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Microfluidic Applications of Artificial Cilia: Recent Progress, Demonstration, and Future Perspectives

Vignesh Sahadevan, Bivas Panigrahi, Chia-Yuan Chen
2022 Micromachines  
This review summarizes the importance and significance of the artificial cilia, delineates the recent progress in artificial cilia-based microfluidics toward microfluidic application, and provides future  ...  The presented knowledge and insights are envisaged to pave the way for innovative advances for the research communities in miniaturization.  ...  The proposed magnetic artificial cilia were fabricated using a tailored molding process.  ... 
doi:10.3390/mi13050735 pmid:35630202 pmcid:PMC9147031 fatcat:zbpowhmthraqnlxz5mu4gyqatq

Manipulation of zebrafish's orientation using artificial cilia in a microchannel with actively adaptive wall design

Karthick Mani, Tsung-Chun Chang Chien, Bivas Panigrahi, Chia-Yuan Chen
2016 Scientific Reports  
cilia actuation.  ...  For example, an entrapment device that is agarose-free was reported to position zebrafish in a predictable array using pipettes. Addition access  ...  (d) Top view of the photographed microchannel with an array of artificial cilia and SMA fixture. Figure 2 . 2 Figure 2.  ... 
doi:10.1038/srep36385 pmid:27821862 pmcid:PMC5099576 fatcat:nez4kcj6evhovbabtq6p6qtmcm

Harnessing synthetic cilia to regulate motion of microparticles

Hassan Masoud, Alexander Alexeev
2011 Soft Matter  
We use computer simulations to probe how nonmotile and actuated cilia can be harnessed to control the motion of microscopic particles suspended in a Newtonian fluid.  ...  Functional synthetic cilia lining solid surfaces could potentially yield a unique approach for regulating transport processes at interfaces.  ...  of artificial cilia for fluid pumping and mixing, whereas other potential applications of synthetic cilia in microfluidics still remain unexplored.  ... 
doi:10.1039/c1sm05423f fatcat:dv46zm3xmnhudbp5tqnks2pzse

Fabrication of x-ray absorption gratings via micro-casting for grating-based phase contrast imaging

Yaohu Lei, Yang Du, Ji Li, Zhigang Zhao, Xin Liu, Jinchuan Guo, Hanben Niu
2013 Journal of Micromechanics and Microengineering  
To develop this kind of absorption grating, an array with deep trenches was fabricated by photo-assisted electrochemical etching in a silicon wafer.  ...  The model accurately predicts the propagation delay dependence on actuation voltage of mechanically distinct relay designs.  ...  based on highly magnetic, flexible, high aspectratio, artificial cilia that are fabricated as individual micromixer elements or in arrays for improved mixing performance.  ... 
doi:10.1088/0960-1317/24/1/015007 fatcat:t3acvadwcrhsfcsxtxmefzyhda

Active micromixer based on artificial cilia

Vinayak V. Khatavkar, Patrick D. Anderson, Jaap M. J. den Toonder, Han E. H. Meijer
2007 Physics of Fluids  
The conceptual design consists of an array of individually addressable artificial cilia in the form of microactuators covering the channel wall.  ...  We propose a design for an active micromixer that is inspired by the motion of ciliated micro-organisms occurring in nature.  ...  We plan to mimic the above principle, albeit now for mixing, by covering the microchannel walls with arrays of individually addressable artificial cilia in the form of microactuators that are responsive  ... 
doi:10.1063/1.2762206 fatcat:gcxjrcokzrc33l6blwou24oydu

Biomimetic hair sensors: Utilizing the third dimension

Khalil Najafi
2012 2012 IEEE Sensors  
Hair-like actuators and passive structures are also used for thermal management, filtering, fluid flow control, etc.  ...  This paper discusses opportunities and approaches for developing hair-like biomimetic structures for sensing.  ...  For example, arrays of hair cilia used in the vestibular auditory system deflect in response to inertial forces.  ... 
doi:10.1109/icsens.2012.6411596 fatcat:fuv2wjaplrftpawjqsepsggcwu

Emergent Behaviors in a Bio-Inspired Platform Controlled by a Physical Cellular Automata Cluster

Tareq Assaf, Richard Mayne, Andrew Adamatzky, Chris Melhuish
2016 Biomimetics  
Acknowledgments: The authors would like to thank the Leverhulme Trust for funding this work (Grant number RPG-2013-345). Author Contributions: T. Assaf, R. Mayne, A. Adamatzky and C.  ...  a distributed multi-actuator-sensory array by merging CA control strategy and hardware effectors, inspired by the cilia of the unicellular protist Paramecium caudatum.  ...  Platform Actuation and Characteristics The effectors chosen to address the locomotion task, and mimic in a different scale domain the cilia, are paddles.  ... 
doi:10.3390/biomimetics1010005 fatcat:2g6sni447fbeno44nfb6aadavu

Stimulus-active polymer actuators for next-generation microfluidic devices

Wolfgang Hilber
2016 Applied Physics A: Materials Science & Processing  
Specifically devised actuators based on these materials may have the potential to facilitate integration significantly and hence increase the operational advantage for the end-user while retaining costeffectiveness  ...  ., polymers) for realization of microfluidic components, will make a significant contribution to the proclaimed growth of the LOC market.  ...  Acknowledgments The author wishes to express his deep gratitude professor Siegfried Bauer from the Soft Matter Physics Institute at the JKU Linz for his precious advices during the preparation process  ... 
doi:10.1007/s00339-016-0258-6 fatcat:czmcanbqjjb67clqufgnukabia

A single magnetic nanocomposite cilia force sensor

Ahmed Alfadhel, Mohammed Asadullah Khan, Susana Cardoso, Jurgen Kosel
2016 2016 IEEE Sensors Applications Symposium (SAS)  
The force sensor consists of a single bioinspired, permanent magnetic and highly elastic nanocomposite cilia integrated on a magnetic field sensing element.  ...  For example, instruments such as tweezers with sensitive force sensory heads could provide the ability to sense a variety of physical quantities in real time, such as the amount and direction of the force  ...  Magnetic nanocomposites in which magnetic beads [8] [9] [10] or nanowires (NWs) [7, [11] [12] [13] are included in the polymer matrix enable remote control for heating, actuation or sensing.  ... 
doi:10.1109/sas.2016.7479828 dblp:conf/sas2/AlfadhelKCK16 fatcat:xsp4ybokfjguzpibzjlpk2nkgi


Youssef Osama Elkhayat
2014 JES. Journal of Engineering Sciences  
Actuators It consists of an array of computer-controlled microactuators (Cilia) that are anchored to an elastic membrane.  ...  It consists of an array of computer-controlled actuators (Cilia) that are anchored to an elastic membrane. These actuators represent information by changing their physical orientation.  ... 
doi:10.21608/jesaun.2014.115027 fatcat:c7lblj2tnrcjpj4bpcra5wpdzi

Bioinspired Soft Robots Based on the Moisture‐Responsive Graphene Oxide

Yu‐Qing Liu, Zhao‐Di Chen, Dong‐Dong Han, Jiang‐Wei Mao, Jia‐Nan Ma, Yong‐Lai Zhang, Hong‐Bo Sun
2021 Advanced Science  
Graphene oxide (GO), which has many oxygen functional groups, is a promising candidate for use in moisture-responsive sensors and actuators due to the strong water-GO interaction and the ultrafast transport  ...  In the last 5 years, moisture-responsive actuators based on GO have shown distinct advantages over other stimuli-responsive materials and devices.  ...  [44, 62] For example, inspired by the respiratory cilia that can sweep tiny particles away to prevent bacterial accumulation, our group manufactured an artificial cilia array by assembling two kinds  ... 
doi:10.1002/advs.202002464 pmid:34026430 pmcid:PMC8132057 fatcat:olxoc6ec75bw7mfdmz2oijjcfq

Micropillar Arrays for High Sensitivity Sensors

Youngwoo Kim, Nakhiah Goulbourne
2014 Materials Research Society Symposium Proceedings  
array configured for capacitive pressure sensing (PDMS+ Au), b) closed micropillar array configured for actuation, c) open micropillar array for resistive flow sensing (conductive polymer + Au), d) closed  ...  configuration and intended performance. a) closed micropillar array configured for capacitive pressure sensing (PDMS+ Au), b) closed micropillar array configured for actuation, c) open micropillar array  ... 
doi:10.1557/opl.2014.788 fatcat:w74ufs44nne2dhyhptvltvtqbi

A concise review of microfluidic particle manipulation methods

Shuaizhong Zhang, Ye Wang, Patrick Onck, Jaap den Toonder
2020 Microfluidics and Nanofluidics  
cilia Not described by a specific formula: dependent on artificial cilia configuration and actuation dielectrophoresis.  ...  Following these, we review the recent developments in experimental works on artificial cilia for particle manipulation.  ... 
doi:10.1007/s10404-020-2328-5 fatcat:uknncr5ulvczzk4wisqvy44zre

Elastic Inflatable Actuators for Soft Robotic Applications

Benjamin Gorissen, Dominiek Reynaerts, Satoshi Konishi, Kazuhiro Yoshida, Joon-Wan Kim, Michael De Volder
2017 Advanced Materials  
out of stiff materials and much of the developments in the field have pursued ever more accurate and dynamic robots which thrive in industrial automation settings and will probably continue to do so for  ...  Central to the development of these robots is the fabrication of soft actuators to generate movement.  ...  Acknowledgement This research is supported by the Fund for Scientific Research-Flanders (FWO), and the European Research Council (ERC starting grant HIENA).  ... 
doi:10.1002/adma.201604977 pmid:28949425 fatcat:jdpvffhkybewhflsezifrkcun4

Micromachined biomimetic artificial haircell sensors

Chang Liu
2007 Bioinspiration & Biomimetics  
This paper discusses a number of strategies, using representative material systems, for building artificial haircell sensors and briefly outlines their fabrication method and performance.  ...  The motivation for imitating the biological haircell is also discussed to provide a background for this work.  ...  Acknowledgments The author wishes to thank the following funding agencies for cumulative support: NSF CAREER award, NASA, AFOSR (Bioinspired Concept program) and DARPA (Biological Sensory and Structure  ... 
doi:10.1088/1748-3182/2/4/s05 pmid:18037725 fatcat:twpnv5mkpzajragdmrip6qumem
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