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Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk

Fabian Corlier, George Hafzalla, Joshua Faskowitz, Lewis H. Kuller, James T. Becker, Oscar L. Lopez, Paul M. Thompson, Meredith N. Braskie
2018 NeuroImage  
of genetic and metabolic risk, and physical activity, to regional cortical thickness in AD-relevant brain regions at study year 9.  ...  We found interactions between genetic and environmental factors and structural brain health. Our findings support the role of metabolic risk and peripheral inflammation in age-related brain decline.  ...  A full list of principal CHS investigators and institutions can be found at  ... 
doi:10.1016/j.neuroimage.2017.12.027 pmid:29357308 pmcid:PMC5954991 fatcat:rwfadcgi35favgd3bhxq3bhsue

Precision Aging: Applying Precision Medicine to the Field of Cognitive Aging

Lee Ryan, Meredith Hay, Matt J. Huentelman, Audrey Duarte, Tatjana Rundek, Bonnie Levin, Anja Soldan, Corinne Pettigrew, Matthias R. Mehl, Carol A. Barnes
2019 Frontiers in Aging Neuroscience  
Rather than providing a definitive model of risk for ARCI and cognitive decline, the Precision Aging model is meant as a starting point to guide future research.  ...  To that end, after briefly discussing key risk categories, genetic risks, and brain drivers, we conclude with a discussion of steps that must be taken to move the field forward.  ...  Cardiovascular insufficiency risk factors also share the characteristic that each of them likely contributes to brain aging primarily through chronic systemic and central nervous system (CNS) inflammation  ... 
doi:10.3389/fnagi.2019.00128 pmid:31231204 pmcid:PMC6568195 fatcat:7foqpg6fprc7vfd5c2xop5fbfa

Innate immunity and inflammation in ageing: a key for understanding age-related diseases

Federico Licastro, Giuseppina Candore, Domenico Lio, Elisa Porcellini, Giuseppina Colonna-Romano, Claudio Franceschi, Calogero Caruso
2005 Immunity & Ageing  
This very long activity leads to a chronic inflammation that slowly but inexorably damages one or several organs: this is a typical phenomenon linked to ageing and it is considered the major risk factor  ...  In other words, age-related diseases are "the price we pay" for a life-long active immune system: this system has also the potential to harm us later, as its fine tuning becomes compromised.  ...  Caruso and INRCA was enhanced by a cooperation contract (Longevity and elderly disability biological markers).  ... 
doi:10.1186/1742-4933-2-8 pmid:15904534 pmcid:PMC1166571 fatcat:t6aw76qprbciffpnwshzxb4v5e

Immune aging, dysmetabolism, and inflammation in neurological diseases

Michela Deleidi, Madeline Jäggle, Graziella Rubino
2015 Frontiers in Neuroscience  
The discovery of novel therapeutic strategie targeting age-linked inflammation may promote healthy brain aging and the treatmen of neurodegenerative as well as neuropsychiatric disorders. d l l d n c s  ...  As we age, the immune system undergoes a process of senescence accompanie by the increased production of proinflammatory cytokines, a chronic subclinica condition named as "inflammaging".  ...  Hence, this strengthens the hypothesis that the age-associated dysregulation of immune function and systemic as well as brain inflammaging contribute to increased risk of cognitive dysfunction and neurodegenerative  ... 
doi:10.3389/fnins.2015.00172 pmid:26089771 pmcid:PMC4453474 fatcat:sukmzfuar5hsblgqtcp25xv6zu

Aging, inflammation and the environment

Arsun Bektas, Shepherd H. Schurman, Ranjan Sen, Luigi Ferrucci
2018 Experimental Gerontology  
The resultant physical and cognitive decline that culminates with the frailty syndrome is a tipping point of healthspan and implies a high risk of system decompensation and death.  ...  We explore processes and mechanisms of aging that affect human biology and the possible links of inflammation and the environment to aging, especially those related to metabolism.  ...  Acknowledgments This work was supported by the Intramural Research Program of the National Institutes of Health (NIH), National Institute on Aging and National Institute of Environmental Health Sciences  ... 
doi:10.1016/j.exger.2017.12.015 pmid:29275161 pmcid:PMC5909704 fatcat:qjwhm52t65eixmpnhejnywrpmy

Inflammatory Oxidative Aging: A New Theory of Aging

Angel Julio Romero Cabrera
2016 MOJ Immunology  
The author summarizes the interventions to modulate theoxi-inflamm-aging as a practical application of this theory.  ...  The immune system produces deregulation to chronic low grade inflammatory state in the aging process. That is the basis of a new theory named oxy-inflamm-aging.  ...  Recent clinical trials of restriction of 25% of calories in humans have shown improvement in longevity as predictors of decreased resting metabolic Latas, TNF-α and cardiometabolic risk factors [44]  ... 
doi:10.15406/moji.2016.03.00103 fatcat:nyj3zbjjznhqbjlc3jvok74ioy

Hypertension and aging

Thomas W. Buford
2016 Ageing Research Reviews  
However, there are a number of collateral effects, including risks for dementia, physical disability, and falls/fractures which are increasingly garnering attention in the hypertension literature.  ...  Hypertension is a highly prevalent condition with numerous health risks, and the incidence of hypertension is greatest among older adults.  ...  Scientists too numerous to count are to be commended for their important contributions to each of the aforementioned sub-fields related to hypertension and aging.  ... 
doi:10.1016/j.arr.2016.01.007 pmid:26835847 pmcid:PMC4768730 fatcat:2ijqv5o2tbeftenueihbivvzcq

BioAge: Toward a multi-determined, mechanistic account of cognitive aging

Correne A. DeCarlo, Holly A. Tuokko, Dorothy Williams, Roger A. Dixon, Stuart W.S. MacDonald
2014 Ageing Research Reviews  
We argue that a multivariate and mechanistic BioAge approach will lead to a greater understanding of disease pathology as well as more accurate prediction and early identification of late-life cognitive  ...  In contrast, biological age (BioAge), reflecting the vitality of essential biological systems, represents a promising operationalization of developmental time.  ...  Inflammation Markers of systemic and neuro-inflammation have been linked to both normative age-related cognitive change as well as non-normative decline associated with diseases of the aging process (MCI  ... 
doi:10.1016/j.arr.2014.09.003 pmid:25278166 pmcid:PMC4258131 fatcat:bgkq4yjmb5cy7ntaahy45ctdsm

Biological Versus Chronological Aging

Magda R. Hamczyk, Rosa M. Nevado, Ana Barettino, Valentín Fuster, Vicente Andrés
2020 Journal of the American College of Cardiology  
Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide.  ...  However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging.  ...  Familial dyslipidemias, such as familial hypercholesterolemia, are a group of genetic diseases that alter lipid metabolism and require pharmacological treatment to prevent earlyonset atherosclerosis (76  ... 
doi:10.1016/j.jacc.2019.11.062 pmid:32130928 fatcat:5qrtyr6t7vcx7lijcvsij7phli

Hypertension and Age-Related Cognitive Impairment: Common Risk Factors and a Role for Precision Aging

Meredith Hay, Carol Barnes, Matt Huentelman, Roberta Brinton, Lee Ryan
2020 Current Hypertension Reports  
And, many of the risk factors for developing hypertension, such as diabetes, smoking, stress, viral infection, and age, are shared with the development of ARCI.  ...  Age-related cognitive impairment and preventing and treating ARCI will require an in-depth understanding of the interrelated risk factors, including individual genetic profiles, that affect brain health  ...  2 [155] , and increased brain inflammation and microglia activation as well as changes in cerebral perfusion and brain oxygenation [156] .  ... 
doi:10.1007/s11906-020-01090-w pmid:32880739 pmcid:PMC7467861 fatcat:xatuclq54vcvbicoovrmmgct2u

Maintaining brain health by monitoring inflammatory processes: a mechanism to promote successful aging

Caterina Rosano, Anna L Marsland, Peter J Gianaros
2011 Aging and Disease  
Converging animal and human evidence further suggests that inflammation is a shared mechanism, contributing to both cognitive decline and abnormalities in brain structure and metabolism.  ...  This increased propensity to central inflammation may contribute to poor brain health and premature brain aging.  ...  Among lifestyle factors, attention has recently focused on the role of diet and physical activity as well as to social and cognitive engagement in brain aging [84] .  ... 
pmid:22500269 pmcid:PMC3320802 fatcat:uhoq6humabawpojg5juatyiygi

Bioactive Nutrients and Nutrigenomics in Age-Related Diseases

Tania Rescigno, Luigina Micolucci, Mario Tecce, Anna Capasso
2017 Molecules  
Aging may be viewed as a multifactorial process that results from the interaction of genetic and environmental factors, which include lifestyle.  ...  The state of the art of aging and nutrigenomics research and the molecular mechanisms underlying the beneficial effects of bioactive nutrients on the main aging-related disorders are reviewed herein.  ...  a chronic inflammation that contributes to the deterioration of various organs, becoming a risk factor for all ARDs.  ... 
doi:10.3390/molecules22010105 pmid:28075340 fatcat:jhyrqtp3jzgkfprnxxnoudws2y

Integrative medicine – healthy ageing

D.P. van Velden, M.J. Kotze
2014 Nutrition and Aging  
This will ultimately lead to active and healthy ageing.  ...  Pre-test genetic counselling is performed to determine a risk score of probability to detect a BRCA mutation, applicability of different testing options, the implications, benefits and risks, as well as  ... 
doi:10.3233/nua-130025 fatcat:yka2du7ferfytfzqxavfej2daq

Aging and Neurological Diseases [chapter]

Marta Kowalska, Michal Owecki, Michal Prendecki, Katarzyna Wize, Joanna Nowakowska, Wojciech Kozubski, Margarita Lianeri, Jolanta Dorszewska
2017 Senescence - Physiology or Pathology  
Altogether, these lead to brain damage in old age and greatly increase the risk of developing diseases of the central nervous system, such as stroke, epilepsy, Parkinson's disease, Alzheimer's disease,  ...  Such defects multiply exponentially over time, resembling a "snowball effect," and eventually leading to morphological and functional deterioration of the brain, including progressive neuronal loss, reduced  ...  Acknowledgements This work was supported by the Poznan University of Medical Sciences grant no. 502-01-11111-45-07-467.  ... 
doi:10.5772/intechopen.69499 fatcat:adj2kupnbvag3crd4sflctnw2i

How Environmental Agents Influence the Aging Process

Meryl H. Karol
2009 Biomolecules & Therapeutics  
Aging is a multifaceted biological process that affects all organs and organ systems of the body.  ...  The aging process is largely under genetic control but is highly responsive to diverse environmental influences.  ...  Studies have shown that aging is characterized by low grade systemic inflammation, and moreover, that inflammatory markers are predictors of mortality in the elderly (Vasto et al., 2008) .  ... 
doi:10.4062/biomolther.2009.17.2.113 fatcat:35l4h5voe5eynjvkzuzp5seb7i
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