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Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission

Haixin Zhang, Marco Esposito, Mikael G. Pezet, Juvid Aryaman, Wei Wei, Florian Klimm, Claudia Calabrese, Stephen P. Burr, Carolina H. Macabelli, Carlo Viscomi, Mitinori Saitou, Marcos R. Chiaratti (+3 others)
2021 Science Advances  
This pattern resembled our findings in m.5024C>T tRNA Ala mice (Fig. 1, B and C , and table S5 ) and corresponded to the model predictions (Fig. 4E ) based on our analysis of single oocytes (Figs.  ...  ., quality score ≥ 25; number of reads supporting the alternative variant ≥ 5; variants within five nucleotides from reads ends removed), and heteroplasmy fractions (%) were calculated as ratio between  ... 
doi:10.1126/sciadv.abi5657 pmid:34878831 pmcid:PMC8654302 fatcat:iqdznivfcfat7c3ajocurdpisa

Single-cell Individual Complete mtDNA Sequencing Uncovers Hidden Mitochondrial Heterogeneity in Human and Mouse Oocytes [article]

Chongwei Bi, Lin Wang, Yong Fan, Gerardo Ramos-Mandujano, Baolei Yuan, Xuan Zhou, Jincheng Wang, Yanjiao Shao, Pu-Yao Zhang, Yanyi Huang, Yang Yu, Juan Carlos Izpisua Belmonte (+1 others)
2020 biorxiv/medrxiv   pre-print
the individual mtDNA molecule level. iMiGseq uncovers unappreciated levels of heteroplasmic variants in single healthy human oocytes well below the current 1% detection limit, of which numerous variants  ...  The ontogeny and dynamics of mtDNA heteroplasmy remain unclear due to limitations of current mtDNA sequencing methods.  ...  ACKNOWLEDGEMENTS We thank members of the Li  ... 
doi:10.1101/2020.12.28.424537 fatcat:ffilethevrci7l7mvbsgw45zru

Adaptable Automated Interpretation of Rapid Diagnostic Tests Using Few-Shot Learning [article]

Siddarth Arumugam, Jiawei Ma, Uzay Macar, Guangxing Han, Kathrine K McAulay, Darrell Ingram, Alex Ying, David A.M. Colburn, Robert Stanciu, Thomas E Grys, Shih-Fu Chang, Samuel K Sia
2021 medRxiv   pre-print
From a base model pre-trained on a commercial LFA kit, we demonstrated the ability of adapted models to interpret results from five new COVID-19 LFA kits (three detecting antigens for diagnosing active  ...  A smartphone-based software can automate interpretation of an LFA kit, but such algorithms typically require a very large number of images of assays tested with validated specimens, which is challenging  ...  An inexpensive smartphone-based device for point-of-care ovulation 536 testing. 19, 59-67 (2019). 537 13 Shah, K. G., Singh, V., Kauffman, P. C., Abe, K. & Yager, P. J. A. c.  ... 
doi:10.1101/2021.06.23.21258927 fatcat:i4sp6uxaffcqdnm3lbektaumtu

Foreword of Special Issue on "E-Service and Applications"

Jason C. Hung, Hsing-I Wang
2011 Journal of Computers  
deployment configuration, Web services, Vision on novel advances of automated intelligent business agents and e-Commerce, Modeling and simulation of business processes, e-Supply Chains, e-Logistics, e-Procurement  ...  In this paper, the weight of each criterion in the AHP tree is calculated and examples of demonstrating how the indicators are applied to the real cases to determine the performance of the strategies for  ...  Ranga Naras, the Dean of Graduate School of University of Northern Virginia, who is also the first author's doctoral dissertation research supervisor.  ... 
doi:10.4304/jcp.6.3.387-388 fatcat:6uf2oayvbbfibphaobqewpnkx4

Report on the 6th Genomics in Aquaculture (GIA) Symposium Held in Granada, Spain, 4–6 May 2022

Carmelo Ruiz-Rejón, Roberto de la Herrán, Rafael Navajas-Pérez, Francisca Robles
2022 Aquaculture Journal  
Infectious diseases represent one of the most pressing threats to modern aquaculture at a global scale [...]  ...  We thank Geneaqua SL for their participation and financial support on sequencing.  ...  Funds, the UdG (MPCUdG2016/060) and the Consolidation and Structuring of competitive research units of Xunta de Galicia (ED431C 2018/29) projects.  ... 
doi:10.3390/aquacj2020007 fatcat:s7be2k57effntjumeaue6ssqm4

Sightings of Dwarf ( Kogia sima ) and Pygmy ( K. breviceps ) Sperm Whales from the Main Hawaiian Islands

Robin William Baird
2005 Pacific Science  
The ovulation rates were 0.9 and 0.7 per year for K. breviceps and K. sima, respectively. In K.  ...  For the present study 106 strandings of Kogia breviceps and 85 strandings of K. sima along the South African coastline between 1880 and 1995 were analysed in order to examine the age and growth, male and  ...  p . ( 2 . 3 % ) O m m a s t r e p h e s b a r t r a m i ( 2 . 5 % ) G n a t h o p h a u s i a i n g e n s ( 2 . 4 % ) T e u t h o w e n i a p e l l u c i d a ( 2 . 4 % ) M e r l u c c i u s c a  ... 
doi:10.1353/psc.2005.0031 fatcat:i3uirxgfsfg3jjgtag3detw7jq

Journal of Sustainable Development, Vol. 1, No. 2, July 2008, all in one file

JSD Editor
2009 Journal of Sustainable Development  
Acknowledgments The study was funded through USM short term grant (internal research grant) grant number PTEKIND/ 636054.  ...  Comparison between Fixed-width Strip and Line-Transect Estimates Strip-transect sampling resulted in lower estimates of RJF abundance than the line-transect sampling based on the negative value of PRB  ...  ovule ratio is 20153.  ... 
doi:10.5539/jsd.v1n2p0 fatcat:pwsccbctxnbrfim5joxflk3smq

A review of near patient testing in primary care

Hobbs, Delaney, Fitzmaurice, Wilson, Hyde, Thorpe, Earl-Slater, Jowett, Tobias
1997 Health Technology Assessment  
Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.  ...  Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it.  ...  These include dipstick or related tests for use in fertility testing, ovulation prediction (A7) and the detection of drugs of abuse (A6).  ... 
doi:10.3310/hta1050 fatcat:7ykse2jig5fj7j6gfznkukdwhe


2021 Basic & Clinical Pharmacology & Toxicology  
The emergency medical expenses of the experimental were less than those of the control, with obvious differences between the two groups and statistical significance.  ...  Results: With professional nursing records, both groups received significant therapeutic effects, but the hospital stay of the experimental group was shorter than that of the control group.  ...  Methods: In this paper, on the basis of multi-feature fusion, deep learning based on singleshot multibox device (SSD) and Hoffman forest are used to detect pedestrians.  ... 
doi:10.1111/bcpt.13588 pmid:34041856 fatcat:wobg4mjgunfilgvzqsj5l4an7m

IETS 2006 abstracts

2006 Reproduction, Fertility and Development  
Genomic clones were selected from a porcine CpG Island library based on the presence of a Bstu I site. The inserts from these clones were PCR amplified and spotted on glass slides.  ...  The incorporation of histone B4 from Xenopus egg extracts was observed at the nuclear region of the porcine fibroblasts under both the 37 • C and the 23 • C conditions.  ...  The objective of the current study was to evaluate the effectiveness of gonadotropin administration at initiation of inhibin immunization in bull calves on testicular morphology.  ... 
doi:10.1071/rdv18n2abs fatcat:gygnnsby3ra3tmfxlmrgrtlfwu

Ecology and Physiology of the Red Mangrove

H. H. M. Bowman
1917 Proceedings of the American Philosophical Society  
The ratio may also be expressed by the equation y =Kx+ -C, where C approximates I.05 and K 2%, the ordinates, Y, express units of tannin and the abscissae, X, units of dextrose.  ...  On June 5, at the same place where seedlings were grown off shore in 20 cm. of water, the seedlings were almost similar; T. 34? C. and sp. gr. 1.02I.  ...  Dehiscence occurs by a rupture along a definite line due to the strain on the exothecial cells produced by their shrinkage and the resistance offered by the reinforced cells. 4.  ... 

Abstracts of the 22nd Annual Congress of the European Society of Gynaecological Endoscopy (ESGE), 16–19 October 2013, Berlin

2013 Gynecological Surgery  
A 36 year old patient presented with chronic lower abdominal pain and varicosis of the lower extremities after varicose vein surgery on both sides.  ...  4 lines): Catheter embolisation of the ovarian veins is most commonly performed for treatment of pelvic congestion syndrome. Laparoscopic ovarian vein ligation may offer a feasible alternative.  ...  Fisher tests and t-tests were used to study the significativity of covariates, testing differences between means.  ... 
doi:10.1007/s10397-013-0818-0 fatcat:abq66cvykzcobcib2efrkgbtkq

Use of Real-World Evidence in Hematology/Oncology Treatment Optimization

Julie Vose
2020 Oncology (Williston Park, N.Y.)  
All IRRs started during the fi rst SARCLISA infusion and resolved on the same day in 98% of the cases. The most common symptoms of an IRR included dyspnea, cough, chills, and nausea.  ...  The most common severe signs and symptoms included hypertension and dyspnea. o Cells | 100% placement in Letter/A4 | 60% placement in 6x9/A5 IN THE TREATMENT OF RELAPSED REFRACTORY MULTIPLE MYELOMA IN  ...  The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay.  ... 
doi:10.46883/onc.2020.3411.0459 pmid:33206984 fatcat:oaodh7xhrnhfpdqoc5y2vbx2by

The effects of parental carbamazepine and gemfibrozil exposure on sexual differentiation in zebrafish (Danio rerio )

Kristine M. Hammill, Shamaila Fraz, Abigail H. Lee, Joanna Y. Wilson
2018 Environmental Toxicology and Chemistry  
Predominately, paternal exposure was found to result in a faster development of the testes and male-biased sex ratios.  ...  This is of concern as pharmaceuticals are detected in surface waters at the ng L -1 to µg L -1 range.  ...  Ian Dworkin for advice on the design of the statistical analysis. Funding was provided by the Natural Science and Research Council of Canada in the form of a Discovery Grant to J.Y.W.  ... 
doi:10.1002/etc.4120 pmid:29476637 fatcat:2txtfhoikjgmpk6wyzw3m2rxve

Cross-Dataset Design Discussion Mining

Alvi Mahadi, Karan Tongay, Neil A. Ernst
2020 2020 IEEE 27th International Conference on Software Analysis, Evolution and Reengineering (SANER)  
Our new approach achieves AUC-ROC of 0.88 on within dataset classification and 0.84 on the cross-dataset classification task. iv Contents Supervisory Committee  ...  We first replicate an existing state-of-the-art design mining study to show how conclusion stability is poor on different artifact types and different projects.  ...  Ernst, my supervisor, for his support, motivation, encouragement, patience, and mentoring throughout my Master's program. I personally thank him for giving me the opportunity to work with him.  ... 
doi:10.1109/saner48275.2020.9054792 dblp:conf/wcre/MahadiTE20 fatcat:fvc2tuuc7feitgb6ditdemeely
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