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Resolving relaxometry and diffusion properties within the same voxel in the presence of crossing fibres by combining inversion recovery and diffusion-weighted acquisitions

Silvia De Santis, Daniel Barazany, Derek K. Jones, Yaniv Assaf
2015 Magnetic Resonance in Medicine  
Methods: We demonstrate the method through simulations, in a crossing fibres phantom, in fixed brains and in vivo.  ...  Conclusion: The ability to extract fibre-specific relaxometry properties will provide enhanced specificity and, therefore, sensitivity to differences in white matter architecture, which will be invaluable  ...  This could explain the hyperintensity in the T1 maps of population B of Figure 8 .  ... 
doi:10.1002/mrm.25644 pmid:25735538 pmcid:PMC4737246 fatcat:s2lrlsyxtbbgvhhtjgnlvmwnxy

Why diffusion tensor MRI does well only some of the time: Variance and covariance of white matter tissue microstructure attributes in the living human brain

Silvia De Santis, Mark Drakesmith, Sonya Bells, Yaniv Assaf, Derek K. Jones
2014 NeuroImage  
a r t i c l e i n f o Fundamental to increasing our understanding of the role of white matter microstructure in normal/abnormal function in the living human is the development of MR-based metrics that  ...  Characterising the fibre architectural complexity (in terms of number of fibre populations in a voxel) provides clear insights into correlation/lack of correlation between the different metrics and explains  ...  This work was funded by the EU-FP7 FET programme of the European Commission which supported the CONNECT consortium.  ... 
doi:10.1016/j.neuroimage.2013.12.003 pmid:24342225 pmcid:PMC3988851 fatcat:zqcbyhcyufewvewebd6zuwense

Observation of angular dependence of T1 in the human white matter at 3T

Michael J. Knight, Robin A. Damion, Risto A. Kauppinen
2018 Biomedical Spectroscopy and Imaging  
We have quantified T1 in the human white mater (WM) together with diffusion tensor imaging to study a possible relationship between water T1, diffusional fractional anisotropy (FA) and fibre-to-field angle  ...  The current data point to fibre-to-field-angle dependent T1 relaxation in WM as an indication of effects of microstructure on the longitudinal relaxation of water.  ...  Therefore, angular dependency of T1 in WM may provide information complementary to coherence lifetime anisotropy, which may expand the combined use T1 relaxometry and DTI beyond solving the crossing fibre  ... 
doi:10.3233/bsi-180183 pmid:30931248 pmcid:PMC6436728 fatcat:cx3z45k5anddnanegzvvg7ijv4

Multi-compartment diffusion MRI, T2 relaxometry and myelin water imaging as neuroimaging descriptors for anomalous tissue detection [article]

Elda Fischi-Gomez and Jonathan Rafael-Patino and Marco Pizzolato and Gian Franco Piredda and Tom Hilbert and Tobias Kober and Erick J. Canales-Rodriguez and Jean-Philippe Thiran
2021 arXiv   pre-print
Conventional MRI techniques such as T1-weighted and T2-weighted scans are generally used in the diagnosis and prognosis of the disease.  ...  In this work, we have combined tissue microstructure information derived from multicompartment diffusion MRI and T2 relaxometry models to explore the voxel-based prediction power of a machine learning  ...  grant 754462 to MP, the Swiss National Science Foundation grant PZ00P2 185814/1 to EJC-R and the Centre for Biomedical Imaging of the University of Lausanne, the Swiss Federal Institute of Technology  ... 
arXiv:2104.07502v1 fatcat:ylzpodfbmzhdxas2osr3kqiuwq

A review of the use of magnetic resonance imaging in Parkinson's disease

Nadya Pyatigorskaya, Cécile Gallea, Daniel Garcia-Lorenzo, Marie Vidailhet, Stéphane Lehericy
2013 Therapeutic Advances in Neurological Disorders  
The most well-developed MRI markers in PD include diffusion imaging and iron load using T2/T2* relaxometry techniques.  ...  However, major advances have occurred in the development of magnetic resonance imaging (MRI) biomarkers for PD in the past decade.  ...  Damier, P., Hirsch, E., Agid, Y. and Graybiel, A. (1999) The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 122: 1437-1448.  ... 
doi:10.1177/1756285613511507 pmid:25002908 pmcid:PMC4082302 fatcat:bxgvmd2eqbay5bjce6trzngy5a

Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology

Alberto Lazari, Ilona Lipp
2021 NeuroImage  
Recent years have seen an increased understanding of the importance of myelination in healthy brain function and neuropsychiatric diseases.  ...  We also share a set of 12 recommendations for future studies validating putative MR-based myelin markers and deploying them in vivo in humans.  ...  Supplementary material Supplementary material associated with this article can be found, in the online version, at 10.1016/j.neuroimage.2021.117744 .  ... 
doi:10.1016/j.neuroimage.2021.117744 pmid:33524576 fatcat:jnudmjtbmrad3drvqyflmdepji

Post-processing of structural MRI for individualized diagnostics

Pascal Martin, Benjamin Bender, Niels K Focke
2015 Quantitative Imaging in Medicine and Surgery  
Among several post-processing methods voxel-based morphometry (VBM) of T1- and T2-weighted sequences and T2 relaxometry are routinely applied in pre-surgical diagnostics of cryptogenic epilepsy in epilepsy  ...  context of the multi-modal evaluation of epilepsy patients.  ...  MR-relaxometry Relaxometry describes the quantitative measurement of relaxation times in the brain (usually T1 and/or T2).  ... 
doi:10.3978/j.issn.2223-4292.2015.01.10 pmid:25853079 pmcid:PMC4379317 fatcat:jdbw3hbxsffyloxur7xw4wir6m

Towards multimodal atlases of the human brain

Arthur W. Toga, Paul M. Thompson, Susumu Mori, Katrin Amunts, Karl Zilles
2006 Nature Reviews Neuroscience  
Atlases of the human brain have an important impact on neuroscience.  ...  These integrative approaches have provided significant impetus for the human brain mapping initiatives, and have important applications in health and disease.  ...  , the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke, and by Human Brain Project grants to the International Consortium for Brain Mapping, funded  ... 
doi:10.1038/nrn2012 pmid:17115077 pmcid:PMC3113553 fatcat:vb3kvw2wrjbahd67546jgvxtky

Estimating axon conduction velocity in vivo from microstructural MRI

Mark Drakesmith, Robbert Harms, Suryanarayana Umesh Rudrapatna, Greg D. Parker, C. John Evans, Derek K. Jones
2019 NeuroImage  
In conclusion, we demonstrate accurate CV estimates are possible in regions of the brain where AD is sufficiently large.  ...  The results show that errors in the AVF have the biggest detrimental impact on estimates of CV, particularly for sparse fibre populations (AVF<0.3).  ...  The human MRI data were acquired at the UK National Facility for In Vivo MR Imaging of Human Tissue Microstructure funded by the EPSRC (grant EP/M029778/1), and The Wolfson Foundation.  ... 
doi:10.1016/j.neuroimage.2019.116186 pmid:31542512 pmcid:PMC6854468 fatcat:wlqlpa2tyrgzxjqfzwfl2hqawq

Longitudinal development in the preterm thalamus and posterior white matter: MRI correlations between diffusion weighted imaging and T2 relaxometry

Andrew Melbourne, Zach Eaton-Rosen, Eliza Orasanu, David Price, Alan Bainbridge, M. Jorge Cardoso, Giles S. Kendall, Nicola J. Robertson, Neil Marlow, Sebastien Ourselin
2016 Human Brain Mapping  
Specifically, measurements of myelination and indicators of myelination status in the preterm brain could be predictive of later neurological outcome.  ...  Inference on the myelin water fraction allows us to demonstrate that the change in diffusion properties of the preterm thalamus is not solely due to myelination (that increase in myelin content accounts  ...  On magnetic resonance imaging (MRI), the absence of myelin is a major contributor to the inverted contrast, relative to the adult brain, seen on T1 and T2 weighted images and thus there is interest in  ... 
doi:10.1002/hbm.23188 pmid:26996400 pmcid:PMC4949539 fatcat:wgjloriqobc7bfw6h37czq7scu

Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI

Sophie Adler, Sara Lorio, Thomas S. Jacques, Barbora Benova, Roxana Gunny, J. Helen Cross, Torsten Baldeweg, David W. Carmichael
2017 NeuroImage: Clinical  
Quantitative MRI offers the possibility to probe tissue biophysical properties in vivo and may bridge the gap between radiological assessment and ex-vivo histology.  ...  Future research linking quantitative MRI to FCD histological properties should improve clinical protocols, allow better characterisation of lesions in vivo and tailored surgical planning to the individual  ...  For this reason many studies have used T1 relaxometry to map the in vivo myeloarchitecture of the cerebral cortex at 3T and 7T, highlighting densely myelinated primary and extra-striate visual areas (  ... 
doi:10.1016/j.nicl.2017.04.017 pmid:28491496 pmcid:PMC5413300 fatcat:5hm4i3da25eqffud5my67p5w3q

Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

Samuel Groeschel, Gisela E. Hagberg, Thomas Schultz, Dávid Z. Balla, Uwe Klose, Till-Karsten Hauser, Thomas Nägele, Oliver Bieri, Thomas Prasloski, Alex L. MacKay, Ingeborg Krägeloh-Mann, Klaus Scheffler (+1 others)
2016 PLoS ONE  
in the thickness of their myelin sheaths, and in the presence of crossing or parallel fibre organisation. .  ...  In vivo histology of the myelin gratio with magnetic resonance imaging.  ...  Acknowledgments This study was funded by the Medical Faculty of the University of Tübingen, Germany. We also acknowledge support by Deutsche Forschungsgemeinschaft (DFG) and Open Access  ... 
doi:10.1371/journal.pone.0167274 pmid:27898701 pmcid:PMC5127571 fatcat:fjdfaevmxzdh5jgtf26kskaeoe

Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome

Leighton R. Barnden, Zack Y. Shan, Donald R. Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhuta
2018 NeuroImage: Clinical  
This relationship, previously unreported in either healthy controls or CFS, in view of known thalamic projection-fibre plasticity, suggests brainstem conduction deficits in CFS may stimulate the upregulation  ...  of myelin in the sensorimotor cortex to maintain brainstem - sensorimotor connectivity.  ...  The financial support did not affect any aspect of the study.  ... 
doi:10.1016/j.nicl.2018.07.011 pmid:30497131 pmcid:PMC6309570 fatcat:4mz4makghjayja7pjm6vi2pveu

The Digital Brain Bank: an open access platform for post-mortem datasets [article]

Benjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Amy F.D. Howard, Istvan Huszar, Alexandre A. Khrapitchev, Anna Leonte (+14 others)
2021 bioRxiv   pre-print
This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in seven non-human primate species, and one of the largest post-mortem whole-brain  ...  Taken together, the Digital Brain Bank provides a cross-scale, cross-species investigation framework facilitating the incorporation of post-mortem data into neuroimaging studies.  ...  Acknowledgements The Digital Brain Bank is supported by the Wellcome Trust (202788/Z/16/Z) and Medical Research Council (MRC, MR/K02213X/1).  ... 
doi:10.1101/2021.06.21.449154 fatcat:fyg645rmojea7hpa2sscyku4cq

Studying magnetic susceptibility, microstructural compartmentalisation and chemical exchange in a formalin-fixed ex vivo human brain specimen [article]

Kwok-Shing Chan, Renaud Hedouin, Jeroen Mollink, Anne-Marie van Cappellen van Walsum, Jose P Marques
2021 bioRxiv   pre-print
We, therefore, study the impacts of formalin fixation on magnetic susceptibility, microstructural compartmentalisation and chemical exchange measurement on human brain tissue.  ...  Results: The bulk isotropic magnetic susceptibility of ex vivo whole-brain imaging is comparable to in vivo imaging, with noticeable enhanced non-susceptibility contributions.  ...  the 𝜒i from external field measurement and the mean COSMOS susceptibility in the whole-brain data (cross-session, cross-method; R 2 =0.783, Figure 4B ), and between the 𝜒i from external field measurement  ... 
doi:10.1101/2021.07.30.454493 fatcat:pg2dlskj6nesfcoedkll66wx44
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