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Symmetry Breaking of Phospholipids

Michele Fiore, René Buchet
2020 Symmetry  
(DHAP), which are the key molecules to break symmetry in phospholipids.  ...  components that induced symmetry imbalance.  ...  Pasquale Stano and Peter Strazewski are gratefully acknowledged for the useful discussions on the theme of symmetry breaking and for have reading the first draft of the manuscript.  ... 
doi:10.3390/sym12091488 fatcat:fefijxn5jrgvrjd2vmpgyj4kfi

The PAR network: redundancy and robustness in a symmetry-breaking system

F. Motegi, G. Seydoux
2013 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Two redundant symmetry-breaking inputs feed into the PAR network, which consists of a mutual exclusion module and two positive feedback loops. symmetry breaking centrosome meiosis symmetry breaking  ...  the basic domain of PAR-2 and acidic phospholipids [20, 21] .  ... 
doi:10.1098/rstb.2013.0010 pmid:24062581 pmcid:PMC3785961 fatcat:af44fyq7avfxdbf7irbvsut6i4

Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes

Fumio Motegi, Seth Zonies, Yingsong Hao, Adrian A. Cuenca, Erik Griffin, Geraldine Seydoux
2011 Nature Cell Biology  
In wild-type embryos, depletion of tubulin delays symmetry breaking 18 , raising the possibility that microtubule-dependent loading of PAR-2 contributes to symmetry breaking even in the presence of flows  ...  -2 on the MTOC core during symmetry breaking.  ... 
doi:10.1038/ncb2354 pmid:21983565 pmcid:PMC3208083 fatcat:btgnovelyrdalgmmzaoeiqh2xy

Curvature effects in charge-regulated lipid bilayers [article]

Petch Khunpetch, Arghya Majee, Rudolf Podgornik
2022 arXiv   pre-print
We find that charge regulation of an otherwise symmetric bilayer membrane can induce charge symmetry breaking, non-linear flexoelectricity and anomalous curvature dependence of free energy.  ...  The pH effects investigated go beyond the paradigm of electrostatic renormalization of the mechano-elastic properties of membranes.  ...  the School of Physics, University of Chinese Academy of Sciences.  ... 
arXiv:2201.05257v2 fatcat:lce2gm3vnbh4pp6u7l4z5u2pf4

Connection between the Linoleic Acid and Psychopathology: A Symmetry-Breaking Phenomenon in the Brain?

Massimo Cocchi, Chiara Minuto, Lucio Tonello, Jack A. Tuszynski
2015 Open Journal of Depression  
We draw an analogy with symmetry breaking in physical systems where at a bifurcation point on the phase diagram, infinitesimal perturbations to the state of the system result in a transition to a new global  ...  In this paper we discuss the role of the fatty acid composition of brain cells and in platelets in the emergence of psychiatric disorders such as major depression and the bipolar disorder.  ...  Symmetry breaking phenomena are closely related to phase transitions, many of which (but not all) have underlying broken symmetries.  ... 
doi:10.4236/ojd.2015.44005 fatcat:sy5oevqvxzdq3npsghojp3edme

Curvature effects in charge-regulated lipid bilayers

Petch Khunpetch, Arghya Majee, Rudolf Podgornik
2022 Soft Matter  
We formulate a theory of electrostatic interactions in lipid bilayer membranes where both monolayer leaflets contain dissociable moieties that are subject to charge regulation.  ...  This charge asymmetry corresponds to the charge symmetry breaking in the bilayer.  ...  The first effect depending on the detailed charge regulation mechanism is the charge symmetry breaking, leading to unequal charges of the inner and outer phospholipid membrane surface even if -and this  ... 
doi:10.1039/d1sm01665b pmid:35294512 fatcat:zjv7hwhyezahvd4egi4yshurku

Mechanical behavior of closed lamellar membranes as a possible common mechanism for the establishment of developmental shapes

S Svetina, B Zeks
1991 International Journal of Developmental Biology  
Cell polarity is related to the decrease in symmetry during the transition from the radially symmetrical spherical shape to the asymmetrical shapes of the egg class.  ...  The mechanical behavior of a closed membrane composed of two layers in contact is described as it is obtained by finding the minimum of the membrane bending energy at constant membrane area, constant difference  ...  The low~a limit is the symmetry breaking line where the shapes attain mirror symmetry with respect to the equatorial plane.  ... 
pmid:1814415 fatcat:cczujcakxfbnfa2ypgsgviu5lq

Effects of passive phospholipid flip-flop and asymmetric external fields on bilayer phase equilibria [article]

John J. Williamson, Peter D. Olmsted
2018 Biophysical Journal   accepted
We further account for external symmetry-breaking, such as a preferential substrate interaction, and show how this can stabilise strongly asymmetric equilibrium states.  ...  We address here how phase behaviour is affected by passive phospholipid \textit{flip-flop}, such that the compositional asymmetry is not fixed.  ...  for input on an early version of the manuscript.  ... 
doi:10.1016/j.bpj.2018.10.003 pmid:30393103 pmcid:PMC6303420 arXiv:1807.03751v2 fatcat:nd2jsml2b5dt5k7qqd35perufu

The Chain of Chirality Transfer as Determinant of Brain Functional Laterality. Breaking the Chirality Silence: Search for New Generation of Biomarkers; Relevance to Neurodegenerative Diseases, Cognitive Psychology, and Nutrition Science

Victor V. Dyakin, Justin Lucas, Nika V. Dyakina-Fagnano, Eva V. Posner
2017 Neurology and Neuroscience Research  
The molecular basis of the "symmetry evolution" in the biological systems is a question of interest.  ...  At the cellular level, signal transduction mechanism involves the wave of chiral transformations in the process of protein-protein, protein-phospholipids, and protein-DNA interactions.  ...  ), including symmetry breaking and molecular folding in relation to information minimization or symmetry maximization [86] .  ... 
doi:10.24983/scitemed.nnr.2017.00028 fatcat:zsningm2f5eo5muqyaslw2p3di

Polymorphism of phospholipid monolayers

O. Albrecht, H. Gruler, E. Sackmann
1978 Journal de Physique  
This allows for a break in symmetry at the liquid-to-crystal transition even at very high temperatures.  ...  of the polymorphic states of phospholipid lamellae.  ... 
doi:10.1051/jphys:01978003903030100 fatcat:fcshqqkl25emzozxwehwwg56yq

Influence of chirality on the structure of phospholipid monolayers

C. Böhm, H. Möhwald, L. Leiserowitz, J. Als-Nielsen, K. Kjaer
1993 Biophysical Journal  
INTRODUCTION The chiral carbon centre of phospholipid molecules at the head group has a strong influence on the functional properties of these molecules in their membrane form.  ...  An appropriate system for the study of such an effect on biological membranes are phospholipid monolayers on water, as the head group may assume a free energy minimum configuration in the absence of an  ...  symmetry break.  ... 
doi:10.1016/s0006-3495(93)81386-9 pmid:8457679 pmcid:PMC1262360 fatcat:udv2y7vz3jdf3levjhkqngcfm4

Chiral tubule self-assembly from an achiral diynoic lipid

S. Pakhomov, R. P. Hammer, B. K. Mishra, B. N. Thomas
2003 Proceedings of the National Academy of Sciences of the United States of America  
CD spectroscopy shows that these structures' helical sense of handedness instead originates in a spontaneous cooperative chiral symmetry-breaking process.  ...  We conclude that the chiral symmetry-breaking must originate in the unusual feature common to the chiral and achiral tubule-forming molecules, the diynes centered in their hydrocarbon tails.  ...  We thank Noel Clark of the University of Colorado Physics Department for helpful discussions. B.N.T. was supported by National Science Foundation CAREER Grant CHE-9734266.  ... 
doi:10.1073/pnas.0030051100 pmid:12626752 pmcid:PMC152241 fatcat:vvwnj466ufhopb3btapmofyspu

Phase behavior of planar supported lipid membranes composed of cholesterol and 1,2-distearoyl-sn-glycerol-3-phosphocholine examined by sum-frequency vibrational spectroscopy

Jin Liu, John C. Conboy
2009 Vibrational Spectroscopy  
The intrinsic symmetry constraints of SFVS were exploited to measure the asymmetric distribution of phase segregated phospholipid domains in the proximal and distal layers of DSPC + CHO binary mixtures  ...  These results therefore provide important evidence for the delocalization and segregation of different phase domain structures in PSLBs due to the interaction of cholesterol and phospholipids.  ...  Neivandt for the suggestion of performing a SFVS interference measurement for the determination of the absolute asymmetry in the phospholipid bilayers containing CHO (232 nd ACS National Meeting, San Francisco  ... 
doi:10.1016/j.vibspec.2008.09.004 pmid:20361007 pmcid:PMC2846528 fatcat:rx33lv7zeff6jpppbim5vcwamu

Orientational anisotropy of nuclear spin relaxation in phospholipid membranes

Michael F. Brown, Olle Söderman
1990 Chemical Physics Letters  
One possibility is that rotational isomerixation breaks the symmetry of the static electric field gradient, leading to an asymmetric residual tensor which is further modulated by molecular motions. 158  ...  The observation that the spin-lattice relaxation (RIz) rates of pure phosphotipid lamellar phases depend only weakly on their orientation in the liquid-crystatline state is explained.  ...  The research in this article was supported by grants from the US National Institutes of Health and from the Swedish Natural Sciences Foundation.  ... 
doi:10.1016/0009-2614(90)85088-t fatcat:eapabjjc6bhy7anrl2lp24kzeu

Two-dimensional crystallization of DNA gyrase B subunit on specifically designed lipid monolayers

L. Lebeau, E. Regnier, P. Schultz, J.C. Wang, C. Mioskowski, P. Oudet
1990 FEBS Letters  
Two-dlmenslonal crystals of the gyrase B subumt are formed under physlologlcal condltlons of pH and lomc strength, with no precipitant added to the solution.  ...  The especially deslgned hplds consisted of novoblocm coupled through the 3' or 2" hydroxyl group and a hydrophdous hnker of a given length to dloleoylphosphatldic acid.  ...  It catalyses a number of reactions such as negative supercoiling of close circular duplex DNA (ATP dependent), relaxation of superhelical DNA (in absence of ATP), introduction of double strand breaks at  ... 
doi:10.1016/0014-5793(90)80282-n pmid:2163898 fatcat:qe6uizer4ndk3hu4mwfah7z4pi
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