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Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics

Marco Lorenzi, Andre Altmann, Boris Gutman, Selina Wray, Charles Arber, Derrek P. Hibar, Neda Jahanshad, Jonathan M. Schott, Daniel C. Alexander, Paul M. Thompson, Sebastien Ourselin
2018 Proceedings of the National Academy of Sciences of the United States of America  
| Alzheimer's disease | brain atrophy | TRIB3 | neuroimaging  ...  The joint modeling of brain imaging information and genetic data is a promising research avenue to highlight the functional role of genes in determining the pathophysiological mechanisms of Alzheimer's  ...  The ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering, and it is also funded through generous contributions from the following: AbbVie  ... 
doi:10.1073/pnas.1706100115 pmid:29511103 fatcat:wizqci5xgrhhddfk3xx4culmea

Disease status affects the association between rs4813620 and the expression of Alzheimer's disease susceptibility geneTRIB3

Guiyou Liu, Shuilin Jin, Yang Hu, Qinghua Jiang
2018 Proceedings of the National Academy of Sciences of the United States of America  
This work was partially supported by funding from the National Key R&D Program of China (2016YFC1202302 and 2017YFSF090117), Natural Science Foundation of Heilongjiang Province (F2015006), National Nature  ...  Science Foundation of China Grants 61822108 and 61571152, and the Fundamental Research Funds for the Central Universities (AUGA5710001716).  ...  1 Lorenzi M, et al.; Alzheimer's Disease Neuroimaging Initiative (2018) Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics.  ... 
doi:10.1073/pnas.1812975115 fatcat:ngyledwnvfdutgevv5oaodfgcy

Epidemiology/Genetics

2014 Diabetes  
A 75 g OGTT underwent at 6-8 weeks after delivery in 179 GDM patients.  ...  The rates of DM, IGT, IFG and IGR were 20.1% (36/179), 17.3% (31/179), 3.3% (6/179) and 5% (9/179) respectively. (2) Compared to the women who reverted to normal, women with AGM showed shorter pregnant  ...  Both genetic and epigenetic variation contributes to susceptibility of human disease.  ... 
doi:10.2337/db14-1317-1629 fatcat:osja3wyrmzgsdmn5tfu5t6c42q