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System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia

Rudong Li, Yin Wang, Hui Cheng, Gang Liu, Tao Cheng, Yunlong Liu, Lei Liu
2017 BMC Systems Biology  
Hence, exploring the molecular mechanisms of how the genes act on cell cycle will help revealing the functional alteration of HSCs.  ...  Results: We herein utilize the bioinformatic resources to computationally model the acting mechanisms of Maff and Egr3 on cell cycle.  ...  Acknowledgments We thank all members of our collaborative research groups for their assistances with the experiments and data analysis.  ... 
doi:10.1186/s12918-017-0467-4 pmid:28984203 pmcid:PMC5629552 fatcat:dxmzmeqz6fh2low47ku7we5ghq

Polycomb-like 2 (Mtf2/Pcl2) is Required for Epigenetic Regulation of Hematopoiesis

Janet L. Rothberg, Université D'Ottawa / University Of Ottawa, Université D'Ottawa / University Of Ottawa
2016
In moving beyond the ESC model system, we sought to interrogate the role of Mtf2 in vivo by creating a gene-targeted knockout mouse model.  ...  Additionally, misregulation of Mtf2 in leukemia models contributes to massive leukemic blast expansion at the expense of leukemic stem cell self-renewal.  ...  Mtf2 regulates cell cycle control in HSCs Firstly, in trying to uncover a mechanism of action for Mtf2, our in vivo data suggests cell cycle regulation is affected with the loss of Mtf2.  ... 
doi:10.20381/ruor-281 fatcat:nlbpv7glrzg5lj2ntzna5vbofa

REORGANIZATION OF THE MACROPHAGE EPIGENOME DURING SUSTAINED STIMULATION [article]

SARA POLLETTI
2015
Thus, cells of the immune system must engage a multilayered control system to keep innate immunity and inflammatory responses under control.  ...  Macrophages from septic patients or from animal models of sepsis display alterations in the pro-inflammatory cytokines production (Valledor et al., 2010) .  ... 
doi:10.13130/polletti-sara_phd2015-03-18 fatcat:764ncvsdnnfgjggqxwpvk55yx4

Molecular Characterisation of Interaction between Nurse-like cells and Chronic Lymphocytic Leukaemia cells

Ishaque Mohammad
2021
Nurse like cells (NLCs) are a major component of the CLL microenvironment. However, the exact molecular mechanisms mediating interactions between CLL cells and NLCs are still not fully understood.  ...  The cell line model closely resembled the morphology and phenotype of NLCs.  ...  the the molecular mechanisms mediating the interactions between CLL cells and components of the microenvironment.  ... 
doi:10.17638/03114800 fatcat:upddrgiuyjcbjktrjw45eesbpq

SCIENZE BIOMEDICHE Ciclo XXVII TOWARD A MOLECULAR CLASSIFICATION OF PERIPHERAL T-CELL LYMPHOMAS: THE ROLE OF GENE EXPRESSION PROFILING

Presentata Da:, Maryam Coordinatore, Dottorato Relatore, Cocco, Paolo Pier, Piccaluga, Claudio Agostinelli
unpublished
They are the central element in adaptive immune system, and act different levels including primary response by naïve T-cells, followed by further processing mediated by activated T-cells, and persistence  ...  By producing immunosuppressive cytokines such as TGF-β and IL-10, Treg cells mediate immune responses through contact-dependent and contact-independent mechanisms (16) (17) (18) (19) .  ... 
fatcat:vl74yrek7vbqvgzca7fxdu7jsm