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A Selective Review of Biological Markers in Schizophrenia

S. Szymanski, J. M. Kane, J. A. Lieberman
1991 Schizophrenia Bulletin  
Abnormalities in eye movement, electro-Reprint requests should be sent to Dr.  ...  In a morphometric study of brain structures, Bogerts et al. (1990) measured hippocampalamygdala complex volumes and adjacent temporal horns of 34 first-episode schizophrenic patients and found no correlation  ...  P300 abnormalities seem to correlate with attentional deficits in schizophrenic subjects (Holzman 1987; St. Clair et al. 1989) .  ... 
doi:10.1093/schbul/17.1.99 pmid:1675484 fatcat:modnvhvgvzhgjktd64dgsgh2p4

Comorbid Mood, Psychosis, and Marijuana Abuse Disorders: A Theoretical Review

Natascha Wilson, Jean Lud Cadet
2009 Journal of Addictive Diseases  
Greater interactions between caretakers are bound to impact the care of our patients in a very positive way.  ...  Because substance abuse can acerbate and/or trigger psychosis and mood disorders, it is important to keep these issues in the forefront when evaluating patients.  ...  and healthy controls. 144 More prominent gray matter density as well as volume reduction in the right posterior cingulated cortex have been reported in first episode schizophrenics who used marijuana  ... 
doi:10.1080/10550880903182960 pmid:20155601 pmcid:PMC2922015 fatcat:ihy4efutizd5vlxjy4pgwm7mfu

Decreased Frontal Serotonin2A Receptor Binding in Antipsychotic-Naive Patients With First-Episode Schizophrenia

Hans Rasmussen, David Erritzoe, Rune Andersen, Bjorn H. Ebdrup, Bodil Aggernaes, Bob Oranje, Jan Kalbitzer, Jacob Madsen, Lars H. Pinborg, William Baaré, Claus Svarer, Henrik Lublin (+2 others)
2010 Archives of General Psychiatry  
Objectives: To assess in vivo brain serotonin 2A binding potentials in a large sample of antipsychotic-naive schizophrenic patients and matched healthy controls, and to examine possible associations with  ...  Participants: A sample of 30 first-episode, antipsychoticnaive schizophrenic patients, 23 males and 7 females, and 30 matched healthy control subjects.  ...  In conclusion, this study of serotonin 2A receptor binding in first-episode, antipsychotic-naive schizophrenic patients shows decreased binding in the frontal cortex and a negative correlation with positive  ... 
doi:10.1001/archgenpsychiatry.2009.176 pmid:20048218 fatcat:itao7fgz3janbebegisljq2enq

Neurobiology of Schizophrenia: A Comprehensive Review

Enkhmaa Luvsannyam, Molly S Jain, Maria Kezia Lourdes Pormento, Hira Siddiqui, Angela Ria A Balagtas, Bernard O Emuze, Teresa Poprawski
2022 Cureus  
Specific regions of gray and white matter changes are observed in patients with schizophrenia; gray matter changes being more significant after the onset of psychosis.  ...  These pathological changes may be implicated in the impairment of executive functioning, attention, and working memory.  ...  Jain contributed equally to the work and should be considered co-first authors.  ... 
doi:10.7759/cureus.23959 pmid:35541299 pmcid:PMC9080788 fatcat:u36mh4ebhbcyhl5hrxfm4bpsba

Transcultural psychiatry and schizophrenia [chapter]

2009 Schizophrenia  
Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic-naive schizophrenic patients. Neuroimage 2003; 19(2 Pt 1): 365-75. 97.  ...  Caudate size in first-episode neuroleptic-naive schizophrenic patients measured using an artificial neural network. Biol Psychiatry 1999; 46(5): 712-20. 93.  ... 
doi:10.3109/9781420080063-24 fatcat:g3viiksvhrdkri2hj4tdy4az2m

Structural and functional brain imaging in schizophrenia

J M Cleghorn, R B Zipursky, S J List
1991 Journal of Psychiatry & Neuroscience  
Work in these fields to date, however, has produced strong evidence which suggests that schizophrenia is a disease which involves abnormalities in the structure and function of many brain areas.  ...  Future studies in these fields have the potential to yield critical insights into the pathophysiology of schizophrenia; new directions for studies of schizophrenia using these technologies are identified  ...  ACKNOWLEDGEMENTS Supported in part by MRC Grant MA88 17, NIMH Grant MH44073 and grants from The Scottish Rite and the Medical Research Division of the Department of Veterans Affairs.  ... 
pmid:1911736 pmcid:PMC1188296 fatcat:62a6zxytwzhxtgybfjfxts32r4

Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging

Robert K. McNamara
2013 Prostaglandins, Leukotrienes and Essential Fatty Acids  
Determining the relevance of this evidence to brain disorders in humans has been hampered by an inability to determine antimortem brain DHA levels and limitations associated with a postmortem approach.  ...  Animal studies have found that deficits in brain docosahexaenoic acid (DHA, 22:6n-3) accrual during perinatal development leads to transient and enduring abnormalities in brain development and function  ...  Acknowledgments This work was supported in part by National Institute of Health grants MH083924 and AG03617, and a NARSAD Independent Investigator Award to R.K.M.  ... 
doi:10.1016/j.plefa.2012.03.011 pmid:22521863 pmcid:PMC3458176 fatcat:a4od4e6oevaaxkquoyewo6vfuy

Studies of individuals with schizophrenia never treated with antipsychotic medications: a review

2002 Schizophrenia Research  
The challenge for the future is to use the new molecular techniques to study these brain areas and elevate our understanding of schizophrenia's etiology to the next level. D  ...  It is concluded that schizophrenia is a brain disease in the same sense that Parkinson's disease and multiple sclerosis are, and that the brain abnormalities in schizophrenia are inherent in the disease  ...  Acknowledgements I am grateful to Daniel Ragland, PhD, Raquel Gur, MD, and Ruben Gur, PhD, for kindly recomputing their data to include only those subjects who were antipsychotic-naïve; to Dave Luckenbaugh  ... 
doi:10.1016/s0920-9964(02)00381-x pmid:12409150 fatcat:lmzk4odctvcjjk63jkbkgahjs4

Prospective Study of Psychobiology in First-episode Schizophrenia at Hillside Hospital

J. A. Lieberman, J. Ma. J. Alvir, M. Woerner, G. Degreef, R. M. Bilder, M. Ashtari, D. I. Mayerhoff, S. H. Geisler, A. Loebel, G. Hinrichsen, S. Szymanski, M. Chakos (+5 others)
1992 Schizophrenia Bulletin  
Preliminary results reveal significant abnormalities in brain morphology, growth hormone secretion, eye movement function, and psychotogenic response to dopamine agonists in first-episode, treatment-naive  ...  Despite marked variation in the onset, phenomenology, treatment response and outcome of schizophrenic patients, our ability to identify subtypes is remarkably limited.  ...  In contrast, attentional impairment, a negative symptom likely to be influenced by the level of positive symptoms, was not correlated with time to remission.  ... 
doi:10.1093/schbul/18.3.351 pmid:1411327 fatcat:mokcgz3qtjha5j4nqkjkikk3ju

Sleep and Plasticity in Schizophrenia [chapter]

Kate E. Sprecher, Fabio Ferrarelli, Ruth M. Benca
2015 Current topics in behavioral neurosciences  
Schizophrenia is associated with marked sleep disturbances and memory impairment.  ...  In the healthy brain, these rhythms reflect and participate in plastic processes during sleep.  ...  al. 2010) , or neuroleptic naïve patients (Forest et al. 2007) .  ... 
doi:10.1007/7854_2014_366 pmid:25608723 pmcid:PMC5117633 fatcat:5q436uehynau3n3xeu7vx3q4gu

Society of biological psychiatry 2001 annual meeting

2001 Biological Psychiatry  
Genes were induced in D1 expressing neurons in response to cocaine and in D2 receptor-containing neurons in response to eticlopride.  ...  Activation of these intracellular signaling cascades in turn appear to bi-directionally control synaptic strength, at least in part, by regulation of the trafficking of glutamate receptors to (LTP) and  ...  FUSIFORM GYRUS VOLUME Methods: High-resolution MR images were used to measure the gray matter volume of fusiform gyrus in 22 first-episode patients with schizophrenia (first hospitalization), 20 first-episode  ... 
doi:10.1016/s0006-3223(01)01102-7 fatcat:iyjyq4h4qjavffdvbmr3vlfwj4

Neuroinflammation in Schizophrenia Focused on the Pharmacological and Therapeutic Evidence

Haiyun Xu
2015 Pharmacologia  
The focus of this review was put on pharmacological and therapeutic evidence pointing to a recommendation of anti-inflammatory treatment for patients with schizophrenia.  ...  Although, there are no pathognomonic abnormalities in brains of schizophrenia patients, recent years have witnessed research progresses in revealing pathologic changes in cellular and molecular levels.  ...  In support of this theory, KYNA has been found to be elevated in the CSF of drug-naïve first episode schizophrenia patients 66 , as well as in chronically ill patients 67 .  ... 
doi:10.5567/pharmacologia.2015.438.453 fatcat:bbsejgkmyjh63iudagd5de7gre

Schizotypal Personality Disorder: A Current Review

Daniel R. Rosell, Shira E. Futterman, Antonia McMaster, Larry J. Siever
2014 Current Psychiatry Reports  
In this review we discuss recent findings of SPD related to epidemiology and functional impairment; heritability and genetics; working memory and cognitive impairments; social-affective disturbances; and  ...  Additionally, we examine the challenges associated with treating patients with SPD, as well as clinical recommendations. Finally, we address future directions and areas in need of further exploration.  ...  However, a recent study of neuroleptic-naïve men with SPD demonstrated widespread reductions in cortical gray matter volumes, including the frontal lobe; and no regions were identified with larger cortical  ... 
doi:10.1007/s11920-014-0452-1 pmid:24828284 pmcid:PMC4182925 fatcat:7uoyv5npyrbjfjgdmmbmf226je

Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings

Robert K. McNamara, Ruth H. Asch, Diana M. Lindquist, Robert Krikorian
2017 Prostaglandins, Leukotrienes and Essential Fatty Acids  
Unesterified DHA readily diffuses from plasma to brain [5, 6] , and preferentially accumulates in gray matter synaptasomal and mitochondrial membranes [7] .  ...  PUFA insufficiency leads to cortical AA deficits and associated decreases in the AA/DHA ratio [9] .  ...  Acknowledgments This work was supported in part by National Institute of Health grants DK097599, MH097818, and MH107378 to R.K.M.  ... 
doi:10.1016/j.plefa.2017.05.001 pmid:28529008 pmcid:PMC5680156 fatcat:jh2wrcb7xra5nddrt6epigw54u

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

Piotr Podwalski, Krzysztof Szczygieł, Ernest Tyburski, Leszek Sagan, Błażej Misiak, Jerzy Samochowiec
2020 Pharmacological Reports  
DTI allows us to reconstruct, visualize, and evaluate certain qualities of white matter.  ...  To date, many studies have sought to associate various changes in the distribution of diffusion within the brain with mental diseases and disorders.  ...  Structural changes in the corpus callosum may be present even in the first episode of the diseasesuch patients have decreased FA and increased RD, which is important for identifying biomarkers of this  ... 
doi:10.1007/s43440-020-00177-0 pmid:33125677 fatcat:zg2frykzvjfnphveluhvrcuqjm
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