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Susceptibility induced gray–white matter MRI contrast in the human brain

Christian Langkammer, Nikolaus Krebs, Walter Goessler, Eva Scheurer, Kathrin Yen, Franz Fazekas, Stefan Ropele
2012 NeuroImage  
Keywords: MR phase contrast Susceptibility contrast Gray-white matter contrast Brain iron Myelin MR phase images have shown significantly improved contrast between cortical gray and white matter regions  ...  For a closer investigation of iron and myelin induced susceptibility changes, postmortem MRI of six human corpses (age range at death: 56-80 years) was acquired in situ.  ...  Acknowledgments This work was supported by the Austrian Science Fund (projects P20103 and P23576).  ... 
doi:10.1016/j.neuroimage.2011.08.045 pmid:21893208 pmcid:PMC3236994 fatcat:orcimzqftfbo3pegih55gznteu

The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain

Jongho Lee, Karin Shmueli, Byeong-Teck Kang, Bing Yao, Masaki Fukunaga, Peter van Gelderen, Sara Palumbo, Francesca Bosetti, Afonso C. Silva, Jeff H. Duyn
2012 NeuroImage  
The demyelinated brains showed significantly increased T 2 * in white matter and a substantial reduction in gray-white matter frequency contrast, suggesting that myelin is a primary source for these contrasts  ...  Comparison of in-vivo and in-vitro data showed that, although tissue T 2 * values were reduced by formalin fixation, gray-white matter frequency contrast was relatively unaffected and fixation had a negligible  ...  Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIH, NINDS. The authors appreciate useful comments from Dr. Hang Joon Jo at NIH.  ... 
doi:10.1016/j.neuroimage.2011.10.076 pmid:22056461 pmcid:PMC3288572 fatcat:bvunqeu4lvfytkth6e33pdny4y

On the contribution of deoxy-hemoglobin to MRI gray–white matter phase contrast at high field

Jongho Lee, Yoshiyuki Hirano, Masaki Fukunaga, Afonso C. Silva, Jeff H. Duyn
2010 NeuroImage  
High field (≥ 7 T) MRI studies based on signal phase have been used to improve visualization of the fine structure of the brain, most notably the major white matter fiber bundles, the gray-white matter  ...  gray and white matter.  ...  This research was supported by the Intramural Research Program of the NIH, NINDS. Lee et al.  ... 
doi:10.1016/j.neuroimage.2009.07.017 pmid:19619663 pmcid:PMC2764809 fatcat:hvy5pfb7ubflzdgw3yfcikufmi

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast

Masaki Fukunaga, Tie-Qiang Li, Peter van Gelderen, Jacco A. de Zwart, Karin Shmueli, Bing Yao, Jongho Lee, Dragan Maric, Maria A. Aronova, Guofeng Zhang, Richard D. Leapman, John F. Schenck (+2 others)
2010 Proceedings of the National Academy of Sciences of the United States of America  
Most notably, in cortical gray matter, strong contrast variations have been observed that appear to reflect the local laminar architecture.  ...  However, the susceptibility differences seen in this region are opposite to what is expected for myelin-rich regions based on the contrast differences between white matter and cortex and therefore argue  ...  Areas of increased R 2 * relaxation in the white matter show increased iron staining. In the gray matter, a laminar distribution of iron is observed with a pattern that resembles the MRI contrast.  ... 
doi:10.1073/pnas.0911177107 pmid:20133720 pmcid:PMC2840419 fatcat:bo5yhmahc5d3jkxclgefvmltva

Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings

Wei Li, Bing Wu, Alexandru V. Avram, Chunlei Liu
2012 NeuroImage  
The source of susceptibility anisotropy in white matter is likely to be myelin as evidenced by the loss of anisotropy in the dysmyelinating shiverer mouse brain.  ...  In this study, we investigated the orientation dependence of susceptibility of human brain in vivo and mouse brains ex vivo.  ...  The imaging of mouse brains was carried out at the Center of In Vivo Microscopy of Duke University. In vivo human imaging was conducted at the Brain Imaging and Analysis Center of Duke University.  ... 
doi:10.1016/j.neuroimage.2011.10.038 pmid:22036681 pmcid:PMC3254777 fatcat:ga6ittd2pzhgfo26imjpythvxa

Fusion of quantitative susceptibility maps and T1-weighted images improve brain tissue contrast in primates [article]

Rakshit Dadarwal, Michael Ortiz-Rios, Susann Boretius
2021 bioRxiv   pre-print
AbstractRecent progress in quantitative susceptibility mapping (QSM) has enabled the accurate delineation of submillimeter scale subcortical brain structures in humans.  ...  QSM reflects the magnetic susceptibility arising from the spatial distribution of iron, myelin, and calcium in the brain.  ...  T1w is typically used in human and NHP brain atlases due to its excellent white and gray matter contrast.  ... 
doi:10.1101/2021.10.05.462876 fatcat:zopgdrzhovfq3dvaz3pgbvspzy

The contribution of chemical exchange to MRI frequency shifts in brain tissue

Karin Shmueli, Stephen J. Dodd, Tie-Qiang Li, Jeff H. Duyn
2010 Magnetic Resonance in Medicine  
The sign of the gray-white matter exchange-induced frequency difference was opposite to the overall gray-white matter frequency difference observed in vivo.  ...  macromolecular protons may contribute substantially to the observed gray-white matter frequency contrast.  ...  We also thank Dr Karen Keeran and Dr Tim Hunt for the pig brain tissue. We are grateful to Dr Doug Morris for practical assistance with chemical shift imaging experiments.  ... 
doi:10.1002/mrm.22604 pmid:20928888 pmcid:PMC3005099 fatcat:jcviuskmqraszegtlralpbty2u

Susceptibility-weighted imaging and quantitative susceptibility mapping in the brain

Chunlei Liu, Wei Li, Karen A. Tong, Kristen W. Yeom, Samuel Kuzminski
2014 Journal of Magnetic Resonance Imaging  
; iron; myelin; TBI; traumatic brain injury; multiple sclerosis; stroke TRADITIONALLY, magnetic susceptibility-induced field perturbation is mostly regarded as a source of image artifacts in magnetic resonance  ...  Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique that enhances image contrast by using the susceptibility differences between tissues.  ...  Chemical exchange between mobile protons and proteins does affect the phase contrast between gray and white matter and it decreases the susceptibility-induced contrast (74) .  ... 
doi:10.1002/jmri.24768 pmid:25270052 pmcid:PMC4406874 fatcat:gyq5hcecdrf4dnujswgqtgmicm

Conventional and functional magnetic resonance imaging features of late subacute cortical laminar necrosis in a dog

Neringa Alisauskaite, Adriano Wang‐Leandro, Matthias Dennler, Marta Kantyka, Simone K. Ringer, Frank Steffen, Katrin Beckmann
2019 Journal of Veterinary Internal Medicine  
Three-Tesla MRI examination of the brain revealed bilateral asymmetrical areas of T2-weighted hyperintensity within the occipital, parietal, temporal, and frontal cortex, involving gray and white matter  ...  In humans, these cortical lesions show characteristic linear T1-weighted (T1W) hyperintensity in the late subacute stage.  ...  in a dog. 5, 7, 12 In humans affected by CLN, white matter changes detected on MRI appear approximately 1 month after the hypoxic events and tend to increase with time. 5, 7 In humans, increased T2W  ... 
doi:10.1111/jvim.15526 pmid:31120629 pmcid:PMC6639491 fatcat:uwlcry6oirhunchzk5nkn7j4uu

Monitoring Brain Repair in Stroke Using Advanced Magnetic Resonance Imaging

L. K. Sztriha, R. L. O'Gorman, M. Modo, G. J. Barker, S. C. R. Williams, L. Kalra
2012 Stroke  
The online-only Data Supplement is available with this article at http://stroke.ahajournals.org/lookup/suppl/  ...  to study white matter structure, and MRI also provides tools to measure dimensions of gray matter.  ...  . 72, 85 Increases in gray matter have been demonstrated in compensatory brain regions of chronic stroke patients 86 and after constraint-induced movement therapy in parallel with functional improvements  ... 
doi:10.1161/strokeaha.111.649244 pmid:23010674 fatcat:kcahaifvmng7lizeuxwveluc5y

Prenatal alcohol exposure reduces magnetic susceptibility contrast and anisotropy in the white matter of mouse brains

Wei Cao, Wei Li, Hui Han, Shonagh K. O'Leary-Moore, Kathleen K. Sulik, G. Allan Johnson, Chunlei Liu
2014 NeuroImage  
Diffusion tensor imaging (DTI) has shown that abnormalities in brain white matter especially the corpus callosum are very common in FASD.  ...  Although this is a preclinical study, the technique of QSM is readily translatable to human brain.  ...  Acknowledgments The study was supported in part by the National Institutes of Health (NIH) through grant P41EB015897, R01MH096979, U01-AA017124, U01-AA021651, and P60-AA011605 and the National Multiple  ... 
doi:10.1016/j.neuroimage.2014.08.035 pmid:25175539 pmcid:PMC4252734 fatcat:aahrrphedze3zcakpkjfscezuu

Susceptibility tensor imaging (STI) of the brain

Wei Li, Chunlei Liu, Timothy Q. Duong, Peter C. M. van Zijl, Xu Li
2016 NMR in Biomedicine  
In contrast to diffusion anisotropy, the main determinant factor of susceptibility anisotropy in brain white matter is myelin.  ...  Similar to diffusion tensor imaging (DTI), STI allows mapping of brain white matter fiber orientations and reconstruction of 3D white matter pathways using the principal eigenvectors of the susceptibility  ...  Acknowledgement This work was supported in part by the National Institutes of Health (NIH) through grants R01 MH096979 and R01NS079653 to CL and P41 EB015909 to PvZ, a Research Grant from the William &  ... 
doi:10.1002/nbm.3540 pmid:27120169 pmcid:PMC5083244 fatcat:oaye4p5ekrcl3dyww7ljlllcv4

Quantitative magnetic susceptibility of the developing mouse brain reveals microstructural changes in the white matter

Ioannis Argyridis, Wei Li, G. Allan Johnson, Chunlei Liu
2014 NeuroImage  
During the first two weeks, susceptibility of white matter appeared paramagnetic relative to surrounding gray matter; it then gradually became more diamagnetic.  ...  It is confirmed that the main source of susceptibility contrast in WM is the myelin content.  ...  The authors thank discussions with Carlo Pierpaoli, MD, PhD, on the origins of the apparent paramagnetic susceptibility during early brain development.  ... 
doi:10.1016/j.neuroimage.2013.11.026 pmid:24269576 pmcid:PMC4031305 fatcat:zh2wftkn4rdljj67mn5ik4eium

Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study

Christian Langkammer, Ferdinand Schweser, Nikolaus Krebs, Andreas Deistung, Walter Goessler, Eva Scheurer, Karsten Sommer, Gernot Reishofer, Kathrin Yen, Franz Fazekas, Stefan Ropele, Jürgen R. Reichenbach
2012 NeuroImage  
In conclusion, iron is the dominant source of magnetic susceptibility in deep gray matter and can be assessed with QSM.  ...  was much lower in white matter (r= 0.27, p b 0.001).  ...  Christian Langkammer was supported by the Austrian Science Fund (FWF, project number P23576).  ... 
doi:10.1016/j.neuroimage.2012.05.049 pmid:22634862 pmcid:PMC3413885 fatcat:fnoz53eh5nhsbluxrnwpkkdrjy

Cerebral White and Gray Matter Injury in Newborns

Stephen A. Back
2014 Clinics of Perinatology  
These recently recognized forms of cerebral gray and white matter dysmaturation suggest new therapeutic directions centered on reversal of the processes that promote dysmaturation.  ...  White matter injury results in myelination disturbances related to aberrant responses to death of pre-myelinating oligodendrocytes (preOLs).  ...  Evelyn McClendon for their many helpful suggestions in the preparation of the manuscript.  ... 
doi:10.1016/j.clp.2013.11.001 pmid:24524444 pmcid:PMC3947650 fatcat:jba27f2jnbbzjebq4bognux45m
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