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TRANSPATH â is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. ... The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. ... To start coping with these data and as a basis for the modeling of pathological aberrations of signaling pathways we developed PathoSign, a relational database which collects information about pathologically ...doi:10.1093/nar/gkj107 pmid:16381929 pmcid:PMC1347469 fatcat:nsibv3dy6vfcniy2okxfpcfsge
EndoNet is a new database that provides information 10 about the components of endocrine networks and their relations. ... a network can be reconstructed and visualized. ... such as metabolic and signaling pathways. ...doi:10.1093/nar/gkj121 pmid:16381928 pmcid:PMC1347483 fatcat:7bn4ixyzl5a6hjhjspnvrdqfqa
Trends in glycoscience and glycotechnology
A short description of the individual database modules and the associated programs as well as an outlook to future perspectives is given. ... Associated with these data resources are several programs enabling the user to apply these data contents onto user-specific problems. ... We have implemented this system (TRANSPATH) as an object-oriented database system from which whole pathways can be retrieved and visualized using an XML intermediate. ...doi:10.4052/tigg.12.255 fatcat:t343pbenhfa33c2bqlocadhipy
For the detection of alternative splicing a new method based on an information theoretic concept is introduced to the field of gene expression analysis. ... For biomedical research it is of major interest to identify the activity of genes in specific tissues of an organism. ... Not only he offered me a motivating topic, but competently lead me into computational biology, a dynamic field of science at the interface between mathematics, biology and computer science. ...doi:10.17169/refubium-14074 fatcat:2ewta4zwjnfkffiawob57s52ay
I propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. ... Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated ... UniProt ID is a unique identier for each protein assigned by UniProt database, a resource for protein sequence and functional information  . ...doi:10.18453/rosdok_id00002554 fatcat:7qh6x3qrrzg77omjs767bpwhri