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Home Polysomnography Reveals a First-Night Effect in Patients With Low Sleep Bruxism Activity

Tomi Miettinen, Katja Myllymaa, Taina Hukkanen, Juha Töyräs, Kirsi Sipilä, Sami Myllymaa
2018 Journal of Clinical Sleep Medicine (JCSM)  
Home PSG First Night Effect and Sleep Bruxism T Miettinen, K Myllymaa, T Hukkanen, et al.Home PSG First Night Effect and Sleep Bruxism  ...  57.4 14 28 F Yes 1.8 0.4 0.8 1.0 72.1 15 47 F Yes 0.2 0.5 1.0 0.6 71.3 16 41 F Yes 0.3 1.1 0.6 0.7 60.6 Journal of Clinical Sleep Medicine, Vol. 14, No. 8 August 15, 2018 T Miettinen, K Myllymaa, T Hukkanen  ... 
doi:10.5664/jcsm.7278 pmid:30092900 pmcid:PMC6086957 fatcat:m2z24lq5yng7tei2ohw35vnj7a

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Juho Pirhonen, Johanna Arola, Sanja Sädevirta, Panu Luukkonen, Sanna-Maria Karppinen, Taina Pihlajaniemi, Antti Isomäki, Mika Hukkanen, Hannele Yki-Järvinen, Elina Ikonen, Irene Georgakoudi
2016 PLoS ONE  
and Aims Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD). We tested whether second-harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) microscopy, detecting fibrillar collagen and fat in a label-free manner, might allow automated and sensitive quantification of early fibrosis in NAFLD. Methods We analyzed 32 surgical biopsies from patients covering histological fibrosis
more » ... es 0-4, using multimodal label-free microscopy. Native samples were visualized by SHG and CARS imaging for detecting fibrillar collagen and fat. Furthermore, we developed a method for quantitative assessment of early fibrosis using automated analysis of SHG signals. Results We found that the SHG mean signal intensity correlated well with fibrosis stage and the mean CARS signal intensity with liver fat. Little overlap in SHG signal intensities between fibrosis stages 0 and 1 was observed. A specific fibrillar SHG signal was detected in the liver parenchyma outside portal areas in all samples histologically classified as having no fibrosis. This signal correlated with immunohistochemical location of fibrillar collagens I and III. Conclusions This study demonstrates that label-free SHG imaging detects fibrillar collagen deposition in NAFLD more sensitively than routine histological staging and enables observer-independent quantification of early fibrosis in NAFLD with continuous grading.
doi:10.1371/journal.pone.0147804 pmid:26808140 pmcid:PMC4726624 fatcat:jitxrpr3ezeuppwksol6cwnbyi

Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups

Tomi Miettinen, Katja Myllymaa, Anu Muraja-Murro, Susanna Westeren-Punnonen, Taina Hukkanen, Juha Töyräs, Reijo Lappalainen, Esa Mervaala, Kirsi Sipilä, Sami Myllymaa
2019 Sleep and Breathing  
To determine the accuracy of scoring masticatory muscle activity (MMA) events in seven different polysomnography (PSG) setups. Nineteen volunteers (13 females, 6 males, age 31.1 ± 12.9 years, 12 self-proclaimed bruxers) attended one-night PSG recording, supplemented with audio, video, and a separate frontal electroencephalography electrode set (FES). The same examiner scored the MMA events with seven different setups, with varying number of channels available: (1) one, (2) two, and (3) four EMG
more » ... channels, (4) PSG without audio or video (PSG-N), (5) home PSG with FES and audio (FES-A), (6) PSG with audio (PSG-A), and (7) PSG with audio and video (PSG-AV). A subset (n = 10) of recordings was scored twice to determine intra-scorer reliability. MMA indices and accuracy of scoring the events in different setups were compared against PSG-AV. The intra-class correlation coefficient (ICC) between PSG-AV and PSG-A was high (0.940, p < 0.001) as well as for FES-A (0.927, p < 0.001), whereas for PSG-N, it was lower (0.835, p < 0.001); for setups with only EMG channels, coefficients were very low (ICC < 0.100 for all). Intra-examiner reliability was high (ICC > 0.939 for all setups), with the exception of PSG-N (ICC = 0.764, p = 0.002). When comparing against the MMA events scored in PSG-AV, the sensitivity of MMA event recognition for PSG-A was 78.5% and specificity 95.5%, which were substantially higher than sensitivity (52.0%) and specificity (87.2%) of PSG-N. MMA event scoring accuracy with PSG-A or FES-A is almost comparable to PSG-AV. Since precise event recognition is essential for accurate MMA scoring, it is evident that one cannot rely exclusively on EMG.
doi:10.1007/s11325-019-01915-2 pmid:31402440 fatcat:syzev4rmpzfszkynrn3yekgsxe

Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

Niku K.J. Oksala, F. Güler Ekmekçi, Ergi Özsoy, Şerife Kirankaya, Tarja Kokkola, Güzin Emecen, Jani Lappalainen, Kai Kaarniranta, Mustafa Atalay
2014 Redox Biology  
We thank Taina Vihavainen and Taija Hukkanen for the skillful technical assistance.  ... 
doi:10.1016/j.redox.2014.10.003 pmid:25462062 pmcid:PMC4225528 fatcat:ygai7xzgj5g7tmwkdfsbpi2cli

Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits

Antti Huuskonen, Jani Lappalainen, Niku Oksala, Matti Santtila, Keijo Häkkinen, Heikki Kyröläinen, Mustafa Atalay, Alejandro Lucia
2012 PLoS ONE  
Satu Marttila, Taina Vihavainen and Taija Hukkanen provided skilful technical assistance. Author Contributions  ... 
doi:10.1371/journal.pone.0051635 pmid:23284729 pmcid:PMC3524224 fatcat:yg2a6rlh4ncg7bwnaeqx34y56q

Common Genetic Variation in the IGF1 Associates with Maximal Force Output

ANTTI HUUSKONEN, JANI LAPPALAINEN, NIKU OKSALA, MATTI SANTTILA, KEIJO HÄKKINEN, HEIKKI KYRÖLÄINEN, MUSTAFA ATALAY
2011 Medicine & Science in Sports & Exercise  
Satu Marttila, Taina Vihavainen, and Taija Hukkanen provided skillful technical assistance. Elina Kokkonen is thanked for the statistical assistance. The authors report no conflict of interest.  ... 
doi:10.1249/mss.0b013e3182220179 pmid:21552154 fatcat:j2ytutdunnhllaz2sfeitzyfsi

Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain

Zekine Lappalainen, Jani Lappalainen, Niku K. J. Oksala, David E. Laaksonen, Savita Khanna, Chandan K. Sen, Mustafa Atalay
2009 Journal of applied physiology  
ACKNOWLEDGMENTS We thank Taija Hukkanen, Satu Marttila and Taina Vihavainen for technical assistance.  ... 
doi:10.1152/japplphysiol.91252.2008 pmid:19074570 fatcat:5rgjjdfltzbjfbgkfd5foz2qjy

Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils [article]

Niina Aaltonen, Prosanta Singha, Hermina Jakupovic, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppanen, Kirsi Rilla, Markku Varjosalo, Laura Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kalvala (+3 others)
2019 bioRxiv   pre-print
We thank Mikko Kettunen and Kimmo Jokivarsi for help in MRI and Taina Vihavainen, Taija Hukkanen, Satu Marttila, Eija Rahunen, Shabana Azmy, Juha Niskanen for skillful technical help.  ... 
doi:10.1101/783704 fatcat:yr2o4zootjcwfcq2t32vbkrs7m

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kälvälä (+3 others)
2020 Biological Procedures Online  
We thank Mikko Kettunen and Kimmo Jokivarsi for help in MRI and Taina Vihavainen, Taija Hukkanen, Satu Marttila, Eija Rahunen, Shabana Azmy, Juha Niskanen for skillful technical help.  ... 
doi:10.1186/s12575-020-00118-4 pmid:32190011 pmcid:PMC7073015 fatcat:76fmjifqhvbe7dmsfaqokfdxbe

SISÄLTÖ ESIPUHE 5 ASTE-PROJEKTI 7 TYÖPROSESSIEN KEHITTÄMINEN 12 Turun ammattikorkeakoulun raportteja 104 HOITOTYÖN KIRJAAMISEN KEHITTÄMINEN

Marjale Von Schantz, Heini Toivonen, Kaija Lind, Työprosessien Kehittäminen, Hoitotyön Kirjaamisen Kehittäminen, Marjo Salmela, Johanna Ritvanen, Minna Ylönen, Raportoinnin Kehittäminen, Tiina Pelander, Soili Kirjonen, Työkäytänteiden Yhdenmukaistaminen Vierianalytiikan (+35 others)
unpublished
Hankkeessa työelämän vastuuhenkilöinä toimivat hallintoylihoitaja Taina Soini ja ylihoitaja Minna Ylönen.  ...  Hukkanen, E. & Vallimies-Patomäki, M. 2005. Yhteistyö ja työnjako hoitoon pääsyn turvaamisessa. Selvitys Kansallisen terveyshankkeen työnjakopiloteista. STM selvityksiä 2005:21 Price CP., St.  ... 
fatcat:cteo24wk4fajppd5eubrcnpfxu