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C-MAC Video Laryngoscope versus Conventional Direct Laryngoscopy for Endotracheal Intubation During Cardiopulmonary Resuscitation

Byeong Chul Min, Jong Eun Park, Gun Tak Lee, Tae Rim Kim, Hee Yoon, Won Chul Cha, Tae Gun Shin, Keun Jeong Song, Minsu Park, Heewon Han, Sung Yeon Hwang
2019 Medicina  
and objectives: To compare the first pass success (FPS) rate of the C-MAC video laryngoscope (C-MAC) and conventional Macintosh-type direct laryngoscopy (DL) during cardiopulmonary resuscitation (CPR) in the emergency department (ED). Materials and Methods: This study was a single-center, retrospective study conducted from April 2014 to July 2018. Patients were categorized into either the C-MAC or DL group, according to the device used on the first endotracheal intubation (ETI) attempt. The
more » ... ary outcome was the FPS rate. A multiple logistic regression model was developed to identify factors related to the FPS. Results: A total of 573 ETIs were performed. Of the eligible cases, 263 and 310 patients were assigned to the C-MAC and DL group, respectively. The overall FPS rate was 75% (n = 431/573). The FPS rate was higher in the C-MAC group than in the DL group, but there was no statistically significant difference (total n = 431, 79% compared to 72%, p = 0.075). In the multiple logistic regression analysis, the C-MAC use had higher FPS rate (adjusted odds ratio: 1.80; 95% CI, 1.17–2.77; p = 0.007) than that of the DL use. Conclusions: The C-MAC use on the first ETI attempt during cardiopulmonary resuscitation in the emergency department had a higher FPS rate than that of the DL use.
doi:10.3390/medicina55060225 pmid:31146497 pmcid:PMC6631212 fatcat:z3ygmtw62ncxbmf6mnuovskfpa

Assessment of intratumoral heterogeneity with mutations and gene expression profiles

Ji-Yong Sung, Hyun-Tae Shin, Kyung-Ah Sohn, Soo-Yong Shin, Woong-Yang Park, Je-Gun Joung, Ilya Ulasov
2019 PLoS ONE  
Author Contributions Conceptualization: Hyun-Tae Shin, Je-Gun Joung.  ... 
doi:10.1371/journal.pone.0219682 pmid:31310640 pmcid:PMC6634409 fatcat:hhecmoqr4rhvnclljvpqusgo2a

A Case ofChlamydia trachomatisPeritonitis Mimicking Tuberculous Peritonitis

Hwa Mi Kang, Tae Hoon Oh, Gun Hi Kang, Tae Joo Joen, Dong Dae Seo, Won Chang Shin, Won Choong Choi, Keun Ho Yang
2011 Korean Journal of Gastroenterology  
Lymphocytic ascites with low serum-ascites albumin gradient (SAAG) are observed mainly in tuberculous peritonitis, peritoneal carcinomatosis, and pancreatic disease. However, pelvic inflammatory disease (PID) induced generalized peritonitis causing diffuse ascites has been rarely described. We report a 26-year old female patient, who was diagnosed as generalized peritonitis with diffuse ascites due to Chlamydia trachomatis infection. Gynecologic examination did not show the clue of PID and in
more » ... e analysis of ascites, low SAAG, predominant lymphocyte count and high level of adenosine deaminase were noted. Although the best impression was tuberculous peritonitis on the base of these findings, the laparoscopic finding was consistent with PID and the PCR for C. trachomatis infection in cervical swab was positive. This case suggests that C. trachomatis peritonitis should be considered as a rare cause of low SAAG and lymphocytic ascites in sexually active women and should be intensively evaluated including laparoscopic examination. (Korean J Gastroenterol 2011;58:111-116)
doi:10.4166/kjg.2011.58.2.111 pmid:21873828 fatcat:3qjqkay6cfewlf26vxwdbtpfnq

Ketamine use for endotracheal intubation in severe sepsis and septic shock

Seok Woo Jo, Sung Yeon Hwang, Ik Joon Jo, Tae Rim Lee, Hee Yoon, Won Chul Cha, Min Seob Sim, Tae Gun Shin
2018 Signa Vitae  
Objective. We conducted this study to evaluate the clinical outcomes of patients with severe sepsis and septic shock who were treated with ketamine for endotracheal intubation. Methods. A single-center, retrospective study was carried out to compare the outcomes of patients with severe sepsis and septic shock who received a ketamine or non-ketamine agent for rapid sequence intubation (RSI). We analyzed the sepsis registry for adult patients who presented to the emergency department (ED), met
more » ... criteria for severe sepsis or septic shock, and underwent endotracheal intubation between August 2008 and March 2014. The primary outcome was 28-day mortality. We performed a multivariable logistic regression analysis to assess the association between ketamine use for intubation and 28-day mortality. Results. In all, 170 patients were intubated during the study period. Of the eligible patients, 95 received ketamine and 75 received a non-ketamine agent. The 28-day mortality of the ketamine group was not significantly different from that of the nonketamine group (38% vs. 40%, respectively, P=0.78). The unadjusted odds ratio (OR) of ketamine use for 28-day mortality was 0.92 (95% CI: 0.49-1.70, P=0.78). The association remained insignificant after adjusting for age, gender, malignancy, initial lactate level on ED admission, time to first antibiotic administration, Acute Physiology and Chronic Health Evaluation II score on admission day, and propensity score regarding ketamine use (adjusted OR: 1.09; 95% confidence interval [CI]: 0.49-2.40; P=0.84). Initial serum lactate on ED admission was the only significant predictive factor of 28-day mortality (adjusted OR: 1.23; 95% CI: 1.10-1.38; P<0.01). Conclusions. For patients with severe sepsis and septic shock who were intubated using RSI, we found no significant difference in 28-day mortality between those who received ketamine as a sedative agent and those who received alternative sedatives.
doi:10.22514/sv142.102018.3 fatcat:vdevikrvxvg27pruztjxz6mkz4

The Psychological Effects of a Campus Forest Therapy Program

Jin Gun Kim, Tae Gyu Khil, Youngsuwn Lim, Kyungja Park, Minja Shin, Won Sop Shin
2020 International Journal of Environmental Research and Public Health  
For the office workers, Shin et al. [33] reported that the two-day forest therapy program provided significantly positive changes in workers' job stress and moods.  ...  For example, Lee and Shin [35] reported that the forest therapy program, performed at a university campus forest using university students, provided significantly positive emotional improvement.  ... 
doi:10.3390/ijerph17103409 pmid:32422871 fatcat:c3zjd5irtzh5bgn6ot6xbxwqzi

Finger necrosis after accidental radial artery puncture

Jun Sik Kang, Tae Rim Lee, Won Chul Cha, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
2014 Clinical and Experimental Emergency Medicine  
Radial artery puncture, an invasive procedure, is frequently used for critical patients. Although considered safe, severe complications such as finger necrosis can occur. Herein, we review the clinical course of finger necrosis after accidental radial artery puncture. A 63-year-old woman visited the emergency department (ED) with left second and third finger pain after undergoing intravenous (IV) access in her wrist for procedural sedation. During the IV access, she experienced wrist pain,
more » ... increased during the 12 hours prior to her ED presentation. Emergency angiography revealed a pseudoaneurysm in her left radial artery and absence of blood flow to the proper palmar digital artery. Subsequent angiointervention and urokinase thrombolysis failed. The second finger was eventually amputated owing to gangrene. Radial artery puncture can occur accidentally during IV wrist access, resulting in severe morbidity. Providers should carefully examine the puncture site and collateral flow, followed by multiple examinations to ensure distal circulation. Clin Exp Emerg Med 2014;1(2):130-133 http://dx.
doi:10.15441/ceem.14.045 pmid:27752565 pmcid:PMC5052832 fatcat:kmowwxnehzddxfuhgewt7qegsy

Impact of Personal Protective Equipment on Out-of-Hospital Cardiac Arrest Resuscitation in Coronavirus Pandemic

Hye-Young Ko, Jong-Eun Park, Da-Un Jeong, Tae-Gun Shin, Min-Seob Sim, Ik-Joon Jo, Gun-Tak Lee, Sung-Yeon Hwang
2021 Medicina  
and Objectives: This retrospective study evaluated the clinical impact of enhanced personal protective equipment (PPE) on the clinical outcomes in patients with out-of-hospital cardiac arrest. Moreover, by focusing on the use of a powered air-purifying respirator (PAPR), we investigated the medical personnel's perceptions of wearing PAPR during cardiopulmonary resuscitation. Materials and Methods: According to the arrival time at the emergency department, the patients were categorized into a
more » ... ventional PPE group (1 August 2019 to 20 January 2020) and an enhanced PPE group (21 January 2020, to 31 August 2020). The primary outcomes of this analysis were the return of spontaneous circulation (ROSC) rate. Additionally, subjective perception of the medical staff regarding the effect of wearing enhanced PPE during cardiopulmonary resuscitation (CPR) was evaluated by conducting a survey. Results: This study included 130 out-of-hospital cardiac arrest (OHCA) patients, with 73 and 57 patients in the conventional and enhanced PPE groups, respectively. The median time intervals to first intubation and to report the first arterial blood gas analysis results were longer in the enhanced PPE group than in the conventional PPE group (3 min vs. 2 min; p = 0.020 and 8 min vs. 3 min; p < 0.001, respectively). However, there were no significant differences in the ROSC rate (odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.38–1.67; p = 0.542) and 1 month survival (OR 0.38, 95% CI: 0.07–2.10; p = 0.266) between the two groups. In total, 67 emergent department (ED) professionals responded to the questionnaire. Although a significant number of respondents experienced inconveniences with PAPR use, they agreed that PAPR was necessary during the CPR procedure for protection and reduction of infection transmission. Conclusion: The use of enhanced PPE, including PAPR, affected the performance of CPR to some extent but did not alter patient outcomes. PAPR use during the resuscitation of OHCA patients might positively impact the psychological stability of the medical staff.
doi:10.3390/medicina57121291 pmid:34946236 pmcid:PMC8708039 fatcat:mr66hs2u75gb7pd4ibmce6yyx4

Epidemiology and Outcome of Powered Mobility Device-Related Injuries in Korea

Yongho Shin, Won Cul Cha, Hee Yoon, Sung Yeon Hwang, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Taerim Kim
2020 Journal of Korean medical science  
Conceptualization: Shin Y, Cha WC, Kim T. Data curation: Shin Y, Yoon H, Hwang SY, Shin TG. Formal analysis: Kim T. Methodology: Cha WC. Resources: Shin TG, Sim MS, Jo IS.  ...  Writing -original draft: Shin Y. Writing -review & editing: Kim T. Fig. 2 . 2 Study selection graph for PMD-related injuries.  ... 
doi:10.3346/jkms.2020.35.e60 pmid:32141250 pmcid:PMC7061147 fatcat:jzzc7w6axnfdpilmrpoje77fii

Extracting regulatory modules from gene expression data by sequential pattern mining

Mingoo Kim, Hyunjung Shin, Tae Su Chung, Je-Gun Joung, Ju Han Kim
2011 BMC Genomics  
Identifying a regulatory module (RM), a bi-set of co-regulated genes and co-regulating conditions (or samples), has been an important challenge in functional genomics and bioinformatics. Given a microarray geneexpression matrix, biclustering has been the most common method for extracting RMs. Among biclustering methods, order-preserving biclustering by a sequential pattern mining technique has native advantage over the conventional biclustering approaches since it preserves the order of genes
more » ... r conditions) according to the magnitude of the expression value. However, previous sequential pattern mining-based biclustering has several weak points in that they can easily be computationally intractable in the real-size of microarray data and sensitive to inherent noise in the expression value.
doi:10.1186/1471-2164-12-s3-s5 pmid:22369275 pmcid:PMC3333188 fatcat:lrhcqct5gvf2xarqxwqaluckxm

Accuracy of the qSOFA Score and RED Sign in Predicting Critical Care Requirements in Patients with Suspected Infection in the Emergency Department: A Retrospective Observational Study

Jong Eun Park, Sung Yeon Hwang, Ik Joon Jo, Min Seob Sim, Won Chul Cha, Hee Yoon, Tae Rim Kim, Gun Tak Lee, Hye Seung Kim, InSuk Sohn, Tae Gun Shin
2020 Medicina  
and objectives: We aimed to compare the accuracy of positive quick sequential organ failure assessment (qSOFA) scores and the RED sign in predicting critical care requirements (CCRs) in patients with suspected infection who presented to the emergency department (ED). Materials and Methods: In this retrospective observational study, we examined adult patients with suspected infection in the ED from June 2018 to September 2018. A positive qSOFA (qSOFA+) was defined as the presence of ≥2 of the
more » ... lowing criteria: altered mental status (AMS), systolic blood pressure (SBP) < 100 mmHg, and respiratory rate (RR) ≥ 22 breaths/min. A positive RED sign (RED sign+) was defined as the presence of at least one of the RED sign criteria: AMS, skin mottling, SBP < 90 mmHg, heart rate >130 beats/min, or RR > 30 breaths/min. A qSOFA/RED+ was defined as the presence of qSOFA+ or RED+. We applied these tools twice using the initial values upon ED arrival and all values within 2 h after ED arrival. The accuracy of qSOFA+, RED+, and qSOFA/RED+ in predicting CCR was assessed. Results: Data from 5353 patients with suspected infection were analyzed. The area under the receiver operating characteristic curve (AUC) of RED+ (0.67, 95% confidence interval [CI]: 0.65–0.70) and that of qSOFA/RED+ (0.68, 95% CI: 0.66–0.70, p < 0.01) were higher than the AUC of qSOFA+ (0.59, 95% CI: 0.57–0.60) in predicting CCR on ED arrival. The qSOFA/RED+ within 2 h showed the highest accuracy (AUC 0.72, 95% CI: 0.70–0.75, p < 0.001). Conclusions: The accuracy of the RED sign in predicting CCR in patients with suspected infection who presented at ED was better than that of qSOFA. The combined use of the RED sign and qSOFA (positive qSOFA or RED sign) showed the highest accuracy.
doi:10.3390/medicina56010042 pmid:31963955 pmcid:PMC7022561 fatcat:7wef4ha5zjgcrfevjaep3fwdmu

Effect of typhoons on the Korean national emergency medical service system

Soo Hyun Park, Won Chul Cha, Giwoon Kim, Tae Rim Lee, Sung Yeon Hwang, Tae Gun Shin, Min Seob Sim, Ik Joon Jo
2018 Clinical and Experimental Emergency Medicine  
While the effect of typhoons on emergency medicine has been evaluated, data are scarce on their effects on the emergency medical service (EMS). This study evaluated the effect of typhoons on EMS patients and performance. The study period was January 2010 to December 2012. Meteorological data regarding typhoons were provided by the Korean Meteorological Administration. EMS data were retrieved from the EMS database of the national emergency management agency. The database includes ambulance run
more » ... eets, which contain clinical and operational data. In this case-crossover study, the cases and controls were EMS calls on the day of typhoon warnings and calls one week prior to the typhoon warnings, respectively. During the study period, 11 typhoons affected Korea. A total of 14,521 cases were selected for analysis. Overall, there were no obvious differences between the case and control groups. However, there were statistically significant differences in age, place, and time requests. There were fewer patients between 0 and 15 years of age (P=0.01) and more unconscious patients (P=0.01) in the case group. The EMS operational performance, as measured by the times elapsed between call to start, call to field, and call to hospital did not differ significantly. There was also no significant difference in the time from hospital arrival between the cases (28.67, standard deviation 16.37) and controls (28.97, standard deviation 28.91) (P=0.39). Typhoons did not significantly affect the EMS system in this study. Further study is necessary to understand the reasons for this finding.
doi:10.15441/ceem.17.255 pmid:30571906 pmcid:PMC6301860 fatcat:ej54jdr5k5f57a4cfkmxygtxvy

Epidemiological study of clonorchiasis and metagonimiasis along the Geum-gang (River) in Okcheon-gun (County), Korea

Gye-Sung Lee, In-Sung Cho, Young-Ha Lee, Hyung-Jun Noh, Dae-Whan Shin, Sok-Goo Lee, Tae-Yong Lee
2002 Korean Journal of Parasitology  
DISCUSSION Okcheon-gun lies in the Geum-gang (River) basin in Chungcheongbuk-do, Korea.  ...  In this study, C. sinensis-positive cases were given 3x25 mg/kg in one day at the Okcheon-gun Public Health Center.  ... 
doi:10.3347/kjp.2002.40.1.9 pmid:11949215 pmcid:PMC2721058 fatcat:oyqzut2nuzeexlpt23gvidkgue

Coronary angiography is related to improved clinical outcome of out-of-hospital cardiac arrest with initial non-shockable rhythm

Eunsil Ko, Ji Kyoung Shin, Won Chul Cha, Joo Hyun Park, Tae Rim Lee, Hee Yoon, Guntak Lee, Sung Yeon Hwang, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Joong Eui Rhee (+5 others)
2017 PLoS ONE  
Objective Coronary angiography (CAG) for survivors of out-of-hospital cardiac arrest (OHCA) enables early identification of coronary artery disease and revascularization, which might improve clinical outcome. However, little is known for the role of CAG in patients with initial nonshockable cardiac rhythm. Methods We investigated clinical outcomes of successfully resuscitated 670 adult OHCA patients who were transferred to 27 hospitals in Cardiac Arrest Pursuit Trial with Unique Registration
more » ... Epidemiologic Surveillance (CAPTURES), a Korean nationwide multicenter registry. The primary outcome was 30-day survival with good neurological outcome. Propensity score matching and inverse probability of treatment weighting analyses were performed to account for indication bias. Results A total of 401 (60%) patients showed initial non-shockable rhythm. CAG was performed only in 13% of patients with non-shockable rhythm (53 out of 401 patients), whereas more than half of patients with shockable rhythm (149 out of 269 patients, 55%). Clinical outcome of patients who underwent CAG was superior to patients without CAG in both non-shockable (hazard ratio (HR) = 3.6, 95% confidence interval (CI) = 2.5-5.2) and shockable rhythm (HR = 3.7, 95% CI = 2.5-5.4, p < 0.001, all). Further analysis after propensity score matching or inverse probability of treatment weighting showed consistent findings (HR ranged from 2.0 to 3.2, p < 0.001, all).
doi:10.1371/journal.pone.0189442 pmid:29287074 pmcid:PMC5747431 fatcat:tm6pxzn6sjep7er3rag7rlvo5m

Inhibition of Herpesvirus-6B RNA Replication by Short Interference RNAs

Jong-Sub Yoon, Sun-Hwa Kim, Min-Chul Shin, Dong-Gun Lee, Seong-Karp Hong, Yong-Tae Jung, In-Gu Khang, Wan-Shik Shin, Chun-Choo Kim, Soon-Young Paik
2004 BMB Reports  
RNA interference (RNAi) is a process of sequence-specific gene silencing, which is initiated by double-stranded RNA (dsRNA). RNAi may also serve as an antiviral system in vertebrates. This study describes the inhibition of herpesvirus-6B (HHV-6B) replication by short interference RNAs (siRNAs) that are targeted to the U38 sequence that encodes DNA polymerase. When virusinfected SupT1 cells were treated by siRNA, these cells blocked the cytopathic effect (CPE) and detected the HHV-6B
more » ... ative in indirect immunofluorescence assays (IFA). Our result suggests that RNAi can efficiently block Herpesvirus-6B replication.
doi:10.5483/bmbrep.2004.37.3.383 pmid:15469723 fatcat:pssby2v56faa7pnrbwrpk7dibi

Posterolateral Fusion for Unstable Thoracolumbar Junction

Se-Ang Chang, Hong-Tae Kim, Seong-Gun Moon, Dong-Ju Shin, Jin-Seok Lee
2003 Journal of Korean Society of Spine Surgery  
후방도달 04) Bradford DS and Mcbride GG : Surgical management 술을 통한 단분절 유합술로도 좋은 결과를 얻을 수 있다 Shin JH and Na CO : Survival analysis of posterior short 추체간유합술은 척수원추를 손상시킬 위험성이 많아서 of thoracolumbar spine fractures  ... 
doi:10.4184/jkss.2003.10.2.90 fatcat:6q7yt24mavgdjmcaqjg5zt7j3i
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