulun raportteja 104 HOITOTYÖN KIRJAAMISEN KEHITTÄMINEN
unpublished
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Hankkeessa työelämän vastuuhenkilöinä toimivat hallintoylihoitaja Taina Soini ja ylihoitaja Minna Ylönen. ...
Hukkanen, E. & Vallimies-Patomäki, M. 2005. Yhteistyö ja työnjako hoitoon pääsyn turvaamisessa. Selvitys Kansallisen terveyshankkeen työnjakopiloteista. STM selvityksiä 2005:21
Price CP., St. ...
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